Prolylcarboxypeptidase (PRCP) as a new target for obesity treatment

References

• Eves PC MacNeil S Haycock JW Alpha-Melanocyte stimulating hormone, inflammation and human melanoma Peptides 2006 27 444 452 16274844
   PubMed Web of Science ®Google Scholar
• Lasaga M Debeljuk L Durand D Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation Peptides 2008 29 1825 1835 18625277
   PubMed Web of Science ®Google Scholar
• Oktar BK Alican I Modulation of the peripheral and central inflammatory responses by alpha-melanocyte stimulating hormone Curr Protein Pept Sci 2002 3 623 628 12470216
   PubMed Web of Science ®Google Scholar
• Olszewski PK Bomberg EM Grace MK Alpha-melanocyte stimulating hormone and ghrelin: central interaction in feeding control Peptides 2007 28 2084 2089 17719137
   PubMed Web of Science ®Google Scholar
• Konig S Luger TA Scholzen TE Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin Exp Dermatol 2006 15 751 761 16984256
   PubMed Web of Science ®Google Scholar
• Gao Qian Horvath Tamas L Neurobiology of Feeding and Energy Expenditure Annual Review of Neuroscience 2007 30 367 398 Ref Type: Generic
   Web of Science ®Google Scholar
• Odya CE Marinkovic DV Hammon KJ Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney J Biol Chem 1978 253 5927 5931 28321
   PubMed Web of Science ®Google Scholar
• Dharmani M Mustafa MR Achike FI Effects of angiotensin 1–7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats Eur J Pharmacol 2007 561 144 150 17320855
   PubMed Web of Science ®Google Scholar
• Kassiri Z Zhong J Guo D Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction Circ Heart Fail 2009 2 446 455 19808375
   PubMed Web of Science ®Google Scholar
• Giani JF Gironacci MM Munoz MC Angiotensin-(1–7) has a dual role on growth-promoting signalling pathways in rat heart in vivo by stimulating STAT3 and STAT5a/b phosphorylation and inhibiting angiotensin II-stimulated ERK1/2 and Rho kinase activity Exp Physiol 2008 93 570 578 18448663
   PubMed Web of Science ®Google Scholar
• Nie W Yan H Li S Angiotensin-(1–7) enhances angiotensin II induced phosphorylation of ERK1/2 in mouse bone marrow-derived dendritic cells Mol Immunol 2009 46 355 361 19041135
   PubMed Web of Science ®Google Scholar
• Rice GI Thomas DA Grant PJ Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Biochem J 2004 383 45 51 15283675
   PubMed Web of Science ®Google Scholar
• Huentelman MJ Grobe JL Vazquez J Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats Exp Physiol 2005 90 783 790 16049057
   PubMed Web of Science ®Google Scholar
• Felix D Khosla MC Barnes KL Neurophysiological responses to angiotensin-(1–7) Hypertension 1991 17 1111 1114 2045157
   PubMed Web of Science ®Google Scholar
• Gammelgaard I Wamberg S Bie P Systemic effects of angiotensin III in conscious dogs during acute double blockade of the renin-angiotensin-aldosterone-system Acta Physiol (Oxf) 2006 188 129 138 16948800
   PubMed Web of Science ®Google Scholar
• Al-Aloul B Li JM Benditt D Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn’s syndrome) Pacing Clin Electrophysiol 2006 29 1303 1305 17100688
   PubMed Web of Science ®Google Scholar
• Shariat-Madar Z Mahdi F Schmaier AH Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator J Biol Chem 2002 277 17962 17969 11830581
   PubMed Web of Science ®Google Scholar
• Zhao Y Qiu Q Mahdi F Assembly and activation of HK-PK complex on endothelial cells results in bradykinin liberation and NO formation Am J Physiol Heart Circ Physiol 2001 280 H1821 H1829 11247797
   PubMed Web of Science ®Google Scholar
• Colman RW Schmaier AH Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes Blood 1997 90 3819 3843 9354649
   PubMed Web of Science ®Google Scholar
• Adams GN Zhou Y Larusch G Prolylcarboxypeptidase murine hypomorphs are hypertensive and prothrombotic Journal of Thrombosis and Haemostasis 7 Supplement 2 XXII ISTH Congress, Abstract OC-MO-128 2009 Ref Type: Abstract
   Google Scholar
• Piepoli MF Scott AC Capucci A Skeletal muscle training in chronic heart failure Acta Physiol Scand 2001 171 295 303 11412141
   PubMedGoogle Scholar
• Scott AC Wensel R Davos CH Skeletal muscle reflex in heart failure patients: role of hydrogen Circulation 2003 107 300 306 12538432
   PubMed Web of Science ®Google Scholar
