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Review

An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)

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Pages 1073-1084 | Published online: 05 Dec 2008

References

  • AlioJLColechaJRPastorS2007Symptomatic dry eye treatment with autologous platelet-rich plasmaOphthalmic Res39124917374962
  • AnituaEAndiaIArdanzaB2004Autologous platelets as a source of proteins for healing and tissue regenerationThromb Haemost941514691563
  • AnituaEAndiaISanchezM2005Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in cultureJ Orthop Res23281615779147
  • AnituaESanchezMNurdenAT2006Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activitiesJ Biomed Mater Res7728593
  • AnituaESanchezMNurdenAT2007aReciprocal actions of platelet-secreted TGF-β1 on the production of VEGF and HGF by human tendon cellsPlastic Reconstruct Surg1199509
  • AnituaESánchezMOriveGAndíaI2007bThe potential impact of the preparation rich in growth factors (PRGF) in different medical fieldsBiomaterials2845516017659771
  • AnituaEAguirreJJAlgortaJ2008aEffectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcersJ Biomed Mater Res B8441521
  • AnituaESánchezMOriveG2008bDelivering growth factors for therapeuticsTrends Pharmacol Sci29374118037168
  • AlvarezACacabelosRSanpedroC2007Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer diseaseNeurobiol Aging28533616569464
  • AppelSH1983A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism and Alzehimer’s disease 1981Ann Neurol104995056173010
  • ArakiWWurtmanRJ1998Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cellsMol Brain Res56169779602112
  • AriannaVLauraNCinziaM2007Modification of platelet from Alzheimer disease patients: a possible relation between membrane properties and NO metabolitesNeurobiol Aging289879416815594
  • BarbinGMaloineSA1987Le viellissement cerebral normal and pathologiqueColloques de la Fondation Nationale de Gerontologie11423
  • Belaud-RotureauMALeducqNde GannesFMP2000Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosisApoptosis55516011303914
  • BialekMZarembaPBorowiczKK2004Neuroprotective role of testosterone in the nervous system 2004Polish J Pharmacol5650918
  • BredesenDERaoRVMehlenP2006Cell death in the nervous systemNature44379680217051206
  • BrodskiCVogt WeisenhornMVDechantG2002Therapy of neurodegenerative diseases using neurotrophic factors: cell biological perspectiveExpert Rev Neurotherapeutics28998
  • BrökerLEKruytFAEGiacconeG2005Cell death independent of caspases: a reviewClin Cancer Res1131556215867207
  • BurnsCPRozengurtE1983Serum, Platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in swiss 3T3 cellsBiochem Biophs Res Comm1169318
  • CacabelosR2005Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer’s diseaseAging Health130348
  • CacabelosRTakedaM2006Pharmacogenomics, nutrigenomics and future therapeutics in Alzheimer’s diseaseDrugs Future31Suppl B5146
  • CaoLJiaoXZuzgaDS2004VEGF links hippocampal activity with neurogenesis, learning and memoryNature Genetics368273515258583
  • CardoneRACasavolaVReshkinSJ2005The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasisNature Revs Cancer57869516175178
  • ConsoloUZaffeDBertoldiC2007Platelet-rich plasma activity on maxillary sinus floor augmentation by autologous boneClin Oral Implants Res182526217348891
  • CorzoLZasRRodríguez2007Decreased levels of serum nitric oxide in different forms of dementiaNeurosci Lett420263717556102
  • CountsSEMufsonEJ2005The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer diseaseJ Neuropathol6426372
  • ChaoMVRajagopalRLeeFS2006Neurothropin signalling in health and diseaseClin Sci1101677316411893
  • ChanSLTammarielloSPEstusS1999Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurones: actions prior to mitochondrial dysfunction and caspase activityJ Neurochem735021210428045
