References
- World Health OrganizationThe global burden of diseaseGeneva, SwitzerlandWorld Health Organization Press1996
- BlazerDGMood disorders: epidemiology, in Comprehensive Textbook of PsychiatrySadockBJSadockVALippincottWilliams & WilkinsNew York200012981308
- SimonGESocial and economic burden of mood disordersBiol Psychiatry20035420821512893097
- BostwickJMPankratzVSAffective disorders and suicide risk: a reexaminationAm J Psychiatry20001571925193211097952
- SoloffPHLynchKGKellyTMMaloneKMMannJJCharacteristics of suicide attempts of patients with major depressive episode and borderline personality disorder: a comparative studyAm J Psychiatry200015760160810739420
- World Health OrganizationHealth Systems: Improving Performance. Geneva, Tertiary, 2000.
- MaoYHasselbackPDaviesJWNicholRWigleDTSuicide in Canada: an epidemiological assessmentCan J Public Health1990813243282207962
- National Center for Health Statistics: Advance report of final mortality statisticsNCHS Monthly Vital Stat Rep199240
- MannJJA current perspective of suicide and attempted suicideAnn Intern Med200213630231111848728
- AhrensBLindenMIs there a suicidality syndrome independent of specific major psychiatric disorders? Result of a split half multiple regression analysisActa Psychiatr Scand19969479868883567
- MarttunenMJAroHMHenrikssonMMLonnqvistJKMental disorders in adolescent suicide. DSM-III-R axes I and II diagnoses in suicides among 13- to 19-year-olds in FinlandArch Gen Psychiatry1991488348391929774
- MannJJThe neurobiology of suicideNat Med1998425309427602
- BlumenthalSJKupferDJSuicide over the life cycle: risk factors, assessment, and treatment of suicidal patientsWashington, DCThe American Psychiatric Press, Inc1999
- TureckiGDissecting the suicide phenotype: the role of impulsive-aggressive behaviorsJ Psychiatry Neurosci20053039840816327873
- DumanRSMalbergJNakagawaSD’SaCNeuronal plasticity and survival in mood disordersBiol Psychiatry20004873273911063970
- DumanRSPathophysiology of depression: the concept of synaptic plasticityEur Psychiatry2002330631015177086
- ManjiHKQuirozJASpornJEnhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depressionBiol Psychiatry20035370774212706957
- FossatiPRadtchenkoABoyerPNeuroplasticity: from MRI to depressive symptomsEur Neuropsychopharmacol20045S503S51015550349
- AltshulerLLCasanovaMFGoldbergTEKleinmanJEThe hippocampus and parahippocampus in schizophrenia, suicide, and control brainsArch Gen Psychiatry199047102910342241505
- RajkowskaGMorphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patientsAnn NY Acad Sci U S A1997836253268
- OngurDDrevetsWCPriceJLGlial reduction in the subgenual prefrontal cortex in mood disordersProc Natl Acad Sci U S A19989513290132959789081
- RosoklijaGToomayanGEllisSPStructural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findingsArch Gen Psychiatry20005734935610768696
- CotterDMackayDLandauSKerwinREverallIReduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorderArch Gen Psychiatry20015854555311386983
- RajkowskaGHisopathology of the prefrontal cortex in depression: What does it tell us about dysfunctional monoaminergic circuitsProg Brain Res200012639741211105659
- CotterDMackayDChanaGBeasleyCLandauSEverallIPReduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorderCereb Cortex20021238639411884354
- Miguel-HidalgoJRajkowskaGMorphological brain changes in depression. Can antidepressants reverse themCNS Drugs20021636137212027783
- RajkowskaGCell pathology in mood disordersSemin Clin Neuropsychiatry2002728129212382210
- AganovaEAUranovaNAMorphometric analysis of synaptic contacts in the anterior limbic cortex in the endogenous psychosesNeurosci Behav Physiol19922259651614620
- DrevetsWCOngürDPriceJLReduced glucose metabolism in the subgenual prefrontal cortex in unipolar depressionMol Psychiatry199831901919672886
- DolanRJBenchCJLiddlePFDorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificityJ Neurol Neurosurg Psychiatry199356129012948270929
- AndreasenNCLinking mind and brain in the study of mental illnesses: a project for a scientific psychopathologyScience1997275158615939054346
