97
Views
2
CrossRef citations to date
0
Altmetric
Review

Mycophenolate mofetil: safety and efficacy in the prophylaxis of acute kidney transplantation rejection

, , &
Pages 139-149 | Published online: 13 Jan 2009

References

  • EuguiEMAlmquistSJMullerCDAllisonACLymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletionScand J Immunol19913321611731826793
  • GosioBSperimentate su culture pure di bacilli del carbpnchio demostrarano notevole potere antisetticaG Accad Med Torino198361484
  • FranklinTJCookJMThe inhibition of nucleic acid synthesis by mycophenolic acidBiochem J196911335155245807210
  • MorrisREWangJBlumJRImmunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allograftsTransplant Proc19914232 Suppl 219252063417
  • PlatzKPBechsteinWOEckhoffDESuzukiYSollingerHWRS-61443 reverses acute allograft rejection in dogsSurgery19911104736740discussion 40–41.1925962
  • SollingerHWDeierhoiMHBelzerFODiethelmAGKauffmanRSRS-61443–a phase I clinical trial and pilot rescue studyTransplantation19925324284321346731
  • CarrSFPappEWuJCNatsumedaYCharacterization of human type I and type II IMP dehydrogenasesJ Biol Chem19932683627286272907903306
  • AllisonACEuguiEMMycophenolate mofetil and its mechanisms of actionImmunopharmacology2000472385118
  • HuangHDLiuZHZhuXJChenZHLiLSInhibition of mycophenolic acid on NF-kappaB activity in human endothelial cellsActa pharmacol Sin200223764965312100761
  • LaurentAFDumontSPoindronPMullerCDMycophenolic acid suppresses protein N-linked glycosylation in human monocytes and their adhesion to endothelial cells and to some substratesExp Hematol199624159678536794
  • RaabMDaxeckerHKarimiAIn vitro effects of mycophenolic acid on the nucleotide pool and on the expression of adhesion molecules of human umbilical vein endothelial cellsClin Chim Acta20013101899811485760
  • AllisonACEuguiEMMechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejectionTransplantation2005802 SupplS18119016251851
  • BullinghamRMonroeSNichollsAHaleMPharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administrationJournal of Clinical Pharmacology19963643153248728345
  • SweeneyMJHoffmanDHEstermanMAMetabolism and biochemistry of mycophenolic acidCancer Res1972329180318094629779
  • StaatzCETettSEClinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipientsClin Pharmacokinet2007461135817201457
  • ShawLMMickRNowakIKoreckaMBraymanKLPharmacokinetics of mycophenolic acid in renal transplant patients with delayed graft functionJ Clin Pharmacol19983832682759549665
  • ShawLMNawrockiAKoreckaMSolariSKangJUsing established immunosuppressant therapy effectively: lessons from the measurement of mycophenolic acid plasma concentrationsTher Drug Monit200426434735115257062
  • WeberLTShipkovaMLamersdorfTPharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients. German Study group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant RecipientsJ Am Soc Nephrol199898151115209697675
  • HaleMDNichollsAJBullinghamREThe pharmacokinetic-pharmacodynamic relationship for mycophenolate mofetil in renal transplantationClin Pharmacol Ther19986466726839871432
  • KiberdBALawenJFraserADKeough-RyanTBelitskyPEarly adequate mycophenolic acid exposure is associated with less rejection in kidney transplantationAm J Transplant2004471079108315196064
  • van GelderTLe MeurYShawLMTherapeutic drug monitoring of mycophenolate mofetil in transplantationTher Drug Monit200628214515416628123
  • FillerGMaiILimited sampling strategy for mycophenolic acid area under the curveTher Drug Monit200022216917310774628
  • PawinskiTHaleMKoreckaMFitzsimmonsWEShawLMLimited sampling strategy for the estimation of mycophenolic acid area under the curve in adult renal transplant patients treated with concomitant tacrolimusClin Chem20024891497150412194926
  • Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. European Mycophenolate Mofetil Cooperative Study GroupLancet19953458961132113257752752
