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Review

Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization

Pages 749-774 | Published online: 12 Aug 2010

References

  • KonesRRecent advances in the management of chronic stable angina I. Approach to the patient, diagnosis, pathophysiology, risk stratification, and gender disparitiesVasc Health Risk Manag2010663565620730020
  • van DamRMWillettWCUnmet potential for cardiovascular disease prevention in the United StatesCirculation20091201171117319752318
  • GrundySMPrevention of atherosclerotic cardiovascular disease: why are the benefits of lifestyle therapies neglectedDialogues Cardiovasc Med2005117386
  • FoxKGarciaMAArdissinoDfor Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology; ESC Committee for Practice Guidelines (CPG)Guidelines on the management of stable angina pectoris: executive summary: the Task Force on the Management of Stable Angina Pectoris of the European Society of CardiologyEur Heart J2006271341138116735367
  • GibbonsRJAbramsJChatterjeeKACC/AHA 2002 guideline update for the management of patients with chronic stable angina –summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina)J Am Coll Cardiol20034115916812570960
  • O’RourkeSTNitro vasodilators: pharmacology and use in the treatment of myocardial ischemiaAm J Pharm Educ200266177180
  • LacosteLLTherouxPLidonRMAntithrombotic properties of transdermal nitroglycerin in stable angina pectorisAm J Cardiol19947315105810628198030
  • GoriTParkerJDLong-term therapy with organic nitrates. The pros and cons of nitric oxide replacement therapyJ Am Coll Cardiol20044463263415358032
  • SchiffrinELOxidative stress, nitric oxide synthase, and superoxide dismutase: a matter of imbalance underlies endothelial dysfunction in the human coronary circulationHypertension200851313218071058
  • BergesANassauwLVTimmermansJPVrintsCRole of nitric oxide during coronary endothelial dysfunction after myocardial infarctionEuro J Pharmacol2005 2351616070
  • BottcherMMadsenMMRandsbaekFEffect of oral nitroglycerin and cold stress on myocardial perfusion in areas subtended by stenosed and nonstenosed coronary arteriesAm J Cardiol2002891019102411988188
  • TadamuraEMamedeMKuboSThe effect of oral nitroglycerin on myocardial blood flow in various segments characterized by rest-redistribution thallium SPECTJ Nucl Med20034474575112732676
  • DumontLLeLorierJStanleyPChartrandCEffect of nitroglycerin on regional myocardial blood flow following an experimental coronary spasmAngiology19843595535596435485
  • AbramsJNitroglycerin and long-acting nitrates in clinical practiceAm J Med19837485946407316
  • ThadaniUNitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina, and heart failureCardiovasc Drugs Ther1997107357429110117
  • ParkerJOFarrellBLaheyKAEffect of intervals between doses on the development of tolerance to isosorbide dinitrateN Engl J Med1987316144014443574424
  • de MotsHGlasserSPIntermittent transdermal nitroglycerin therapy in the treatment of chronic stable anginaJ Am Coll Cardiol1989137867952494240
  • DaiberAMülschAHinkUThe oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazineAm J Cardiol2005967B25i36i15979427
  • MünzelTSayeghHFreemanBATarpeyMMHarrisonDGEvidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-toleranceJ Clin Invest19959511871947814613
  • JakschikBNeedlemanPSulfhydryl reactivity of organic nitrates: biochemical basis for inhibition of glyceraldehyde-P dehydrogenase and monoamine oxidaseBiochem Biophys Res Commun1973535395444197820
  • DaiberAOelzeMWenzelPNitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stressPharmacol Rep2009611334819307691
  • ChenZZhangJStamlerJSIdentification of the enzymatic mechanism of nitroglycerin bioactivationProc Natl Acad Sci U S A2002998306831112048254
  • KnotHJNitrate tolerance in hypertension: new insight into a century-old problemCirc Res20039379980114592995
  • GerzanichVIvanovAIvanovaSAlternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscleCirc Res20039380581214512447
  • CheitlinMDHutterAMJrBrindisRGACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular diseaseJ Am Coll Cardiol1999332732829935041
  • PepineCJCohnPFDeedwaniaPCEffects of treatment on outcome in mildly symptomatic patients with ischemia during daily life. The Atenolol Silent Ischemia Study (ASIST)Circulation1994907627688044945
  • FreemantleNClelandJYoungPβ-blockade after myocardial infarction: systematic review and meta regression analysisBr Med J19993181730173710381708
  • MillerRROlsonHGAmsterdamEAPropranolol withdrawal rebound phenomenon: exacerbation of coronary events after abrupt cessation of antianginal therapyN Engl J Med19752934164181097925
  • PsatyBMKoepsellTDWagnerEHThe relative risk of incident coronary heart disease associated with recently stopping the use of β-blockersJAMA1990263165316571968518
  • HeidenreichPAMcDonaldKMHastieTMeta-analysis of trials comparing beta-blockers, calcium antagonists, and nitrates for stable anginaJAMA19992811927193610349897
