127
Views
19
CrossRef citations to date
0
Altmetric
Review

Update on the use of deferasirox in the management of iron overload

&
Pages 857-868 | Published online: 30 Oct 2009

References

  • PorterJBPractical management of iron overloadBr J Haematol2001115223925211703317
  • PootrakulPKitcharoenKYansukonPThe effect of erythroid hyperplasia on iron balanceBlood1988714112411293355891
  • GabuttiVPigaAResults of long-term iron-chelating therapyActa Haematol199695126368604584
  • OlivieriNFNathanDGMacMillanJHSurvival in medically treated patients with homozygous β-thalassemiaN Engl J Med199433195745788047081
  • OlivieriNFBrittenhamGMIron-chelating therapy and the treatment of thalassemiaBlood19978937397619028304
  • DeleaTEEdelsbergJSofryginOConsequences and costs of non compliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature reviewTransfusion200747101919192917880620
  • Ferriprox. Summary of Product Characteristics. Apotex; 1999
  • CeciABaiardiPFelisiMThe safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patientsBr J Haematol2002118133033612100170
  • CohenARGalanelloRPigaADe SanctisVTrictaFSafety and effectiveness of long-term therapy with the oral iron chelator deferiproneBlood200310251583158712763939
  • Duffy-WarrenFChesiARigourdSFrederickAExjade® (deferasirox) Basic Prescribing InformationURL http://wwwexjadecom/indexjsp2008
  • NickHAcklinPLattmannRDevelopment of tridentate iron chelators: from desferrithiocin to ICL670Curr Med Chem200310121065107612678677
  • SteinhauserSHeinzUBartholomaMWeyhermüllerTNickHHegetschweilerKComplex formation of ICL670 and related ligands with FeIII and FeIIEur J Inorg Chem20042141774192
  • GlicksteinHElBRLinkGAction of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequencesBlood200610893195320316835377
  • WoodJCOtto-DuesselMGonzalesIDeferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbilTransl Res2006148527228017145573
  • NickHWongAAcklinPICL670A: preclinical profileAdv Exp Med Biol200250918520312572995
  • PigaAGalanelloRForniGLRandomized phase II trial of deferasirox (Exjade®, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overloadHaematologica200691787388016818273
  • GalanelloRPigaAAlbertiDRouanMCBiglerHSechaudRSafety, tolerability, and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron overload due to β-thalassemiaJ Clin Pharmacol200343656557212817519
  • Nisbet-BrownEOlivieriNFGiardinaPJEffectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trialLancet200310361(9369):1597160212747879
  • GalanelloRPigaACappelliniMDEffect of food, type of food, and time of food intake on deferasirox bioavailability: recommendations for an optimal deferasirox administration regimenJ Clin Pharmacol200848442843518281442
  • CappelliniMDCohenAPigaAA phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemiaBlood200610793455346216352812
  • GalanelloRPigaAForniGLPhase II clinical evaluation of deferasirox, a once-daily oral chelating agent, in pediatric patients with β-thalassemia majorHaematologica200691101343135117018383
  • PorterJGalanelloRSaglioGRelative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective studyEur J Haematol200880216817618028431
  • VichinskyEOnyekwereOPorterJA randomized comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell diseaseBr J Haematol2007136350150817233848
  • TaherAEl-BeshlawyAElalfyMSEfficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with β-thalassaemia: the ESCALATOR studyEur J Haematol200982645846519187278
  • TaherAEl-BeshlawyAElalfyMDeferasirox significantly reduces iron burden in heavily iron-overloaded patients with beta-thalassaemia: 2.7 year results from the ESCALATOR studyHaematologica200994Suppl 2abstr 209.
  • CappelliniMDPorterJEl-BeshlawyATailoring iron chelation by iron intake and serum ferritin: Prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemiasHaematologica2009In press.