  • A blinded randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. The Tricontinental Mycophenolate Mofetil Renal Transplantation Study GroupTransplantation1996617102910378623181
  • SollingerHWMycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. US Renal Transplant Mycophenolate Mofetil Study GroupTransplantation19956032252327645033
  • HalloranPMathewTTomlanovichSGrothCHooftmanLBarkerCMycophenolate mofetil in renal allograft recipients: a pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. The International Mycophenolate Mofetil Renal Transplant Study GroupsTransplantation199763139479000658
  • RemuzziGLestiMGottiEMycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trialLancet2004364943350351215302193
  • RemuzziGCravediPCostantiniMMycophenolate mofetil versus azathioprine for prevention of chronic allograft dysfunction in renal transplantation: the MYSS follow-up randomized, controlled clinical trialJ Am Soc Nephrol20071861973198517460145
  • MathewTHA blinded, long-term, randomized multicenter study of mycophenolate mofetil in cadaveric renal transplantation: results at three years. Tricontinental Mycophenolate Mofetil Renal Transplantation Study GroupTransplantation19986511145014549645801
  • OjoAOMeier-KriescheHUHansonJAMycophenolate mofetil reduces late renal allograft loss independent of acute rejectionTransplantation200069112405240910868649
  • Meier-KriescheHUSteffenBJHochbergAMMycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deteriorationTransplantation20037581341134612717227
  • Meier-KriescheHUSteffenBJHochbergAMLong-term use of mycophenolate mofetil is associated with a reduction in the incidence and risk of late rejectionAm J Transplant200331687312492713
  • Mycophenolate mofetil for the treatment of refractory, acute, cellular renal transplant rejection. The Mycophenolate Mofetil Renal Refractory Rejection Study GroupTransplantation19966157227298607174
  • Mycophenolate mofetil for the treatment of a first acute renal allograft rejection: The Mycophenolate Mofetil Acute Renal Rejection Study GroupTransplantation19986522352419458021
  • FlechnerSMMinimizing calcineurin inhibitor drugs in renal transplantationTransplant Proc2003353 SupplS118121
  • CalneRYWhiteDJThiruSCyclosporin A in patients receiving renal allografts from cadaver donorsLancet197828104513231327
  • HariharanSJohnsonCPBresnahanBATarantoSEMcIntoshMJStableinDImproved graft survival after renal transplantation in the United States, 1988 to 1996N Engl J Med2000342960561210699159
  • CurtisJJLukeRGDubovskyEDiethelmAGWhelchelJDJonesPCyclosporin in therapeutic doses increases renal allograft vascular resistanceLancet1986285054774792875236
  • KeoghACalcineurin inhibitors in heart transplantationJ Heart Lung Transplant2004235 SupplS20220615093806
  • SandersCEJrCurtisJJRole of hypertension in chronic renal allograft dysfunctionKidney Int199552S4347
  • Smak GregoorPJvan GelderTvan BesouwNMvan der MastBJJNIJWeimarWRandomized study on the conversion of treatment with cyclosporine to azathioprine or mycophenolate mofetil followed by dose reductionTransplantation200070114314810919591
  • AbramowiczDManasDLaoMCyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen in stable kidney transplant recipients: a randomized, controlled studyTransplantation200274121725173412499889
  • SchnuellePvan der HeideJHTegzessAOpen randomized trial comparing early withdrawal of either cyclosporine or mycophenolate mofetil in stable renal transplant recipients initially treated with a triple drug regimenJ Am Soc Nephrol200213253654311805185
  • DudleyCPohankaERiadHMycophenolate mofetil substitution for cyclosporine a in renal transplant recipients with chronic progressive allograft dysfunction: the “creeping creatinine” studyTransplantation200579446647515729174
  • FlechnerSMGoldfarbDModlinCKidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporineTransplantation20027481070107612438948
