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Review

Postulated vasoactive neuropeptide immunopathology affecting the blood–brain/blood–spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?

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Pages 81-89 | Published online: 25 Nov 2022

References

  • GhaffarOFeinsteinAThe neuropsychiatry of multiple sclerosis: a review of recent developmentsCurr Opin Psychiatry2007202788517415083
  • GalvinJECognitive change in Parkinson diseaseAlzheimer Dis Assoc Disord2006203021017132978
  • PhukanJPenderNPHardimanOCognitive impairment in amyotrophic lateral sclerosisLancet Neurol20076994100317945153
  • MichielsVCluydtsRNeuropsychological functioning in chronic fatigue syndrome: a reviewActa Psychiatr Scand2001103849311167310
  • VaudryDGonzalezBJBasilleMPituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functionsPharmacol Rev20005226932410835102
  • ZhouCJShiodaSYadaTPACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signalling pathwaysCurr Protein Pept Sci200234233912370005
  • BrennemanDENeuroprotection: a comparative view of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptidePeptides2007281720617513014
  • DelgadoMLecetaJGaneaDVasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microgliaJ Leukoc Biol2003731556412525573
  • IgarashiYUtsumiHChibaHGlial cell line-derived neurotrophic factor induces barrier function of endothelial cell forming the blood-brain barrierBiochem Biophys Res Commun19992611081210405331
  • Baranczyk-KuzmaAAudusKLGuillotFLEffects of selected vasoactive substances on adenylate cyclase activity in brain, isolated brain microvessels and primary cultures of brain microvessel endothelial cellsNeurochem Res199217209141311435
  • CorrealeJVillaAThe blood-brain-barrier in multiple sclerosis: functional roles and therapeutic targetingAutoimmunity2007401486017453713
  • RiteIMachadoACanoJBlood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neuronsJ Neurochem200710115678217437543
  • Garbuzova-DavisSHallerESaportaSUltrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modelling ALSBrain Res200711571263717512910
  • OzturkMHAydinogozUComparison of MR signal intensities of cerebral perivascular (Virchow–Robin) and subarachnoid spacesComput Assist Tomogr2002269024
  • EsiriMMGayDImmunological and neuropathological significance of the Virchow–Robin spaceJ Neurol Sci19901001–2382089138
  • ZhangETInmanCBWellerROInterrelationships of the pia mater and the perivascular (Virchow–Robin) spaces in the human cerebrumJ Anat1990170111232254158
  • BechmannIGaleaIPerryVHWhat is the blood-brain barrier (not)?Trends Immunol20072851117140851
  • BecherBBechmannIGreterMAntigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognise the brainJ Mol Med2006845324316773356
  • TakedaNMurozonoMWatanabeSNeuroprotective effects of novel derivatives of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide in two brain ischemic models on miceMasui200554240815794099
  • BanksWAUchidaDArimuraATransport of pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier and the prevention of ischemia-induced death of hippocampal neuronsAnn N Y Acad Sci199680527078993409
  • Masmoudi-KoukiOGandolfoPCastelHRole of PACAP and VIP in astroglial functionsPeptides20072817536017655978
  • VauquelinGvon MentzerB2007G-protein coupled receptorsMolecular Pharmacology New JerseyWiley
  • DelgadoMAbadCMartinezCPACAP in immunity and inflammationAnn N Y Acad Sci20039921415712794054
  • KogaSMorrisSOgawaSTNF modulates endothelial properties by decreasing cAMPAm J Physiol1995268C1104137762602
  • TomimotoHAkiguchiIAkiyamaHT-cell infiltration and expression of MHC class II antigen by macrophages and microglia in a heterogeneous group in leukoencephalopathyAm J Pathol1993143579868102032
  • ZhangETMikkelsenJDFahrenkrugJPreprovasoactive intestinal polypeptide-derived peptide sequences in cerebral blood vessels of rats: on the functional anatomy of metabolic autoregulationJ Cereb Blood Flow Metab19911193281939387