  • CohenARGlimmEPorterJBEffect of transfusional iron intake on response to chelation therapy in β-thalassemia majorBlood2008111258358717951527
  • CappelliniMDGalanelloRPigaAEfficacy and safety of deferasirox (Exjade®) with up to 4.5 years of treatment in patients with thalassemia major: a pooled analysisBlood200811211abstr 5411.
  • PigaAForniGLKattamisADeferasirox (Exjade®) in pediatric patients with β-thalassemia: update of 4.7-year efficacy and safety from extension studiesBlood200811211abstr 3883.
  • CappelliniMDElalfyMSKattamisAEfficacy and safety of once-daily, oral iron chelator deferasirox (Exjade®) in a large group of regularly transfused patients with β-thalassemia majorBlood200811211abstr 3878.
  • GattermannNSchmidMDella PortaMEfficacy and safety of deferasirox (Exjade®) during 1 year of treatment in transfusion-dependent patients with myelodysplastic syndromes: results from EPIC trialBlood200811211abstr 633.
  • LeeJWYoonSSShenZXIron chelation in regularly transfused patients with aplastic anemia: efficacy and safety results from the large deferasirox EPIC trialBlood200811211abstr 439.
  • PorterJBLinKHHabrDDomokosGHmissiATheinSLDeferasirox efficacy and safety for the treatment of transfusion-dependent iron overload in patients with a range of rare anemiasBlood200811211abstr 1419.
  • PorterJBForniGLBerisPEfficacy and safety of 1 year’s treatment with deferasirox (Exjade®): assessment of regularly transfused patients with Diamond-Blackfan anemia enrolled in the EPIC studyBlood200811211abstr 1048.
  • TaherACappelliniMDVichinskyEEfficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overloadBr J Haematol2009[Epub ahead of print].
  • Borgna-PignattiCRugolottoSDe StefanoPSurvival and complications in patients with thalassemia major treated with transfusion and deferoxamineHaematologica200489101187119315477202
  • PathareATaherADaarSDeferasirox (Exjade®) significantly improves cardiac T2* in heavily iron-overloaded patients with beta-thalassemia majorAnn Hematol2009[Epub ahead of print].
  • RoghiACassinerioEProtoPThe effect of deferasirox on myocardial iron overload and cardiac function: a prospective independent monocentric study using cardiovascular magnetic resonance T2* (MRI T2*)Haematologica200994Suppl 2abstr 762.
  • WoodJThompsonAPaleyCDeferasirox reduces cardiac iron burden in chronically transfused β-thalassemia patients with mild-to-moderate cardiac siderosis as demonstrated by MRI T2*Haematologica200994Suppl 2abstr 763.
  • EleftheriouPTannerMPennellDPorterJBResponse of myocardial T2* to oral deferasirox monotherapy for 1 year in 29 patients with transfusion-dependent anaemias; a subgroup analysisHaematologica200691Suppl 1abstr 999.
  • PennellDPorterJBCappelliniMDEfficacy and safety of deferasirox (Exjade®) in reducing cardiac iron in patients with β-thalassemia major: results from the cardiac substudy of the EPIC trialBlood200811211abstr 3873.
  • PennellDSutcharitchanPEl-BeshlawyAEfficacy and safety of deferasirox (Exjade®) in preventing cardiac iron overload in β-thalassemia patients with normal baseline cardiac iron: results from the cardiac substudy of the EPIC trialBlood200811211abstr 3874.
  • LadisVBerdoussiHKattamisATreatment with deferasirox for non-transfusional iron overload in patients with thalassemia intermediaHaematologica200994Suppl 2abstr 1279.
  • VoskaridouEKonstantinidouMDouskouMTreatment with deferasirox effectively decreases iron burden in patients with thalas-semia intermediaHaematologica200994Suppl 2abstr 204.
