Mifepristone (RU-486) treatment for depression and psychosis: a review of the therapeutic implications

References

• AshokPWWagaarachchiPTTempletonA2002The antiprogestogen mifepristone: a reviewCurrent Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents27190
   Google Scholar
• BachmannCGLinthorstACHolsboerF2003Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axisNeuropsychopharmacology2810566712700716
   PubMed Web of Science ®Google Scholar
• BehlCTrappTSkutellaT1997Protection against oxidative stress-induced neuronal cell death – a novel role for RU486Eur J Neurosci9912209182944
   PubMed Web of Science ®Google Scholar
• BelanoffJKDeBattistaC2004Mifepristone in psychotic major depressionBiol Psychiatry55Suppl191S
   Google Scholar
• BelanoffJKFloresBHKalezhanM2001Rapid reversal of psychotic depression using mifepristoneJ Clin Psychopharmacol215162111593077
   PubMed Web of Science ®Google Scholar
• BelanoffJKRothschildAJCassidyF2002An open label trial of C-1073 (mifepristone) for psychotic major depressionBiol Psychiatry523869212242054
   PubMed Web of Science ®Google Scholar
• BerneRMLevyMN1998Physiology4th edSt LouisMosby Inc
   Google Scholar
• BoardFPerskyHHamburgDA1956Psychological stress and endocrine functions; blood levels of adrenocortical and thyroid hormones in acutely disturbed patientsPsychosom Med183243313350458
   PubMed Web of Science ®Google Scholar
• BrouwerJPAppelhofBCHoogendijkWJG2005Thyroid and adrenal axis in major depression: a controlled study in outpatientsEur J Endocrinol1521859115745924
   PubMed Web of Science ®Google Scholar
• BrownESChandlerPA2001Mood and cognitive changes during systemic corticosteroid therapyPrim Care Companion J Clin Psychiatry3172115014624
   PubMedGoogle Scholar
• CastroPLemaireMToscano-AguilarM1983Abnormal DST results in patients with chronic schizophreniaAm J Psychiatry14012616614251
   PubMed Web of Science ®Google Scholar
• ChristieJEWhalleyLJDickH1986Raised plasma cortisol concentrations a feature of drug-free psychotics and not specific for depressionBr J Psychiatry14858653955320
   PubMed Web of Science ®Google Scholar
• ChuJWMatthiasDFBelanoffJ2001Successful long-term treatment of refractory Cushing’s disease with high-dose mifepristone (RU 486)J Clin Endocrinol Metab8635687311502780
   PubMed Web of Science ®Google Scholar
• de KloetEROitzlMSJoelsM1999Stress and cognition: are corticosteroids good or bad guys?Trends Neurosci22422610481183
   PubMed Web of Science ®Google Scholar
• DeBattistaCBelanoffJ2004A double-blind, placebo controlled trial of C-1073 (mifepristone) in the treatment of psychotic major depressionNeuropsychopharmacology29SupplS98
   Google Scholar
• DeuschleMSchweigerUWeberB1997Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controlsJ Clin Endocrinol Metab8223488989265
   PubMed Web of Science ®Google Scholar
• DornLDBurgessESFriedmanTC1997The longitudinal course of psychopathology in Cushing’s syndrome after correction of hypercortisolismJ Clin Endocrinol Metab8291299062506
   PubMed Web of Science ®Google Scholar
• DuvalFMokraniMCCrocqMA2000Dopaminergic function and the cortisol response to dexamethasone in psychotic depressionProg Neuropsychopharmacol Biol Psychiatry242072510800744
   PubMed Web of Science ®Google Scholar
• ElvevagBGoldbergTE2000Cognitive impairment in schizophrenia is the core of the disorderCrit Rev Neurobiol1412111253953
   PubMed Web of Science ®Google Scholar
• FirstMBSpitzerRLWilliamsJBW1995Structured clinical interview for DSM-IV (SCID-I), research versionNew YorkBiometrics Research Department, New York State Psychiatric Institute
   Google Scholar
• FlemingSKBlaseyCSchatzbergAF2004Neuropsychological correlates of psychotic features in major depressive disorders: a review and meta-analysisJ Psychiatr Res38273514690768
   PubMed Web of Science ®Google Scholar