  • ChoiB-MPaeH-OJangSIl2002Nitric oxide as pro-apoptotic as well as anti-apoptotic modulatorJ Biochem Mol Biol351162616248976
  • DassBWarren OlanovCKordoverJH2006Gene transfer of trophic factors and stem cells grafting as treatments for Parkinson’s diseaseNeurology66S89S10316717256
  • Del BoRScarlatoMGhezziS2005Vascular endothelial growth factor gene variability is associated with increased risk for ADAnn Neurol573738015732116
  • DeshmukhMJohnsonEM1997Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neuronesMol Pharmacol518979069187255
  • DeshmukhMKuidaKJohnsonEM2000Caspase inhibition extends the commitment to neural death beyond cytochrome C release to the point of mitochondrial depolarizationJ Cell Biol1501314310893262
  • DiGiammarinoJLeeADSCadwellC2000A novel mechanism of tumorogenesis involving pH-dependent desestabilization of a mutant p53 tetramerNature Struct Biol9121611753428
  • Di SarioASvegliati BaroniGBendiaE2001Intracellular pH regulation and Na+/H+ exchange activity in human hepatic stellate cells: effect of platelet-derived growth factor, insulin-like growth factor 1 and insulinJ Hepatology3437885
  • Di SarioABendiaEOmenettiA2007Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cellsDigestive Liver Dis39609
  • EbertADSvendsenCN2005A new tool in the battle against Alzheimer’s disease and aging: ex vivo gene therapyRejuvenation Res8131416144466
  • EstévezAGSampsonJBZhuangYX2000Liposome-derived superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawalFree Rad Biol Med284374610699756
  • EstévezAJordánJ2002Nitric acid and superoxide, a deadly cocktailAnn NYAS96220711
  • EstévezASahawnehMALangePS2006Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neuronsJ Neurosci268512616914676
  • FadenAIKnoblachSMMovsesyanVA2004Novel small peptides with neuroprotective and nootropic propertiesJ Alzheimer Dis6S93S97
  • FamulskiKEMacDonaldDPatersonMC1999Activation of low pH-dependent nuclease by apoptotic agentsCell Death Differ6281910200579
  • FarragTYLeharMVerhaegenP2007Effect of platelet rich plasma and fibrin sealant on facial nerve regeneration in a rat modelLaryngoscope1171576517202946
  • FediPTronickSRAaronsonSAHollandJFBastRCMortonDL1997Growth factorsCancer MedicineBaltimoreWilliams and Wilkins4774
  • Fernández-VizarraPFernándezAPCastro-BlancoS2004Expression of nitric oxide system in clinically evaluated cases of Alzheimer diseaseNeurobiol Dis1528730515006699
  • FurlongIJAscasoRLopez RivasA1997Intracellular acidification induces apoptosis by stimulating ICE-like protease activityJ Cell Sci110653619092947
  • GottliebRAGiesingHAZhuJY1995Cell acidification and apoptosis: granulocyte colony-stimulating factor delays programmed cell death by up-regulating the vacuolar ATPaseProc Natl Acad Sci U S A92596587541139
  • GottliebRANordbergJSkowronskiE1996Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidificationProc Natl Acad Sci U S A9365488570610
  • GrinsteinSRotinDMasonMJ1989Na+/H+ exchange and growth factor-induced cytosolic changes. Role in cellular proliferationBiochem Biophys Acta98873972535787
  • GuoQSopherBJFurukawaK1997Alzheimer presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and β-amiloid peptide: involvement of calcium and oxyradicalsJ Neurosci174212229151738
  • HamiltonGCosentiniEPTelekyB1993The multidrug-resistance modifiers verapamil, cyclosporine A and tamoxifen induce an intracellular acidification in colon carcinoma cell lines in vitroAnticancer Res136A2059637905252
  • HanahanDWeinbergRA2000The hallmarks of cancerCell100577010647931
  • HarguindeySCragoeEJJrKleymanThRSimchowitzL1992aUse of Na+/H+ antiporter inhibitors as a novel approach to cancer treatmentAmiloride and its analogs: unique cation transport inhibitorsNew YorkVCH Publishers Inc31734
  • HarguindeyS2002Integrating fields of cancer research through pivotal mechanisms and synthetic final pathways: A unifying and creative overviewMed Hypotheses5844452 Erratum. 2003. Med Hypotheses, 61:318–1912323109