  • NissenSETuzcuEMLibbyPfor the CAMELOT InvestigatorsEffect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trialJAMA20042922217222515536108
  • RiceKRGervinoEJarischWRStonePHEffects of nifedipine on myocardial perfusion during exercise in chronic stable anginaAm J Cardiol199065109711012184649
  • TappRJSharpAStantonAVfor the ASCOT InvestigatorsDifferential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) SubstudyJ Am Coll Cardiol2010551875188120413040
  • PepineCJHandbergEMCooper-DeHoffRMfor the INVEST InvestigatorsA calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trialJAMA20032902805281614657064
  • Poole-WilsonPALubsenJKirwanBAEffect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trialLancet200436484985715351192
  • SierraCCocaAThe ACTION study: nifedipine in patients with symptomatic stable angina and hypertensionExpert Rev Cardiovasc Ther2008681055106218793108
  • PackerMO’ConnorCMGhaliJKEffect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study GroupN Engl J Med1996335110711148813041
  • GoldsteinREBoccuzziSJCruessDNattelSDiltiazem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction. The Adverse Experience Committee; and the Multicenter Diltiazem Postinfarction Research GroupCirculation19918352601984898
  • KonesRAfter cardiac surgery, how does nutrition fit in with risk factors?J Parent Enteral Nutr2010342163167
  • LeonMBRosingDRBonowROEpsteinSECombination therapy with calcium-channel blockers and beta blockers for chronic stable angina pectorisAm J Cardiol19855569B80B
  • WaysbortJMeshulamNBrunnerDIsosorbide-5-mononitrate and atenolol in the treatment of stable exertional anginaCardiology199179Suppl 219261760824
  • PepineCJAbramsJMarksRGCharacteristics of a contemporary population with angina pectoris. TIDES investigatorsAm J Cardiol1994742262318037126
  • MannheimerCCamiciPChesterMRThe problem of chronic refractory angina; report from the ESC Joint Study Group on the Treatment of Refractory AnginaEur Heart J20022335537011846493
  • JahangirATerzicAShenWKPotassium channel openers: therapeutic potential in cardiology and medicineExpert Opin Pharmacother200121995201011825331
  • ZingmanLVAlekseevAEHodgson-ZingmanDMTerzicAATP-sensitive potassium channels: metabolic sensing and cardioprotectionJ Appl Physiol200710351888189317641217
  • JahangirATerzicAK(ATP) channel therapeutics at the bedsideJ Mol Cell Cardiol2005399911215953614
  • JohnSAWeissJNXieLHRibaletBMolecular mechanism for ATP-dependent closure for the K+ channel Kir6.2J Physiol (Lond)2003552233412860923
  • IONA Study GroupEffect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trialLancet20023591269127511965271
  • MarkhamAPloskerGLGoaKLNicorandil: an updated review of its use in ischemic heart disease with emphasis on its cardioprotective effectsDrugs20006095597411085202
  • CiampricottiRSchotborghCEde KamPJvan HerwaardenRHA comparison of nicorandil with isosorbide mononitrate in elderly patients with stable coronary heart disease: the SNAPE StudyAmer Heart J2000139593994310827372
  • SimpsonDWellingtonKNicorandil: a review of its use in the management of stable angina pectoris, including high-risk patientsDrugs2004641941195515329045
  • SavelievaICamAJIf inhibition with ivabradine: electrophysiological effects and safetyDrug Saf2008319510718217787
  • BorerJSFoxKJaillonPLereboursGfor Ivabradine Investigators GroupAntianginal and antiischemic effects of ivabradine, an If inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trialCirculation200310781782312591750
  • Lopez-BescosLFilipovaSMartosRLong-term safety and efficacy of ivabradine in patients with chronic stable anginaCardiology200710838739617890862
  • TardifJCFordITenderaMBourassaMGFoxKfor INITIATIVE InvestigatorsEfficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable anginaEur Heart J2005262529253616214830
  • RuzylloWTenderaMFordIFoxKMAntianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trialDrugs20076739340517335297
  • FoxKFordIStegPGTenderaMFerrariRfor BEAUTIFUL InvestigatorsIvabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trialLancet200837280781618757088
  • TardifJCPonikowskiPKahanTfor the ASSOCIATE Study InvestigatorsEfficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4 month, randomized, placebo-controlled trialEur Heart J20093054054819136486
  • MarzilliMDoes timetazidine prevent myocardial injury after percutaneous coronary interventionNat Clin Pract Cardiovasc Med20085161717940516
  • StanleyWCMarzilliMMetabolic therapy in the treatment of ischemia heart disease: the pharmacology of trimetazidineFundam Clin Pharmacol20031713314512667223
  • KantorPFLucienAKozakRLopaschukGDThe antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolaseCirc Res20008658058810720420
  • ChazovEILepakchinVKZharovaEATrimetazidine in angina combination therapy – the TACT study: trimetazidine versus conventional treatment in patients with stable angina pectoris in a randomized, placebo-controlled, multicenter studyAm J Ther200512354215662290
  • KolbelFBadaVTrimetazidine in geriatric patients with stable angina pectoris: the TIGER studyInt J Clin Pract20035786787014712887