• Scott AC Wensel R Davos CH Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on Ace-inhibitor therapy for chronic heart failure Eur Heart J 2004 25 1806 1813 15474695
   PubMed Web of Science ®Google Scholar
• Mallela J Yang J Shariat-Madar Z Prolylcarboxypeptidase: a cardioprotective enzyme Int J Biochem Cell Biol 2009 41 477 481 18396440
   PubMed Web of Science ®Google Scholar
• Catania A Rajora N Capsoni F The neuropeptide alpha-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro Peptides 1996 17 675 679 8804079
   PubMed Web of Science ®Google Scholar
• Wallingford N Perroud B Gao Q Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents J Clin Invest 2009 119 2291 2303 19620781
   PubMed Web of Science ®Google Scholar
• Chiao H Foster S Thomas R Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation J Clin Invest 1996 97 2038 2044 8621792
   PubMed Web of Science ®Google Scholar
• Kim F Pham M Maloney E Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance Arterioscler Thromb Vasc Biol 2008 28 1982 1988 18772497
   PubMed Web of Science ®Google Scholar
• Pieper GM Dondlinger L Glucose elevations alter bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells Cardiovasc Res 1997 34 169 178 9217887
   PubMed Web of Science ®Google Scholar
• Bullo M Casas-Agustench P migo-Correig P Inflammation, obesity and comorbidities: the role of diet Public Health Nutr 2007 10 1164 1172 17903326
   PubMed Web of Science ®Google Scholar
• Kaneki M Shimizu N Yamada D Nitrosative stress and pathogenesis of insulin resistance Antioxid Redox Signal 2007 9 319 329 17184170
   PubMed Web of Science ®Google Scholar
• Tai MH Weng WT Lo WC Role of nitric oxide in alpha-melanocyte-stimulating hormone-induced hypotension in the nucleus tractus solitarii of the spontaneously hypertensive rats J Pharmacol Exp Ther 2007 321 455 461 17283224
   PubMed Web of Science ®Google Scholar
• DeBold CR Menefee JK Nicholson WE Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome Mol Endocrinol 1988 2 862 870 2845257
   PubMedGoogle Scholar
• Tatro JB Reichlin S Specific receptors for alpha-melanocyte-stimulating hormone are widely distributed in tissues of rodents Endocrinology 1987 121 1900 1907 2822378
   PubMed Web of Science ®Google Scholar
• Young JI Otero V Cerdan MG Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice J Neurosci 1998 18 6631 6640 9712635
   PubMed Web of Science ®Google Scholar
• Voisey J Carroll L van DA Melanocortins and their receptors and antagonists Curr Drug Targets 2003 4 586 597 14535656
   PubMed Web of Science ®Google Scholar
• Cool DR Normant E Shen F Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice Cell 1997 88 73 83 9019408
   PubMed Web of Science ®Google Scholar
• Rouille Y Duguay SJ Lund K Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases Front Neuroendocrinol 1995 16 322 361 8557169
   PubMed Web of Science ®Google Scholar
• Guo L Munzberg H Stuart RC N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin Proc Natl Acad Sci U S A 2004 101 11797 11802 15280541
   PubMed Web of Science ®Google Scholar
• Chhajlani V Wikberg JE Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA FEBS Lett 1992 309 417 420 1516719
   PubMed Web of Science ®Google Scholar
• Cone RD Mountjoy KG Robbins LS Cloning and functional characterization of a family of receptors for the melanotropic peptides Ann N Y Acad Sci 1993 680 342 363 8390157
   PubMed Web of Science ®Google Scholar
• Gantz I Miwa H Konda Y Molecular cloning, expression, and gene localization of a fourth melanocortin receptor J Biol Chem 1993 268 15174 15179 8392067
   PubMed Web of Science ®Google Scholar
• Roselli-Rehfuss L Mountjoy KG Robbins LS Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system Proc Natl Acad Sci U S A 1993 90 8856 8860 8415620
   PubMed Web of Science ®Google Scholar
• Konda Y Gantz I DelValle J Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor J Biol Chem 1994 269 13162 13166 8175743
   PubMed Web of Science ®Google Scholar
• Kojima I Kojima K Rasmussen H Role of calcium and cAMP in the action of adrenocorticotropin on aldosterone secretion J Biol Chem 1985 260 4248 4256 2579947
   PubMed Web of Science ®Google Scholar
• Englaro W Rezzonico R Durand-Clement M Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells J Biol Chem 1995 270 24315 24320 7592642
