A review of the role of capecitabine in the treatment of colorectal cancer

References

• AndréTColinPLouvetCSemimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: results of a Randomized TrialJ Clin Oncol200321289690312885807
   PubMed Web of Science ®Google Scholar
• AndréTBoniCMounedji-BoudiafLOxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancerN Engl J Med200435023435115175436
   PubMed Web of Science ®Google Scholar
• ArkenauHSchmollHKubickaSInfusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) versus capecitabine plus oxaliplatin (CAPOX) as first line treatment of metastatic colorectal cancer (MCRC): Results of the safety and efficacy analysisProceedings American Society of Clinicial Oncology Annual Meeting2005 23, 16s (abstract 3507)
   Google Scholar
• AscheleCFrisoMLPucciarelliSA phase I-II study of weekly oxaliplatin, 5-fluorouracil continuous infusion and preoperative radiotherapy in locally advanced rectal cancerAnn Oncol2005161140615894548
   PubMed Web of Science ®Google Scholar
• BajettaEDi BartolomeoMMarianiLRandomized multicenter phase II trial of two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinomaCancer20051527987
   Google Scholar
• BornerMMSchoffskiPde WitRPatient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancerEur J Cancer2002383495811818199
   PubMed Web of Science ®Google Scholar
• BornerMMBernhardJDietrichDA randomized phase II trial of capecitabine and two different schedules of irinotecan in first-line treatment of metastatic colorectal cancer: efficacy, quality-of-life and toxicityAnn Oncol200516282815668285
   PubMed Web of Science ®Google Scholar
• CammàCGiuntaMFioricaFPreoperative radiotherapy for resectable rectal cancer. A meta-analysisJAMA200028410081510944647
   PubMed Web of Science ®Google Scholar
• CassidyJTaberneroJTwelvesJXELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancerJ Clin Oncol20042220849115169795
   PubMed Web of Science ®Google Scholar
• CassidyJDouillardJ-YTwelvesCPharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes’C colon cancer: the X-ACT trialBr J Cancer2006941122916622438
   PubMed Web of Science ®Google Scholar
• CassidyJClarkeSDiaz RubioEXELOX vs FOLFOX4: Efficacy results from XELOX-1/NO16966, a randomized phase III trial in first-line metastatic colorectal cancer (MCRC)Proceedings ASCO Gastrointestinal Cancer Symposium2007 abstract 270
   Google Scholar
• ChauIBrownGCunninghamDNeoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging–defined poor-risk rectal cancerJ Clin Oncol2006246687416446339
   PubMed Web of Science ®Google Scholar
• Colorectal Cancer Collaborative GroupAdjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomised trialsLancet2001358129130411684209
   PubMed Web of Science ®Google Scholar
• ComellaPNataleDFarrisACapecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal cancer. Final results of the Southern Italy Cooperative Oncology Group (SICOG) trial 0108Cancer2005a104282915948167
   PubMed Web of Science ®Google Scholar
• ComellaPMassiddaBPalmeriSBiweekly oxaliplatin combined with oral capecitabine (OXXEL regimen) as first-line treatment of metastatic colorectal cancer patients, A Southern Italy Cooperative Oncology Group phase II studyCancer Chemother Pharmacol2005b56481615902461
   PubMed Web of Science ®Google Scholar
• DasPLinEHBhatiaSPreoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: A matched-pair analysisInt J Radiat Oncol Biol Phys20066613788317056196
   PubMed Web of Science ®Google Scholar
• de GramontAFigerASeymourMLeucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancerJ Clin Oncol20001829384710944126
   PubMed Web of Science ®Google Scholar
• De PaoliAChiaraSLuppiGCapecitabine in combination with preoperative radiation therapy in locally advanced, respectable, rectal cancer: a multicentric phase II studyAnn Oncol200672.651
   Google Scholar
• DouillardJYCunninghamDRothADIrinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicenter randomised trialLancet20003551041710744089
   PubMed Web of Science ®Google Scholar
• EggintonSTappendenPPandorACost-effectiveness of oxaliplatin and capecitabine in the adjuvant treatment of stage III colon cancerBr J Cancer200695119520117031407
   PubMed Web of Science ®Google Scholar
• FeliuJEscuderoPLlosaFCapecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: an Oncopaz Cooperative Group studyJ Clin Oncol20052331041115860870