  • FlechnerSMKurianSMSolezKDe novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two yearsAm J Transplant20044111776178515476476
  • GrinyoJMGil-VernetSCruzadoJMCalcineurin inhibitor-free immunosuppression based on antithymocyte globulin and mycophenolate mofetil in cadaveric kidney transplantation: results after 5 yearsTranspl Int2003161182082712879230
  • KreisHCisterneJMLandWSirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipientsTransplantation20006971252126010798738
  • LoAEgidiMFGaberLWComparison of sirolimus-based calcineurin inhibitor-sparing and calcineurin inhibitor-free regimens in cadaveric renal transplantationTransplantation20047781228123515114090
  • StegallMDLarsonTSPrietoMKidney transplantation without calcineurin inhibitors using sirolimusTransplant Proc2003353 SupplS125127
  • TheodorakisJSchneebergerHIllnerWDStanglMZankerBLandWNephrotoxicity-free, mycophenolate mofetil-based induction/maintenance immunosuppression in elderly recipients of renal allografts from elderly cadaveric donorsTransplantation proceedings2000321A SupplS9S11
  • TranHTAcharyaMKMcKayDBAvoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroidsJ Am Soc Nephrol200011101903190911004222
  • VincentiFRamosEBrattstromCMulticenter trial exploring calcineurin inhibitors avoidance in renal transplantationTransplantation20017191282128711397963
  • LarsonTSDeanPGStegallMDComplete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimusAm J Transplant20066351452216468960
  • FlechnerSMGoldfarbDSolezKKidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugsTransplantation200783788389217460558
  • EkbergHTedesco-SilvaHDemirbasAReduced exposure to calcineurin inhibitors in renal transplantationN Engl J Med2007357252562257518094377
  • SrinivasTRScholdJDGuerraGEaganABucciCMMeier-KriescheHUMycophenolate mofetil/sirolimus compared to other common immunosuppressive regimens in kidney transplantationAm J Transplant20077358659417229066
  • VeenstraDLBestJHHornbergerJSullivanSDHricikDEIncidence and long-term cost of steroid-related side effects after renal transplantationAm J Kidney Dis199933582983910213637
  • MontagninoGTarantinoAMaccarioMElliACesanaBPonticelliCLong-term results with cyclosporine monotherapy in renal transplant patients: a multivariate analysis of risk factorsAm J Kidney Dis20003561135114310845828
  • ParrottNRHammadAQWatsonCJLodgeJPAndrewsCDMulti-center, randomized study of the effectiveness of basiliximab in avoiding addition of steroids to cyclosporine a monotherapy in renal transplant recipientsTransplantation200579334434815699766
  • HricikDEWhalenCCLautmanJWithdrawal of steroids after renal transplantation–clinical predictors of outcomeTransplantation199253141451733083
  • HricikDEO’TooleMASchulakJAHersonJSteroid-free immunosuppression in cyclosporine-treated renal transplant recipients: a meta-analysisJ Am Soc Nephrol199346130013058130356
  • KasiskeBLChakkeraHALouisTAMaJZA meta-analysis of immunosuppression withdrawal trials in renal transplantationJ Am Soc Nephrol200011101910191711004223
  • SquiffletJPVanrenterghemYvan HooffJPSalmelaKRigottiPSafe withdrawal of corticosteroids or mycophenolate mofetil: results of a large, prospective, multicenter, randomized studyTransplantation proceedings20023451584158612176495
  • VanrenterghemYLebranchuYHeneROppenheimerFEkbergHDouble-blind comparison of two corticosteroid regimens plus mycophenolate mofetil and cyclosporine for prevention of acute renal allograft rejectionTransplantation20007091352135911087152
  • MatasAJRamcharanTParaskevasSRapid discontinuation of steroids in living donor kidney transplantation: a pilot studyAm J Transplant20011327828312102262
  • MatasAJKandaswamyRHumarALong-term immunosuppression, without maintenance prednisone, after kidney transplantationAnnals of surgery20042403510516discussion 6–7.15319722
