126
Views
16
CrossRef citations to date
0
Altmetric
Review

Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer’s disease

Pages 29-39 | Published online: 06 Nov 2008

References

  • AkiyamaHBargerSBarnumS2000Inflammation and Alzheimer’s diseaseNeurobiol Aging2138342110858586
  • AlvarezACacabelosRSanpedroC2007Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer diseaseNeurobiol Aging28533616569464
  • AlzheimerA1907Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift fur Psychiatrie under Psychisch-Gerichtliche Medizin641468
  • AlzheimerAStelzmannRASchnitzleinHN1995An English translation of Alzheimer’s 1907 paper, “Uber eine eigenartige Erkankung der Hirnrinde”Clin Anat8429318713166
  • BalossoSRavizzaTPeregoC2005Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptorsAnn Neurol578041215852477
  • BardFCannonCBarbourR2000Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseNat Med6916910932230
  • BateCVeerhuisREikelenboomP2004Microglia kill amyloid-beta1–42 damaged neurons by a CD14-dependent processNeuroreport1514273015194867
  • BeachTGKuoYMSpiegelK2000The cholinergic deficit coincides with Abeta deposition at the earliest histopathologic stages of Alzheimer diseaseJ Neuropathol Exp Neurol593081310759186
  • BeattieECStellwagenDMorishitaW2002Control of synaptic strength by glial TNFalphaScience2952282511910117
  • BenzingWCWujekJRWardEK1999Evidence for glial-mediated inflammation in aged APP(SW) transgenic miceNeurobiol Aging20581910674423
  • BertazzaLMocellinS2008Tumor necrosis factor (TNF) biology and cell deathFront Biosci1327364317981749
  • BillingsLMOddoSGreenKN2005Intraneuronal Abeta causes the onset of early Alzheimer’s disease-related cognitive deficits in transgenic miceNeuron456758815748844
  • BirksJ2006Cholinesterase inhibitors for Alzheimer’s diseaseCochrane Database Syst Rev1CD00559316437532
  • BlaskoISchmittTLSteinerE1997Tumor necrosis factor alpha augments amyloid beta protein (25–35) induced apoptosis in human cellsNeurosci Lett23817209464644
  • BraakHBraakE1991Neuropathological stageing of Alzheimer-related changesActa Neuropathol82239591759558
  • BreitnerJCWelshKAHelmsMJ1995Delayed onset of Alzheimer’s disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugsNeurobiol Aging16523308544901
  • CaiXDGoldeTEYounkinSG1993Release of excess amyloid beta protein from a mutant amyloid beta protein precursorScience259514168424174
  • CarswellEAOldLJKasselRL1975An endotoxin-induced serum factor that causes necrosis of tumorsProc Natl Acad Sci U S A723666701103152
  • CaselliRJBeachTGYaariR2006Alzheimer’s disease a century laterJ Clin Psychiatry67178480017196061
  • CitronMOltersdorfTHaassC1992Mutation of the beta-amyloid precursor protein in familial Alzheimer’s disease increases beta-protein productionNature36067241465129
  • CollinsJSPerryRTWatsonBJr2000Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics InitiativeAm J Med Genet968233011121190
  • EikelenboomPVeerhuisR1996The role of complement and activated microglia in the pathogenesis of Alzheimer’s diseaseNeurobiol Aging17673808892339
  • EvansDA1990Estimated prevalence of Alzheimer’s disease in the United StatesMilbank Q68267892233632
  • FarlowMRCummingsJL2007Effective pharmacologic management of Alzheimer’s diseaseAm J Med1203889717466645
  • FillitHDingWHBueeL1991Elevated circulating tumor necrosis factor levels in Alzheimer’s diseaseNeurosci Lett129318201745413
  • FlickDAGiffordGE1986Production of tumor necrosis factor in unprimed mice: mechanism of endotoxin-mediated tumor necrosisImmunobiology17132083527951
  • FrautschySAYangFIrrizarryM1998Microglial response to amyloid plaques in APPsw transgenic miceAm J Pathol152307179422548
  • GandySDeMattosRBLemereCA2004Alzheimer’s Abeta vaccination of rhesus monkeys (Macaca mulatta)Mech Ageing Dev1251495115037022
  • GlennerGGWongCW1984Alzheimer’s disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril proteinBiochem Biophys Res Commun122113156236805
