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Review

Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A

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Pages 161-176 | Published online: 08 Feb 2008

References

  • AkinDManierDHSanders-BushESignal transduction abnormalities in melancholic depressionInt J Neuropsychopharmacology20058516
  • AltarCAWhiteheadREChenREffects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brainBiol Psychiatry200354703914512210
  • AngelucciFMatheAAAloeLBrain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administrationJ Neurosci Res2000607839410861791
  • BarbanyGPerssonHRegulation of neurotrophin mRNA expression in the rat brain by glucocorticoidsEur J Neurosci1992439640312106347
  • BeebeSJThe cAMP-dependent protein kinases and cAMP signal transductionSemin Cancer Biol19945285947803765
  • BelmakerRHZoharJEbsteinRPCyclic nucleotides in mental disorderAdv Cyclic Nucleotide Res198012187986250353
  • BenesFMVincentSLTodtenkopfMThe density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjectsBiol Psychiatry20015039540611566156
  • BerrettiniWHCappellariCBNurnbergerJIβ-adrenergic receptors on lymphoblasts. A study of manic-depressive illnessNeuropsychobiology1987171582819764
  • BerrutiGcAMP activates Rap1 in differentiating mouse male germ cells: a new signaling pathway mediated by the cAMP-activated exchange factor Epac?Cell Mol Biol200349381812887090
  • BornfeldtKEKrebsEGCrosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscleCell Signal1999114657710405757
  • BorrelliEMontmayeurJPFoulkesNSSignal transduction and gene control: The cAMP pathwayCrit Rev Oncog19923321381329990
  • BosJLde RooijJReedquistKARap1 signalling: adhering to new modelsNat Rev Mol Cell Biol200123697711331911
  • BrandonEPLogueSFAdamsMRDefective motor behavior and neural gene expression in RIIβ-protein kinase A mutant miceJ Neurosci1998183639499570795
  • BrownESRushAJMcEwenBSHippocampal remodeling and damage by corticosteroids: implications for mood disordersNeuropsychopharmacology1999214748410481830
  • BugrimAERegulation of Ca2+ release by cAMP-dependent protein kinase A mechanism for agonist-specific calcium signaling?Cell Calcium1999252192610378083
  • ChangALiPPWarshJJAltered cAMP-dependent protein kinase subunit immunolabeling in postmortem brain from patients with bipolar affective disorderJ Neurochem2003a847819112562522
  • ChangALiPPWarshJJcAMP-dependent protein kinase (PKA) subunit mRNA levels in postmortem brain from patients with bipolar affective disorder (BD)Mol Brain Res2003b116273712941458
  • ChenACShirayamaYShinKHExpression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effectBiol Psychiatry2001497536211331083
  • ChenBDowlatshahiDMacQueenGMIncreased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medicationBiol Psychiatry200150260511522260
  • ChenBWangJFHillBCLithium and valproate differentially regulate brain regional expression of phosphorylated CREB and c-FosMol Brain Res199970455310381542
  • Cho-ChungYSRole of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapyCancer Res19905070931002224844
  • CleggCHMcKnightGSGenetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinaseProc Natl Acad Sci U S A198885370373375237
  • ConstantinescuAGordonASDiamondIcAMP-dependent protein kinase types I and II differentially regulate cAMP response element-mediated gene expressionJ Biol Chem200227718810611886856
  • de RooijJZwartkruisFJVerheijenMHEpac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPNature199839647479853756
  • DowlatshahiDMacQueenGMWangJFIncreased temporal cortex CREB concentrations and antidepressant treatment in major depressionLancet1998352175459848357
  • DruganJKRogers-GrahamKGilmerTThe Ras/p120 GTPase-activating protein (GAP) interaction is regulated by the p120 GAP pleckstrin homology domainJ Biol Chem200027535021710954709
  • DumanRSHeningerGRNestlerEJA molecular and cellular theory of depressionArch Gen Psychiatry1997545976069236543
  • DumanRSMalbergJNakagawaSNeuronal plasticity and survival in mood disordersBiol Psychiatry200048732911063970
  • DumanRSStructural alterations in depression: cellular mechanisms underlying pathology and treatment of mood disordersCNS Spectr20027140215220856