  • GreenbergPLSchifferCKollerCAGlynosTPaleyCChange in liver iron concentration (LIC), serum ferritin (SF) and labile plasma iron (LPI) over 1 year of deferasirox (DFX/Exjade®) therapy in a cohort of myelodysplastic patientsBlood200811211abstr 5083.
  • ListAFBaerMRSteensmaDIron chelation with deferasirox (Exjade®) improves iron burden in patients with myelodysplastic syndromes (MDS)Blood200811211abstr 634.
  • WimazalFNosslingerTBaumgartnerCSperrWRPfeilstockerMValentPDeferasirox induces regression of iron overload in patients with myelodysplastic syndromesEur J Clin Invest20093940641119320908
  • MinYHKimHJLeeKHA multi-center, open label study evaluating the efficacy of iron chelation therapy with deferasirox in transfusional iron overload patients with myelodysplastic syndromes or aplastic anemia using quantitative R2 MRIBlood200811211abstr 3649.
  • MessaECilloniDMessaFDeferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosisActa Haematol20081202707418827475
  • GattermannNSchmidMGuerci-BreslerAReduction in serum ferritin (SF) is associated with improvement in liver transaminase levels during treatment with deferasirox (Exjade®) in iron overloaded patients with myelodysplastic syndromes (MDS)Leuk Res200933Suppl 1S140S141(abstr P140).
  • DeleaTEHagiwaraMPhatakPDRetrospective study of the association between transfusion frequency and potential complications of iron overload in patients with myelodysplastic syndrome and other acquired hematopoietic disordersCurr Med Res Opin200925113914719210147
  • SchaferAICheronRGDluhyRClinical consequences of acquired transfusional iron overload in adultsN Engl J Med198130463193246777701
  • BennettJMConsensus statement on iron overload in myelodysplastic syndromesAm J Hematol20088385886118767130
  • GattermannNPorterJLopesLFConsensus statement on iron overload in myelodysplastic syndromesHematol Oncol Clin North Am200519Suppl 11825
  • VichinskyECoatesTThompsonAADeferasirox (Exjade®), the once-daily oral iron chelator, demonstrates safety and efficacy in patients with sickle cell disease (SCD): 3.5-year follow-upBlood200811211abstr 1420.
  • CancadoROlivatoMCBrunieraPChiattoneCDeferasirox for the treatment of transfusional iron overload in sickle cell anemia: a 1-yr prospective studyHaematologica200994Suppl 2abstr 210.
  • VoskaridouEDouskouMPlataETreatment with deferasirox effectively decreases iron burden in patients with sickle cell syndromesHaematologica200994Suppl 2abstr 215.
  • RoseCGattermannNGlimmERabaultBDeferasirox (Exjade, ICL670), the novel, once-daily oral iron chelator, is well tolerated and effective in treating transfusional iron overload in patients with a range of rare anaemiasHaematologica200691Suppl 1abstr 22.
  • TcherniaGVichinskyEJengMThe once-daily oral iron chelator ICL670 is well tolerated and effective in treating transfusional iron overload in Diamond-Blackfan anaemia patientsHaematologica200590Suppl 2192
  • PigaAKebailiKGalanelloRCumulative efficacy and safety of 5-year deferasirox (Exjade®) treatment in pediatric patients with thalassemia major: a Phase II multicenter prospective trialBlood200811211abstr 5413.
  • TaherAAl JefriAElalfyMSDeferasirox (Exjade®) treatment in pediatric β-thalassemia patients with high iron burden: 2.8 years results from ESCALATOR trialBlood200811211abstr 3879.
  • KruszewskiMThe role of labile iron pool in cardiovascular diseasesActa Biochim Pol200451247148015218543
  • EspositoBPBreuerWSirankaprachaPLabile plasma iron in iron overload: redox activity and susceptibility to chelationBlood20031022670267712805056
  • DaarSPathareANickHReduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with β-thalassaemiaEur J Haematol200982545445719191863
  • PorterJBCappelliniMDEl-BeshlawyAEffect of deferasirox (Exjade®) on labile plasma iron levels in heavily iron-overloaded patients with transfusion-dependent anemias enrolled in the large-scale, prospective 1-year EPIC trialBlood200811211abstr 3881.