  • GoateAChartier-HarlinMCMullanM1991Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s diseaseNature34970461671712
  • GraeberMBMehraeinP1999Reanalysis of the first case of Alzheimer’s diseaseEur Arch Psychiatry Clin Neurosci249Suppl 310310654094
  • GralleMFerreiraST2007Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its partsProg Neurobiol82113217428603
  • GrellMWajantHZimmermannG1998The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factorProc Natl Acad Sci U S A9557059435233
  • GriffinWSShengJGRoystonMC1998Glial-neuronal interactions in Alzheimer’s disease: the potential role of a ‘cytokine cycle’ in disease progressionBrain Pathol865729458167
  • GunawardenaSGoldsteinLS2001Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in DrosophilaNeuron3238940111709151
  • Harris-WhiteMEChuTBalverdeZSigelJJ1998Effects of transforming growth factor-beta (isoforms 1–3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice culturesJ Neurosci1810366749852574
  • HePZhongZLindholmK2007Deletion of tumor necrosis factor death receptor inhibits amyloid {beta} generation and prevents learning and memory deficits in Alzheimer’s miceJ Cell Biol1788294117724122
  • HebertLEScherrPABieniasJL2003Alzheimer disease in the US population: prevalence estimates using the 2000 censusArch Neurol6011192212925369
  • HeldmannUThoredPClaasenJH2005TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brainExp Neurol196204816157335
  • HerzJBeffertU2000Apolipoprotein E receptors: linking brain development and Alzheimer’s diseaseNat Rev Neurosci151811252768
  • HockCKonietzkoUStrefferJR2003Antibodies against beta-amyloid slow cognitive decline in Alzheimer’s diseaseNeuron385475412765607
  • HoeflichKPYehWCYaoZ1999Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)Oncogene1858142010523862
  • HohmannHPRemyRPoschlB1990Tumor necrosis factors-alpha and -beta bind to the same two types of tumor necrosis factor receptors and maximally activate the transcription factor NF-kappa B at low receptor occupancy and within minutes after receptor bindingJ Biol Chem2651518382168404
  • HornstenALieberthalJFadiaS2007APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viabilityProc Natl Acad Sci U S A1041971617267616
  • HullMFiebichBLLiebK1996Interleukin-6-associated inflammatory processes in Alzheimer’s disease: new therapeutic optionsNeurobiol Aging177958008892354
  • In ‘t VeldBALaunerLJHoesAW1998NSAIDs and incident Alzheimer’s disease. The Rotterdam StudyNeurobiol Aging196071110192221
  • JanelsinsMCMastrangeloMAOddoS2005Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer’s disease miceJ Neuroinflammation22316232318
  • KitazawaMOddoSYamasakiTR2005Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer’s diseaseJ Neurosci2588435316192374
  • Koenigsknecht-TalbooJLandrethGE2005Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokinesJ Neurosci258240916148231
  • KukullWAHigdonRBowenJD2002Dementia and Alzheimer disease incidence: a prospective cohort studyArch Neurol5917374612433261
  • LeeEBLengLZZhangB2006Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic miceJ Biol Chem2814292916361260
  • LehmannJMLenhardJMOliverBB1997Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugsJ Biol Chem2723406109013583
  • LemereCAMaronRSelkoeDJ2001Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer’s diseaseDNA Cell Biol207051111788048
  • LemereCASpoonerETLeveroneJF2002Intranasal immunotherapy for the treatment of Alzheimer’s disease: Escherichia coli LT and LT(R192G) as mucosal adjuvantsNeurobiol Aging23991100012470794
  • LemereCAMaierMPengY2007Novel Abeta immunogens: is shorter better?Curr Alzheimer Res44273617908047
  • LemereCABeierschmittAIglesiasM2004Alzheimer’s disease abeta vaccine reduces central nervous system abeta levels in a nonhuman primate, the Caribbean vervetAm J Pathol1652839715215183
  • LemereCALoperaFKosikKS1996The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathologyNat Med21146508837617
  • LiMBegAA2000Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cellsJ Virol747470710906200