  • OdoardiFKawakamiNKlinkertWEBlood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical diseaseProc Natl Acad Sci U S A2007104186253018000062
  • RomagnaniSRegulation of the T cell responseClin Exp Allergy20063613576617083345
  • DelgadoMChornyAGonzalez-ReyEVasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivoJ Leukoc Biol20057813273816204628
  • LecetaJGomarizRPMartinezCVasoactive intestinal peptide regulates Th17 function in autoimmune inflammationNeuroimmunomodulation2007143–4134818073504
  • OukkaMInterplay between pathogenic Th17 and regulatory T cellsAnn Rheum Dis200766S8790
  • StromnesIMCerrettiLMLiggittDDifferential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cellsNat Med2008143374218278054
  • RicciardelliILindeyKJLondieMAnti tumour necrosis-alpha therapy increases the number of FOXP3 (+) regulatory T cells in children affected by Crohn’s diseaseImmunology20081251788318422560
  • VandenbarkAACulbertsonNEBartholomewRMTherapeutic vaccination with trivalent T cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosisImmunology2008123667817944900
  • van HorssenJBoLVosCMBasement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role influx and transport of leukocytesJ Neuropath Exp Neurol200564722916106221
  • GayFWEarly cellular events in multiple sclerosis. Intimations of an extrinsic myelinolytic antigenClin Neurol Neurosurg20061082344016364541
  • GordonTPBolstadAIRischumellerMAutoantibodies in primary Sjogren’s syndrome: new insights into mechanisms of autoantibody diversification and disease pathogenesisAutoimmunity2001341233211905842
  • DelgadoMGaneaDInhibition of IFN-gamma-induced janus kinase-1-STAT1 activation in macrophages by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptideJ Immunol20001653051710975815
  • BroadwellRDSofroniewMVSerum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous systemExp Neurol1993120245638491281
  • MuellerCASchluesenerHJConardSSpinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokineEMAP II J Neurotrauma200320100715
  • ShiratoriKMrowkaMToussaintAExtreme unilateral widening of Virchow–Robin spaces: case reportNeuroradiology200244990212483444
  • GrossPMWallKMPangJJMicrovascular specialization promoting rapid interstitial solute dispersion in nucleus tractus solitariusAm J Physiol1990259R113182260724
  • GrossPMMorphology and physiology of capillary systems in subregions of the subfornical organ and area postremaCan J Physiol Pharmacol1991691010251954559
  • NicholKEKimRCotmanCWBcl-2 family protein behaviour in frontotemporal dementia implies vascular involvementNeurology20015611 Suppl 4S354011402149
  • MartinJACraftDKSuJHAstrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusionNeurobiol Aging20012219520711182469
  • OsawaAMaeshimaSShimamotoYRelationship between cognitive function and regional cerebral blood flow in different types of dementiaDisabil Rehabil2004267394515204497
  • PatankarYFMitraDVarmaADilatation of the Virchow–Robin space is a sensitive indicator of cerebral microvascular disease: study in elderly patients with dementiaAJNR Am J Neuroradiol20052615122015956523
  • NakanoSAsadaTYamashitaFRelationship between antisocial behaviour and regional cerebral blood flow in frontotemporal dementiaNeuroimage200632301616624585
  • IchiseMSalitIEAbbeySEAssessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndromeNuel Med Commun19921376772
  • YoshiuchiKFarakasJNatelsonBHPatients with chronic fatigue syndrome have reduced absolute cortical blood flowClin Physiol Funct Imaging20062683616494597
  • LewisDHMaybergHSFischerMEMonozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECTRadiology20012197667311376266
  • ZhouJKongHHuaXAltered blood-brain barrier integrity in adult aquaporin-4 knockout miceNeuroreport2008191518281883
  • JariusSPaulFFranciottaDMechanisms of disease: aquaporin-4 antibodies in neuromyelitis opticaNat Clin Pract Neurol200842021418334978
