353
Views
68
CrossRef citations to date
0
Altmetric
Review

Interleukin-6 inhibitors in the treatment of rheumatoid arthritis

&
Pages 767-775 | Published online: 08 Aug 2008

References

  • AndrewsNC2004Anemia of inflammation: the cytokine-hepcidin linkJ Clin Invest11391271615124018
  • ChoyEHSIsenbergDAGarroodT2002Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis. A randomized, double-blind, placebo-controlled, dose-escalation trialArthritis Rheum4631435012483717
  • CronsteinBN2007Interleukin-6: A key mediator of systemic and local symptoms in rheumatoid arthritisBull NYU Hosp Jt Dis65Suppl 1S111517708739
  • GartlehnerGHansenRAJonasBL2006The comparative Efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysisJ Rheumatol33239840817225293
  • GenoveseMMcKayJNasonovE2007IL-6 receptor inhibition with Tocilizumab reduces disease activity in patients with rheumatoid arthritis with inadequate response to a range of DMARDs: The TOWARD studyACR/ARHP Scientific Meeting 2007Presentation L15.
  • Gomez-ReinoJJFairfaxMJPavelkaK2007Targeted inhibition of IL-6 signaling with tocilizumab improves quality of life and function in patients with rheumatoid arthritis with inadequate response to a range of DMARDsACR/ARHP Scientific Meeting 2007Poster 522.
  • HeinrichPCBehrmannIHaanS2003Principles of interleukin (IL)-6-type cytokine signaling and its regulationBiochem J37412012773095
  • IshibashiTShikamaYKimuraH1993Thrombopoietic effects of inter-leukin-6 in long-term administration in miceExp Hematol2164068513864
  • ItoH2005Treatment of Crohn’s disease with anti-IL-6 receptor antibodyJ Gastroenterol40Suppl 1632415902961
  • KavanaughACohenSCushJ2004The evolving use of TNF inhibitors in rheumatoid arthritisJ Rheumatol311881415468347
  • KudoOSabokbarAPocockA2003nterleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanismBone321712584029
  • LipskyPE2006Interleukin-6 and rheumatic diseasesArthritis Res Ther8Suppl 2S416899108
  • MadhokRCrillyAMurphyE1993bGold therapy lowers serum interleukin 6 levels in rheumatoid arthritisJ Rheumatol2063038496855
  • MadhokRCrillyAWatsonJ1993aSerum interleukin 6 levels in rheumatoid arthritis: correlation with clinical and laboratory indices of disease activityAnn Rheum Dis52232588484679
  • MainiRNTaylorPCSzechinskiJ2006Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexateArthritis Rheum5428172916947782
  • NishimotoNHashimotoJMiyasakaN2007bStudy of active controlled monotherapy used for rheumatoid arthritis, and IL-6 inhibitor (SAMURAI): -Evidence of clinical and radiographic benefit from an x-ray reader-blinded randomized controlled trial of tocilizumabAnn Rheum Dis661162717485422
  • NishimotoNMiyasakaNYamamotoK2007aLong-term safety and Efficacy of tocilizumab (an anti-IL-6 receptor monoclonal antibody) in monotherapy in patients with rheumatoid arthritisAnn Rheum Dis66Suppl IIOP0227
  • NishimotoNSasaiMShimaY2000Improvement in Castleman’s disease by humanized anti-interleukin-6 receptor antibody therapyBlood95566110607684
  • NishimotoNYoshizakiKMaedaK2003Toxicity, pharmacokinetics and dose finding study of repetitive treatment with the humanized anti-interleukin-6 receptor antibody MRA in rheumatoid arthritisJ Rheumatol3014263512858437
  • NishimotoNYoshizakiKMiyasakaN2004Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multi-center, double-blind, placebo-controlled trialArthritis Rheum501761915188351
  • OhsugiYKishimotoT2008The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritisExpert Opin Biol Ther86698118407769
  • ParkJYPillingerMH2007Interleukin-6 in the pathogenesis of rheumatoid arthritisBull NYU Hosp Jt Dis65Suppl 1S41017708744
  • PrevooMLvan GestelAMvan T HofMA1996Remission in a prospective study of patients with rheumatoid arthritis: American Rheumatism Association preliminary remission criteria in relation to the disease activity scoreBr J Rheumatol35110158948296
  • Rose-JohnSWaetzigGHSchellerJ2007The IL-6/IL-6R complex as a novel target for therapeutic approachesExpert Opin Ther Targets1161362417465721
  • Rose-JohnS2003Interleukin-6 biology is coordinated by membrane bound and soluble receptorsActa Biochim Pol506031114515143
  • SerioloBPaolinoSSulliA2006Effects of anti-TNF-alpha treatment on lipid profile in patients with active rheumatoid arthritisAnn N Y Acad Sci1069414916855168
  • SmolenJBeaulieuARubbert-RothA2008Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trialLancet37196179879718358926
  • StraubRHMuller-LadnerULichtingerT1997Decrease of interleukin 6 during the first 12 months is a prognostic marker for clinical outcome during 36 months treatment with disease-modifying anti-rheumatic drugsBr J Rheumatol3612983039448591
  • YokotaSImagawaTMoriM2008Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trialLancet3719617998100618358927
  • YoshizakiKNishimotoNMiharaM1998Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with humanized anti-IL-6 receptor antibodySpringer Seminar Immunopathol2024759