  • LiXYangYAshwellJD2002TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2Nature416345711907583
  • LiebermanJSchleissnerLTachikiKH1995Serum alpha 1-antichymotrypsin level as a marker for Alzheimer-type dementiaNeurobiol Aging16747538532107
  • LleoAGreenbergSMGrowdonJH2006Current pharmacotherapy for Alzheimer’s diseaseAnnu Rev Med575133316409164
  • LleoAGaleaESastreM2007Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseasesCell Mol Life Sci6414031817447008
  • LoperaFArdillaAMartinezA1997Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutationJAMA27779399052708
  • LukiwWJBazanNG2000Neuroinflammatory signaling upregulation in Alzheimer’s diseaseNeurochem Res2511738411059791
  • MaSLTangNLLamLC2004Association between tumor necrosis factor-alpha promoter polymorphism and Alzheimer’s diseaseNeurology62307914745077
  • MackenzieIRMunozDG1998Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in agingNeurology50986909566383
  • MackenzieIRHaoCMunozDG1995Role of microglia in senile plaque formationNeurobiol Aging167978048532113
  • MannDMYatesPOMarcyniukB1985Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer’s diseaseNeurosci Lett565154011048
  • MastersCLSimmsGWeinmanNA1985Amyloid plaque core protein in Alzheimer disease and Down syndromeProc Natl Acad Sci U S A82424593159021
  • McGeerEGMcGeerPL2003Inflammatory processes in Alzheimer’s diseaseProg Neuropsychopharmacol Biol Psychiatry27741912921904
  • McGeerPLItagakiSTagoH1987Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DRNeurosci Lett791952003670729
  • MorganDDiamondDMGottschallPE2000A beta peptide vaccination prevents memory loss in an animal model of Alzheimer’s diseaseNature408982511140686
  • MorrisJCStorandtMMillerJP2001Mild cognitive impairment represents early-stage Alzheimer diseaseArch Neurol5839740511255443
  • MorrisRGSalmonDP2007The centennial of Alzheimer’s disease and the publication of “Uber eine eigenartige Erkankung der Hirnrinde” by Alois AlzheimerCortex43821517941340
  • MrakREShengJGGriffinWS1995Glial cytokines in Alzheimer’s disease: review and pathogenic implicationsHum Pathol26816237635444
  • MurrayKMDahlSL1997Recombinant human tumor necrosis factor receptor (p75) Fc fusion protein (TNFR:Fc) in rheumatoid arthritisAnn Pharmacother311335389391689
  • NeeLEPolinskyRJEldridgeR1983A family with histologically confirmed Alzheimer’s diseaseArch Neurol4020386600923
  • NicollJAYamadaMFrackowiakJ2004Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer’s disease. Pro-CAA position statementNeurobiol Aging2558997 discussion 603–415172734
  • NicollJAWilkinsonDHolmesC2003Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case reportNat Med94485212640446
  • NicollJABartonEBocheD2006Abeta species removal after abeta42 immunizationJ Neuropathol Exp Neurol651040817086100
  • ObeidLMLinardicCMKarolakLA1993Programmed cell death induced by ceramideScience2591769718456305
  • OrgogozoJMGilmanSDartiguesJF2003Subacute meningoencephalitis in a subset of patients with AD after Abeta 42 immunizationNeurology61465412847155
  • PaganelliRDi IorioAPatricelliL2002Proinflammatory cytokines in sera of elderly patients with dementia: levels in vascular injury are higher than those of mild-moderate Alzheimer’s disease patientsExp Gerontol372576311772511
  • PapassotiropoulosAFountoulakisMDunckleyT2006Genetics, transcriptomics, and proteomics of Alzheimer’s diseaseJ Clin Psychiatry676527016669732
  • PerryVHGordonS1988Macrophages and microglia in the nervous systemTrends Neurosci11273772465626
  • PinquartMSorensenS2003Differences between caregivers and noncaregivers in psychological health and physical health: a meta-analysisPsychol Aging182506712825775
  • QiaoXCumminsDJPaulSM2001Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouseEur J Neurosci144748211553297
  • RathmannKLConnerCS2007Alzheimer’s disease: clinical features, pathogenesis, and treatment. 1984Ann Pharmacother41149950417698893
