242
Views
15
CrossRef citations to date
0
Altmetric
Reviews

The role for N-acetylcysteine in the management of COPD

&
Pages 99-106 | Published online: 20 Oct 2022

References

  • AbboudRTFeraTRichterA1985Acute effect of smoking on the functional activity of alpha1- protease inhibitor in bronchoalveolar lavage fluidAm Rev Respir Dis13179853871315
  • AkaikeTAndoMOdaT1990Dependence on O2− generation by xanthine oxidase of pathogenesis of influenza virus infection in miceJ Clin Invest85739452155924
  • AruomaOIHalliwellBHoeyBM1989The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acidJ Free Radic Biol Med65937
  • BarnesPJ2000Chronic obstructive pulmonary diseaseN Engl J Med34342698010911010
  • BergstrandHBjörnsonAEklundA1986Stimuli-induced superoxide radical generation in vitro by human alveolar macrophages from smokers: modulation by N-acetylcysteine treatment in vivoJ Free Radic Biol Med2119273029208
  • BiagioliMCKaulPSinghI1999The role of oxidative stress in rhinovirus induced elaboration of IL-8 by respiratory epithelial cellsJ Free Radic Biol Med2645462
  • BridgemanMMMarsdenMMacNeeW1991Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteineThorax4639421871695
  • BridgemanMMMarsdenMSelbyC1994Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissueThorax4967058066561
  • BridgesRB1985Protective action of thiols on neutrophil functionEur J Respir Dis66Suppl 1394082858401
  • BorgstromLKagedalBPaulsenO1986Pharmacokinetics of N-acetylcysteine in manEur J Clin Pharmacol31217223803419
  • BorregaardNJensenHSBjerrumOW1987Prevention of tissue damage: inhibition of myeloperoxidase mediated inactivation of alpha 1-proteinase inhibitor by N-acetyl cysteine, glutathione, and methionineAgents Actions22255602833080
  • CantinACrystalRG1985Oxidants, antioxidants and the pathogenesis of emphysemaEur J Respir Dis66Suppl 139717
  • CantinAMNorthSLHubbardR1987Normal alveolar epithelial lining fluid contains high levels of glutathioneJ Appl Physiol6315273040659
  • CorradiMMontuschiPDonnellyLE2001Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseasesAm J Respir Crit Care Med163854811282756
  • CotgreaveIA1997N-acetylcysteine: pharmacological considerations and experimental and clinical applicationsAdv Pharmacol38205278895810
  • CotgreaveIAEklundALarssonK1987No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluidEur J Respir Dis707373817074
  • CotgreaveIAMoldeusP1987Lung protection by thiol-containing antioxidantsBull Eur Physiopathol Respir2327573318962
  • De BenedettoFAcetoADraganiB2005Long-term treatment oral N-actylcysteine (NAC) reduces exhaled hydrogen peroxide in stable COPDPulm Pharmacol Ther1841715607126
  • DecramerMRutten-van MolkenMDekhuijzenPNR2005Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary diseases (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trialLancet36515526015866309
  • De FloraSGrassiCCaratiL1997Attenuation of influenza symptomatology and improvement of immunological parameters due to long-term treatment with N-acetylcysteineEur Respir J101535419230243
  • DekhuijzenPNR2004Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary diseaseEur Respir J236293615083766
  • DekhuijzenPNRAbenKKHDekkerI1996Increased exhalation of hydrogen peroxide in patients with stable and unstable COPDAm J Respir Crit Care Med15481368810624
  • DemedtsMBehrJBuhlRIFIGENIA Study Group2005High-dose acetylcysteine in idiopathic pulmonary fibrosisN Engl J Med35322294216306520
  • DrostELannanSBridgemanMME1991Lack of effect of N-acetylcysteine on the release of oxygen radicals from neutrophils and alveolar macrophagesEur Respir J472391889500
  • EklundAErikssonOHakanssonL1988Oral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variablesEur Respir J183282852604
  • GhezziPDinarelloCABianchiM1991Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mono-nuclear cellsCytokine3189941883957
  • GrandjeanEMBerthetPRuffmannR2000Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trialsClin Ther222092110743980
  • JankowskaRPassowicz MuszynskaEMedralaW1993The influence of n-acetylcysteine on chemiluminescence of granulocytes in peripheral blood of patients with chronic bronchitisPneumonol Alergol Pol61586918148757
  • JefferyPK2002The pathology of COPD and exacerbationsEur Respir Rev1224
  • JefferyPKRogersDFAyersMM1985Effect of oral acetylcysteine on tobacco smoke-induced secretory cell hyperplasiaEur J Respir Dis66Suppl 13911722
  • KasielskiMNowakD2001Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary diseaseRespir Med954485611421501
  • KnobilKChoiAMWeigandGW1998Role of oxidants in influenza virus-induced gene expressionAm J Physiol274L134429458811
  • LaurentPJanoffAKaganHM1983Cigarette smoke blocks cross-linking of elastin in vitroAm Rev Respir Dis127189926830036