  • CiapponiAPizarroRHarrisonJTrimetazidine for stable anginaCochrane Database of Systematic Reviews20054CD003614
  • TuunanenHEngblomENaumATrimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathyCirculation20081181250125818765391
  • FragassoGPalloshiAPuccettiPA randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failureJ Am Coll Cardiol20064899299816949492
  • CeraMSalernoAFragassoGBeneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failureJ Cardiovasc Pharmacol Ther2010151243020100903
  • VicariRMChaitmanBKeefeDfor Fasudil Study GroupEfficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trialJ Am Coll Cardiol2005461803181116286163
  • BarthASTomaselliGFCardiac metabolism and arrhythmiasCirc Arrhythm Electrophysiol2009232733519808483
  • BelardinelliLAntzelevitchCFraserHInhibition of late (sustained/persistent) sodium current: a potential drug target to reduce intracellular sodium dependent calcium overload and its detrimental effects on cardiomyocyte functionEur Heart J200461317
  • UndrovinasAIBelardinelliLUndrovinasNARanolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium currentJ Cardiovasc Electrophysiol200617Suppl 1S169S17716686675
  • MaltsevVASabbahHNHigginsRSDSilvermanNLeschMUndrovinasAINovel, ultraslow inactivating sodium current in human ventricular cardiomyocytesCirculation199898254525529843461
  • PikeMMKitakazeMMarbanENa-NMR measurement of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusionAm J Physiol1990259H1767H17732260701
  • AntzelevitchCBelardinelliLZygmuntACElectrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic propertiesCirculation200411090491015302796
  • BersDMBarryWHDespaSIntracellular Na+ regulation in cardiac myocytesCardiovasc Res20035789791212650868
  • MurphyECrossHSteenbergenCSodium regulation during ischemia versus reperfusion and its role in injuryCirc Res1999841469147010381900
  • KusuokaHMarbanECellular mechanisms of myocardial stunningAnnu Rev Physiol1992542432561562175
  • KusuokaHHurtadoMCCMarbanERole of sodium/calcium exchange in the mechanism of stunning: protective effect of reperfusion with high sodium solutionJ Am Coll Cardiol1993212402488417067
  • ImahashiKKusuokaHHashimotoKYoshiokaJYamaguchiHNishimuraTIntracellular sodium accumulation during ischemia as the substrate for reperfusion injuryCirc Res1999841401140610381892
  • ImahashiKMraicheFSteenbergenCMurphyEFliegelLOver-expression of the Na+/H+ exchanger and ischemia-reperfusion injury in the myocardiumAm J Physiol Heart Circ Physiol20072925H2237H224717209001
  • TaegtmeyerHModulation of responses to myocardial ischemia: metabolic features of myocardial stunning, hibernation, and ischemic preconditioningDilsizianVMyocardial Viability: A Clinical and Scientific TreatiseArmonk, New YorkFutura Publishing20002536
  • BakerCRimoldiOCamiciPRepetitive myocardial stunning in pigs is associated with the increased expression of inducible and constitutive nitric oxide synthasesCardiovasc Res199943368569710690340
  • TaniMNeelyJRRole of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchangeCirc Res198965104510562551525
  • BelardinelliLShryockJCFraserHInhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazineHeart200692Suppl 4iv6iv1416775092
  • ChaitmanBRRanolazine for the treatment of chronic angina and potential use in other cardiovascular conditionsCirculation20061132462247216717165
  • WasserstromJASharmaRO’TooleMJRanozaline antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heartJ Pharmacol Exp Ther2009331238239119675298
  • SteenbergenCMurphyELevyLLondonREElevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heartCirc Res1987607007073109761
  • HayashidaWvan EyllCRousseauMFPouleurHEffects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart diseaseCardiovasc Drugs Ther199487417477873471
  • JerlingMHuanBHLeungKChuNAbdallahHHusseinZStudies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjectsJ Clin Pharmacol20054542243315778423
  • MingEEDavidsonMHGandiSKConcomitant use of statins and CYP3A4 inhibitors in administrative claims and electronic medical records databasesJ Clin Lipidol20082453463
  • DrewBJAckermanMJFunkMfor the American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the American College of Cardiology FoundationPrevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology FoundationJ Am Coll Cardiol201055993494720185054
  • SauerAJMossAJMcNittSLong QT syndrome in adultsJ Am Coll Cardiol20074932933717239714
  • BelardinelliLAntzelevitchCVosMAAssessing predictors of drug-induced torsade de pointesTrends Pharmacol Sci20032461962514654302
  • PepineCJWolffAAA controlled trial with a novel anti-ischemic agent, ranolazine, in chronic stable angina pectoris that is responsive to conventional anti-anginal agentsAm J Cardiol199984465010404850
  • RousseauMFPouleurHCoccoGWolffAAComparative efficacy of ranolazine versus atenolol for chronic angina pectorisAm J Cardiol20059531132615670536