   PubMed Web of Science ®Google Scholar
• FeliuJSaludAEscuderoPXELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancerBr J Cancer2006949697516552438
   PubMed Web of Science ®Google Scholar
• FuchsCMarshallJMitchellEA randomized trial of first-line irinotecan/fluoropymidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C)Proceedings American Society of Clinicial Oncology Annual Meeting2006 24, 18S, (abstract 3506)
   Google Scholar
• GérardJ-PChapetONemozCPreoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: The Lyon R0–04 phase II trialJ Clin Oncol20032111192412637479
   PubMed Web of Science ®Google Scholar
• GillSLoprinziCLSargentDJPooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much?J Clin Oncol200415179780615067028
   PubMed Web of Science ®Google Scholar
• Glynne-JonesRSebag-MontefioreDSamuelLSocrates phase II study results: capecitabine (CAP) combined with oxaliplatin (OX) and preoperative radiation (RT) in patients (pts) with locally advanced rectal cancer (LARC) [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2005 23, 16S (abstract 3527)
   Google Scholar
• GollinsSWMyintSLevineERadiotherapy plus concurrent irinotecan (CPT-11) and capecitabine (CAP) as preoperative downstaging treatment for locally advanced inoperable rectal cancer: A phase I/II study [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2006 24, 18S (abstract 13519)
   Google Scholar
• GrotheyADeschlerBKroeningHPhase III study of bolus 5-fluorouracil (5-FU)/ folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/FA + oxaliplatin (OXA) (FUFOX) in advanced colorectal cancer (ACRC) [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2002 21, (abstract 512)
   Google Scholar
• HochsterHSHartLLRamanathanRKSafety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC): Final analysis of the TREE-Study [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2006 24, 18S (abstract 3510)
   Google Scholar
• HoffPMAnsariRBatistGComparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients metastatic colorectal cancer: results of a randomized phase III studyJ Clin Oncol20011922829211304782
   PubMed Web of Science ®Google Scholar
• HofheinzR-Dvon Gerstenberg-HelldorfBWenzFPhase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancerJ Clin Oncol2005231350715684318
   PubMed Web of Science ®Google Scholar
• IshikawaTUtohMSawadaNTumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancerBiochem Pharmacol199855109179605432
   PubMed Web of Science ®Google Scholar
• JemalAMurrayTWardECancer statisticsCA Cancer J Clin200555103015661684
   PubMed Web of Science ®Google Scholar
• KapiteijnEMarijnenCAMNagtegaalIDPreoperative radiotherapy combined with total mesorectal excision for resectable rectal cancerN Engl J Med20013456384611547717
   PubMed Web of Science ®Google Scholar
• KhrishnanSJanjanNASkibberJMPhase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancerInt J Radiat Biol Phys20066676271
   Web of Science ®Google Scholar
• KimDYJungKHKimTHComparison of 5-fluorouracil/leucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancerInt J Radiat Oncol Biol Phys2006118 Epub ahead of print
   Web of Science ®Google Scholar
• KlautkeGKüchenmeisterUFoitzikTConcurrent chemoradiation with capecitabine and weekly irinotecan as preoperative treatment for rectal cancer: results from a phase I/II studyBr J Cancer2006949768116552435
   PubMed Web of Science ®Google Scholar
• KöhneCde GreveJBokemeyerCCapecitabine plus irinotecan versus 5FU/FA/irinotecan +/- celecoxib in the first line treatment of metastatic colorectal cancer: safety results of the prospective multicenter EORTC phase III study 40015 [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2005 23, 16s (abstract 3525)
   Google Scholar
• LiuGFranssenEFitchMIPatient preferences for oral versus intravenous palliative chemotherapyJ Clin Oncol19971511058996131
   PubMed Web of Science ®Google Scholar
• MachielsJ-PDuckLHonhonBPhase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape studyAnn Oncol200516189890516219623
   PubMed Web of Science ®Google Scholar
• MassutiBGómezASastreJRandomized phase III trial of the TTD Group comparing capecitabine and oxaliplatin (XELOX) vs. oxaliplatin and 5-fluorouracil in continuous infusion (FUFOX) as first line treatment in advanced or metastatic colorectal cancer (CRC) [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2006 24, 18S (abstract 3580)
