A review of ramelteon in the treatment of sleep disorders

References

• AmakyeDDHibberdMStevensonSJA phase I study to investigate the absolute bioavailability of a single oral dose of ramelteon (TAK-375) in healthy male subjectsSleep200427Abstract SupplA54
   Google Scholar
• DeMiccoMWang-WeigandSZhangJLong-term therapeutic effects of ramelteon treatment in adults with chronic insomnia: A 1-year studySleep200629Abstract SupplA234
   Google Scholar
• ErmanMSeidenDZammitGAn efficacy, safety, and dose-response study of ramelteon in patients with chronic primary insomniaSleep Med20067172416309958
   PubMed Web of Science ®Google Scholar
• FranceCPWeltmanRHKoekWAcute and chronic effects of ramelteon in rhesus monkeys (macaca mulatta): dependence liability studiesBehav Neurosci20061205354116768605
   PubMed Web of Science ®Google Scholar
• GreenblattDJHarmatzJSKarimAAge and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2J Clin Pharmacol2007474859617389558
   PubMed Web of Science ®Google Scholar
• GriffithsRRJohnsonMWRelative abuse liability of hypnotic drugs: A conceptual framework and algorithm for differentiating among compoundsJ Clin Psychiatry200566Suppl 9314116336040
   PubMed Web of Science ®Google Scholar
• HajakGEbrahimIHibberdMRamelteon, unlike zopiclone, has no effect on body sway at peak plasma levels in insomnia patientsSleep200730Abstract SupplA245
   Google Scholar
• HibberdMStevensonSJA phase-I open-label study of the absorption, metabolism, and excretion of (14C)-ramelteon (TAK-375) following a single oral dose in healthy male subjectsSleep200427Abstract SupplA54
   Google Scholar
• HiraiKKitaMOhtaHRamelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in ratsJ Biol Rhythms200520273715654068
   PubMed Web of Science ®Google Scholar
• JohnsonMSuessPGriffithsRRamelteon: a novel hypnotic lacking abuse liability and sedative effectsArch Gen Psychiatry20066311495717015817
   PubMed Web of Science ®Google Scholar
• KarimABradfordDSiebertFPharmacokinetic effect of multiple oral doses of donepezil on ramelteon, and vice versa, in healthy adultsSleep2007b30Abstract SupplA244
   PubMedGoogle Scholar
• KarimABradfordDZhaoZEffect of multiple oral doses of venlafaxine on the systemic availability of ramelteon, an MT1/MT2 receptor agonistInt J Neuropsychopharmacol2006d9Suppl 1S138
   Google Scholar
• KarimABradfordDZhaoZEffect of multiple oral doses of sertraline on the systemic availability of ramelteon, an MT1/MT2 receptor agonistJ Clin Pharmacol2006c461090 Abstract 120
   Web of Science ®Google Scholar
• KarimABradfordDSiebertFEffect of multiple doses of escitalopram on the systemic exposure of ramelteon, a selective MT1/MT2 receptor agonist in healthy adultsSleep2006b29Abstract SupplA237
   Google Scholar
• KarimACaoCZhaoZPharmacokinetic interaction between ramelteon (TAK-375) and ethanol in healthy adultsAAPS Pharm Sci2004e6 Available from: www.aapspharmsci.org/
   Google Scholar
• KarimAMooreRZhen ZhaoZOpen-label assessment of the pharmacokinetics of ramelteon 8 mg and zolpidem 10 mg coadministration in healthy adultsJ Clin Pharmacol2007a471206 Abstract 103
   Web of Science ®Google Scholar
• KarimATolbertDCaoCDisposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomniaJ Clin Pharmacol2006a46140816432265
   PubMed Web of Science ®Google Scholar
• KarimATolbertDCaoCEffect of food on the systemic exposure of ramelteon (TAK-375) following a single doseJ Clin Pharmacol2004a441210
   Web of Science ®Google Scholar
• KarimATolbertDCaoCThe effect of multiple doses of ramelteon (TAK-375) on the single-dose pharmacokinetic profile of midazolam in healthy adult subjectsSleep2004b27Abstract SupplA47A48
   Google Scholar
• KarimATolbertDCaoCA multi-dose open-label study to evaluate the effect of rifampin on the pharmacokinetics of ramelteon (TAK-375) in healthy men and womenAASP Pharm Sci2004c6 Available from: http://www.aapspharmsci.org/
   Google Scholar
• KarimATolbertDCaoCEffects of fluconazole and ketoconazole on the pharmacokinetics of ramelteon (TAK-375) in normal healthy male and female subjectsSleep2004d27Abstract SupplA53A54
   Google Scholar
• KarimATolbertDCaoCStudy to assess the steady-state drug-drug interaction of omeprazole with ramelteon in healthy adultsSleep2005a28Abstract SupplA46
   Google Scholar
• KarimATolbertDCaoCOpen-label assessment of the pharmacokinetics and pharmacodynamics of warfarin in the presence of multiple doses of ramelteon in healthy adultsSleep2005b28Abstract SupplA45A46
   Google Scholar
• KarimATolbertDZhaoZSingle and multiple dose pharmacokinetic evaluation of ramelteon (TAK-375) in subjects with and without hepatic impairmentJ Clin Pharmacol2004f441210
   Web of Science ®Google Scholar
• KatoKHiraiKNishiyamaKNeurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonistNeuropharmacology2005483011015695169
   PubMed Web of Science ®Google Scholar
• KrygerMWang-WeigandSZhangJEffect of ramelteon, a selective MT1/MT2 receptor-agonist, on respiration during sleep in COPD subjectsSleep Breath2008In press
   Web of Science ®Google Scholar
