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Review

Metabolism of ciclesonide in the upper and lower airways: review of available data

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Pages 11-18 | Published online: 07 Sep 2008

References

  • BarnesPJ1990Effect of corticosteroids on airway hyperresponsivenessAm Rev Respir Dis141S7062178516
  • BergerWE2003Overview of allergic rhinitisAnn Allergy Asthma Immunol90Suppl71212839106
  • BergerWE2006Ciclesonide: A closer look at its systemic and oropharyngeal safety profileCurr Drug Saf12657018690937
  • BlaisLSuissaSBoivinJF1998First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthmaThorax531025910195073
  • BonsmannUBachertCDelankKW2001Presence of fluticasone propionate on human nasal mucosal surface and in human nasal tissue over a period of 24 h after intranasal applicationAllergy56532511421898
  • BousquetJVan CauwenbergePKhaltaevN2001Allergic rhinitis and its impact on asthmaJ Allergy Clin Immunol108Suppl 5S147S33411707753
  • BousquetJJacquotWVignolaAM2004Allergic rhinitis: a disease remodeling the upper airways?J Allergy Clin Immunol11343914713906
  • CanonicaGW2006Treating asthma as an inflammatory diseaseChest13021S8S16840365
  • ChapmanKRPatelPD’UrzoAD2005Maintenance of asthma control by once-daily inhaled ciclesonide in adults with persistent asthmaAllergy60330715679718
  • CKS2007Allergic rhinitis Clinical knowledge summaries [online. URL: http://www.cks.library.nhs.uk/allergic_rhinitis/view_whole_guidance.
  • DentG2002Ciclesonide (Byk Gulden)Curr Opin Investig Drugs37883
  • DietzelKEngelstätterRKellerA2001Ciclesonide: an on-site-activated steroidHanselTTBarnesPJNew drugs for asthma, allergy and COPDBasel, SwitzerlandKarger913
  • DrollmannAWatzHNaveR2006In vivo metabolism of ciclesonide in the human lungProc Am Thorac Soc3A75
  • EdsbäckerSBrattsandR2002Budesonide fatty-acid esterification: A novel mechanism prolonging binding to airway tissue. Review of available dataAnn Allergy Asthma Immunol886091612086369
  • GelfandEW2004Inflammatory mediators in allergic rhinitisJ Allergy Clin Immunol114S135S815536444
  • EngelstätterRBanerjiDSteinijansVW2004Low incidence of oropharyngeal adverse events in asthma patients treated with ciclesonide: results from a pooled analysis [abstract]Am J Respir Crit Care Med169Suppl Abstract A92.
  • EsmailpourNHoggerPRohdewaldP2000Binding of glucocorticoids to human nasal tissue in vitroInt Arch Allergy Immunol122151410878494
  • GelfandEW2004Inflammatory mediators in allergic rhinitisJ Allergy Clin Immunol114S135S815536444
  • GeorgitisJ1999The 1997 asthma management guidelines and therapeutic issues relating to the treatment of asthmaChest11521079925086
  • GINA Global Initiative for Asthma2005National Institutes of Health, National Heart, Lung and Blood Institute URL: www.ginasthma.com.
  • GuZZhaoXNaveR2007Comparative in vitro metabolism of 14C-ciclesonide in hepatocytes from the mouse, rat, rabbit, dog, and humanAm J Ther142809017515705
  • JanciauskieneSOrbjörnCSjölinP2007Corticosteroid lipophilicity is a more important determinant of corticosteroid uptake into human hepatocytes than serum protein bindingEur Respir J30Suppl 51351S
  • KimKWeiswasserMNaveR2007Safety of once-daily ciclesonide nasal spray in children with perennial allergic rhinitisPediatr Asthma Allergy Immunol2022942
  • LangdonCGAdlerMMehraS2005Once-daily ciclesonide 80 or 320 microg for 12 weeks is safe and effective in patients with persistent asthmaRespir Med9912758516024244
  • LexmullerKGullstrandHAxelssonBO2007Differences in endogenous esterification and retention in the rat trachea between budesonide and ciclesonide active metaboliteDrug Metab Dispos3517889617627977