  • ChuJYChungSCLamAKPhenotypes developed in secretin receptor-null mice indicated a role for secretion in regulating renal water reabsorptionMol Cell Biol200727249951117283064
  • LeeMLeeSJChoiHJRegulation of AQP4 protein expression in rat brain astrocytes: role of P2X7 receptor activationBrain Res2008119511118206860
  • KauszMMuraiZArimuraADistribution of pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactive elements in the brain stem of rats studied by immunohistochemistryNeurobiology (Bp)19997193110746248
  • ReglodiDTamasALubicsAMorphological and functional effects of PACAP in 6-hydroxydopamine-induced lesion of the substantia nigra in ratsRegul Pept20041231–3859415518897
  • DejdaASokolowskaPNowakJZNeuroprotective potential of three neuropeptides PACAP, VIP and PHIPharmacol Rep2005573072015985713
  • WangGQiCFanGHPACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex 1 inhibitor, rotenoneFEBS Lett200557940051116004991
  • VaudryDPamantungTFBasilleMPACAP protects cerebellar granule neurons against oxidative stress-induced apoptosisEur J Neurosci20021514516012028355
  • DelgadoMGaneaDNeuroprotective effect of vasoactive intestinal peptide (VIP) in a mouse model of Parkinson’s disease by blocking microglial activationFASEB J200317944612626429
  • WerdelinLGjerrisABoysenGNeuropeptides and neural cell adhesion molecule (NCAM) in CSF from patients with ALSActa Neurol Scand198979177812718735
  • IwasakiYIkedaKIchikawaYVasoactive intestinal peptide influences neurite outgrowth in cultured rat spinal cord neuronsNeurol Res200123851411760877
  • SunWHongJZangYCAltered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosisInt Immunol200618169170017077178
  • BarnettMHSuttonIThe pathology of multiple sclerosis: a paradigm shiftCurr Opin Neurol200619242716702829
  • BalabanovRBeaumontTDore-DuffyPThe role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytesJ Neurosci Res1999555788710082080
  • ContiACBlendyJARegulation of antidepressant activity by cAMP response element binding proteinsMol Neurobiol2004301435515475624
  • ItohTTokukuraMAbeKEffects of rolipram, a phosphodiesterase 4 inhibitor, in combination with imipramine on depressive behaviour, CRE-binding activity and BDNF level in learned helplessness ratsEur J Pharmacol20044981–31354215363987
  • KnuuttilaJEToronenPCastrenEEffects of antidepressant drug imipramine on gene expression in rat prefrontal cortexNeurochem Res20042912354415176480
  • SommerNLoschmannPANorthoffGHThe antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitisNat Med1995124487585041
  • CastroAJerezMJGilCCyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitorsMed Res Rev2005252294415514991
  • KambayashiTWallinRPLjunggrenHGcAMP-elevating agents suppress dendritic functionJ Leukoc Biol2001709031011739553
  • BeshayEPrud’hommeGJInhibitors of phosphodiesterase isoforms III or IV suppress islet-cell nitric oxide productionLab Invest20018111091711502862
  • BeshayECrozeFPrud’hommeGJThe phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivoClin Immunol200198272911161985
  • AbbasNZouLPPelidouSHProtective effect of Rolipram in experimental autoimmune neuritis: protection is associated with down-regulation of IFN-gamma and inflammatory chemokines as well as up-regulation of IL-4 in peripheral nervous systemAutoimmunity20003293911078155
  • Dal PiazVGiovannoniMPPhosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologiesEur J Med Chem2000354638010889326
  • XuHStrassmannGChanCCProtective effect of the type IV phosphodiesterase inhibitor rolipram in EAU: protection is independent of IL-10- inducing activityInvest Ophthalmol Vis Sci1999409425010102291
  • MartinezIPuertaCRedondoCType IV phosphodiesterase inhibition in experimental allergic encephalomyelitis of Lewis rats: sequential gene expression analysis of cytokines, adhesion molecules and the inducible nitric oxide synthaseJ Neurol Sci1999164132310385042
