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Review

Narcolepsy: current treatment options and future approaches

Pages 557-566 | Published online: 26 Nov 2022

References

  • AkimotoHHondaYTakahashiYPharmacotherapy in narcolepsyDis Nerv Syst19602113
  • American Academy of Sleep MedicineInternational classification of sleep disordersDiagnostic and coding manual20052Westchester, IllinoisAmerican Academy of Sleep Medicine
  • Arias-CarrionOMurillo-RodriguezEXuMTransplantation of hypocretin neurons into the pontine reticular formation:preliminary resultsSleep20042714657015683135
  • Arias-CarrionODrucker-ColinRMurillo-RodriguezESurvival rates through time of hypocretin grafted neurons within their projection siteNeurosci lett200640493716762505
  • BeerBStarkJKrieterPDOV 216,303, a ‘triple’ reuptake inhibitor: safety, tolerability, and pharmacokinetic profileJ Clin Pharmacol2004441360715545306
  • BeuersterienKMRogersAAEWalslebenJAHealth-related quality of life effects of modafinil for treatment of narcolepsySleep1999227576510505821
  • BilliardMBassettiCDauvilliersYEFNS guidelines on management of narcolepsyEur J Neurol20061310354816987156
  • BilliardMBessetAMontplaisirJModafinil: a double-blind multicenter studySleep199417Suppl10712
  • BilliardMNicoletADauvilliersYBassettiCBilliardMMignotEModafinil: the European experienceInforma Healthcare2007New YorkNarcolepsy and hypersomnia5619
  • BlackJHoughtonWCSodium oxybate improves excessive daytime sleepiness in narcolepsySleep200629394616895262
  • BoeveBFSilberMHFermanTJMelatonin for treatment of REM sleep behavior disorder in neurological disorders:results in 14 patientsSleep Med20034281414592300
  • BrittonTHansenAHicksJGuidelines on the diagnosis and management of narcolepsy in adults and childrenEvidence-based guidelines for the UK with graded recommendations2002Ashtead, UKTaylor Patten Communications Ltd
  • BroughtonRGhanemQHishikawaYLife effects of narcolepsy in 180 patients from North-America, Asia and Europe compared to matched controlsCan J Neurol Sci198182993047326610
  • BroughtonRJFlemingJAEGeorgeCFPRandomized, double-blind placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsyNeurology199749444519270575
  • BroughtonRMamelakMThe treatment of narcolepsy-cataplexy with nocturnal gamma-hydroxybutyrateCan J Neurol Sci1979616264152
  • BroughtonRJMurrayBJBassettiCBilliardMMignotEThe behavioral management of narcolepsyNarcolepsy and hypersomnia2007New YorkInforma Healthcare497512
  • ChemelliRMWillieJTSintonCMNarcolepsy in orexin knockout mice:molecular genetics of sleep regulationCell1999984375110481909
  • ChenWBlackJEinenMLate onset narcolepsy presenting as rapidly progressing muscle weaknes:response to plasmaphoresisAnn Neurol2005584899016130098
  • ChokrovertySSleep apnea in narcolepsySleep1986925033704450
  • DauvilliersYCarlanderBTouchonJSuccessful management of cataplexy with intravenous immunoglobulins at narcolepsy onsetAnn Neurol200456905815562415
  • DauvilliersYMontplaisirJMolinariNAge at onset of narcolepsy in two large populations of patients in France and QuebecNeurology20015720293311739821
  • FronczekROvereemSLammersGJAltered skin-temperature regulation in narcolepsy relates to sleep propensitySleep20062914444917162991
  • FronczekRRaymannRJEMRomeijnNManipulation of core body and skin temperature improves vigilance and maintenance of wakefulness in narcolepsySleep2008312334018274271
  • FronczekRVerschuurenJLammersGJResponse to intravenous immnoglobulin and placebo in a patient with narcolepsy with cataplexyJ Neurol20072541607817762946
  • GuilleminaultCAmphetamines and narcolepsy:use of the Stanford databaseSleep1993161992018506450
  • GuilleminaultCMancusoJQuera-SalvaMAViloxazine hydrochloride in narcolepsy:a preliminary reportSleep19869275793704453
  • HansonLRMartinezPMTaheriSIntranasal administration of hypocretin-1 (orexin A) bypasses the blood-brain barrier and targets the brain:a new strategy for the treatment of narcolepsyDrug Delivery Technol200446671
  • HarshJRHaydukRRosenbergRThe efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsyCurr Med Res Opin2006227617416684437
  • HechtMLinLKushidaCAReport of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsySleep2003268091014655912
  • HublinCKaprioJPartinenMThe prevalence of narcolepsy:an epidemiological study of the Finnish Twin CohortAnn Neurol1994a35709168210228