- HonerWGAssessing the machinery of mind: synapses in neuropsychiatric disordersJ Psychiatry Neurosci19992411612110212553
- ToniNBuchsPANikonenkoIBronCRMullerDLTP promotes formation of multiple spine synapses between a single axon terminal and a dendriteNature199940242142510586883
- HajszaTMacLuskyNJLeranthCShort-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampusEur J Neurosci20052112991230315813939
- McEwenBSEffects of adverse experiences for brain structure and functionBiol Psychiatry20004871371411063967
- ShelineYI3D MRI studies of neuroanatomic changes in unipolar depression: the role of stress and medical comorbidityBiol Psychiatry20004879180011063975
- SalaMPerezJSoloffPStress and hippocampal abnormalities in psychiatric disordersEur Neuropsychopharmacol20041439340515336301
- FrodlTSchaubABanacSReduced hippocampal volume correlates with executive dysfunctioning in depressionJ Psychiatry Neurosci20063131632316951734
- RajkowskaGMiguel-HidalgoJJGliogenesis and glial pathology in depressionCNS Neurol Disord Drug Targets2007621923317511618
- SackeimHAFunctional brain circuits in depression and remissionArch Gen Psychiatry20015864965011448370
- HoranWPPoggeDLBorgaroSRStokesJMHarveyPDLearning and memory in adolescent psychiatric inpatients with depression: a normative study of the California Verbal Learning TestArch Clin Neuropsychol19971257558414590669
- PorterRJGallagherPThompsonJMYoungAHNeurocognitive impairment in drug-free patients with major depressive disorderBr J Psychiatry200318221422012611784
- BeardenCEGlahnDCMonkulESPatterns of memory impairment in bipolar disorder and unipolar depressionPsychiatry Res200614213915016631256
- LewinGRBardeYAPhysiology of the neurotrophinsAnnu Rev Neurosci1996192893178833445
- McAllisterAKNeurotrophins and neuronal differentiation in the central nervous systemCell Mol Life Sci2001581054106011529498
- SofroniewMVGalletlyNPIsacsonOSvendsenCNSurvival of adult basal cholinergic neurons after loss of target neuronsScience19902473383421688664
- CooperJDSkepperJNBerzaghiMDLindholmDSofroniewMVDelayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the ratExp Neurol19961391431558635561
- McAllisterAKKatzLCLoDCNeurotrophins and synaptic plasticityAnnu Rev Neurosci19992229531810202541
- ThoenenHNeurotrophins and activity-dependent plasticityProg Brain Res200012818319111105678
- ChaoMVRajagopalRLeeFSNeurotrophin signaling in health and diseaseClin Sci (Lond)200611016717316411893
- ReichardtLFNeurotrophin-regulated signalling pathwaysPhilos Trans R Soc Lond B Biol Sci20063611545156416939974
- BarbacidMNeurotrophic factors and their receptorsCurr Opin Cell Biol199571481557612265
- SchweigreiterRThe dual nature of neurotrophinsBioessays20062858359416700063
- SeidahNGBenjannetSPareekSChrétienMMurphyRACellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertasesFEBS Lett19963792472508603699
- LuBPangPTWooNHThe yin and yang of neurotrophin actionNat Rev Neurosci2005660361416062169
- EganMFKojimaMCallicottJHThe BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionCell200311214414512553902
- MowlaSJPareekSFarhadiHFDifferential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neuronsJ Neurosci1999192069208010066260
- MowlaSJFarhadiHFPareekSBiosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factorJ Biol Chem2001276126601266611152678
- ChenZYIeraciATengHSortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathwayJ Neurosci2005256156616615987945
- LeeRKermaniPTengKKHempsteadBLRegulation of cell survival by secreted proneurotrophinsScience20012941945194811729324
- PangPTTengHKZaitsevECleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityScience200430648749115486301
- MellstromBTorresBLinkWANaranjoJRThe BDNF gene: exemplifying complexity in Ca2+ -dependent gene expressionCrit Rev Neurobiol200416434915581398
- PykelESLife stress, depression and attempted suicideJ Human Stress19762312
- LuscombRLClumGAPatsiokasATMediating factors in the relationship between life stress and suicide attemptingJ Nerv Ment Disord1980168644650