  • HarguindeySCragoeEJJr1992bThe Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolismMed Hypotheses39229371335544
  • HarguindeySPedrazJLGarcía CañeroR1995Hydrogen ion-dependent oncogenesis and parallel new avenues to cancer prevention and treatment using a H+-mediated unifying approach: pH-related and pH-unrelated mechanismsCritical Rev Oncog61338573605
  • HarguindeySPedrazJLGarcía CañeroR2000Edelfosine, apoptosis, MDR and Na+/H+ exchanger: induction mechanisms and treatment implicationsApoptosis587911227496
  • HarguindeySOriveGPedrazJL2005The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin-one single natureBioch Biopyhs Acta Revs Cancer1756124
  • HarguindeySReshkinSJOriveG2007Growth and trophic factors and the pH, Na+/H+ exchanger in Alzheimer’s disease, other neurodegenerative diseases and cancer: new therapeutic possibilities and potential dangersCurr Alzheimer Res4536517316166
  • HarguindeySOriveGAnituaE2008Hacia un nuevo enfoque integrado del tratamiento de las enfermedades neurodegenerativas (ENDs): de etiopatogenia a tratamiento. El síndrome de deficiencia de factores tróficos y de crecimiento (SDFC)Gen T3829
  • HeftiF1983Alzheimer’s disease caused by a lack of nerve growth factor?Ann Neurol13109106830157
  • HirakuraYLinM-ChKaganBL1999Alzheimer amyloid aβ1-42 channels: effect of solvent, pH, and congo redJ Neurosci Res574586610440895
  • HirparaJClémentM-VPervaizS2001Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cellsJ Biol Chem2765142111016925
  • IshaqueAAl-RubeaiM1998Use of intracellular pH and annexin V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell cultureJ Immunol Methods22143579894897
  • IzumiHTTorigoeTIshiguchiH2003Cellular pH regulators: potentially promising molecular targets of cancer chemotherapyCancer Treat Rev29541914585264
  • JinKZhuYSunY2002Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivoProc Natl Acad Sci U S A99119465012181492
  • KerrJFWyllieAHCurrieAR1972Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kineticsBr J Cancer26239574561027
  • KhaledARMoorANLiA2001Thropic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinizationMol Cell Biol2175455711604491
  • KirklandRAFranklinJI2003Prooxidant effects of NGF withdrawal and MEK inhibition in sympathetic neuronesAntioxid Redox Signal5635914580320
  • KutCMac GabhannFPopelS2007Where is VEGf in the body? A meta-analysis of EGF distribution in cancerBr J Cancer979788517912242
  • Lagadic-GossmannDHucLLecureurV2004Alterations of intracellular pH homeostasis in apoptosis: origins and rolesCell Death Differ119536115195071
  • L’AllemainGFranchiACragoeEJ1984Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblastsJ Biol Chem259431396323465
  • LavrikINGolksAKrammerPH2005Caspases: pharmacological manipulation of cell deathJ Clin Invest11526657216200200
  • LambrechtsDStorkebaumEMorimotoM2003VEGF is a modifier of amyothropic lateral sclerosis in mice and humans and protects motoneurons against ischemic deathNat Genet34357812923539
  • LetaiAG2008Diagnosing and exploiting cancer’s addition to blocks in apoptosisNature Revs Cancer81213218202696
  • LiJEastmanA1995Apoptosis in an interleukin-2-dependent cytotoxic T lympohcyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiportJ Biol Chem2703203117852405
  • LieberthalWTriacaVKohJS1998Role of superoxide in apoptosis induced by growth factor withdrawalAm J Physiol275F691F7029815127
  • LiuDMartinoGThangarajuM2000Caspase-8-mediated intracellular acidification preceds mitochondrial dysfunction in somatostatin-induced apoptosisJ Biol Chem27592445010734062
  • MarchesRVitettaESUhrJW2001A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomasProc Natl Acad Sci U S A983434911248096
  • MateoILlorcaIInfanteJ2007Low serum VEGF levels are associated with Alzheimer’s diseaseActa Neurol Scand11656817587256
