102
Views
6
CrossRef citations to date
0
Altmetric
Review

Degarelix and its therapeutic potential in the treatment of prostate cancer

, &
Pages 215-223 | Published online: 05 May 2009

References

  • JemalASiegelRWardECancer statistics, 2008CA Cancer J Clin2008582719618287387
  • WiltTJMacDonaldRRutksIShamliyanTATaylorBCKaneRLSystematic review: comparative effectiveness and harms of treatments for clinically localized prostate cancerAnn Intern Med2008148643544818252677
  • KlotzLActive surveillance for prostate cancer: trials and tribulationsWorld J Urol200826543744218813934
  • AntonarakisESBlackfordALGarrett-MayerEEisenbergerMASurvival in men with nonmetastatic prostate cancer treated with hormone therapy: a quantitative systematic reviewJ Clin Oncol200725314998500817971600
  • ThompsonIThrasherJBAusGAUA Prostate Cancer Clinical Guideline Update Panel. Guideline for the management of clinically localized prostate cancer: 2007 updateJ Urol200717762106213117509297
  • LoblawDAVirgoKSNamRAmerican Society of Clinical Oncology. Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guidelineJ Clin Oncol200725121596160517404365
  • HugginsCStevensREJrHodgesCVStudies on prostate cancer. II. The effect of castration on advanced carcinoma of the prostate glandArch Surg194143209223
  • MontironiRMagi-GalluzziCMuzzonigroGPreteEPolitoMFabrisGEffects of combination endocrine treatment on normal prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinomaJ Clin Pathol199447109069137525657
  • CastellónEClementiMHitschfeldCEffect of leuprolide and cetrorelix on cell growth, apoptosis, and GnRH receptor expression in primary cell cultures from human prostate carcinomaCancer Invest200624326126816809153
  • SeidenfeldJSamsonDJHasselbladVSingle-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysisAnn Intern Med2000132756657710744594
  • McLeodDGHormonal therapy: historical perspective to future directionsUrology2003612 Suppl 13712667881
  • CookTSheridanWPDevelopment of GnRH antagonists for prostate cancer: new approaches to treatmentOncologist20005216216810794807
  • HuirneJALambalkCBGonadotropin-releasing-hormone-receptor antagonistsLancet200135892951793180311734258
  • KlotzLBoccon-GibodLShoreNDThe efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in patients with prostate cancerBJU Int2008102111531153819035858
  • JiangGStalewskiJGalyeanRGnRH antagonists: a new generation of long acting analogues incorporating p-Ureido-phenylalanines at position 5 and 6J Med Chem200144345346711462984
  • BroquaPRivierePJMConnPMRivierJEAubertMLJunienJLPharmacological profile of a new, potent and long-acting gonadotropin-releasing hormone antagonist: degarelixJ Pharmacol Exp Ther200230119510211907162
  • SchwachGOudryNDelhommeSLuckMLindnerHGurnyRBiogradable microparticles for sustained release of a new GnRH antagonist – part I: screening commercial PLGA and formulation technologiesEur J Pharm Biophar2003563327336
  • WestonPMTHammondsJVaughton OlesenTKJensenJKEskerodOPerssonBEDegarelix; a novel GnRH antagonist tested in a multicentre, randomized dose-finding study in prostate cancer patientsBJU Int200494Suppl 25715217431
  • TammelaTIversenPJohanssonJPerssonBJensenOlsenTDegarelix Study groupDegarelix; a phase II multicenter, randomised dose-escalating study testing a novel GnRH receptor blocker in prostate cancer patientsEur Urol Suppl200543228
  • GittelmanMPommervillePJPerssonBEJensenJKOlesenTKDegarelix Study GroupA 1-year, open label, randomized phase II dose finding study of degarelix for the treatment of prostate cancer in North AmericaJ Urol200818051986199218801505
  • Van PoppelHTombalBde la RosetteJJDegarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker–results from a 1-yr, multicentre, randomised, phase 2 dosage-finding study in the treatment of prostate cancerEur Urol200854480581318538469
  • DoehnCSommerauerMJochamDDrug evaluation: Degarelix – a potential new therapy for prostate cancerIDrugs20069856557216871466
  • US Food and Drug AdministrationDegarelix. Dec 29, 2008. Accessed on Feb 14, 2009. Available from: http://www.fda.gov/cder/Offices/OODP/whatsnew/Degarelix.htm
  • BubleyGJIs the flare phenomenon clinically significant?Urology2001582 Suppl 15911502435
  • US Food and Drug AdministrationPlenaxis (abarelix for injectable suspension) Nov 25, 2003. Accessed on Feb 14, 2009. Available from: http://www.fda.gov/cder/drug/infopage/plenaxis/default.htm
  • Speciality European Pharma2009Accessed on Feb 14, 2009. Available from: http://www.specialityeuropeanpharma.com
  • Lu-YaoGLAlbertsenPCMooreDFSurvival following primary androgen deprivation therapy among men with localized prostate cancerJAMA2008300217318118612114
  • KeatingNLO’MalleyAJSmithMRDiabetes and cardiovascular disease during androgen deprivation therapy for prostate cancerJ Clin Oncol200624274448445616983113
  • PotoskyALKnopfKCleggLXQuality-of-life outcomes after primary androgen deprivation therapy: results from the Prostate Cancer Outcomes StudyJ Clin Oncol200119173750375711533098
  • SharifiNGulleyJLDahutWLAndrogen deprivation therapy for prostate cancerJAMA2005294223824416014598
  • MottetNPrayer-GalettiTHammererPKattanMWTunnUOptimizing outcomes and quality of life in the hormonal treatment of prostate cancerBJU Int2006981202716566812
  • SaigalCSGoreJLKrupskiTLHanleyJSchonlauMLitwinMSAnd the Urologic Diseases in America ProjectAndrogen deprivation therapy increases cardiovascular morbidity in men with prostate cancerCancer200711071493150017657815