Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2

References

• Van BuskirkEMCioffiGAGlaucomatous optic neuropathyAm J Ophthalmol19921134474521558122
   PubMed Web of Science ®Google Scholar
• World Health OrganizationMagnitude and causes of visual impairment. Fact Sheet Number 282: World Health Organization2004 Available at: http://www.who.int/mediacentre/factsheets/fs282/en/. Accessed May 12, 2010.
   Google Scholar
• QuigleyHAGreenWRThe histology of human glaucoma cupping and optic nerve damage: Clinicopathologic correlation in 21 eyesOphthalmology19798618031830553256
   PubMed Web of Science ®Google Scholar
• GoldbergLDClinical guidelines for the treatment of glaucomaManag Care200211162415357535
   PubMedGoogle Scholar
• KassMAHeuerDKHigginbothamEJThe Ocular Hypertension Treatment Study: A randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucomaArch Ophthalmol200212070113 discussion 829–830.12049574
   PubMed Web of Science ®Google Scholar
• HeijlALeskeMCBengtssonBHymanLHusseinMReduction of intraocular pressure and glaucoma progression: Results from the Early Manifest Glaucoma TrialArch Ophthalmol20021201268127912365904
   PubMed Web of Science ®Google Scholar
• KrakauCEIntraocular pressure elevation – cause or effect in chronic glaucoma?Ophthalmologica19811821411477267002
   PubMed Web of Science ®Google Scholar
• BonomiLMarchiniGMarraffaMMorbioRThe relationship between intraocular pressure and glaucoma in a defined population. Data from the Egna-Neumarkt Glaucoma StudyOphthalmologica2001215343811125267
   PubMed Web of Science ®Google Scholar
• AlvaradoJMurphyCJusterRTrabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normalsOphthalmology1984915645796462622
   PubMed Web of Science ®Google Scholar
• RohenJWLutjen-DrecollEFlugelCMeyerMGriersonIUltrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG)Exp Eye Res1993566836928595810
   PubMed Web of Science ®Google Scholar
• VeachJFunctional dichotomy: Glutathione and vitamin E in homeostasis relevant to primary open-angle glaucomaBr J Nutr20049180982915182385
   PubMed Web of Science ®Google Scholar
• FindlORainerGDallingerSAssessment of optic disk blood flow in patients with open-angle glaucomaAm J Ophthalmol200013058959611078837
   PubMed Web of Science ®Google Scholar
• ButtZO’BrienCMcKillopGAspinallPAllanPColor Doppler imaging in untreated high- and normal-pressure open-angle glaucomaInvest Ophthalmol Vis Sci1997386906969071223
   PubMed Web of Science ®Google Scholar
• FerreiraSMLernerSFBrunziniREvelsonPALlesuySFOxidative stress markers in aqueous humor of glaucoma patientsAm J Ophthalmol2004137626914700645
   PubMed Web of Science ®Google Scholar
• LevinLAClarkJAJohnsLKEffect of lipid peroxidation inhibition on retinal ganglion cell deathInvest Ophthalmol Vis Sci199637274427498977490
   PubMed Web of Science ®Google Scholar
• SaccaSCPascottoACamicionePCaprisPIzzottiAOxidative DNA damage in the human trabecular meshwork: Clinical correlation in patients with primary open-angle glaucomaArch Ophthalmol200512345846315824217
   PubMed Web of Science ®Google Scholar
• FleenorDLShepardARHellbergPEJacobsonNPangIHClarkAFTGFbeta2-induced changes in human trabecular meshwork: Implications for intraocular pressureInvest Ophthalmol Vis Sci20064722623416384967
   PubMed Web of Science ®Google Scholar
• MinSHLeeTIChungYSKimHKTransforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyesKorean J Ophthalmol20062016216517004630
   PubMedGoogle Scholar
• NickellsRWApoptosis of retinal ganglion cells in glaucoma: An update of the molecular pathways involved in cell deathSurv Ophthalmol199943Suppl 1S151S16110416758
   PubMed Web of Science ®Google Scholar
• Garcia-ValenzuelaEShareefSWalshJSharmaSCProgrammed cell death of retinal ganglion cells during experimental glaucomaExp Eye Res19956133447556468
   PubMed Web of Science ®Google Scholar
• KerriganLAZackDJQuigleyHASmithSDPeaseMETUNEL-positive ganglion cells in human primary open-angle glaucomaArch Ophthalmol1997115103110359258226
   PubMed Web of Science ®Google Scholar