  • DwivediYConleyRRRobertsRC[3H]cAMP binding sites and protein kinase A activity in the prefrontal cortex of suicide victimsAm J Psychiatry2002a159667311772692
  • DwivediYMondalACRizaviHSDifferential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victimsArch Gen Psychiatry2006636394816754837
  • DwivediYMondalACShuklaPKAltered protein kinase A in brain of learned helpless rats: effects of acute and repeated stressBiol Psychiatry2004b56304015219470
  • DwivediYPandeyGNAdrenal glucocorticoids modulate [3H]cyclic AMP binding to protein kinase A (PKA), cyclic AMP-dependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brainJ Pharmacol Exp Ther2000294103610871301
  • DwivediYRaoJSRizaviHSAbnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjectsArch Gen Psychiatry2003a602738212622660
  • DwivediYRizaviHSConleyRRmRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victimsNeuropsychopharmacology2002b2749951712377388
  • DwivediYRizaviHSConleyRRAltered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjectsArch Gen Psychiatry2003b608041512912764
  • DwivediYRizaviHSShuklaPKProtein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunitsBiol Psychiatry2004a552344314744463
  • EbsteinRPLererBShapiraBCyclic AMP second-messenger signal amplification in depressionBr J Psychiatry198815266592844354
  • ExteinITallmanJSmithCCChanges in lymphocyte beta-adrenergic receptors in depression and maniaPsychiatry Res197911917233157
  • FieldsALiPPKishSJIncreased cyclic AMP-dependent protein kinase activity in postmortem brain from patients with bipolar affective disorderJ Neurochem19997317041010501218
  • FimiaGMSassone-CorsiPCyclic AMP signalingJ Cell Sci20011141971211493633
  • FinkbeinerSCalcium regulation of the brain-derived neurotrophic factor geneCell Mol Life Sci20005739440110823240
  • FrancisSHCorbinJDCyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP actionCrit Rev Clin Lab Sci19993627532810486703
  • FukumotoTMorinobuSOkamotoYChronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brainPsychopharmacology2001158100611685390
  • HattoriMMinatoNRap1 GTPase: functions, regulation, and malignancyJ Biochem20031344798414607972
  • HealyDCarneyPALeonardBEMonoamine-related markers of depression - changes following treatmentJ Psychiatr Res198317251606821276
  • HirschfeldRMWeissmanMMDavisKLCharneyDCoyleJTNemeroffCRisk factors for major depression and bipolar disorderNeuropsychopharmacology – the fifth generation of progress2002PhiladelphiaLippincott Williams and Wilkins101725
  • HuangEJReichardtLFNeurotrophins: Roles in neuronal development and functionAnnu Rev Neurosci20012467773611520916
  • JansLAWRiedelWJMarkusCRSerotonergic vulnerability and depression: assumptions, experimental evidence and implicationsMol Psychiatry2007125224317160067
  • JeanningrosRMazzolaPAzorinJMβ-adrenoceptor density of intact mononuclear leukocytes in subgroups of depressive disordersBiol Psychiatry199129789981675894
  • JordanJDLandauEMIyengarRSignaling networks: the origins of cellular multitaskingCell200010319320011057893
  • KanofPDCoccaroEFJohnsCACyclic-AMP production by polymorphonuclear leukocytes in psychiatric disordersBiol Psychiatry198925413202539205
  • KanofPDJohnsCDavidsonMProstaglandin receptor sensitivity in psychiatric disordersArch Gen Psychiatry198643987933019269
  • KanofPDJohnsCADavidsonMPlatelet alpha2-adrenergic receptor function in psychiatric disordersPsychiatry Res19882311222834762
  • KaregeFPerretGBondolfiGDecreased serum brain-derived neurotrophic factor levels in major depressed patientsPsychiatry Res2002b109143811927139
  • KaregeFSchwaldMCisseMThe cAMP-PKA activity and BDNF expression in lymphoblast cells of bipolar disorder patientsInt J Neuropsychopharmacol2002a5S59
  • KaregeFSchwaldMPapadimitriouPThe cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorderJ Affect Disord2004791879215023493
  • KayGSargeantMMcGuffinPThe lymphoblast beta-adrenergic receptor in bipolar depressed patients: characterization and down-regulationJ Affect Disord199327163728386731
  • KesslerRCMcGonagleKAZhaoSLifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity SurveyArch Gen Psychiatry1994518198279933
  • KitayamaHSugimotoYMatsuzakiTA ras-related gene with transformation suppressor activityCell19895677842642744
  • KlysnerRGeislerARosenbergREnhanced histamine and beta-adrenoreceptor-mediated cyclic AMP formation in leukocytes from patients with endogenous depressionJ Affect Disord198713227322824589