- AratoMBankiCMBissetteGNemeroffCBElevated CSF CRF in suicide victimsBiol Psychiatry1989253553592536563
- DooleyDCatalanoRRookKSerxnerSEconomic stress and suicide: multilevel analyses. Part 1: Aggregate time-series analyses of economic stress and suicideSuicide Life Threat Behav1989a193213362609362
- DooleyDCatalanoRRookKSerxnerSEconomic stress and suicide: multilevel analyses. Part 2: Crosslevel analyses of economic stress and suicidal ideationSuicide Life Threat Behav1989b193373512609363
- LandauSFRehavGSuicide and attempted suicide: their relation to subjective social stress indicatorsGenet Soc Gen Psychol Monogr19891152732742792740
- JosephoSAPlutchikRStress, coping, and suicide risk in psychiatric inpatientsSuicide Life Threat Behav19942448578203008
- WestrinAStress system alterations and mood disorders in suicidal patientsBiomed Pharmacother20005414214510840591
- FranceRDUrbanBKrishnanKRCSF corticotrophin releasing factor-like immunoactivity in chronic pain patients with and without depressionBiol Psychiatry19882386882962646
- NemeroffCBOwensMJBissetteGAndornACStanleyMReduced corticotropin releasing factor binding sites in the frontal cortex of suicide victimsArch Gen Psychiatry1988455775792837159
- LopezJFPalkovitsMAratoMMansourAAkilHWatsonSJLocalization and quantification of proopiomelanocortin mRNA and glucocorticoid receptor mRNA in pituitaries of suicide victimsNeuroendocrinology1992564915011335553
- SzigethyEConwellYForbesNTCoxCCaineEDAdrenal weight and morphology in victims of completed suicideBiol Psychiatry1994363743807803598
- DumserTBarockaASchubertEWeight of adrenal glands may be increased in persons who commit suicideAm J Forensic Med Pathol19981972769539397
- LopezJFChalmersDTLittleKYWatsonSJRegulation of serotoninlA, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depressionBiol Psychiatry1998435475739564441
- LesterDThe dexamethasone suppression test as an indicator of suicide: a meta-analysisPharmacopsychiatry1992252652701494592
- CoryellWSchlesserMThe dexamethasone suppression test and suicide predictionAm J Psychiatry200115874875311329397
- CoryellWYoungECarrollBHyperactivity of the hypothalamic-pituitary-adrenal axis and mortality in major depressive disorderPsychiatry Res20061429910416631257
- JokinenJCarlborgAMårtenssonBForslundKNordströmALNordströmPDST non-suppression predicts suicide after attempted suicidePsychiatry Res200715029730317316825
- JokinenJNordströmALNordströmPCSF 5-HIAA and DST non-suppression – orthogonal biologic risk factors for suicide in male mood disorder inpatientsPsychiatry Res2009a1659610219062105
- JokinenJNordströmPHPA axis hyperactivity and attempted suicide in young adult mood disorder inpatientsJ Affect Disord2009b11611712019054569
- SmithMAMakinoSKvetnanskyRPostRMStress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampusJ Neurosci199515176817777891134
- UeyamaTKawaiYNemotoKSekimotoMTonéSSenbaEImmobilization stress reduced the expression of neurotrophins and their receptors in the rat brainNeurosci Res1997281031109220467
- VaidyaVAMarekGJAghajanianGKDumanRS5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortexJ Neurosci199717278527959092600
- RasmussonAMShiLDumanRDownregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshockNeuropsychopharmacology20022713314212093587
- PizarroJMLumleyLAMedinaWAcute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in miceBrain Res20041025102015464739
- RoceriMHendriksWRacagniGEllenbroekBARivaMAEarly maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampusMol Psychiatry2002760961612140784
- ChaoHMSakaiRRMaLYMcEwenBSAdrenal steroid regulation of neurotrophic factor expression in the rat hippocampusEndocrinology1998139311231189645683
- SchaafMJMHoetelmansRWMde KloetERVreugdenhilECorticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampusJ Neurosci Res1997483343419169859
- SchaafMJMde JongJde KloetERVreugdenhilEDownregulation of BDNF mRNA and protein in the rat hippocampus by corticosteroneBrain Res19988131121209824681
- DwivediYRizaviHSPandeyGNAntidepressants reverse corticosterone-mediated decrease in BDNF expression: Dissociation in regulation of specific exons by antidepressants and corticosteroneNeuroscience2006a1391017102916500030