• KrygerMWang-WeigandSRothTSafety of ramelteon in individuals with mild to moderate obstructive sleep apneaSleep Breath2007111596417294232
   PubMed Web of Science ®Google Scholar
• MiniLWang-WeigandSZhangJSelf-reported efficacy and tolerability of ramelteon 8 mg in older adults experiencing severe sleep-onset difficultyAm J Geriatr Pharmacother200751778417996657
   PubMedGoogle Scholar
• MiyamotoMNishikawaHDokenYThe sleep-promoting action of ramelteon (TAK-375) in freely moving catsSleep20042713192515586784
   PubMed Web of Science ®Google Scholar
• National Institutes of HealthNational institutes of health state of the science conference statement on manifestations and management of chronic insomnia in adults, June 13–15, 2005Sleep20052810495716268373
   PubMed Web of Science ®Google Scholar
• NishidaNSasakiMWakasaYReinforcing effect of ramelteon assessed by intravenous self-administration experiments in rhesus monkeysSleep200528Abstract SupplA45
   Google Scholar
• RichardsonGSThe human circadian system in normal and disordered sleepJ Clin Psychiatry2005663916336035
   PubMed Web of Science ®Google Scholar
• RichardsonGZammitGRodriquezLEvaluation of circadian phase-shifting effects of ramelteon in healthy subjects2005TurkeySociety for Chronobiology
   Google Scholar
• RichardsonGSWang-WeigandSSainatiSA double-blind, placebo-controlled Phase III study of the long-term effects of ramelteon on endocrine function in adults with chronic insomniaSleep2006c29Abstract SupplA232
   PubMedGoogle Scholar
• RichardsonGSWang-WeigandSZhangJLong-term safety of ramelteon treatment in adults with chronic insomnia: A 1-year studySleep2006a29Abstract SupplA233
   Google Scholar
• RichardsonGZeePWang-WeigandSRodriguezLCircadian phase-shifting effects of daily ramelteon in healthy adults2006bSociety for Research of Biological Rhythms 10th Biennial Meeting Program and AbstractsMay 21–251312 Abstract 196
   Google Scholar
• RothTSeidenDWang-WeigandSA 2-night, 3-period, crossover study of ramelteon’s efficacy and safety in older adults with chronic insomniaCurr Med Res Opin20072310051417519067
   PubMed Web of Science ®Google Scholar
• RothTStubbsCWalshJKRamelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environmentSleep200528303716173650
   PubMed Web of Science ®Google Scholar
• RothTSeidenDSainatiSEffects of ramelteon on patient-reported sleep latency in older adults with chronic insomniaSleep Med200673121816709464
   PubMed Web of Science ®Google Scholar
• SainatiSMKarimATolbertDEffects of multiple doses of fluoxetine on the systemic exposure of a single dose of ramelteon (TAK-375) in healthy adultsSleep200427Abstract SupplA48
   Google Scholar
• SainatiSTsymbalovSDemissieSDouble-blind, placebo-controlled, two-way crossover study of ramelteon in subjects with mild to moderate chronic obstructive pulmonary diseaseSleep200528Abstract SupplA162
   Google Scholar
• Takeda Pharmaceuticals North AmericaRozerem prescribing information2006
   Google Scholar
• TolbertDKarimAZhaoZEvaluation of the single and multiple dose pharmacokinetics of ramelteon (TAK-375) in subjects with and without renal impairmentJ Clin Pharmacol2004d441210
   Web of Science ®Google Scholar
• TolbertDKarimACaoCStudy to assess drug interaction between ramelteon (TAK-375) and dextromethorphan in healthy adultsSleep2004a27Abstract SupplA50
   Google Scholar
• TolbertDKarimACaoCMultiplle-dose study to assess the effect of ramelteon (TAK-375) on the pharmacokinetics of digoxin in healthy subjectsAAPS Pharm Sci2004b6 Available from: http://www.aapspharmsci.org/
   Google Scholar
• TolbertDKarimAJohnsonJTwo-period crossover study to assess the drug interaction between ramelteon (TAK-375) and theophylline in healthy adultsSleep2004c27Abstract SupplA48
   Google Scholar
• TolbertDKarimADemissieSA phase I study to evaluate the short-term effects of ramelteon (TAK-375) on endocrine function in healthy adult subjectsJ Clin Pharmacol2004e441012
   PubMed Web of Science ®Google Scholar
• TurekFWGilletteMUMelatonin, sleep, and circadian rhythms: Rationale for development of specific melatonin agonistsSleep Med200455233215511698
   PubMed Web of Science ®Google Scholar
• Wang-WeigandSMayerGRoth-SchechterBLong-term efficacy and safety of ramelteon 8 mg treatment in adults with chronic insomnia: results of a six-month, double-blind, placebo-controlled, polysomnography trialSleep Biol Rhythms20075Suppl 1A156 Abstract PO525
   Google Scholar
• Wang-WeigandSZammitGPengXPlabeco-controlled, double-blind trial examining the effects of ramelteon vs placebo with zolpidem as a reference on balance in older adults after middle-of-the-night awakenings2007Presented at the Annual Meeting of the American Psychiatric AssociationMay, 2007San Diego, CA Abstract NR604
   Google Scholar
• YukuhiroNKimuraHNishikawaHEffects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeysBrain Res20041027596615494157
   PubMed Web of Science ®Google Scholar
• ZammitGErmanMWang-WeigandSEvaluation of the efficacy and safety of ramelteon in subjects with chronic insomniaJ Clin Sleep Med2007349550417803013
   PubMed Web of Science ®Google Scholar