  • ChaitmanBRSkettinoSLParkerJOfor the MARISA InvestigatorsAnti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe anginaJ Am Coll Cardiol2004431375138215093870
  • ChaitmanBRPepineCJParkerJOfor the CARISA InvestigatorsEffects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trialJAMA200429130931614734593
  • KorenMJCragerMRSweeneyMLong-term safety of a novel antianginal agent in patients with severe chronic stable angina: the ranolazine open label experience (ROLE)J Am Coll Cardiol2007491027103417349881
  • MarkDBHlatkyMAHarrellFEJrLeeKLCaliffRMPryorDBExercise treadmill score for predicting prognosis in coronary artery diseaseAnn Intern Med19871067938003579066
  • AlexanderKPShawLJDelingERMarkDBPetersonEDValue of exercise treadmill testing in womenJ Am Coll Cardiol199832165716649822093
  • StonePHGratsianskyNABlokhinAHuangIZMengLAntianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine In Chronic Angina) trialJ Am Coll Cardiol20064856657516875985
  • MorrowDASciricaBMKarwatowska-ProkopczukEEffects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes. The MERLIN-TIMI 36 trialJAMA2007297161775178317456819
  • WilsonSRSciricaBMBraunwaldEEfficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN – TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 trialJ Am Coll Cardiol200953171510151619389561
  • MorrowDASciricaBMSabatineMSB-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes 36) trialJ Am Coll Cardiol201055121189119620298924
  • CaliffRMShahSHNewbyLKBiomarker bonanzaJ Am Coll Cardiol2010551197119920298925
  • JaxTWPetersAJKhattabAAHeintzenMPSchoebelFCPercutaneous coronary revascularization in patients with formerly “refractory angina pectoris in end-stage coronary artery disease” – Not “end-stage” after allBMC Cardiovasc Disord2009942 http://www.biomedcentral.com/1471-2261/9/4219715566
  • KonesRMechanical circulatory assistance: present statusN Y State J Med1974745165314594914
  • MichaelsADAccadMPortsTAGrossmanWLeft ventricular systolic unloading and augmentation of intracoronary pressure and Doppler flow during enhanced external counterpulsationCirculation20021061237124212208799
  • AroraRRLopesSSaricMEnhanced external counterpulsation improves systolic function by echocardiography in patients with coronary artery diseaseHeart Lung20053412212515761457
  • SoranOTreatment options for refractory angina pectoris: enhanced external counterpulsation therapyCurr Treat Options Cardiovasc Med2009111546019141261
  • BonettiPOBarsnessGWKeelanPCEnhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery diseaseJ Am Coll Cardiol2003411761176812767662
  • CaseyDPContiCRNicholsWWChoiCYKhuddusMABraithRWEffect of enhanced external counterpulsation on inflammatory cytokines and adhesion molecules in patients with angina pectoris and angiographic coronary artery diseaseAm J Cardiol2008101330030218237588
  • AkhtarMWuGFDuZMZhengZSMichaelsADEffect of external counterpulsation on plasma nitric oxide and endothelin-1 levelsAm J Cardiol200698283016784915
  • AroraRRChouTMJainDThe MUlticenter STudy of Enhanced External CounterPulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodesJ Am Coll Cardiol1999331833184010362181
  • MichaelsADLinnemeierGSoranOKelseySFKennardEDTwo-year outcomes after enhanced external counterpulsation for stable angina pectoris (from the International EECP Patient Registry [IEPR])Am J Cardiol20049346146414969624
  • LawsonWEHuiJCZhengZSImproved exercise tolerance following enhanced external counterpulsation: cardiac or peripheral effectCardiology1996872712758793157
  • ErdlingABondessonSPettersonTEdvinssonLEnhanced external counterpulsation in treatment of refractory angina pectoris: two year outcome and baseline factors associated with treatment failureBMC Cardiovasc Disord2008813919094202
  • LawsonWEHuiJCConnPFLong term prognosis of patients with angina treated with enhanced external counterpulsation: five-year follow-up studyClin Cardiol20002325425810763072
  • BarsheshetAHodHShechterMThe effects of external counter pulsation therapy on circulating endothelial progenitor cells in patients with angina pectorisCardiology2008110316016618057883
  • BravermanDLEnhanced external counterpulsation: an innovative physical therapy for refractory anginaPhys Med Rehabil200913268276
  • CohnPFEECP – new data on possible mechanisms of actionEur Heart J2001221363136411482912
  • BeainiYMorleyCEECP: a non-invasive therapy for refractory anginaPractitioner20092531715273119326660
  • KumarAAronowWSVadnerkarAEffect of enhanced external counterpulsation on clinical symptoms, quality of life, 6-minute walking distance, and echocardiographic measurements of left ventricular systolic and diastolic function after 35 days of treatment and at 1-year follow up in 47 patients with chronic refractory angina pectorisAm J Ther200916211611819300038
  • CampbellARSatranDZenovichAGEnchanced external counterpulsation improves systolic blood pressure in patients with refractory anginaAm Heart J200815661217122219033023