- BarbanyGPerssonHRegulation of Neurotrophin mRNA Expression in the Rat Brain by GlucocorticoidsEur J Neurosci1992439640312106347
- TimmuskTPalmKMetsisMMultiple promoters direct tissue-specific expression of the rat BDNF geneNeuron1993104754898461137
- NakayamaMGaharaYKitamuraTOharaODistinctive four promoters collectively direct expression of brain-derived neurotrophic factor geneMol Brain Res1994212062188170345
- MarmigereFGivaloisLRageFArancibiaSTapia-ArancibiaLRapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult ratsHippocampus20031364665512921353
- RageFGivaloisLMarmigereFTapia-ArancibiaLArancibiaSImmobilization stress rapidly modulates BDNF mRNA expression in the hypothalamus of adult male ratsNeurosci2002112309318
- NibuyaMMorinobuSDumanRSRegulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatmentsJ Neurosci199515753975477472505
- NibuyaMNestlerEJDumanRSChronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampusJ Neurosci199616236523728601816
- Russo-NeustadtABeardRCCotmanCWExercise, antidepressant medications, and enhanced brain derived neurotrophic factor expressionNeuropsychopharmacology19992167968210516964
- CoppellALPeiQZetterströmTSBi-phasic change in BDNF gene expression following antidepressant drug treatmentNeuropharmacology20034490391012726822
- DiasBGBanerjeeSBDumanRSVaidyaVADifferential regulation of brain-derived neurotrophin factor transcripts by antidepressant treatments in the adult rat brainNeuropharmacology20034555356312907316
- Van HoomissenJDChamblissHOHolmesPVDishmanRKEffects of chronic exercise and imipramine on mRNA for BDNF after olfactory bulbectomy in ratBrain Res200397422823512742641
- XuHSteven RichardsonJLiXMDose-related effects of chronic antidepressants on neuroprotective proteins BDNF, Bcl-2 and Cu/Zn-SOD in rat hippocampusNeuropsychopharmacology200328536212496940
- GarzaAAHaTGGarciaCChenMJRusso-NeustadtAAExercise, antidepressant treatment, and BDNF mRNA expression in the aging brainPharmacol Biochem Behav20047720922014751447
- De FoubertGCarneySLRobinsonCSFluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatmentNeuroscience200412859760415381288
- VinetJCarraSBlomJMBrunelloNBardenNTasceddaFChronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptorNeuropharmacology2004471062106915555640
- RogózZSkuzaGLegutkoBRepeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in ratsJ Physiol Pharmacol20055666167116391422
- NeeperSAGómez-PinillaFChoiJCotmanCWPhysical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brainBrain Res199672649568836544
- MüllerMBToschiNKresseAEPostAKeckMELong-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brainNeuropsychopharmacology20002320521510882847
- MarvanováMLaksoMPirhonenJNawaHWongGCastrénEThe neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brainMol Cell Neurosci20011824725811591126
- NewtonSSCollierEFHunsbergerJGene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factorsJ Neurosci200323108411085114645477
- AltarCALaengPJurataLWElectroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathwaysJ Neurosci2004242667267715028759
- LauterbornJCTruongGSBaudryMBiXLynchGGallCMChronic elevation of brain-derived neurotrophic factor by ampakinesJ Pharmacol Exp Ther200330729730512893840
- Russo-NeustadtAAAlejandreHGarciaCIvyASChenMJHippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exerciseNeuropsychopharmacology2004292189219915199375
- AlfonsoJFrickLRSilbermanDMPalumboMLGenaroAMFraschACRegulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatmentsBiol Psychiatry20065924425116140276
- FujimakiKMorinobuSDumanRSAdministration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampusNeuropsychopharmacology200022425110633490
- AltieriMMariniFArbanRVitulliGJanssonBOExpression analysis of brain-derived neurotrophic factor (BDNF) mRNA isoforms after chronic and acute antidepressant treatmentBrain Res2004100014815515053962
- ZetterströmTSPeiQMadhavTRCoppellALLewisLGrahame-SmithDGManipulations of brain 5-HT levels affect gene expression for BDNF in rat brainNeuropharmacology1999381063107310428425