• QuigleyHANickellsRWKerriganLAPeaseMEThibaultDJZackDJRetinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosisInvest Ophthalmol Vis Sci1995367747867706025
   PubMed Web of Science ®Google Scholar
• CaoYWeiHPfafflMDaBLiZApoptosis of human trabecular meshwork cells induced by transforming growth factor-beta2 in vitroJ Huazhong Univ Sci Technolog Med Sci20042487899415165125
   PubMedGoogle Scholar
• ZiangirovaGGAntonovaOVLipid peroxidation in the pathogenesis of primary open-angle glaucomaVestn Oftalmol20031195455 Russian.12934509
   PubMedGoogle Scholar
• AronsonALPharmacotherapeutics of the newer tetracyclinesJ Am Vet Med Assoc1980176106110687216873
   PubMed Web of Science ®Google Scholar
• PoirierRHEllisonACOcular penetration of orally administered minocyclineAnn Ophthalmol19791118591861556140
   PubMedGoogle Scholar
• KleinNCCunhaBATetracyclinesMed Clin North Am1995797898017791423
   PubMed Web of Science ®Google Scholar
• RyanMEGreenwaldRAGolubLMPotential of tetracyclines to modify cartilage breakdown in osteoarthritisCurr Opin Rheumatol199682382478796985
   PubMedGoogle Scholar
• WirostkoEWirostkoWJWirostkoBMAge-related macular degeneration is an inflammatory disease possibly treatable with minocyclineActa Ophthalmol Scand20048224324415043554
   PubMedGoogle Scholar
• ChenMOnaVOLiMMinocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington diseaseNat Med2000679780110888929
   PubMed Web of Science ®Google Scholar
• YrjanheikkiJKeinanenRPellikkaMHokfeltTKoistinahoJTetracyclines inhibit microglial activation and are neuroprotective in global brain ischemiaProc Natl Acad Sci U S A19989515769157749861045
   PubMed Web of Science ®Google Scholar
• ZhuSStavrovskayaIGDrozdaMMinocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in miceNature2002417747811986668
   PubMed Web of Science ®Google Scholar
• Sanchez MejiaROOnaVOLiMFriedlanderRMMinocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunctionNeurosurgery20014813939 discussion 1399–1401.11383749
   PubMed Web of Science ®Google Scholar
• PopovicNSchubartAGoetzBDZhangSCLiningtonCDuncanIDInhibition of autoimmune encephalomyelitis by a tetracyclineAnn Neurol20025121522311835378
   PubMed Web of Science ®Google Scholar
• DuYMaZLinSMinocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson’s diseaseProc Natl Acad Sci U S A200198146691467411724929
   PubMed Web of Science ®Google Scholar
• KrausRLPasiecznyRLariosa-WillinghamKTurnerMSJiangATraugerJWAntioxidant properties of minocycline: Neuroprotection in an oxidative stress assay and direct radical-scavenging activityJ Neurochem20059481982716033424
   PubMed Web of Science ®Google Scholar
• TikkaTFiebichBLGoldsteinsGKeinanenRKoistinahoJMinocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microgliaJ Neurosci2001212580258811306611
   PubMed Web of Science ®Google Scholar
• WangJWeiQWangCYHillWDHessDCDongZMinocycline up-regulates Bcl-2 and protects against cell death in mitochondriaJ Biol Chem2004279199481995415004018
   PubMed Web of Science ®Google Scholar
• Levkovitch-VerbinHKalev-LandoyMHabot-WilnerZMelamedSMinocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transectionArch Ophthalmol200612452052616606878
   PubMed Web of Science ®Google Scholar
• KerntMKampikAIntraocular caspofungin: In vitro safety profile for human ocular cellsMycoses2192010 [Epub ahead of print]
   Google Scholar
• KerntMLieglRGRuepingJSorafenib protects human optic nerve head astrocytes from light-induced overexpression of vascular endothelial growth factor, platelet-derived growth factor, and placenta growth factorGrowth Factors2192010 [Epub ahead of print]
   Google Scholar
• KerntMNeubauerASUlbigMWKampikAWelge-LussenUIn vitro safety of intravitreal moxifloxacin for endophthalmitis treatmentJ Cataract Refract Surg20083448048818299076
   PubMed Web of Science ®Google Scholar
• SiegnerAMayCAWelge-LussenUWBloemendalHLutjen-DrecollEAlpha B-crystallin in the primate ciliary muscle and trabecular meshworkEur J Cell Biol1996711651698905293
   PubMed Web of Science ®Google Scholar
• Welge-LussenUEichhornMBloemendalHLutjen-DrecollEClassification of human scleral spur cells in monolayer cultureEur J Cell Biol19987578849523158