  • HublinCPartinenMHeinonenESelegiline in the treatment of narcolepsyNeurology1994b4420951017969965
  • IijimaSSugitaYTshimaYTherapeutic effects of mazindol on narcolepsySleep1986926583704452
  • IvanenkoATaumanRGauzalDModafinil in the treatment of excessive daytime sleepiness in childrenSleep Med200345798214607353
  • KalesAVela-BuenoAKalesJDSleep disorders:sleep apnea and narcolepsyAnn Intern Med1987106434433544995
  • KeamSWalkerMCTherapies for narcolepsy with or without cataplexy:evidence based reviewCurr Opin Neurol20072069970317992092
  • KentJMSnaRIs, NaSSAs, and NARIs:new agents for the treatment of depressionLancet200035591118 Erratum in: Lancet, 355:200010752718
  • LangdonNShindlerJParkesJDFluoxetine in the treatment of cataplexySleep937133509809
  • LarrosaOde la LlaveYBarioSStimulant and anticataplectic effects of reboxetine in patients with narcolepsySleep200124282511322710
  • LecendreuxMMaretSBassettiCClinical efficacy of high-dose intravenous immunoglobulins near the onset of narcolepsy in a 10-year-old boyJ Sleep Res200312347814633248
  • LinLFaracoJLiRThe sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 geneCell1999983657610458611
  • LinJSBrain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neuronsSleep Med Rev2000447150317210278
  • LinJSSakaiKVanni-MercierGInvolvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the catBrain Res1990523325302169324
  • MaitreMThe gamma-hydroxybutyrate signalling system in brain organisation and functional implicationsProg Neurobiol199751337619089792
  • MarelliSFantiniMBusekPAssociation between REM sleep behavior disorder and narcolepsy with and without cataplexySleep200629Abstract SupplA22930
  • Martinez-RodriguezJIranzoASantamariaJStatus cataplecticus induced by abrupt withdrawal of clomipramineNeurologia200217113611864561
  • MayerGMeier-EwertKSelegiline hydrochloride treatment in narcolepsy. A double-blind, placebo-controlled studyClin Neuropharmacol199518306198665543
  • MayerGPeterHKesperKKomorbidität bei NarkolepsiepatientenDtsch Med Wochenschr200212719424612239653
  • MerritSLCohenFLSmithKMGoswamiMDepressive symptomatology in narcolepsyPsychosocial Aspects of Narcolepsy1992New YorkThe Haworth Press539
  • MiedaMWillieJTHaraJOrexin peptides prevent cataplexy and improve wakefulness in an orexin-neuron-ablated model of narcolepsy in miceProc Natl Acad Sci USA200410146495415070772
  • MignotENishinoSGuilleminaultCModafinil binds to the dopamine uptake carrier site with low affinitySleep19941743677991954
  • MitlerMMAldrichMSKoobGFNarcolepsy and its treatment with stimulants (ASDA standards of practice)Sleep199417352717973321
  • MitlerMMShaforRHajdukovikRTreatment of narcolepsy:objective studies on methylphenidate, pemoline,and protriptylineSleep1986926043704451
  • MoldofskyHBroughtonRJHillJDA randomized trial of the long-term, continued efficacy and safety of modafinil in narcolepsySleep Med200011091610767651
  • MontplaisirJMichaudMDenesleRPeriodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopaminergic impairmentSleep Med20001163710767664
  • MorgenthalerTIKapurVKBrownTPractice parameters for the treatment of narcolepsy and other hypersomnias of central originSleep20073017051118246980
  • MuraliHKotagalSOff-label treatment of severe childhood narcolepsy-cataplexy with sodium oxybateSleep2006291025916944670
  • NiederhoferHAtomoxetine also effective in patients suffering from narcolepsy?Sleep200528118916268387
  • NightingaleSOrgillJCEbrahimIOThe association between narcolepsy and REM behavior disorder (RBD)Sleep Med20056253815854856
  • NishinoSArrigoniJSheltonJEffects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsyJ Neurosci199717640189236248
  • NishinoSKanbayashiTSymptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin systemSleep Med Rev2005926931016006155
  • NishinoSMaoJSampathkumaranRIncreased dopaminergic transmission mediates the wake-promoting effects of CNS stimulantsSleep Res Online19981496111382857
  • NishinoSMignotEPharmacological aspects of human and canine narcolepsyProgr Neurobiol1997522778
  • OhayonMMPriestRGZulleyJPrevalence of narcolepsy symptomatology and diagnosis in the European general populationNeurology20025818263312084885
  • PardiDBlackJGHB/sodium oxybate:neurobiology and impact on sleep and wakefulnessCNS Drugs200620993101817140279
  • ParkesJDDahlitzMAmphetamine prescriptionSleep19931620138506451
  • PeyronCFaracoJRogersWA mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brainsNat Med20006991710973318