   PubMed Web of Science ®Google Scholar
• Buggy JJ Binding of alpha-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway Biochem J 1998 331 Pt 1 211 216 9512481
   PubMed Web of Science ®Google Scholar
• Rodrigues AR Pignatelli D Almeida H Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism Mol Cell Endocrinol 2009 303 74 81 19428994
   PubMed Web of Science ®Google Scholar
• Wikberg JE Melanocortin receptors: perspectives for novel drugs Eur J Pharmacol 1999 375 295 310 10443584
   PubMed Web of Science ®Google Scholar
• Donatien PD Hunt G Pieron C The expression of functional MSH receptors on cultured human melanocytes Arch Dermatol Res 1992 284 424 426 1337693
   PubMed Web of Science ®Google Scholar
• Suzuki I Cone RD Im S Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis Endocrinology 1996 137 1627 1633 8612494
   PubMed Web of Science ®Google Scholar
• Xia Y Skoog V Muceniece R Polyclonal antibodies against human melanocortin MC1 receptor: preliminary immunohistochemical localisation of melanocortin MC1 receptor to malignant melanoma cells Eur J Pharmacol 1995 288 277 283 7774671
   PubMed Web of Science ®Google Scholar
• Mountjoy KG Robbins LS Mortrud MT The cloning of a family of genes that encode the melanocortin receptors Science 1992 257 1248 1251 1325670
   PubMed Web of Science ®Google Scholar
• Chhajlani V Distribution of cDNA for melanocortin receptor subtypes in human tissues Biochem Mol Biol Int 1996 38 73 80 8932521
   PubMedGoogle Scholar
• Xia Y Wikberg JE Chhajlani V Expression of melanocortin 1 receptor in periaqueductal gray matter Neuroreport 1995 6 2193 2196 8595200
   PubMed Web of Science ®Google Scholar
• Hartmeyer M Scholzen T Becher E Human dermal microvascular endothelial cells express the melanocortin receptor type 1 and produce increased levels of IL-8 upon stimulation with alpha-melanocyte-stimulating hormone J Immunol 1997 159 1930 1937 9257858
   PubMed Web of Science ®Google Scholar
• Wong KY Rajora N Boccoli G A potential mechanism of local anti-inflammatory action of alpha-melanocyte-stimulating hormone within the brain: modulation of tumor necrosis factor-alpha production by human astrocytic cells Neuroimmunomodulation 1997 4 37 41 9326743
   PubMed Web of Science ®Google Scholar
• Star RA Rajora N Huang J Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone Proc Natl Acad Sci U S A 1995 92 8016 8020 7544012
   PubMed Web of Science ®Google Scholar
• Boston BA Cone RD Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line Endocrinology 1996 137 2043 2050 8612546
   PubMed Web of Science ®Google Scholar
• Luger TA Scholzen T Grabbe S The role of alpha-melanocyte-stimulating hormone in cutaneous biology J Investig Dermatol Symp Proc 1997 2 87 93
   PubMedGoogle Scholar
• Lipton JM Catania A Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH Immunol Today 1997 18 140 145 9078687
   PubMedGoogle Scholar
• Manna SK Aggarwal BB Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents J Immunol 1998 161 2873 2880 9743348
   PubMed Web of Science ®Google Scholar
• Schioth HB Chhajlani V Muceniece R Major pharmacological distinction of the ACTH receptor from other melanocortin receptors Life Sci 1996 59 797 801 8761313
   PubMed Web of Science ®Google Scholar
• Xia Y Wikberg JE Localization of ACTH receptor mRNA by in situ hybridization in mouse adrenal gland Cell Tissue Res 1996 286 63 68 8781213
   PubMed Web of Science ®Google Scholar
• Slominski A Ermak G Mihm M ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin J Clin Endocrinol Metab 1996 81 2746 2749 8675607
   PubMed Web of Science ®Google Scholar
• Kapas S Hagi-Pavli E Brown DW Direct effects of corticotrophin on oral keratinocyte cell proliferation Eur J Biochem 1998 256 75 79 9746348
   PubMedGoogle Scholar
• Gantz I Tashiro T Barcroft C Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2–q13.3 by fluorescence in situ hybridization Genomics 1993 18 166 167 8276410
   PubMed Web of Science ®Google Scholar
• Mountjoy KG Wong J Obesity, diabetes and functions for proopiomelanocortin-derived peptides Mol Cell Endocrinol 1997 128 171 177 9140088
   PubMed Web of Science ®Google Scholar
• Gantz I Konda Y Tashiro T Molecular cloning of a novel melanocortin receptor J Biol Chem 1993 268 8246 8250 8463333
   PubMed Web of Science ®Google Scholar