  • KochJMKellSHinze-SelchDChanges in CREB-phosphorylation during recovery from major depressionJ Psychiatr Res2002363697512393305
  • LandmarkBFOyenOSkalheggBSCellular localization and age-dependent changes of the regulatory subunits of cAMP-dependent protein kinase in rat testisJ Reprod Fertil199399323348107013
  • LaraJKusanoKHouseSInteractions of cyclic adenosine monophosphate, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor treatment on the survival and growth of postnatal mesencephalic dopamine neurons in vitroExp Neurol2003180324512668147
  • LiMWangXMeintzerMKCyclic AMP promotes neuronal surival by phosphorylation of glycogen synthase kinase 3βMol Cell Biol20002093566311094086
  • LiesiPRechardtLWartiovaaraJNerve growth factor induces adrenergic neuronal differentiation in F9 teratocarcinoma cellsNature198330626576139754
  • LindefortsNBrodinEMetsisMSpatiotemporal selective effects on brain-derived neurotrophic factor and trkB messenger RNA in rat hippocampus by electroconvulsive shockNeuroscience199565661707609868
  • LiuMSimonMIRegulation by cAMP-dependent protein kinase of a G-protein-mediated phospholipase CNature19963828378657310
  • LudvigNRibakCEScottJDImmunocytochemical localization of the neural-specific regulatory subunit of the type II cyclic AMP-dependent protein kinase to postsynaptic structures in the rat brainBrain Res1990520901022207649
  • MajMArianoMGArenaFPlasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity in manic-depressive patients. A longitudinal studyNeuropsychobiology198411168736089030
  • ManierDHEiringASheltonRC(-adrenoceptor-linked protein kinase A (PKA) activity in human fibroblasts from normal subjects and from patients with major depressionNeuropsychopharmacology199615555618946429
  • ManierDHSheltonRCEllisTCHuman fibroblasts as a relevant model to study signal transduction in affective disordersJ Affect Disord20006151811099740
  • MannJJBrownRPHalperJPReduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitationN Eng J Med198531371520
  • MarshallRDragunowMIs CREB a key to neuronal survival?Trends Neurosci200023485310652539
  • MatsushitaMNairnACInhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinaseJ Biol Chem1999274100869310187789
  • McEwenBSStress and hippocampal plasticityAnnu Rev Neurosci1999221052210202533
  • MeredithGCallenSScheuerDBrain-derived neurotrophic factor expression is increased in the rat amygdala, piriform cortex and hypothalamus following repeated amphetamine administrationBrain Res20029492182712213320
  • Miguel-HidalgoJJRajkowskaGMorphological brain changes in depression. Can antidepressants reverse them?Curr Opin20021636172
  • MontminyMRGonzalezGAYamamotoKKRegulation of cAMP-inducible genes by CREBTrends Neurosci19901318481693237
  • MooreANWaxhamMNDashPKNeuronal activity increases the phosphorylation of the transcription factor cyclic AMP response element binding protein (CREB) in rat hippocampus and cortexJ Biol Chem199627114214208662977
  • MurphyDLDonnellyCMoskowitzJCatecholamine receptor functions in depressed patientsAm J Psychiatry19741311389944372899
  • NakataKUjikeHSakaiAAssociation study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorderNeurosci Lett2003337172012524161
  • NestlerEJGreengardPSiegelGJAlbersRWAgranoffBWMolinoffPProtein phosphorylation and the regulation of neuronal functionBasic neurochemistry: molecular, cellular, and medical aspects1994BostonLittle Brown44974
  • Neves-PereiraMMundoEMugliaPThe brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association studyAm J Hum Genet200271651512161822
  • NibuyaMMorinobuSDumanRSRegulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatmentsJ Neurosci1995157539477472505
  • NibuyaMNestlerEJDumanRSChronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampusJ Neurosci1996162365728601816
  • OdagakiYGarcia-SevillaJAHugueletPCyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victimsBrain Res20018982243111306008
  • OyenOSandbergMEskildWDifferential regulation of messenger ribonucleic acids for specific subunits of cyclic adenosine 3’, 5’-monophosphate (cAMP)-dependent protein kinase by cAMP in rat Sertoli cellsEndocrinology19881222658662836170