  • MatsuyamaSLlopisJDeverauxQL2000Changes in intramitchondrial and cytosolic pH: early events that modulate caspase activation during apoptosisNature Cell Biol23182510854321
  • MatsuyamaSReedJC2000Mitochondria-dependent apoptosis and cellular pH regulation 2000Cell Death Differ711556511175252
  • McCarthyMJRubinLLPhilottKL1997Involvement of caspases in sympathetic neuron apoptosisJ Cell Sci1102165739378766
  • Meléndez HeviaE2001Natural selection and thermodynamics in biological evolution: from the origin of life to cancerServicio de Publicaciones de la Universidad de La LagunaTenerife, Spain188
  • MiragliaEViarisioDRigantiCH2005Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicinInt J Cancer115924915729714
  • MoolenarWHMummeryCLvan der Saag1983Na+/H+ exchange and cytoplasmatic pH in the action of growth factors in human fibroblastsNature30464586410286
  • OriveGReshkinSJHarguindeyS2003Hydrogen ion dynamics and the Na+/H+ antiporter in cancer angiogenesis and antiangiogenesisBr J Cancer893959
  • ParkHSLeeBKParkS2005Effects of sabiporide, a specific Na+/H+ exchange inhibitor on neuronal cell death and brain ischemiaBrain Res1061677116225853
  • Pérez-SalaDCollado-EscobarDMollinedoF1995Intracellular alkalinization supresses lovastatin-induced apoptosis in HL60 cells through the inactivation of a pH-dependent endonucleaseJ Biol Chem2706235427890761
  • MishraAPavelkoT2007Treatment of chronic elbow tendinosis with buffered platelet-rich plasmaAm J Sports Med341774816735582
  • MurrayMMSpindlerKPAbreuE2007Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligamentJ Orthop Res25819117031861
  • PangI-HZengHFleenorD2007Pigment epithelium-derived factor protects retinal ganglion cellsBMC Neurosci811117199885
  • ParkHJLyonsJCOhtsubo1999Acidic environment causes apoptosis by increasing caspase activityBr J Cancer801892710471036
  • PeronaRSánchez-PérezI2007Signalling pathways involved in clinical responses to chemotherapyClin Transl Oncol96253317974523
  • PolitiLERotsteinNPSalvadorG2001Insulin-like growth factor- I is a potential trophic factor for amacrine cellsJ Neurochem76119921111181839
  • PoserSImpeySXiaZ2003Brain-derived neurotrophic factor protection of cortical neurones from serum withdrawal-induced apoptosis is inhibited by cAMPJ Neurosci234420712805282
  • PoüysségurJDayanFMazureNM2006Hypoxia signalling in cancer and approaches to enforce tumor regressionNature4414374316724055
  • ProdanCIRossEDVincentAS2007Coated-platelets correlate with disease progression in Alzheimer’s diseaseJ Neurol254548917380246
  • RainaAKZhuXRottkampCA2000Cyclin’ towards dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer’s diseaseJ Neurosci Res611283310878584
  • RainaAKHochmanAIckesH2003Apoptotic promoters and inhibitors in Alzheimer’s disease: who wins out?Prog Neuropsychopharmacol Biol Psych272514
  • RaySBritschgiMHerbertCH2007Classification and prediction of clinical Alzheimer’s diagnosis based on plasma signaling proteinsNature Med1313596217934472
  • RebolloAGómezJde AragónAM1995Apoptosis induced by IL-2 withdrawal is associated with an intracellular acidificationExp Cell Res21858157796894
  • ReedJC2002Apoptosis-based therapiesNat Revs Drug Discov11112112120092
  • ReedJC2004Apoptosis mechanisms: Implications for cancer drug discoveryOncology18112015651172
  • RenzABerdelWEKreuterM2001Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivoBlood981542811520805
  • ReshkinSJBellizziACaldeiraS2000Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypesFASEB J1421859711053239
  • ReshkinSJBellizziACardoneM2003Paclitaxel induces apoptosis via Protein Kinase A- and p38 Mitogen-activated Protein-dependent inhibition of the Na+/H+ Exchanger (NHE) Isoform 1 in Human Breast cancer cellsClinical Cancer Res923667312796407
  • ResnickLFennellM2004Targeting JNK3 for the treatment of neurodegenerative disordersDrug Disc Today99329