  • WuMKomoriNQinCFarberJPLinderothBForemanRDRoles of peripheral terminals of transient receptor potential vanilloid-1 containing sensory fibers in spinal cord stimulation-induced peripheral vasodilationBrain Res20071156809217540346
  • MeyersonBALinderothBSpinal cord stimulation: mechanisms of action in neuropathic and ischemic painSimpsonBAElectrical Stimulation and the Relief of Pain15New York, NYElsevier Publishers2003161182
  • LinderothBForemanRDMechanisms of spinal cord stimulation in painful syndromes: role of animal modelsPain Med20067S14S26
  • MannheimerCAugustinssonLECarlssonCAManhemKWilhelmssonCEpidural spinal electrical stimulation in severe angina pectorisBr Heart J19885956613257701
  • González-DarderJMCanelaPGonzález-MartinezVHigh cervical spinal cord stimulation for unstable angina pectorisStereotact Funct Neurosurg19915620271682982
  • QinCFarberJPLinderothBShahidAForemanRDNeuromodulation of thoracic intraspinal visceroreceptive transmission by electrical stimulation of spinal dorsal column and somatic afferents in ratsJ Pain20089717817974489
  • LinderothBMeyersonBSpinal cord stimulation: mechanisms of actionBurchielKSurgical Management of PainNew York, NYThieme Medical Publishers Inc2002505526
  • OldroydKGHarveyKGrayCEBeta-endorphin release in patients after spontaneous and provoked acute myocardial ischaemiaBr Heart J1992672302351313275
  • MannheimerCCarlssonCAEmanuelssonHThe effects of transcutaneous electrical nerve stimulation in patients with severe angina pectorisCirculation19855271116
  • HaustvastRWMTer HorstGJde JongBMRelative changes in regional cerebral blood flow during spinal cord stimulation in patients with refractory angina pectorisEur J Neurosci19979117811839215701
  • de VriesJde JongsteMJLZijlstraFLong-term effects of electrical neurostimulation in patients with unstable angina. Refractory to conventional therapiesNeuromodulation200710345348
  • SandersonJEIbrahimBWaterhouseDSpinal electrical stimulation for intractable angina – long-term clinical outcome and safetyEur Heart J1994158108148088270
  • AndersenCEnggardTPSchererCSpinal cord stimulation has a proven benefit on pain and quality of life in patients with angina pectoris when less invasive therapies have failedNeuromodulation20069314319
  • EddicksSMaier-HauffKSchenkMThoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomised studyHeart20079358559017237126
  • CameronTSafety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20 year literature reviewJ Neurosurg200410025426715029914
  • Di PedeFLanzaGAZuinGImmediate and long-term clinical outcome after spinal cord stimulation for refractory stable angina pectorisAm J Cardiol20039195195512686334
  • ChauhanAMullinsPAThuraisinghamGEffects of transcutaneous electrical nerve stimulation in coronary blood flowCirculation1994896947028313557
  • EmanuelssonHCMannheimerFWaagsteinCCatecholamine metabolism during pacing-induced angina pectoris and the effect of transcutaneous electrical nerve stimulationAm Heart J1987114136013663500628
  • AnselminoMRaveraLde LucaASpinal cord stimulation and 30-minute heart rate variability in refractory angina patientsPacing Clin Electrophysiol2009321374219140911
  • HautvastRWde JongsteMJStaalMJvan GilstWHLieKISpinal cord stimulation in chronic intractable angina pectoris: a randomized, controlled efficacy studyAm Heart J1998136111411209842028
  • MannheimerCEliassonTAugustinssonLEElectrical stimulation versus coronary artery bypass surgery in severe angina pectoris. The ESBY studyCirculation199897115711639537342
  • ErkeOEliassonTNorrsellHLong-term effects of spinal cord stimulation and coronary artery bypass grafting on quality of life and survival in the ESBY studyEur Heart J2002231938194512473256
  • EckertSDongasAGüldnerHImmediate and long-term clinical outcome after spinal cord stimulation for refractory stable angina pectoris in patients with chronic pacemaker- and ICD-treatmentEur Heart J200627Suppl 6463S
  • TaylorRSde VriesJBuchserEde JongsteMJSpinal cord stimulation in the treatment of refractory angina: systematic review and meta-analysis of randomised controlled trialsBMC Cardiovasc Disord200991319320999
  • HorvathKATransmyocardial laser revascularizationJ Card Surg20082326627618435649
  • UwatokuTItoKAbeKExtracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigsCoron Artery Dis20071839740417627190
  • FukumotoYItoAUwatokuTExtracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery diseaseCoron Artery Dis200617637016374144
  • KhattabAABrodersenBSchuermann-KuchenbrandtDExtracorporeal cardiac shock wave therapy: first experience in the everyday practice for treatment of chronic refractory angina pectorisInt J Cardiol2007121848517097167
  • LeschkeMSchoebelFCMecklenbeckWLong-term intermittent urokinase therapy in patients with end-stage coronary artery disease and refractory angina pectoris: a randomized dose-response trialJ Am Coll Cardiol1996275755848606267
  • KimMCKiniASharmaSKRefractory angina pectoris: mechanism and therapeutic optionsJ Am Coll Cardiol200239692393411897431
  • The Framingham Heart Study site: http://www.framinghamheartstudy.org. Accessed Apr 2, 2010.