  • PlazziGMontagnaPProviniFTreatment of narcolepsy with cataplexyLancet2007369108117398305
  • PrinzmetalMBloombergWThe use of benzedrine for treatment of narcolepsyJAMA193510520514
  • RiehlJHondaKKwanMChronic oral administration of CG-3703, a thyrotropin-releasing hormone analog, increase wake and decreases cataplexy in canine narcolepsyNeuropsychopharmacology200023344510869884
  • RogersAEAldrichMSLinXComparison of three different sleep schedules for reducing daytime sleepiness in narcolepsySleep2001243859111403522
  • RoselaarSELangdonNLockCBSelegiline in the treatment of narcolepsySleep19871049153120270
  • SchachterMParkesJDFluvoxamine and clomipramine in the treatment of cataplexyJ Neurol Neurosurg Psychiatr19804317146766990
  • SchenckCHMahowaldMWMotor dyscontrol in narcolepsy:rapid-eye-movement (REM) sleep without atonia and REM sleep behavior disorderAnn Neurol1992323101642469
  • SchwartzJRNelsonMTSchwartzEREffects of modafinil on wakefulness and executive function in patients with narcolepsy experiencing late-day sleepinessClin Neuropharmacol20042774915252267
  • ShibaTFujikiNWisorJWake promoting effects of thioperamide, a histamine H3 antagonist in orexin/ataxin-3 narcoleptic miceSleep200427Abstract SupplA2412
  • ShindlerJSchachterMBrincatSAmphetamines, mazindol and fencamfamin in narcolepsyBMJ19852901167702859077
  • SilberMHBlackJLKrahnLEBassettiCBilliardMMignotEAutoimmune studies in narcolepsyNarcolepsy and hypersomnia2007New YorkInforma Healthcare4517
  • SilberMHKrahnLEOlsonEJThe epidemiology of narcolepsy in Olmsted county, Minnesota:a population-based studySleep20022519720211902429
  • SmithMParkesJDDahlitzMVenlafaxine in the treatment of the narcoleptic syndromeJ Sleep Res19965Suppl 1217
  • Standards of Practice CommitteePractice parameters for the treatment of narcolepsy:an update for 2000Sleep2001244516611403530
  • Standards of Practice Committee of the American Sleep Disorders AssociationPractice parameters for the use of stimulants in the treatment of narcolepsySleep199417348517973320
  • TatsumiMGroshanKBlakelyRDPharmacological profile of antidepressants and related compounds at human monoamine transportersEur J Pharmacol1997340249589537821
  • TedfordCEEdgarDMSeidelWFEffects of a novel, selective and potent histamine H3 receptor antagonist, GT-2332, on rat sleep/wakefulness and canine cataplexyAbstr Soc Neurosci1999251134
  • ThannickalTCMooreRYNienhuisRReduced number of hypocretin neurons in human narcolepsyNeuron2000274697411055430
  • The Xyrem® International Study GroupA double-blind, placebo-controlled study demonstrates that sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsyJ Clin Sleep Med20051391717564408
  • ThorpyMJBlackJErmanMKThe safety profile of modafinil in disorders of sleep and wakefulnessNeurology200462Suppl 5A567
  • ThorpyMJSnyderMAloesFSShort-term triazolam use improves nocturnal sleep of narcolepsticsSleep19921521261621021
  • US Modafinil in Narcolepsy Multicenter Study GroupRandomized trial of modafinil for the treatment of pathological somnolence in narcolepsyAnn Neurol19984388979450772
  • US Modafinil in Narcolepsy Multicenter Study GroupRandomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsyNeurology20005411667510720292
  • US Xyrem® Multicenter Study GroupA randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsySleep20022542911833860
  • US Xyrem® Multicenter Study GroupA 12-month, open-label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsySleep20032631512627729
  • US Xyrem® Multicenter Study GroupSodium oxybate demonstrates long-term efficacy for the treatment of cataplexy in patients with narcolepsySleep Med200451192315033130
  • Xyrem® International Study GroupFurther evidence supporting the use of sodium oxybate for the treatment of cataplexy:a double-blind, placebo-controlled study in 228 patientsSleep Med200564152116099718
  • WingYKLiRHLamCWThe prevalence of narcolepsy among Chinese in Hong-KongAnn Neurol2002515788412112103
  • WisorJPNishinoSSoraIDopaminergic role in stimulant induced wakefulnessJ Neurosci20012117879411222668
  • WyattRJFramDHBuchbinderRTreatment of intractable narcolepsy with a monoamine oxidase inhibitorN Engl J Med1971285987914328710
  • ZuberiSMMignotELingLVariable response to intravenous immunoglobulin therapy in childhood narcolepsyJ Sleep Res200413Suppl 1828

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