• Ollmann MM Wilson BD Yang YK Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein Science 1997 278 135 138 9311920
   PubMed Web of Science ®Google Scholar
• Bagnol D Lu XY Kaelin CB Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain J Neurosci 1999 19 RC26 10479719
   PubMed Web of Science ®Google Scholar
• Jegou S Boutelet I Vaudry H Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleus J Neuroendocrinol 2000 12 501 505 10844578
   PubMed Web of Science ®Google Scholar
• Cowley MA Smart JL Rubinstein M Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus Nature 2001 411 480 484 11373681
   PubMed Web of Science ®Google Scholar
• Marks DL Hruby V Brookhart G The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R) Peptides 2006 27 259 264 16274853
   PubMed Web of Science ®Google Scholar
• Li WD Joo EJ Furlong EB Melanocortin 3 receptor (MC3R) gene variants in extremely obese women Int J Obes Relat Metab Disord 2000 24 206 210 10702772
   PubMed Web of Science ®Google Scholar
• Schalin-Jantti C Valli-Jaakola K Oksanen L Melanocortin-3-receptor gene variants in morbid obesity Int J Obes Relat Metab Disord 2003 27 70 74 12532156
   PubMed Web of Science ®Google Scholar
• Lee YS Poh LK Loke KY A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity J Clin Endocrinol Metab 2002 87 1423 1426 11889220
   PubMed Web of Science ®Google Scholar
• Rached M Buronfosse A Begeot M Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity Biochim Biophys Acta 2004 1689 229 234 15276649
   PubMed Web of Science ®Google Scholar
• Tao YX Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects Biochim Biophys Acta 2007 1772 1167 1174 17964765
   PubMed Web of Science ®Google Scholar
• Calton MA Ersoy BA Zhang S Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study Hum Mol Genet 2009 18 1140 1147 19091795
   PubMed Web of Science ®Google Scholar
• Mountjoy KG Mortrud MT Low MJ Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain Mol Endocrinol 1994 8 1298 1308 7854347
   PubMed Web of Science ®Google Scholar
• Huszar D Lynch CA Fairchild-Huntress V Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 1997 88 131 141 9019399
   PubMed Web of Science ®Google Scholar
• Yen TT Gill AM Frigeri LG Obesity, diabetes, and neoplasia in yellow A(vy)/– mice: ectopic expression of the agouti gene FASEB J 1994 8 479 488 8181666
   PubMed Web of Science ®Google Scholar
• Marks DL Ling N Cone RD Role of the central melanocortin system in cachexia Cancer Res 2001 61 1432 1438 11245447
   PubMed Web of Science ®Google Scholar
• Fathi Z Iben LG Parker EM Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype Neurochem Res 1995 20 107 113 7739752
   PubMed Web of Science ®Google Scholar
• bdel-Malek ZA Melanocortin receptors: their functions and regulation by physiological agonists and antagonists Cell Mol Life Sci 2001 58 434 441 11315190
   PubMed Web of Science ®Google Scholar
• Chen W Kelly MA Opitz-Araya X Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides Cell 1997 91 789 798 9413988
   PubMed Web of Science ®Google Scholar
• Hatta N Dixon C Ray AJ Expression, candidate gene, and population studies of the melanocortin 5 receptor J Invest Dermatol 2001 116 564 570 11286624
   PubMed Web of Science ®Google Scholar
• Chhajlani V Muceniece R Wikberg JE Molecular cloning of a novel human melanocortin receptor Biochem Biophys Res Commun 1996 218 638 8561809
   PubMed Web of Science ®Google Scholar
• Chagnon YC Chen WJ Perusse L Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study Mol Med 1997 3 663 673 9392003
   PubMed Web of Science ®Google Scholar
• Watson SJ Akil H Richard CWIII Evidence for two separate opiate peptide neuronal systems Nature 1978 275 226 228 211426
   PubMed Web of Science ®Google Scholar
• Jacobowitz DM O’Donohue TL alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain Proc Natl Acad Sci U S A 1978 75 6300 6304 366617
   PubMed Web of Science ®Google Scholar
• Cone RD Anatomy and regulation of the central melanocortin system Nat Neurosci 2005 8 571 578 15856065
   PubMed Web of Science ®Google Scholar
• Broberger C Johansen J Johansson C The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice Proc Natl Acad Sci U S A 1998 95 15043 15048 9844012
   PubMed Web of Science ®Google Scholar
• Shintani M Ogawa Y Ebihara K Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway Diabetes 2001 50 227 232 11272130