  • PachecoMAStockmeierCMeltzerHYAlterations in phosphoinositide signaling and G-protein levels in depressed suicide brainBrain Res199672337458813380
  • PandeyGNDyskenMWGarverDLBeta-adrenergic receptor function in affective illnessAm J Psychiatry19791366758219719
  • PeetMPetersSDrug-induced maniaDrug Saf199512146537766338
  • PerezJTarditoDMoriSAbnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorderArch Gen Psychiatry1999562485310078502
  • PerezJTarditoDMoriSAltered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorderJ Psychiatr Res2000349910410758250
  • PerezJTarditoDRacagniGProtein kinase A and Rap1 levels in platelets of untreated patients with major depressionMol Psychiatry2001644911244484
  • PerezJZanardiRMoriSAbnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorderAm J Psychiatry1995152120467625472
  • PettyFShermanADReversal of learned helplessness by imipramineCommun Psychopharmacol197933713575771
  • PostRMGoldPRubinowDRPeptides in the cerebrospinal fluid of neuropsychiatric patients: an approach to central nervous system peptide functionLife Sci1982311156180277
  • QiMZhuoMSkalheggBSImpaired hippocampal plasticity in mice lacking the Cβ catalytic subunit of cAMP-dependent protein kinaseProc Natl Acad Sci U S A199693157168643673
  • RahmanSLiPPYoungLTReduced [3H]cyclic AMP binding in postmortem brain from subjects with bipolar affective disorderJ Neurochem1997682973048978738
  • RajkowskaGCell pathology in mood disordersSemin Clin Neuropsychiatry200272819212382210
  • RajkowskaGPostmortem studies in mood disorders indicate altered numbers of neurons and glial cellsBiol Psychiatry200048766711063973
  • RaoJSBazinetRPRapoprtSILeeHJChronic administration of carbamazepine downregulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortexBiol Psychiatry2007611546116806101
  • RaoJSErtleyRNLeeHJDeMarJCJrArnoldJTRapoportSIBazinetRPn-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanismMol Psychiatry200712364616983391
  • ReiachJSLiPPWarshJJReduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victimsJ Affect Disord1999561415110701471
  • RiccioAAhnSDavenportCMMediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neuronsScience199928623586110600750
  • RydelREGreeneLAcAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factorProc Natl Acad Sci USA1988851257612829221
  • SapolskyRMStress, glucocorticoids and damage to the nervous system: the current state of confusionStress199611119807058
  • SapolskyRMThe possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron deathBiol Psychiatry2000487556511063972
  • SarkarDErlichmanJRubinCSIdentification of a calmodulin-binding protein that co-purifies with the regulatory subunit of brain protein kinase IIJ Biol Chem1984259984066086653
  • SeligmanMEMaierSFFailure to escape traumatic shockJ Exp Psychol196774196032570
  • ScottJDGlaccumMBZollerMJThe molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brainProc Natl Acad Sci USA198784519263037538
  • ScottJDStofkoREMcDonaldJRType II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinaseJ Biol Chem19902652156162147685
  • SenSNesseRMStoltenbergSFA BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depressionNeuropsychopharmacology20032839740112589394
  • SheltonRCManierDHPetersonCSCyclicAMP-dependent protein kinase in subtypes of major depression and normal volunteersInt J Neuropsychopharmacol199921879211281988
  • SheltonRCManierDHSulserFcAMP-dependent protein kinase activity in major depressionAm J Psychiatry19961531037428678172
  • ShermanADSacquitneJLPettyFSpecificity of the learned helplessness model of depressionPharmacol Biochem Behav198216449547200610
  • ShimizuEHashimotoKOkamuraNAlterations of serum levels of brain-derived neurotrphic factor (BDNF) in depressed patients with or without antidepressantsBiol Psychiatry20035470512842310
  • ShirayamaYChenACHNakagawaSBrain-derived neurotrophic factor produces antidepressant effects in behavioral models of depressionJ Neurosci20022232516111943826
  • SieverLJKafkaMSTargumSPlatelet alpha-adrenergic binding and biochemical responsiveness in depressed patients and controlsPsychiatry Res1984112873026330782
  • SilvaAJKoganJHFranklandPWCREB and memoryAnnu Rev Neurosci199821127489530494
  • SiuciakJALewisDRWiegandSJAntidepressant-like effect of brain derived neurotrophic factor (BDNF)Pharmacol Biochem Beh1996561317
  • SkalheggBSTaskenKSpecificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKAFront Biosci20005D6789310922298
  • SklarPGabrielSBMcInnisMGFamily-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factorMol Psychiatry200275799312140781
  • SmithMAMakinoSKimSYStress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitaryEndocrinology1995a1363743507649080
  • SmithMAMakinoSKvetnanskyREffects of stress on neurotrophic factor expression in the rat brainAnn N Y Acad Sci1995b77123498597402
  • SoaresJCMannJJThe anatomy of mood disorders-review of structural imaging studiesBiol Psychiatry199741861068988799
  • SongHJPooMMSignal transduction underlying growth cone guidance by diffusible factorsCurr Opin Neurobiol199993556310395576
  • SpauldingSWThe ways in which hormones change cyclic adenosine 3’5’-monophosphate-dependent protein kinase subunits, and how such changes affect cell behaviorEndocr Rev199314632508262010
  • SpearingMBipolar disorder2001Washington, DC NIH Publication No. 02-3679
  • SrivastavaKLeeYNNoguchiKThe RIIβ regulatory subunit of protein kinase A binds to cAMP response element: an alternative cAMP signaling pathwayProc Natl Acad Sci USA1998956687929618473
  • SteinbergRAAgardDATurnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMPJ Biol Chem19812561073146270127
  • StewartRJChenBDowlatshahiDAbnormalities in the cAMP signaling pathway in postmortem brain tissue from the Stanley Neuropathology ConsortiumBrain Res Bull200155625911576759
  • SulserFThe role of CREB and other transcription factors in the pharmacotherapy and etiology of depressionAnn Med2002343485612452479
  • TangWJGilmanAGType-specific regulation of adenylyl cyclase by G protein β gamma subunitsScience1991254150031962211
  • TaskenKAKnutsenHKEikvarLProtein kinase C activation by 12-O-tetradecanoylphorbol 13-acetate modulates messenger ribonucleic acid levels for two of the regulatory subunits of 3’,5’-cyclic adenosine monophosphate-dependent protein kinases (RII alpha and RI alpha) via multiple and distinct mechanismsEndocrinology19921301271801311233
  • ThoenenHNeurotrophins and neuronal plasticityScience199527059387570017
  • ThomeJSakaiNShinKcAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatmentJ Neurosci2000204030610818138
  • TsaiSJIs mania caused by overactivity of central brain-derived neurotrophic factor?Med Hypotheses200462192214728999
  • UeyamaTKawaiYNemotoKImmobilization stress reduced the expression of neurotrophins and their receptors in the rat brainNeurosci Res199728103109220467
  • UhlerMDChriviaJCMcKnightGSEvidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinaseJ Biol Chem19862611536033023318
  • VollenweiderFXMaguireRPLeendersKLEffects of high amphetamine dose on mood and cerebral glucose metabolism in normal volunteers using positron emission tomography (PET)Psychiatry Res199883149629849724
  • WangJFAsghariVRockelCCyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cellsNeuroscience199991771610366032
  • WangYCPandeyGNMendelsJPlatelet adenylate cyclase responses in depression: implications for a receptor defectPsychopharmacologia1974362913004367922
  • WatanabeYGouldEMcEwenBSStress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neuronsBrain Res199258834151393587
  • WenYAnwerKSinghSPProtein kinase A inhibits phospholipase C activity and alters protein phosphorylation in rat myometrial plasma membranesEndocrinology19921311377821324160
  • WolfSMartinezCMajzoubJAInducible binding of cyclic adenosine 3′,5′-monophosphate (cAMP)-responsive element binding protein (CREB) to a cAMP-responsive promoter in vivoMol Endocrinol1999136596910319317
  • WoolleyCSGouldEMcEwenBSExposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neuronsBrain Res1990531225311705153
  • YamadaSYamamotoMOzawaHReduced phosphorylation of cyclic AMP-responsive element binding protein in the postmortem orbitofrontal cortex of patients with major depressive disorderJ Neural Transm20031106718012768362
  • YoungLTLiPPKishSJCerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorderJ Neurochem19936189088395565
  • ZanardiRRacagniGSmeraldiEDifferential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjectsPsychopharmacology (Berl)19971294479122362
  • ZubenkoGSHughesHB3rdMaherBSGenetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depressionAm J Med Genet2002114980712457397