  • GhotiHFibachEMerkelDDecrease in intra- and extra-cellular free iron species and oxidative stress parameters and increase in serum and urinary hepcidin during treatment with deferasirox in iron-loaded patients with MDSHaematologica200994Suppl 2abstr 797.
  • BennettWPonticelliCPigaAKattamisAGlimmEFordJSummary of long-term renal safety data in transfused patients with secondary iron overload receiving deferasirox (Exjade®, ICL670)Blood200610811abstr 3816.
  • KuczmarskiRJOgdenCLGrummer-StrawnLMCDC growth charts: United StatesAdv Data200031412711183293
  • VichinskyECoatesTThompsonASafety and efficacy of iron chelation therapy with deferasirox in patients with sickle cell disease (SCD): 3.5-year follow-upHaematologica200994Suppl 2abstr 200.
  • OlivieriNFBuncicJRChewEVisual and auditory neurotoxicity in patients receiving subcutaneous deferoxamine infusionsN Engl J Med1986314148698733485251
  • PorterJBJaswonMSHuehnsEREastCAHazellJWDesferrioxamine ototoxicity: evaluation of risk factors in thalassaemic patients and guidelines for safe dosageBr J Haematol19897334034092605127
  • PorterJBPigaACohenAFordJMBodnerJCappelliniMDAssessment of safety in patients receiving longer-term iron chelation therapy with deferasirox who had achieved serum ferritin levels of <1000 ng/mL during the study courseHaematologica200994Suppl 2abstr 199.
  • PorterJBPigaACohenASafety of deferasirox (Exjade®) in patients with transfusion-dependent anemias and iron overload who achieve serum ferritin levels <1000 ng/mL during long-term treatmentBlood200811211abstr 5423.
  • BrittenhamGMGriffithPMNienhuisAWEfficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia majorN Engl J Med199433195675738047080
  • RenfroeJLForbesPBraunsteinJNeufeldEJRelationship of transfusion and iron-related complications to cost of care in thalassemiaBlood200510611abstr 2240.
  • DeleaTESofryginOThomasSKBaladiJFPhatakPDCoatesTDCost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients. US healthcare system perspectivePharmacoeconomics200725432934217402805
  • KarnonJTolleyKOyeeJJewittKOssaDAkehurstRCost-utility analysis of deferasirox compared to standard therapy with desferrioxamine for patients requiring iron chelation therapy in the United KingdomCurr Med Res Opin20082461609162118439348
  • CappelliniMDBejaouiMAgaogluLProspective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with β-thalassemiaClin Ther200729590991717697909
  • PorterJBBowdenDGanserASatisfaction and adherence significantly improves in patients with β-thalassemia and myelodysplastic syndromes treated with deferasirox (Exjade®)Blood200811211abstr 1306.
  • TaherAAl JefriAElalfyMImproved treatment satisfaction and convenience with deferasirox in iron-overloaded patients with β-thalassemia: Results from ESCALATOR trialHaematologica200893Suppl 1abstr 799.
  • VichinskyEPakbazZOnyekwereOPatient-reported outcomes of deferasirox (Exjade®, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis: substudy of a randomized open-label Phase II trialActa Haematol2008119313314118408362
  • PorterJBBowdenDGanserAImproved health-related quality of life in patients with hematological disorders receiving deferasirox (Exjade®)Blood200811211abstr 1307.
  • AldouriMAWonkeBHoffbrandAVHigh incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelationActa Haematol19908431131172123060
  • AndersonLJWestwoodMAHoldenSMyocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonanceBr J Haematol2004127334835515491298
  • DavisBAPorterJBLong-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk β-thalassemiaBlood20009541229123610666195