   PubMed Web of Science ®Google Scholar
• Niswender KD Baskin DG Schwartz MW Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis Trends Endocrinol Metab 2004 15 362 369 15380807
   PubMed Web of Science ®Google Scholar
• Challis BG Coll AP Yeo GS Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3–36) Proc Natl Acad Sci U S A 2004 101 4695 4700 15070780
   PubMed Web of Science ®Google Scholar
• Kamegai J Tamura H Shimizu T Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression Endocrinology 2000 141 4797 4800 11108296
   PubMed Web of Science ®Google Scholar
• Rao TL Kokare DM Sarkar S GABAergic agents prevent alpha-melanocyte stimulating hormone induced anxiety and anorexia in rats Pharmacol Biochem Behav 2003 76 417 423 14643840
   PubMed Web of Science ®Google Scholar
• Cummings DE Purnell JQ Frayo RS A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 2001 50 1714 1719 11473029
   PubMed Web of Science ®Google Scholar
• Tschop M Wawarta R Riepl RL Post-prandial decrease of circulating human ghrelin levels J Endocrinol Invest 2001 24 RC19 21 11434675
   PubMed Web of Science ®Google Scholar
• Ariyasu H Takaya K Tagami T Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans J Clin Endocrinol Metab 2001 86 4753 4758 11600536
   PubMed Web of Science ®Google Scholar
• Tschop M Weyer C Tataranni PA Circulating ghrelin levels are decreased in human obesity Diabetes 2001 50 707 709 11289032
   PubMed Web of Science ®Google Scholar
• Hewson AK Dickson SL Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats J Neuroendocrinol 2000 12 1047 1049 11069119
   PubMed Web of Science ®Google Scholar
• Cowley MA Smith RG Diano S The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron 2003 37 649 661 12597862
   PubMed Web of Science ®Google Scholar
• Shaw AM Irani BG Moore MC Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice Peptides 2005 26 1720 1727 16005545
   PubMed Web of Science ®Google Scholar
• Wilding JP Ajala MO Lambert PD Additive effects of lactation and food restriction to increase hypothalamic neuropeptide Y mRNA in rats J Endocrinol 1997 152 365 369 9071956
   PubMed Web of Science ®Google Scholar
• Clark JT Kalra PS Crowley WR Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats Endocrinology 1984 115 427 429 6547387
   PubMed Web of Science ®Google Scholar
• Levine AS Morley JE Neuropeptide Y: a potent inducer of consummatory behavior in rats Peptides 1984 5 1025 1029 6549409
   PubMed Web of Science ®Google Scholar
• Zarjevski N Cusin I Vettor R Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity Endocrinology 1993 133 1753 1758 8404618
   PubMed Web of Science ®Google Scholar
• Tiesjema B Adan RA Luijendijk MC Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior J Neurosci 2007 27 14139 14146 18094253
   PubMed Web of Science ®Google Scholar
• Yang L Scott KA Hyun J Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance J Neurosci 2009 29 179 190 19129396
   PubMed Web of Science ®Google Scholar
• Garcia de YE Li S Fournier A Regulation of proopiomelanocortin gene expression by neuropeptide Y in the rat arcuate nucleus Brain Res 1995 674 112 116 7773678
   PubMed Web of Science ®Google Scholar
• Abid K Rochat B Lassahn PG Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3–35: a new peptide generated by plasma kallikrein J Biol Chem 2009 284 24715 24724 19620246
   PubMed Web of Science ®Google Scholar
• Watson BJr Nowak NJ Myracle AD The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension Genomics 1997 44 365 367 9325062
   PubMed Web of Science ®Google Scholar
• Wang L Feng Y Zhang Y Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia Am J Obstet Gynecol 2006 195 162 171 16681991
   PubMed Web of Science ®Google Scholar
• Yan ZHANG Xiu-mei Hong Hou-xun E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients Chinese Med J 2009 122 2461 2465
   Web of Science ®Google Scholar
• Arai K Shibasaki T [Genetic abnormalities of regulatory mechanism of appetite] Nippon Rinsho 2001 59 449 455 11268592
   PubMedGoogle Scholar
• Ichiyama T Sakai T Catania A Systemically administered alpha-melanocyte-stimulating peptides inhibit NF-kappaB activation in experimental brain inflammation Brain Res 1999 836 31 37 10415402
   PubMed Web of Science ®Google Scholar