- MiróXPérez-TorresSArtigasFPuigdomènechPPalaciosJMMengodGRegulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization studyNeuropharmacology2002431148115712504921
- SaarelainenTHendolinPLucasGActivation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effectsJ Neurosci20032334935712514234
- MonteggiaLMBarrotMPowellCMEssential role of brain-derived neurotrophic factor in adult hippocampal functionProc Natl Acad Sci U S A2004101108271083215249684
- BarbacidMThe Trk family of neurotrophin receptorsJ Neurobiol199425138614037852993
- DechantGRodriguez-TebarABradeYANeurotrophin receptorsProg Neurobiol1994423473728008834
- MiddlemasDSLindbergRAHunterTTrkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptorsMol Cell Biol1991111431531846020
- SchlessingerJUllrichAGrowth factor signaling by receptor tyrosine kinasesNeuron199293833911326293
- WatsonFLHeerssenHMMohebanDBRapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complexJ Neurosci1999197889790010479691
- AllendoerferKLCabelliRJEscandonEKaplanDRNikolicsKShatzCJRegulation of neurotropin receptors during the maturation of the mammalian visual systemJ Neurosci19944179518118126572
- ArmaniniMPMcMahonSBSutherlandJSheltonDLPhilipsHSTruncated and catalytic isoforms of TrkB are co-expressed in neurons of rat and mouse CNSEur J Neurosci19957140314097582115
- EideEFViningEREideBLZangKWangXYReichardtLFNaturally occurring truncated TrkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signalingJ Neurosci199616312331298627351
- RantamäkiTKnuuttilaJEHokkanenMECastrénEThe effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortexNeuropharmacology20065042142716300803
- RantamäkiTHendolinPKankaanpääAPharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-C gamma signaling pathways in mouse brainNeuropsychopharmacology2007322152216217314919
- ZörnerBWolferDPBrandisDForebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”Biol Psychiatry20035497298214625139
- SiuciakJALewisDRWiegandSJLindsayRMAntidepressant-like effect of brain-derived neurotrophic factor (BDNF)Pharmacol Biochem Behav1997J561311378981620
- ShirayamaYChenACNakagawaSRussellDSDumanRSBrain-derived neurotrophic factor produces antidepressant effects in behavioral models of depressionJ Neurosci2002223251326111943826
- AltarCANeurotrophins and depressionTrends Pharmacol Sci199920596110101965
- HoshawBAMalbergJELuckiICentral administration of IGF-I and BDNF leads to long-lasting antidepressant-like effectsBrain Res2005103720420815777771
- ChenBDowlatshahiDMacQueenGMWangJFYoungLTIncreased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medicationBiol Psychiatry20015026026511522260
- KaregeFSchwaldMCisseMPostnatal developmental profile of brain-derived neurotrophic factor in rat brain and plateletsNeurosci Lett200232826126412147321
- KaregeFPerretGBondolfiGSchwaldMBertschyGAubryJMDecreased serum brain-derived neurotrophic factor levels in major depressed patientsPsychiatry Res200210914314811927139
- KaregeFBondolfiGGervasoniNSchwaldMAubryJMBertschyGLow brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivityBiol Psychiatry2005a571068107215860348
- GonulASAkdenizFTaneliFDonatOEkerCVahipSEffect of treatment on serum brain-derived neurotrophic factor levels in depressed patientsEur Arch Psychiatry Clin Neurosci200525538138615809771
- PiccinniAMarazzitiDCatenaMPlasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatmentsJ Affect Disord200810527928317553570
- MatriscianoFBonaccorsoSRicciardiAChanges in BDNF serum levels in patients with depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxineJ Psychiatr Res20094324725418511076
- AydemirODeveciATaneliFThe effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary studyProg Neuropsychopharmacol Biol Psychiatry20052926126515694233
- YoshimuraRMitomaMSugitaAEffects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patientsProg Neuropsychopharmacol Biol Psychiatry200731034103717459550
- HellwegRZiegenhornAHeuserIDeuschleMSerum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatmentPharmacopsychiatry200841667118311687
- LangUEBajboujMGallinatJHellwegRBrain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulationPsychopharmacology (Berl)2006187156159
- Bocchio-ChiavettoLZanardiniRBortolomasiMElectroconvulsive Therapy (ECT) increases serum Brain Derived Neurotrophic Factor (BDNF) in drug resistant depressed patientsEur Neuropsychopharmacol20061662062416757154
- BrunoniARLopesMFregniFA systematic review and meta-analysis of clinical studies on depression and BDNF levels: implications for the role of neuroplasticity in depressionInt J Neuropsychopharmacol2008111169118018752720
- SenSDumanRSanacoraGSerum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implicationsBiol Psychiatry20086452753218571629
- ChenZYPatelPDSantGVariant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neuronsJ Neurosci2004244401441115128854
- ShelineYIWangPWGadoMHCsernanskyJGVannierMWHippocampal atrophy in recurrent depressionProc Natl Acad Sci U S A199693390839138632988
- ShelineYIGadoMHKraemerHCUntreated depression and hippocampal volume lossAm J Psychiatry20031601516151812900317
- FrodlTSchüleCSchmittGAssociation of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in depressionArch Gen Psychiatry20076441041617404118
- PezawasLVerchinskiBAMattayVSThe brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphologyJ Neurosci200424100991010215537879
- SzeszkoPRLipskyRMentschelCBrain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formationMol Psychiatry20051063163615768049
- BuellerJAAftabMSenSGomez-HassanDBurmeisterMZubietaJKBDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjectsBiol Psychiatry20065981281516442082
- HaririARGoldbergTEMattayVSBrain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performanceJ Neurosci2003236690669412890761
- KleimJAChanSPringleEBDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortexNat Neurosci2006973573716680163
- CheeranBTalelliPMoriFA common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMSJ Physiol20085865717572518845611
- TsaiSJChengCYYuYWChenTJHongCJAssociation study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant responseAm J Med Genet B Neuropsychiatr Genet2003123B192214582140
- ChoiMJKangRHLimSWOhKSLeeMSBrain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorderBrain Res2006111817618216979146
- LicinioJDongCWongMLNovel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment responseArch Gen Psychiatry20096648849719414708
- HwangJPTsaiSJHongCJYangCHLirngJFYangYMThe Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depressionNeurobiol Aging2006271834183716343697
- DuncanLEHutchisonKECareyGCraigheadWEVariation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depressionJ Affect Disord200911521521918842305
- SavitzJvan der MerweLSteinDJSolmsMRamesarRGenotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variantsBiol Psychiatry2007643919
- Grassi-OliveiraRSteinLMLopesRPTeixeiraALBauerMELow plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression – a preliminary reportBiol Psychiatry20086428128518406398
- GattJMNemeroffCBDobson-StoneCInteractions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxietyMol Psychiatry20091468169519153574
- AguileraMAriasBWichersMEarly adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general populationPsychol Med2009
- LangUEHellwegRKalusPAssociation of a functional BDNF polymorphism and anxiety-related personality traitsPsychopharmacology (Berl)2005180959915918078
- HünnerkopfRStrobelAGutknechtLBrockeBLeschKPInteraction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traitsNeuropsychopharmacology2007322552256017392738
- JoffeRTGattJMKempAHBrain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illnessHum Brain Mapp2009301246125618548532
- TerraccianoASannaSUdaMGenome-wide association scan for five major dimensions of personalityMol Psychiatry2008
- SavitzJSolmsMRamesarRThe molecular genetics of cognition: dopamine, COMT and BDNFGenes Brain Behav2006531132816716201
- MillJPetronisAMolecular studies of major depressive disorder: the epigenetic perspectiveMol Psychiatry20071279981417420765
- ChenWGChangQLinYDerepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2Science200330288588914593183
- MartinowichKHattoriDWuHDNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulationScience200330289089314593184
- FuchikamiMMorinobuSKurataAYamamotoSYamawakiSSingle immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampusInt J Neuropsychopharmacol200912738218544182
- TsankovaNMBertonORenthalWKumarANeveRLNestlerEJSustained hippocampal chromatin regulation in a mouse model of depression and antidepressant actionNat Neurosci2006951952516501568
- DwivediYRizaviHSConleyRRRobertsRCTammingaCAPandeyGNAltered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjectsArch Gen Psychiatry200360
- KaregeFVaudanGSchwaldMPerroudNLa HarpeRNeurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugsBrain Res Mol Brain Res2005b136293715893584
- KoziczTTilburg-OuwensDFaludiGPalkovitsMRoubosEGender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with depressionNeuroscience20081521015102318329817
- PandeyGNRenXRizaviHSConleyRRRobertsRCDwivediYBrain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victimsInt J Neuropsychopharmacol2008111047106118611289
- DeveciAAydemirOTaskinOTaneliFEsen-DanaciASerum BDNF levels in suicide attempters related to psychosocial stressors: a comparative study with depressionNeuropsychobiology200756939718037819
- KimYKLeeHPWonSDLow plasma BDNF is associated with suicidal behavior in depressionProg Neuropsychopharmacol Biol Psychiatry20073157857917134810
- LeeBHKimHParkSHKimYKDecreased plasma BDNF level in depressive patientsJ Affect Disord200710123924417173978
- LeeBHKimYKReduced platelet BDNF level in patients with depressionProg Neuropsychopharmacol Biol Psychiatry2009414 [Epub ahead of print].
- DawoodTAndersonJBartonDReduced overflow of BDNF from the brain is linked with suicide risk in depressive illnessMol Psychiatry20071298198317957235
- HongCJHuoSJYenFCTungCLPanGMTsaiSJAssociation study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behaviorNeuropsychobiology20034818618914673216
- KimBKimCYHongJPKimSYLeeCJooYHBrain-derived neurotrophic factor Val/Met polymorphism and bipolar disorder. Association of the Met allele with suicidal behavior of bipolar patientsNeuropsychobiology20085829710318843195
- SarchiaponeMCarliVRoyAAssociation of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patientsNeuropsychobiology20085713914518600033
- ZarrilliFAngiolilloACastaldoGBrain derived neurotrophic factor (BDNF) genetic polymorphism (Val66Met) in suicide: A study of 512 casesAm J Med Genet B Neuropsychiatr Genet2008829 [Epub ahead of print].
- PerroudNCourtetPVinczeIInteraction between BDNF Val66Met and childhood trauma on adult’s violent suicide attemptGenes Brain Behav2008731432217883407
- FryerRHKaplanDRFeinsteinSCRadekeMJGraysonDRKromerLFDevelopmental and mature expression of full-length and truncated TrkB receptors in the rat forebrainJ Comp Neurol199637421408891944
- DwivediYRizaviHZhangHNeurotrophin receptor activation and expression in human postmortem brain: effect of suicideBiol Psychiatry20096531932818930453
- ErnstCDelevaVDengXAlternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completersArch Gen Psychiatry200966223219124685
- FradeJMBardeYANerve growth factor: two receptors, multiple functionsBioEssays1998201371459631659
- HasegawaYYamagishiSFujitaniMYamashitaTp75 neurotrophin receptor signaling in the nervous systemBiotechnol Annu Rev20041012314915504705
- HempsteadBLMartin-ZancaDKaplanDRParadaLFChaoMVHigh-affinity NGF binding requires co-expression of the trk proto-oncogene and the low-affinity NGF receptorNature19913506786831850821
- BenedettiMLeviAChaoMVDifferential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsivenessProc Natl Acad Sci U S A199390785978638356095
- EspositoDPatelPStephensRMThe cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factorJ Biol Chem2001276326873269511435417
- MeldolesiJScioratiCClementiEThe p75 receptor: first insights into the transduction mechanisms leading to either cell death or survivalTrends Pharmacol Sci20002124224310871890
- RabizadehSOhJZhongLYangJBitlerCMButcherLLInduction of apoptosis by the low-affinity NGF receptorScience19932613453588332899