  • KannelWBDawberTRKaganARevotskieNStokesJIIIFactors of risk in the development of coronary heart disease – six-year follow-up experience: The Framingham StudyAnn Intern Med196155335013751193
  • WilsonPWFD’AgostinoRLevyDBelangerASilbershatzHKannelWPrediction of coronary heart disease using risk factor categoriesCirculation199897183718479603539
  • WilsonPClustering of risk factors, obesity, and syndrome XNutr Clin Care19981Suppl4450
  • BrotmanDWalkerELauerMSO’BrienRGIn search of fewer independent risk factorsArch Intern Med200516513814515668358
  • MayoWThe aims and ideals of the American Medical Association. Address given at: the 66th Annual Meeting of the National Education Association; 1928 Jul 1–6; MinneapolisProc Natl Educ Assoc192866158163
  • GonçalvesIStenströmKSkogGMattssonSNitulescuMNilssonJShort communication: dating Components of human atherosclerotic plaquesCirc Res20101061174117720167929
  • PasterkampGde KleijnDCold war battle against hot atherosclerotic plaquesCirc Res20101061017101820360263
  • BanksJMarmotMOldfieldZSmithJPDisease and disadvantage in the United States and in EnglandJAMA20062952037204516670412
  • StarfieldBHydeJGervasJHeathIThe concept of prevention: a good idea gone astrayJ Epidemiol Community Health20086258058318559439
  • KullerLHNutrition, lipids, and cardiovascular disease: clinical benefits without biochemical effects and biochemical effects without clinical benefitsCurr Cardiovasc Risk Reports20082914
  • YusufSHawkenSOunpuuSEffect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control studyLancet200436493795215364185
  • HuGTuomilehtoJSilventoinenKSartiCMännistöSJousilahtiPBody mass index, waist circumference, and waist-hip ratio on the risk of total and type-specific strokeArch Intern Med20071671420142717620537
  • MaruthurNMWangNYAppelLJLifestyle interventions reduce coronary heart disease risk: results from the PREMIER trialCirculation20091192026203119349322
  • RogerVLLifestyle and cardiovascular health: individual and societal choices [editorial]JAMA2009302443743919622826
  • DjousséLDriverJAGazianoJMRelation between modifiable lifestyle factors and lifetime risk of heart failureJAMA2009302439440019622818
  • FormanJPStampferMJCurhanGCDiet and lifestyle risk factors associated with incident hypertension in womenJAMA2009302440141119622819
  • FordESBergmannMMKrögerJSchienkiewitzAWeikertCBoeingHHealthy living is the best revenge: findings from the European prospective investigation into cancer and nutrition – potsdam studyArch Intern Med82009169151355136219667296
  • KatzDLLife and death, knowledge and power: why knowing what matters is not what’s the matterArch Intern Med2009169151362136319667297
  • MozaffarianDKamineniACarnethonMDjousséLMukamalKJSiscovickDLifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health studyArch Intern Med200916979880719398692
  • ChiuveSEMcCulloughMLSacksFMRimmEBHealthy lifestyle factors in the primary prevention of coronary heart disease among men: benefits among users and nonusers of lipid-lowering and anti-hypertensive medicationsCirculation200611416016716818808
  • ChowCKJollySRao-MelaciniPFoxKAAnandSSYusufSAssociation of diet, exercise, and smoking modification with risk of early cardiovascular events after acute coronary syndromesCirculation201012175075820124123
  • PatelNBBaladyGJThe rewards of good behaviorCirculation201012173373520124131
  • DanaeiGRimmEBOzaSKulkarniSCMurrayCEzzatiMThe promise of prevention: the effects of four preventable risk factors on national life expectancy and life expectancy disparities by race and county in the United StatesPLoS Med201073e100024820351772
  • PhillipsLSTwomblyJGIt’s time to overcome clinical inertiaAnn Intern Med200814878378518490691
  • RoseGIncubation period of coronary heart diseaseInt J Epidemiol200534224224415764698
  • LabartheDRPreventing the risk to heart health, from womb to tombCVD Prevention19981259265
  • SnydermanRDinanMAImproving health by taking it personalJAMA2010303436336420103762
  • KvaavikEBattyGDUrsinGHuxleyRGaleCRInfluence of individual and combined health behaviors on total and cause-specific mortality in men and women: the United Kingdom health and lifestyle surveyArch Intern Med2010170871171820421558