  • McCrackenNWBlainPGWilliamsFM1993Human xenobiotic metabolising esterases in liver and bloodBiochem Pharmacol46112598216361
  • MutchENaveRMcCrackenN2007The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissueBiochem Pharmacol7316576417331475
  • NaveRHummelRPWohlsenA2004The active metabolite of ciclesonide, des-isobutyryl ciclesonide, forms highly lipophilic fatty acid conjugates in precision-cut rat lung slicesAm J Respir Crit Care Med169Suppl 7A91
  • NaveRZechKBethkeTD2005aLower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjectsEur J Clin Pharmacol61203815824911
  • NaveRMeyerWFuhstR2005bFormation of fatty acid conjugates of ciclesonide active metabolite in the rat lung after 4-week inhalation of ciclesonidePulm Pharmacol Ther18390616179214
  • NaveRFisherRZechK2006aIn vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slicesBiopharm Drug Dispos2719720716566061
  • NaveRWingertzahnMABrookmanS2006bSafety, tolerability, and exposure of ciclesonide nasal spray in healthy and asymptomatic subjects with seasonal allergic rhinitisJ Clin Pharmacol46461716554455
  • NaveRFisherRMcCrackenN2007In vitro metabolism of beclomethasone dipropionate, budesonide, ciclesonide, and fluticasone propionate in human lung precision-cut tissue slicesRespir Res86517883839
  • [NIH] National Institutes of Health: National Heart Lung and Blood Institute1997National Asthma Education and Prevention Program Expert Panel Report 2. Clinical practice guidelines: Guidelines for the diagnosis and management of asthmaBethesda, MarylandNational Institutes of Health/National Heart, Lung, and Blood Institute NIH publication no. 97–4051.
  • NonakaTSugiyamaHSatoH2008Prolonged anti-inflammatory activity of ciclesonide in human bronchial epithelial cells SUBMITTED MANUSCRIPT
  • NonakaTNaveRMcCrackenN2007Ciclesonide Uptake and Metabolism in Human Alveolar Type II Epithelial Cells (A549)BMC Pharmacol71217900334
  • PeetCFEnosTNaveR2005Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomesEur J Drug Metab Pharmacokinet302758616435573
  • PetersenHKullbergAEdsbackerS2001Nasal retention of budesonide and fluticasone in man: formation of airway mucosal budesonide-esters in vivoBr J Clin Pharmacol511596311259988
  • PostmaDSSevetteCMartinatY2001Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or eveningEur Respir J171083811491148
  • RatnerPHWingertzahnMAvan BavelJH2006Efficacy and safety of ciclesonide nasal spray for the treatment of seasonal allergic rhinitisJ Allergy Clin Immunol1181142817088141
  • RichterKKanniessFBibergerC2005Comparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthmaJ Clin Pharmacol451465215647406
  • RohatagiSLuoYShenL2005Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonideAm J Ther12201915891262
  • RyrfeldtAAnderssonPEdsbackerS1982Pharmacokinetics and metabolism of budesonide, a selective glucocorticoidEur J Respir Dis Suppl12286956958498
  • SatoHNaveRNonakaT2006In vitro activation of the corticosteroid ciclesonide in animal nasal mucosal homogenatesBiopharm Drug Dispos28596417163410
  • SatoHNaveRNonakaT2007aIn vitro metabolism of ciclesonide in human nasal epithelial cells. BiopharmDrug Dispos284350
  • SatoHNaveRNonakaT2007bUptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosaBMC Pharmacol7717553148
  • SkonerDP2001Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosisJ Allergy Clin Immunol108SupplS2S811449200
  • StormsWW2004Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitisJ Allergy Clin Immunol114S146S5315536446
  • TunekASjödinKHallströmG1997Reversible formation of fatty acid esters of budesonide, an anti-asthma glucocorticoid, in human lung and liver microsomesDrug Metab Dispos251311179351909
  • Van den BrinkKIMvan den BrekelIJSBoorsmaM2005Evidence of in vivo esterification of budesonide in humansEur Respir J Suppl26Suppl 49370s