• FoldesiIFalkayGKovacsL1996Determination of RU486 (mifepristone) in blood by radioreceptorassay; a pharmacokinetic studyContraception5427328804805
   PubMed Web of Science ®Google Scholar
• ForgetHLacroixACohenH2002Persistent cognitive impairment following surgical treatment of Cushing’s syndromePsychoneuroendocrinology273678311818172
   PubMed Web of Science ®Google Scholar
• GallagherPWatsonSSmithMS2005Effects of adjunctive mifepristone (RU-486) administration on neurocognitive function and symptoms in schizophreniaBiol Psychiatry571556115652874
   PubMed Web of Science ®Google Scholar
• GhoumariAMDusartIEl-EtrM2003Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellumProc Natl Acad Sci U S A1007953812810951
   PubMed Web of Science ®Google Scholar
• GibbonsJL1964Cortisol secretion rate in depressive illnessArch Gen Psychiatry10572514159257
   PubMed Web of Science ®Google Scholar
• GrunbergSMWeissMHSpitzIM1991Treatment of unresectable meningiomas with the antiprogesterone agent mifepristoneJ Neurosurg7486162033444
   PubMed Web of Science ®Google Scholar
• HazraBGPoreVS2001Mifepristone (RU-486), the recently developed antiprogesterone drug and its analoguesJ Indian Inst Sci8128798
   Google Scholar
• HerrmannWWyssRRiondelA1982The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancyC R Seances Acad Sci III29493386814714
   PubMedGoogle Scholar
• HolmesAHeiligMRupniakNMJ2003Neuropeptide systems as novel therapeutic targets for depression and anxiety disordersTrends Pharmacol Sci24580814607081
   PubMed Web of Science ®Google Scholar
• HøybergØJWikGMehtonenOP2002ORG 34517, a selective glucocorticoid receptor antagonist with potent antidepressant activity: First clinical resultsInt J Neuropsychopharmacol5S148
   Google Scholar
• IsmailKMurrayRMWheelerMJ1998The dexamethasone suppression test in schizophreniaPsychol Med28311179572089
   PubMed Web of Science ®Google Scholar
• JahnHSchickMKieferF2004Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trialArch Gen Psychiatry6112354415583115
   PubMed Web of Science ®Google Scholar
• Jung-TestasIBaulieuEE1983Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new anti-glucocorticosteroid of high affinity for the glucocorticosteroid receptorExp Cell Res147177826617759
   PubMed Web of Science ®Google Scholar
• KesselsRPde HaanEHKappelleLJ2001Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesionsBrain Res Brain Res Rev3529530311423159
   PubMed Web of Science ®Google Scholar
• KesselsRPPostmaAWijnaldaEM2000Frontal-lobe involvement in spatial memory: evidence from PET, fMRI, and lesion studiesNeuropsychol Rev101011310937918
   PubMed Web of Science ®Google Scholar
• KlingMAWhitfieldHJJBrandtHA1989Effects of glucocorticoid antagonism with RU 486 on pituitary-adrenal function in patients with major depression: time-dependent enhancement of plasma ACTH secretionPsychopharmacol Bull25466722560555
   PubMedGoogle Scholar
• KnableMBTorreyEFWebsterMJ2001Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology ConsortiumBrain Res Bull55651911576762
   PubMed Web of Science ®Google Scholar
• KrishnanKRReedDWilsonWH1992RU486 in depressionProgress in Neuro-Psychopharmacology & Biological Psychiatry16913201325068
   PubMed Web of Science ®Google Scholar
• KunzelHEZobelAWNickelT2003Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effectsJ Psychiatr Res375253314563384
   PubMed Web of Science ®Google Scholar
• LahteenmakiPHeikinheimoOCroxattoH1987Pharmacokinetics and metabolism of RU 486J Steroid Biochem27859633695508
   PubMedGoogle Scholar
• LaueLLotzeMTChrousosGP1990Effect of chronic treatment with the glucocorticoid antagonist RU 486 in man: toxicity, immunological, and hormonal aspectsJ Clin Endocrinol Metab711474802172280
   PubMed Web of Science ®Google Scholar
• LeminenRRantaSvon HertzenH2003Pharmacokinetics of 10 mg of mifepristoneContraception68427914698072
   PubMed Web of Science ®Google Scholar