  • StainesDRAre multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides?Med Hypotheses200870413817582695
  • StainesDRIs Parkinson’s disease an autoimmune disorder of endogenous vasoactive neuropeptides?Med Hypotheses20076912081117562359
  • StainesDRPostulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesisClin Devel Immunol200613253916603442
  • StainesDRPhosphodiesterase inhibitors may be indicated in the treatment of postulated vasoactive neuropeptide autoimmune fatigue-related disordersMed Hypotheses200666203416171950
  • BenagianoVVirgintinoDMaioranoEVIP-like immunoreactivity within neurons and perivascular neuronal processes of the human cerebral cortexEur J Histochem1996405368741100
  • HenningRJSawmillerDRVasoactive intestinal peptide: cardiovascular effectsCardiovasc Res200149273711121793
  • MonahanAJWarrenMCarveyPMNeuroinflammation and peripheral immune infiltration in Parkinson’s disease: an autoimmune hypothesisCell Transplant2008173637218522239
  • DesaiBSMonahanAJCarveyPMBlood-brain barrier pathology in Alzheimer’s and Parkinson’s disease: implications for drug therapyCell Transplant2007162859917503739
  • Niebroj-DoboszIDziewulskaDJanikPAuto-antibodies against proteins of spinal cord cells in cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS)Folia Neuropathol200644191617039414
  • PenderMPGreerJMImmunology of multiple sclerosisCurr Allergy Asthma Rep200772859217547851
  • DelgadoMGaneaDAnti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agentsBrain Behav ImmunEpub 2008614
  • WuerfelJHaertleMWaicziesHPerivascular spaces – MRI marker of inflammatory activity in the brain?Brain200813123324018676439
  • StrongMJThe syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosisAmyotroph Lateral SclerEpub2008827
  • CostantinoCMBaecher-AllanCHaflerDAMultiple sclerosis and regulatory T cellsJ Clin ImmunolEpub 200892
  • Gonzalez-ReyEVarelaNChornyATherapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulatorCurr Pharm Des20071311133917430175
  • MennitiFSFaraciWSSchmidtCJPhosphodiesterases in the CNS: targets for drug developmentNat Rev Drug Discov200656607016883304
  • PaintliaASPaintliaMKSinghICombination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosisGliaEpub2008820
  • FolcikVASmithTO’BryantSTreatment with BBB022A or rolipram stabilizes the blood-brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitorsJ Neuroimmunol1999971–21192810408965
  • DinterHPhosphodiesterase type 4 inhibitors: potential in the treatment of multiple sclerosis?BioDrugs200013879418034515
  • WeishaarRECainMHBristolJAA new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivityJ Med Chem198528537452985781
  • GiorgiMD’AngeloVEspositoZLowered cAMP and cGMP signalling in the brain during levodopa-induced dyskinesias in hemiparkinsonian rats: new aspects in the pathogenetic mechanismsEur J Neurosci2008289415018717735
  • YangLCalingasanNYLorenzoBJAttenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IVExp Neurol2008211311418328479
  • TomimatsuNArakawaYSurvival-promoting activity of pituitary adenylate cyclase-activating polypeptide in the presence of phosphodiesterase inhibitors on rat motoneurons in culture: cAMP-protein kinase A-mediated survivalJ NeurochemEpub2008918
  • LuJZhengMHYanJEffects of vasoactive intestinal peptide on phenotypic and functional maturation of dendritic cellsInt Immunopharmacol2008814495418599382
  • DelgadoMPozoDGaneaDThe significance of vasoactive intestinal peptide in immunomodulationPharmacol Rev2004562499015169929
  • CarsonMJMicroglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosisGlia2002402183112379909
  • PocockJMKettenmannHNeurotransmitter receptors on microgliaTrends Neurosci2007305273517904651
  • BenderATBeavoJACyclic nucleotide phosphodieskrases: molecular regulation to clinical usePharmacol Rev20065848852016968949
  • ZlokovicBVThe blood–brain barrier in health and chronic neurodegenerative disordersNeuron20085717820118215617

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