   PubMed Web of Science ®Google Scholar
• MosmannTRapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysJ Immunol Methods19836555636606682
   PubMed Web of Science ®Google Scholar
• Welge-LussenUMayCAEichhornMBloemendalHLutjen-DrecollEAlpha B-crystallin in the trabecular meshwork is inducible by transforming growth factor-betaInvest Ophthalmol Vis Sci1999402235224110476788
   PubMed Web of Science ®Google Scholar
• KahnMGGiblinFJEpsteinDLGlutathione in calf trabecular meshwork and its relation to aqueous humor outflow facilityInvest Ophthalmol Vis Sci198324128312876885312
   PubMed Web of Science ®Google Scholar
• De La PazMAEpsteinDLEffect of age on superoxide dismutase activity of human trabecular meshworkInvest Ophthalmol Vis Sci199637184918538759353
   PubMed Web of Science ®Google Scholar
• LevineAJp53, the cellular gatekeeper for growth and divisionCell1997883233319039259
   PubMed Web of Science ®Google Scholar
• McKinnonSJLehmanDMKerrigan-BaumrindLACaspase activation and amyloid precursor protein cleavage in rat ocular hypertensionInvest Ophthalmol Vis Sci2002431077108711923249
   PubMed Web of Science ®Google Scholar
• MiyashitaTReedJCTumor suppressor p53 is a direct transcriptional activator of the human bax geneCell1995802932997834749
   PubMed Web of Science ®Google Scholar
• MiyashitaTHarigaiMHanadaMReedJCIdentification of a p53-dependent negative response element in the bcl-2 geneCancer Res199454313131358205530
   PubMed Web of Science ®Google Scholar
• HockenberyDMThe bcl-2 oncogene and apoptosisSemin Immunol199244134201286168
   PubMedGoogle Scholar
• DeverauxQLTakahashiRSalvesenGSReedJCX-linked IAP is a direct inhibitor of cell-death proteasesNature19973883003049230442
   PubMed Web of Science ®Google Scholar
• HolcikMGibsonHKornelukRGXIAP: Apoptotic brake and promising therapeutic targetApoptosis2001625326111445667
   PubMed Web of Science ®Google Scholar
• SasakiTLopesMBHankinsGRHelmGAExpression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous systemActa Neuropathol (Berl)200210410510912070671
   PubMed Web of Science ®Google Scholar
• McKinnonSJLehmanDMTahzibNGBaculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma modelMol Ther2002578078712027563
   PubMed Web of Science ®Google Scholar
• PetrinDBakerACouplandSGStructural and functional protection of photoreceptors from MNU-induced retinal degeneration by the X-linked inhibitor of apoptosisInvest Ophthalmol Vis Sci2003442757276312766084
   PubMed Web of Science ®Google Scholar
• SuzukiAItoTKawanoHSurvivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell deathOncogene2000191346135310713676
   PubMed Web of Science ®Google Scholar
• SuzukiAHayashidaMItoTSurvivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activationOncogene2000193225323410918579
   PubMed Web of Science ®Google Scholar
• ShinSSungBJChoYSAn anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7Biochemistry2001401117112311170436
   PubMed Web of Science ®Google Scholar
• NeufeldAHNitric oxide: A potential mediator of retinal ganglion cell damage in glaucomaSurv Ophthalmol199943Suppl 1S129S13510416755
   PubMed Web of Science ®Google Scholar
• KumarDMAgarwalNOxidative stress in glaucoma: A burden of evidenceJ Glaucoma20071633434317438430
   PubMed Web of Science ®Google Scholar
• BjornbergARoupeGSusceptibility to infections during long-term treatment with tetracyclines in acne vulgarisDermatologica19721453343374265960
   PubMedGoogle Scholar
• MargolisDJAntibiotics, acne, and upper respiratory tract infectionsLDI Issue Brief2006111416708431
   PubMedGoogle Scholar
• GouldenVGlassDCunliffeWJSafety of long-term high-dose minocycline in the treatment of acneBr J Dermatol19961346936958733373
   PubMed Web of Science ®Google Scholar
• TopouzisFTranosPKoskosasARisk of sudden visual loss following filtration surgery in end-stage glaucomaAm J Ophthalmol200514066166616226517
   PubMed Web of Science ®Google Scholar
• AgarALiSAgarwalNCoroneoMTHillMARetinal ganglion cell line apoptosis induced by hydrostatic pressureBrain Res2006108619120016638612
   PubMed Web of Science ®Google Scholar