• LopezJFLittleKYLopez-FigueroaAL2003Glucocorticoid and mineralocorticoid receptor mRNA levels in the hippocampus and prefrontal cortex of subjects with mood disorders and schizophreniaBiol Psychiatry53489
   Web of Science ®Google Scholar
• LupienSJMcEwenBS1997The acute effects of corticosteroids on cognition: integration of animal and human model studiesBrain Res Brain Res Rev241279233540
   PubMed Web of Science ®Google Scholar
• MackinPGallagherPFroomK2005Antiglucocorticoid treatments in mood disorders: efficacy and safety. (Protocol)The Cochrane Database Syst Rev1 [online]. Art nr CD00516810.1002/14651858.CD005168 URL: http://www.thecochranelibrary.com
   Google Scholar
• McAllister-WilliamsRHFerrierINYoungAH1998Mood and neuropsychological function in depression: the role of corticosteroids and serotoninPsychol Med28573849626714
   PubMed Web of Science ®Google Scholar
• McQuadeRYoungAH2000Future therapeutic targets in mood disorders: the glucocorticoid receptorBr J Psychiatry177390511059990
   PubMed Web of Science ®Google Scholar
• ModellSYassouridisAHuberJ1997Corticosteroid receptor function is decreased in depressed patientsNeuroendocrinology65216229088003
   PubMed Web of Science ®Google Scholar
• Muck-SelerDPivacNJakovljevicM1999Platelet serotonin, plasma cortisol, and dexamethasone suppression test in schizophrenic patientsBiol Psychiatry451433910356625
   PubMed Web of Science ®Google Scholar
• MurphyBEPFilipiniDGhadirianAM1993Possible uses of glucocorticoid receptor antagonists in the treatment of major depression: Preliminary results using RU-486J Psychiatry Neurosci18209138297920
   PubMed Web of Science ®Google Scholar
• NiemanLKChrousosGPKellnerC1985Successful treatment of Cushing’s syndrome with the glucocorticoid antagonist RU 486J Clin Endocrinol Metab61536402991327
   PubMed Web of Science ®Google Scholar
• OitzlMSFluttertMde KloetER1998aAcute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in ratsBrain Res797159629630598
   PubMed Web of Science ®Google Scholar
• OitzlMSFluttertMSutantoW1998bContinuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in ratsEur J Neurosci103759669875354
   PubMed Web of Science ®Google Scholar
• OwenAMMorrisRGSahakianBJ1996Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in manBrain11915976158931583
   PubMed Web of Science ®Google Scholar
• OwenAMSahakianBJSempleJ1995Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in manNeuropsychologia331247731533
   PubMed Web of Science ®Google Scholar
• ParianteCM2003Depression, Stress and the Adrenal axisJ Neuroendocrinol158111212834443
   PubMed Web of Science ®Google Scholar
• ParianteCM2004Glucocorticoid receptor function in vitro in patients with major depressionStress72091916019586
   PubMed Web of Science ®Google Scholar
• ParianteCMThomasSALovestoneS2004aDo antidepressants regulate how cortisol affects the brain?Psychoneuroendocrinology294234714749091
   PubMed Web of Science ®Google Scholar
• ParianteCMVassilopoulouKVelakoulisD2004bPituitary volume in psychosisBr J Psychiatry18551015231549
   PubMed Web of Science ®Google Scholar
• PatelPDLopezJFLyonsDM2000Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brainJ Psychiatr Res343839211165305
   PubMed Web of Science ®Google Scholar
• PomaraNDoraiswamyPMTunH2002Mifepristone (RU 486) for Alzheimer’s diseaseNeurology581436712011303
   PubMed Web of Science ®Google Scholar
• PorterRJGallagherPThompsonJM2003Neurocognitive impairment in drug-free patients with major depressive disorderBr J Psychiatry1822142012611784
   PubMed Web of Science ®Google Scholar
• PorterRJGallagherPWatsonS2004Corticosteroid-serotonin interactions in depression: a review of the human evidencePsychopharmacology (Berl)17311715007595
   PubMed Web of Science ®Google Scholar
• PosenerJADeBattistaCWilliamsGH200024-hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depressionArch Gen Psychiatry577556010920463