- Casaccia-BonnefilPCarterBDDobrowskyRTChaoMVDeath of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75Nature19963837167198878481
- FriedmanWJGrossmanJNeurotrophins induce death of cultured hippocampal neuronsSoc Neurosci Abstr199925767
- FriedmanWNeurotrophins induce death of hippocampal neurons via the p75 receptorJ Neurosci2000286340634610964939
- RouxPPColicosMABarkerPAKennedyTEp75 neurotrophin receptor expression is induced in apoptotic neurons after seizureJ Neurosci1999196887689610436046
- MillerFDKaplanDRNeurotrophin signaling pathways regulating neuronal apoptosisCell Mol Life Sci2001581045105311529497
- DwivediYMondalACRizaviHSConleyRRSuicide brain is associated with decreased expression of neurotrophinsBiol Psychiatry20055831532415939410
- MukaiJHachiyaTShoji-HoshinoSNADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTRJ Biol Chem2000275175661757010764727
- SalehiAHRouxPPKubuCJNRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosisNeuron20002727928810985348
- JordanBWDinevDLeMellayVNeurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell deathJ Biol Chem2001276399853998911546791
- WhitfieldJNeameSJPaquetLBernardOHamJDominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c releaseNeuron20012962964311301023
- YoonSOCassaccia-BonnefilPCarterBChaoMVCompetitive signaling between TrkA and p75 nerve growth factor receptors determines cell survivalJ Neurosci199818327332819547236
- MazzoniIESaidFAAloyzRMillerFDKaplanDRas regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathwayJ Neurosci1999199716972710559381
- DobrowskyRTJenkinsGMHannunYANeurotrophins induce sphingomyelin hydrolysis-modulation by co-expression of p75NTR with trk receptorsJ Biol Chem199527022135221427673191
- BilderbackTRGazulaVRDobrowskyRTPhosphoinositide 3-kinase crosstalk between Trk A tyrosine kinase and p75NTR dependent sphingolipid signaling pathwaysNeurochem20017615401551
- MüllerGStorzPBourteeleSDöpplerHPfizenmaierKMischakHRegulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signallingEMBO J1998177327429450998
- ZhouHSummersSABirnbaumMJPittmanRNInhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosisJ Biol Chem199827316568165759632728
- ZundelWSchindlerCHaas-KoganDKoongAKaperFChenELoss of PTEN facilitates HIF-1-mediated gene expressionGenes Dev20001439139610691731
- DwivediYRizaviHSRobertsRCConleyRCTammingaCAPandeyGNReduced activation and expression of ERK1/2 MAP kinase in the postmortem brain of depressed suicide subjectsJ Neurochem20017791692811331420
- DwivediYRizaviHSConleyRRPandeyGNERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-RafMol Psychiatry2006b11869816172610
- DwivediYRizaviHSTeppenTLower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI 3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjectsNeuropsycho-pharmacology [Epub ahead of print] PMID: 18075493.2008
- HempsteadBLThe many faces of p75NTRCurr Opin Neurobiol20021226026712049931
- WooNHTengHKSiaoCJActivation of p75NTR by proBDNF facilitates hippocampal long-term depressionNat Neurosci200581069107716025106
- FigurovAPozzo-MillerLDOlafssonPWangTLuBRegulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampusNature19963817067098649517
- McGregorSStraussJBulginNp75(NTR) gene and suicide attempts in young adults with a history of childhood-onset mood disorderAm J Med Genet B Neuropsychiatr Genet2007144B69670017357149
- MacQueenGMRamakrishnanKCrollSDPerformance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depressionBehav Neurosci20011151145115311584927
- KoponenEVoikarVRiekkiRTransgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of trkB/PLC-? pathway, reduced anxiety, and facilitated learningMol Cell Neurosci20042616618115121188
- KoponenERantamäkiTVoikarVSaarelainenTMacDonaldECastrénEEnhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoaminesCell Mol Neurobiol2005697398016392030
- TakeiNInamuraNKawamuraMBrain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendritesJ Neurosci2004249760976915525761
- SchrattGMTuebingFNighEAA brain-specific microRNA regulates dendritic spine developmentNature200643928328916421561