  • CarnethonMWhitselLPFranklinBAfor the American Heart Association Advocacy Coordinating Committee; Council on Epidemiology and Prevention; Council on the Kidney in Cardiovascular Disease; and Council on Nutrition, Physical Activity and MetabolismWorksite wellness programs for cardiovascular disease prevention: a policy statement from the American Heart AssociationCirculation20091201725174119794121
  • Lloyd-JonesDAdamsRJBrownTMfor American Heart Association Statistics Committee and Stroke Statistics SubcommitteeHeart disease and stroke statistics – 2010 update: a report from the American Heart AssociationCirculation2010121e46e21520019324
  • Lloyd-JonesDHongYLabartheDfor American Heart Association Strategic Planning Task Force and Statistics CommitteeDefining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic impact goal through 2020 and beyondCirculation201012158661320089546
  • StrasserTReflections on cardiovascular diseasesInterdisc Sci Rev19783225230
  • RoseGStrategy of prevention: lesions from cardiovascular diseaseBr Med J (Clin Res Ed)198128218471851
  • JohnsonRKAppelLJBrandsMfor the American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism and the Council on Epidemiology and PreventionDietary sugars intake and cardiovascular health: a scientific statement from the American Heart AssociationCirculation20091201011102019704096
  • Bethesda, National Heart, Lung, and Blood InstituteMorbidity and Mortality: 2009 Chart Book on Cardiovascular, Lung, and Blood DiseasesNational Institutes of Health2009
  • CapewellSFordESCroftJBCritchleyJAGreenlundKJLabartheDRCardiovascular risk factor trends and potential for reducing coronary heart disease mortality in the United States of AmericaBull World Health Organ20108812013020428369
  • Department of Health and Human ServicesHealthy People 2010: Understanding and Improving Health and Objectives for Improving HealthWashington, DCGovernment Printing Office2000 Available at: http://www.cdc.gov/nchs/healthy_people.htm. Accessed Apr 4, 2010.
  • FrakerTDJrFihnSDfor 2002 Chronic Stable Angina Writing Committee2007chronic angina focused update of the ACC/AHA 2002 guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 guidelines for the management of patients with chronic stable anginaJ Am Coll Cardiol2007502264227418061078
  • RedbergRFBenjaminEJBittnerVACCF/AHA 2009 performance measures for primary prevention of cardiovascular disease in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures for Primary Prevention of Cardiovascular Disease) developed in collaboration with the American Academy of Family Physicians; American Association of Cardiovascular and Pulmonary Rehabilitation; and Preventive Cardiovascular Nurses Association: Endorsed by the American College of Preventive Medicine, American College of Sports Medicine, and Society for Women’s Health ResearchCirculation200912012961336 andJ Am Coll Cardiol20095413641405
  • MoscaLBankaCLBenjaminEJEvidence-based guidelines for cardiovascular disease prevention in women: 2007 updateCirculation20071151481150117309915
  • SmithSCJrAllenJBlairSNAHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update endorsed by the National Heart, Lung, and Blood InstituteJ Am Coll Cardiol2006472130213916697342
  • deBGAmbrosioniEBorch-JohnsenKEuropean guidelines on cardiovascular disease and prevention in clinical practiceAtherosclerosis200317114515514686332
  • JBS 2Joint British Societies’ guidelines on prevention of cardiovascular disease in clinical practiceHeart200591Suppl 5v1v5216365341
  • GrahamIAtarDBorch-JohnsenKEuropean guidelines on cardiovascular disease prevention in clinical practice: executive summaryEur Heart J2007282375241417726041
  • BassandJPHammCWArdissinoDfor The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of CardiologyGuidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromesEur Heart J2007281598166017569677
  • AndersonJLAdamsCDAntmanEMACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction)J Am Coll Cardiol200750e1e15717692738
  • CroweELovibondKGrayHfor Guideline Development GroupEarly management of unstable angina and non-ST elevation myocardial infarction: summary of NICE guidanceBMJ2010340c113420335335
  • GibbonsRJBaladyGJBeasleyJWfor ACC/AHA Guidelines for Exercise TestingA report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing)J Am Coll Cardiol19973012603119207652