   Google Scholar
• MiwaMUraMNishidaMDesign of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissueEur J Cancer1998381274819849491
   PubMed Web of Science ®Google Scholar
• MohiuddinMWinterKMitchellERandomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012J Clin Oncol200624650516446336
   PubMed Web of Science ®Google Scholar
• PluzanskaAMainwaringPCassidyJFinal results of a randomized phase III study evaluating the addition of oxaliplatin first-line to 5-FU followed by irinotecan at progression in advanced colorectal cancer (LIFE study) [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2005 23, 250s (abstract 3517)
   Google Scholar
• RödelCGrabenbauerGGPapadopoulosTPhase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancerJ Clin Oncol200321309810412915600
   PubMed Web of Science ®Google Scholar
• RuttenHSebag-MontefioreDGlynne-JonesRCapecitabine, oxaliplatin, radiotherapy, and excision (CORE) in patients with MRI-defined locally advanced rectal adenocarcinoma: Results of an international multicenter phase II study [abstract]Proceedings American Society of Clinicial Oncology Annual Meeting2006 24, 18S (abstract 3528)
   Google Scholar
• RyanDPNiedzwieckiDHollisDPhase I/II study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer: Cancer and Leukemia Group B 89901J Clin Oncol20062425576216636336
   PubMed Web of Science ®Google Scholar
• SaltzLBCoxJVBlankeCIrinotecan plus fluorouracil and leucovorin for metastatic colorectal cancerN Engl J Med20003439051411006366
   PubMed Web of Science ®Google Scholar
• SaltsLBClarkeSDiaz RubioEBevacizumab (Bev) in combination with XELOX or FOLFOX4: Efficacy results from XELOX-1/NO16966, a randomized phase III trial in the first-line metastatic colorectal cancer (MCRC) [abstract]Proceedings ASCO Gastrointestinal Cancer Symposium2007 abstract 238
   Google Scholar
• SauerRBeckerHHohenbergerWPreoperative versus postoperative chemoradiotherapy for rectal cancerN Engl J Med200435117314015496622
   PubMed Web of Science ®Google Scholar
• ScheithauerWKornekGVRadererMRandomized multicenter phase II trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancerJ Clin Oncol20032113071212663719
   PubMed Web of Science ®Google Scholar
• SchmollHJCartwrightTTaberneroJMPhase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancerJ Clin Oncol200725102717194911
   PubMed Web of Science ®Google Scholar
• The Meta-Analysis Group in CancerModulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysisJ Clin Oncol20042237667515365073
   PubMed Web of Science ®Google Scholar
• TwelvesCBoyerMFindlayMCapecitabine (Xeloda) improves medical resource use compared with 5-fluorouracil plus leucovorin in a phase III trial conducted in patients with advanced colorectal carcinomaEur J Cancer20013759760411290435
   PubMed Web of Science ®Google Scholar
• TwelvesCButtsCACassidyJCapecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: post hoc analysis of a large phase II studyClin Colorectal Cancer2005a5101716098250
   PubMedGoogle Scholar
• TwelvesCWongANovackiMPCapecitabine as adjuvant treatment for stage III colon cancerN Engl J Med2005b352269670415987918
   PubMed Web of Science ®Google Scholar
• TwelvesCGollinsSGrieveRA randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancerAnn Oncol200672394516344278
   PubMed Web of Science ®Google Scholar
• Van CutsemEFindlayMOsterwalderBCapecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II studyJ Clin Oncol20001813374510715306
   PubMed Web of Science ®Google Scholar
• Van CutsemETwelvesCCassidyJOral capecitabine compared with fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III studyJ Clin Oncol200119409710611689577
   PubMed Web of Science ®Google Scholar
• Van CutsemEHoffPMHarperPOral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomized, phase III trialsBr J Cancer2004901190715026800
   PubMed Web of Science ®Google Scholar
• WardSEKaltenthalerECowanJThe clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancerBr J Cancer200695273416804526
   PubMed Web of Science ®Google Scholar
• WillekeFHorisbergeKKraus-TiefenbacherUA phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as Neoadjuvant treatment of locally advanced rectal cancerBr J Cancer200796912717325705
   PubMed Web of Science ®Google Scholar