  • ReynoldsJELiJFCraigRW1996BCL-2 and MCL-1 expression in chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporineExp Cell Res22543068660932
  • RichIRWorthington-WhiteDGardenOA2000Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na+/H+ exchangerBlood9514273410666221
  • RideoutHJStefanisL2001Caspase inhibition: a potential strategy in neurological diseasesHistol Histopathol689590811510981
  • RiedlAJShiY2004Molecular mechanisms of caspase regulation during apoptosisNature Revs Mol Cell Biol589790715520809
  • RigasBSunY2008Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancerBr J Cancer9811576018253125
  • RivaMMolteniRBedogniF2005Emerging role of the FGF system in psychiatric disordersTrends Pharmacol Sci262283115860368
  • RoepePDWeiLYCruzJ1993Lower electrical membrane and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoproteinBiochemistry3211042568105888
  • RoepePDGilliesRG2001pH and multidrug resistanceThe tumor microenvironment: causes and consequences of hypoxia and acidity Novartis Foundation Symposium, No. 240Chichester, New YorkJohn Wiley and Sons Ltd23247
  • SajadiABensadounJ-ChSchneiderBL2006Transient striatal delivery of GNDF via encapsulated cells to sustained behavioral improvement in a bilateral model of Parkinson’s diseaseNeurobiol Dis221192916300956
  • Schulte-HerbrüggenOJockers-ScherübiMCHellwegR2008Neurotropins: from physiopathology to treatment of Alzheimers’s diseaseCurr Alz Res53844
  • ShackaJJRothKA2005Regulation of neural cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implicationsCurr Drug Targets CNS Neurol Dis42539
  • SehgalIPowersSHuntleyB1994Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancerProc Natl Acad Sci U S A91467378197117
  • SimonSGilliesR2001The multiple mechanisms of drug resistance and cellular pHThe tumor microenvironment: causes and consequences of hypoxia and acidity Novartis Foundation Symposium No. 240Chichester, New YorkJohn Wiley and Sons, Ltd26981
  • SlevinJTGashDMSmithCD2006Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson’s disease: response to 1 year each of treatment and withdrawalNeurosurg Focus20E116711657
  • SolerteSBFerrariECuzzoniG2005Decrease release of the angiogenic peptide vascular endothelial growth factor in Alzheimer’s disease: recovering effect with insulin and DHEA sulphateDement Geriatr Cogn Disord1911015383738
  • SortwellCEBowersWJCountsSE2007Effect of ex vivo transduction of mesencephalic reagggregates with bcl-2 on grafted dopamine neuron survivalBrain Res113433417196186
  • SperandioSde BelleIBredesenDE2000An alternative, nonapoptotic form of programmed cell deathProc Natl Acad Sci U S A97143768111121041
  • StorkebaumECarmelietP2004aVEGF: a critical player in neurodegenerationJ Clin Invest113141814702101
  • StorkebaumELambrechtsDDewerchinM2004bTreatment of motoneuron degeneration by intraventricular delivery of VEGF in a rat model of ALSNature Neurosci8859215568021
  • SzakácsGPatersonJKLudwigJA2006Targeting multidrug resistance in cancerNature Revs521931
  • TafaniMCohnJAKarpinichNO2003Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine on tumor necrosis factor-alphaJ Biol Chem277495697612393866
  • TaetleRDos SantosBOhsuigiY1994Effect of combined antigrowth factor receptor treatment on in vitro growth of multiple myelomaJ Natl Cancer Inst8645058120920
  • TakashakiAMasudaSunM2004Oxidative stress-induced apoptosis is associated with alterations in mitochondrial caspase activity and Bcl-2-dependent alterations in mitochondrial pH (pHm)Brain Res Bull6249750415036564
  • TangDGLiLChopraDP1998Extended survivability of prostate cancer cells in the absence of trophic factors: increased proliferation, evasion of apoptosis, and the role of apoptosis proteinsCancer Res583466799699682
  • TattonWGChamblers-RedmanRJuWJH2002Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cellsJ Pharm Exp Therap30175364