  • RemarqueEJBollenELWeverling-RijnsburgerAW2001Patients with Alzheimer’s disease display a pro-inflammatory phenotypeExp Gerontol36171611162920
  • RichardsSJHodgmanCSharpeM1995Reported sequence homology between Alzheimer amyloid770 and the MRC OX-2 antigen does not predict functionBrain Res Bull3830567496825
  • Rovelet-LecruxAHannequinDRauxG2006APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathyNat Genet3824616369530
  • ScheinfeldN2004A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumabJ Dermatolog Treat152809415370396
  • SchenkDBarbourRDunnW1999Immunization with amyloidbeta attenuates Alzheimer-disease-like pathology in the PDAPP mouseNature400173710408445
  • SelkoeDJBellDSPodlisnyMB1987Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer’s diseaseScience23587373544219
  • ShengJGGriffinWSRoystonMC1998Distribution of interleukin- 1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer’s diseaseNeuropathol Appl Neurobiol24278839775393
  • ShengJGBoraSHXuG2003Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic miceNeurobiol Dis141334513678674
  • ShiraiTYamaguchiHItoH1985Cloning and expression in Escherichia coli of the gene for human tumour necrosis factorNature31380363883195
  • SpillantiniMGMurrellJRGoedertM1998Mutation in the tau gene in familial multiple system tauopathy with presenile dementiaProc Natl Acad Sci U S A957737419636220
  • St George-HyslopPHTanziREPolinskyRJ1987The genetic defect causing familial Alzheimer’s disease maps on chromosome 21Science235885902880399
  • StellwagenDMalenkaRC2006Synaptic scaling mediated by glial TNF-alphaNature4401054916547515
  • StewartWFKawasCCorradaM1997Risk of Alzheimer’s disease and duration of NSAID useNeurology48626329065537
  • SulcinerDJIraniKYuZX1996rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activationMol Cell Biol167115218943367
  • TachidaYNakagawaKSaitoT2007Interleukin-1beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta productionJ Neurochem
  • TanZSBeiserASVasanRS2007Inflammatory markers and the risk of Alzheimer disease: the Framingham StudyNeurology681902817536046
  • TanziREBertramL2005Twenty years of the Alzheimer’s disease amyloid hypothesis: a genetic perspectiveCell1205455515734686
  • ThalDRGhebremedhinEOrantesM2003Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive declineJ Neuropathol Exp Neurol62128730114692704
  • TheunsJBrouwersNEngelborghsS2006Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer diseaseAm J Hum Genet789364616685645
  • TobinickEGrossHWeinbergerA2006TNF-alpha modulation for treatment of Alzheimer’s disease: a 6-month pilot studyMedGenMed82516926764
  • TobinickELGrossH2008Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administrationJ Neuroinflammation5218184433
  • TobiumeKMatsuzawaATakahashiT2001ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosisEMBO Rep2222811266364
  • TomlinsonBEBlessedGRothM1970Observations on the brains of demented old peopleJ Neurol Sci11205425505685
  • van der WalEAGomez-PinillaFCotmanCW1993Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologiesNeuroreport469728453039
  • VarfolomeevEEAshkenaziA2004Tumor necrosis factor: an apoptosis JuNKie?Cell116491714980217
  • VietorISchwengerPLiW1993Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblastsJ Biol Chem2681899497689564
  • WajantHPfizenmaierKScheurichP2003Tumor necrosis factor signalingCell Death Differ10456512655295
  • WhalenBMSelkoeDJHartleyDM2005Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degenerationNeurobiol Dis2025426616242634
  • WhitehousePJPriceDLStrubleRG1982Alzheimer’s disease and senile dementia: loss of neurons in the basal forebrainScience215123797058341
  • WisniewskiHMWegielJ1995The neuropathology of Alzheimer’s diseaseNeuroimaging Clin N Am545577743084
  • WongGHGoeddelDV1988Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanismScience24294143263703
  • Wyss-CorayTMasliahEMalloryM1997Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer’s diseaseNature38960369335500