  • LindenMWieslanderEEklundA1988Effects of oral N-acetylcysteine on cell content and macrophage function in bronchoalveolar lavage from healthy smokersEur Respir J1645502846345
  • LundbäckBLindströmMAnderssonS1992Possible effect of acetylcystein on lung functionEur Respir J5Suppl 15S289
  • MacNeeW2000Oxidants/antioxidants and COPDChest117Suppl 1S30317
  • MacNeeW2001Oxidative stress and lung inflammation in airways diseaseEur J Pharmacol42919520711698041
  • MacNeeWRahmanI1999Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med160S586510556172
  • MacNeeWWiggsBBelzbergAS1989The effect of cigarette smoking on neutrophil kinetics in human lungsN Engl J Med32192482779614
  • MateosFBrockJHPerez-ArellanoJL1998Iron metabolism in the lower respiratory tractThorax535946009797761
  • MaranzanaAMehlhornRJ1998Loss of glutathione, ascorbate recycling, and free radical scavenging in human erythrocytes exposed to filtered cigarette smokeArch Biochem Biophys350169829473290
  • MaruiNOffermannMKSwerlickR1993Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cellsJ Clin Invest921866747691889
  • MetinkoAPKunkelSLStandifordTJ1992Anoxia-hyperoxia induces monocyte-derived interleukin-8J Clin Invest9079181522234
  • MoldeusPBerggrenMGraffströmR1985N-acetylcysteine protection against the toxicity of cigarette smoke and cigarette smoke condensates in various tissues and cells in vitroEur J Respir Dis66Suppl 1391239
  • MoldeusPCotgreaveIABerggrenM1986Lung protection by a thiol-containing antioxidant: N-acetylcysteineRespiration5031423809741
  • MontuschiPCollinsJVCiabattoniG2000Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokersAm J Respir Crit Care Med1621175710988150
  • MorrisonDRahmanILannanS1999Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokersAm J Respir Crit Care Med15947399927360
  • NowakDKasielskiMAntczakA1999Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smokingRespir Med933899610464820
  • PauwelsRABuistASCalverleyPMAon behalf of the GOLD Scientific Committee2001Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop SummaryAm J Respir Crit Care Med16312567611316667
  • PoolePJBlackPN2001Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic reviewBr Med J3221271411375228
  • RahmanIMacNeeW1996Role of oxidants/antioxidants in smoking-induced lung diseasesFree Radic Biol Med21669818891669
  • RahmanIMacNeeW1999Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway diseaseAm J Physiol277L10678810600876
  • RahmanIMacNeeW2000Oxidative stress and regulation of glutathione in lung inflammationEur Respir J165345411028671
  • RahmanIMorrisonDDonaldsonK1996Systemic oxidative stress in asthma, COPD, and smokersAm J Respir Crit Care Med1541055608887607
  • RahmanISkwarskaEMacNeeW1997Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary diseaseThorax5256589227727
  • RepineJELankhorstILMDebackerWA1997Oxidative stress in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med156341579279209
  • RodensteinDDeCosterAGazzanigaA1978Pharmacokinetics of oral acetylcysteine: absorption, binding and metabolism in patients with respiratory disordersClin Pharmacokinet324754657688
  • RiiseGCQvarfordtILarssonS2000Inhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitroRespiration67552811070462
  • RubioMLSanchez-CifuentesMVOrtegaM2000N-acetylcysteine prevents cigarette smoke induced small airways alterations in ratsEur Respir J155051110759444
  • SadowskaAMvan OverveldFJGoreckaD2005The interrelationship between markers of inflammation and oxidative stress in chronic obstructive pulmonary disease: modulation by inhaled steroids and antioxidantRespir Med99241915715193
  • SchleissMBHolzOBehnkeM2000The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rateEur Respir J161115811292115
  • SchreckRAlbermannKBaeuerlePA1992Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review)Free Radic Res Commun17221371473734
  • SheffnerALMedlerEMBaileyKR1966Metabolic studies with acetylcysteineBiochem Pharmacol151523355971807
  • SteyCSteurerJBachmannS2000The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic reviewEur Respir J162536210968500
  • StreightoffFRedmanCEDeLongDC1996In vivo antiviral chemotherapy. II. Anti-influenza action of compounds affecting mucous secretionsAntimicrobial Agents Chemother65038
  • VoisinCAertsCWallaertB1987Prevention of in vitro oxidant-mediated alveolar macrophage injury by cellular glutathione and precursorsBull Eur Physiopathol Respir23309132825864
  • WarrenJSJohnsonKJWardPACrystalRGWestJBWeibelER1997Consequences of oxidant injuryThe lung: scientific foundations2nd edNew YorkRaven Press, Ltd227988
  • ZuinRPalamideseANegrinR2005High-dose N-acetylcysteine in patients with exacerbations of chronic obstructive pulmonary diseaseClin Drug Invest254018