   PubMed Web of Science ®Google Scholar
• ReulJMde KloetER1985Two receptor systems for corticosterone in rat brain: microdistribution and differential occupationEndocrinology1172505112998738
   PubMed Web of Science ®Google Scholar
• RitsnerMMaayanRGibelA2004Elevation of the cortisol/ dehydroepiandrosterone ratio in schizophrenia patientsEur Neuropsychopharmacol142677315163435
   PubMed Web of Science ®Google Scholar
• RushAJGilesDESchlesserMA1996The dexamethasone suppression test in patients with mood disordersJ Clin Psychiatry57470848909334
   PubMed Web of Science ®Google Scholar
• RyanMCSharifiNCondrenR2004Evidence of basal pituitary-adrenal overactivity in first episode, drug naive patients with schizophreniaPsychoneuroendocrinology2910657015219658
   PubMed Web of Science ®Google Scholar
• RybakowskiJKTwardowskaK1999The dexamethasone/corticotropin-releasing hormone test in depression in bipolar and unipolar affective illnessJ Psychiatr Res333637010504004
   PubMed Web of Science ®Google Scholar
• SartorOCutlerGBJr1996Mifepristone: treatment of Cushing’s syndromeClin Obstet Gynecol39506108734015
   PubMed Web of Science ®Google Scholar
• SchmiderJLammersCHGotthardtU1995Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: IBiol Psychiatry387978028750037
   PubMed Web of Science ®Google Scholar
• SimpsonGMEl SheshaiALozaN2005An 8-week open-label trial of a 6-day course of mifepristone for the treatment of psychotic depressionJ Clin Psychiatry6659860215889946
   PubMed Web of Science ®Google Scholar
• Sitruk-WareRSpitzIM2003Pharmacological properties of mifepristone: toxicology and safety in animal and human studiesContraception684092014698070
   PubMed Web of Science ®Google Scholar
• SpitzIMBardinCW1993Clinical pharmacology of RU 486–an antiprogestin and antiglucocorticoidContraception48403448275693
   PubMed Web of Science ®Google Scholar
• StarkmanMNGiordaniBBerentS2001Elevated cortisol levels in Cushing’s disease are associated with cognitive decrementsPsychosom Med639859311719638
   PubMed Web of Science ®Google Scholar
• StricklandPLDeakinJFPercivalC2002Bio-social origins of depression in the community. Interactions between social adversity, cortisol and serotonin neurotransmissionBr J Psychiatry1801687311823330
   PubMed Web of Science ®Google Scholar
• ThompsonJMGallagherPHughesJH2005Neurocognitive impairment in euthymic bipolar disorderBr J Psychiatry186324015630121
   PubMed Web of Science ®Google Scholar
• van der LelyAJFoekenKvan der MastRC1991Rapid reversal of acute psychosis in the Cushing syndrome with the cortisol-receptor antagonist mifepristone (RU 486)Ann Intern Med11414341984391
   PubMed Web of Science ®Google Scholar
• WatsonSGallagherPRitchieJC2004Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorderBr J Psychiatry18449650215172943
   PubMed Web of Science ®Google Scholar
• WebsterMJKnableMBO’GradyJ2002Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disordersMol Psychiatry79859412399952
   PubMed Web of Science ®Google Scholar
• YoungAHGallagherPPorterRJ2002Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patientsAm J Psychiatry1591237912091208
   PubMed Web of Science ®Google Scholar
• YoungAHGallagherPWatsonS2004Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorderNeuropsychopharmacology2915384515127079
   PubMed Web of Science ®Google Scholar
• YoungAHSahakianBJRobbinsTW1999The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteersPsychopharmacology (Berl)145260610494574
   PubMed Web of Science ®Google Scholar
• YoungEALopezJFMurphy-WeinbergV2003Mineralocorticoid receptor function in major depressionArch Gen Psychiatry6024812511169
   PubMed Web of Science ®Google Scholar
• ZobelAWNickelTKunzelHE2000Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treatedJ Psychiatr Res341718110867111
   PubMed Web of Science ®Google Scholar