  • TattonWChenDChamblers-RedmanR2003Hypotheses for a common basis for neuroprotection in glaucoma and Alzheimer’s disease: antiapoptosis by alpha-2-adrenergic receptor activationSurvey Ophtalmol48Suppl 1s25s37
  • ThangarajuMSharmaKLeberB1999Regulation of acidification and apoptosis by SHP-1 and BCL-2J Biol Chem274295495710506221
  • ThompsonCBBauerDELumJJ2005How do cancer cells acquire the fuel needed to support cell growth?Cold Spring Harbor Symp Quant Biol703576216869772
  • TorigoeTUIzumiHIseT2002Vacuolar H+-ATPase: functional mechanisms and potential as a target for cancer chemotherapyAnticancer Drugs132374311984067
  • TroyCMStefanisLProchiantzA1996The contrasting roles of ICE family proteases and inteleukin-1β in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulationProc Natl Acad Sci U S A935635408643629
  • VaghefiHHughesAlNeetKE2004Nerve growth factor withdrawal-mediated apoptosis in naïve and differentiated PC12 cells through p53/caspase-3-dependent and -independent pathwaysJ Biol Chem279156041414739302
  • VaronSManthorpeMWilliamsLR1983Neuronotrophic and neurite-promoting factors and their clinical potentialsDev Neurosci673866088207
  • Vende VeldeChClevelandDW2005VEGF: multitasking in ALSNature Neurosci85715622408
  • VincentAMTenBroeckeMMaieseK1999Neuronal intracellular pH directly mediates nitric oxide-induced programmed cell deathJ Neurobiol401718410413448
  • WagnerBNatajaranAGrünaugS2006Neuronal survival depends on EGFR signalling in cortical but not in midbrain astrocytesEMBO J257526216467848
  • WahlMLOwenJABurdR2002Regulation of intracellular pH in human melanoma: potential therapeutic implicationsMol Cancer Therap16172812479222
  • WaibelMKramerSLauderK2007Mitochondria are not required for death-receptor mediated cytosolic acidificaction during apoptosisApoptosis126233017195091
  • WaldeimerPCTattonW2004Interrupting apoptosis in neurodegenerative disease: potential for effective therapy?Drug Discover Today92108
  • WaldeimerPC2003Prospects for antiapoptotic drug therapy of neurodegenerative diseasesProg Neuropsychopharm Biol Psychiatry2730321
  • WallaceJLDicayMMcKnightW2006Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factorBr J Pharmacol148274816565732
  • WilkinsANikodemovaMCompstonA2004Minocycline attenuates nitric oxide-mediated neuronal axonal destruction in vitroNeuron Glia Biol129730518634603
  • WilliamsACTCollardJParaskevaC1999An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesisOncogene18319920410359525
  • YanCYFerrariGGreeneLA1995N-acetylcysteine-promotes survival of PC12 cells is gluthation-independent but transcription-dependentAm Soc Biochem Mol Biol2702682732
  • YangSPBaeAGKangHJ2004Co-accumulation of vascular endothelial growth factor with β-amyloid in the brain of patients with Alzheimer’s diseaseNeurobiol Aging252839015123332
  • YangJXuesongLiuKapilBhalla1997Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blockedScience751129329027314
  • YangS-PDong-GooBaeKangHJ2004Co-accumulation of vascular endothelial growth factor with β-amyloid in the brain of patients with Alzheimer’s diseaseNeurobiol Aging252839015123332
  • ZankeBWLeeCArabS1998Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and can not be inhibited by Bcl-2 expression or inteleukin 1β-converting enzyme inhibitionCancer Res58280189661894
  • ZhiuhaXSchendelSMatsuyamaS1998Acidic pH promotes dimerization of Bcl-2 family proteinsBiochemistry376410189572858
  • ZhuJKSunYMaoXO2002Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivoProc Natl Acad Sci U S A99119465012181492
  • ZhuXOgawaOWangY2003JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer’s diseaseJ Neurochem85879312641730
  • ZubenkoGSCohenBMReynoldsCF1987aPlatelet membrane fluidity in Alzheimer’s disease and major depressionAm J Psychiatry14486083605398
  • ZubenkoGSWusylkoMCohenBM1987bFamily study of platelet membrane fluidity in Alzheimer’s diseaseScience238539423659926

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