  • VincentiFMonacoAGrinyoJKinkhabwalaMRozaAMulticenter randomized prospective trial of steroid withdrawal in renal transplant recipients receiving basiliximab, cyclosporine microemulsion and mycophenolate mofetilAm J Transplant20033330631112614286
  • VincentiFSchenaFPParaskevasSHauserIAWalkerRGGrinyoJA randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipientsAm J Transplant20088230731618211506
  • ter MeulenCGvan RiemsdijkIHeneRJSteroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a prospective, randomized, multicenter studyAm J Transplant20044580381015084178
  • GallonLGWinotoJLeventhalJRParkerMAKaufmanDBEffect of prednisone versus no prednisone as part of maintenance immunosuppression on long-term renal transplant functionClin J Am Soc Nephrol2006151029103817699323
  • PascualJQueredaCZamoraJHernandezDUpdated metaanalysis of steroid withdrawal in renal transplant patients on calcineurin inhibitor and mycophenolate mofetilTransplant Proc20053793746374816386525
  • HardingerKLBrennanDCLowellJSchnitzlerMALong-term outcome of gastrointestinal complications in renal transplant patients treated with mycophenolate mofetilTranspl Int2004171060961615517170
  • PelletierRPAkinBHenryMLThe impact of mycophenolate mofetil dosing patterns on clinical outcome after renal transplantationClin Transplant200317320020512780668
  • TierceJCPorterfield-BaxaJPetrillaAAKilburgAFergusonRMImpact of mycophenolate mofetil (MMF)-related gastrointestinal complications and MMF dose alterations on transplant outcomes and healthcare costs in renal transplant recipientsClin Transplant200519677978416313325
  • KnollGAMacDonaldIKhanAVan WalravenCMycophenolate mofetil dose reduction and the risk of acute rejection after renal transplantationJ Am Soc Nephrol20031492381238612937317
  • WangKZhangHLiYSafety of mycophenolate mofetil versus azathioprine in renal transplantation: a systematic reviewTransplant Proc20043672068207015518748
  • ChanLMulgaonkarSWalkerRArnsWAmbuhlPSchiavelliRPatient-reported gastrointestinal symptom burden and health-related quality of life following conversion from mycophenolate mofetil to enteric-coated mycophenolate sodiumTransplantation20068191290129716699457
  • BunnapradistSLentineKLBurroughsTEMycophenolate mofetil dose reductions and discontinuations after gastrointestinal complications are associated with renal transplant graft failureTransplantation200682110210716861948
  • BuddeKBauerSHambachPPharmacokinetic and pharmacodynamic comparison of enteric-coated mycophenolate sodium and mycophenolate mofetil in maintenance renal transplant patientsAm J Transplant20077488889817391132
  • SalvadoriMHolzerHde MattosAEnteric-coated mycophenolate sodium is therapeutically equivalent to mycophenolate mofetil in de novo renal transplant patientsAm J Transplant20044223123614974944
  • SalvadoriMHolzerHCivatiGLong-term administration of enteric-coated mycophenolate sodium (EC-MPS; myfortic) is safe in kidney transplant patientsClinical nephrology200666211211916939067
  • BuddeKGlanderPDiekmannFEnteric-coated mycophenolate sodium: safe conversion from mycophenolate mofetil in maintenance renal transplant recipientsTransplant Proc2004362 SupplS524527
  • BuddeKKnollGCurtisJSafety and efficacy after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium: results of a 1-year extension studyTransplant Proc200537291291515848573
  • LegendreCCohenDZeierMRostaingLBuddeKEfficacy and safety of enteric-coated mycophenolate sodium in de novo renal transplant recipients: pooled data from three 12-month multicenter, open-label, prospective studiesTransplant Proc20073951386139117580145
  • PietruckFAbbud-FilhoMVathsalaAMassariPUPo-HuangLNashanBConversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in stable maintenance renal transplant patients: pooled results from three international, multicenter studiesTransplant Proc200739110310817275484