  • KingSBSmithSCJrHirshfeldJWJr2007 focused update of the 2005 guideline update for percutaneous coronary intervention American College of Cardiology/American Heart Association Task Force on Practice Guidelines 2007 Writing Group to Review New Evidence and Update the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention, Writing on Behalf of the 2005 Writing CommitteeJ Am Coll Cardiol20085117220918191745
  • CushmanWCEvansGWByingtonRPfor the ACCORD study groupEffects of intensive blood pressure control in type 2 diabetes mellitusNew Engl J Med2010362171575158520228401
  • NilssonPMACCORD and risk-factor control in type 2 diabetesNew Engl J Med2010362171628163020228405
  • CurrieCJPetersJPTynanASurvival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort studyLancet2010375971348148920110121
  • BalkauBSimonDSurvival in people with type 2 diabetes as a function of HbA1cLancet2010375971343844020110122
  • FeldmanDNGadeCLSlotwinerAJComparison of outcomes of percutaneous coronary interventions in patients of three age groups (<60, 60 to 80, and >80 years) (from the New York State Angioplasty Registry)Am J Cardiol2006981334133917134624
  • KirtaneAJCohenDJWhen is better not good enough? Insights from the COURAGE economic studyCirc Cardiovasc Qual Outcomes200814620031780
  • LinGADudleyRALucasFLMalenkaDJVittinghoffERedbergRFFrequency of stress testing to document ischemia prior to elective percutaneous coronary interventionJAMA20083001765177318854538
  • KatritsisDGIoannidisJPPercutaneous coronary intervention versus conservative therapy in non-acute coronary artery disease: a meta-analysisCirculation20051112906291215927966
  • BodenWEO’RourkeRATeoKKfor the COURAGE Trial Research GroupOptimal medical therapy with or without PCI for stable coronary diseaseN Engl J Med2007356151503151617387127
  • StoneGWMosesJWEllisSGSafety and efficacy of sirolimus- and paclitaxel-eluting coronary stentsN Engl J Med2007356998100817296824
  • GargSSerruysPWDrug-eluting stents: a reappraisalHeart20109648949320350985
  • BhattDLControversies in non-ST-elevation acute coronary syndromes and percutaneous coronary interventionsCleve Clin J Med20107710110920124267
  • HilliardAAFromAMLennonRJPercutaneous revascularization for stable coronary artery disease: temporal trends and impact of drug-eluting stentsJ Am Coll Cardiol Intv20103172179
  • CostaJRJrSousaAMoreiraACIncidence and predictors of very late (≥4 years) major cardiac adverse events in the DESIRE (Drug-Eluting Stents in the Real World)-Late registryJ Am Coll Cardiol Intv201031218
  • WindeckerSRaberLThe DESIRE-Late registry: what is left to be desiredJ Am Coll Cardiol Intv201031921
  • NewbyLKPetersonEDDoes ranolazine have a place in the treatment of acute coronary syndromes?JAMA2007297161823182517456825
  • SerruysPWUngerFSousaJEComparison of coronary-artery bypass surgery and stenting for the treatment of multivessel diseaseN Eng J Med20013441511171124
  • SdringolaSLoghinCBoccalandroFGouldKLMechanisms of progression and regression of coronary artery disease by PET related to treatment intensity and clinical events at long-term follow-upJ Nucl Med200647596716391188
  • HochmanJSStegPGDoes preventive PCI workN Eng J Med200735615721574
  • PetersonEDDaiDDeLongERfor NCDR Registry ParticipantsContemporary mortality risk prediction for percutaneous coronary intervention: results from 588,398 procedures in the National Cardiovascular Data RegistryJ Am Coll Cardiol2010551923193220430263
  • WeintraubWSBodenWEZhangZfor Department of Veterans Affairs Cooperative Studies Program No. 424 (COURAGE Trial) Investigators and Study CoordinatorsCost-effectiveness of percutaneous coronary intervention in optimally treated stable coronary patientsCirc Cardiovasc Qual Outcomes20081122020031783
  • WeintraubWSSpertusJAKolmPfor the COURAGE Trial Research GroupEffect of PCI on quality of life in patients with stable coronary diseaseN Engl J Med200835967768718703470
  • DavidsonMHClinical significance of statin pleiotropic effects: hypotheses versus evidenceCirculation20051112280228115883224
  • ShawLJBermanDSMaronDJOptimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudyCirculation20081171283129118268144
  • DiamondGAKaulSCOURAGE under fire. On the management of stable coronary diseaseJ Am Coll Cardiol2007501604160917936162
  • PetersonEDRumsfeldJSFinding the courage to reconsider medical therapy for stable anginaN Engl J Med200835975175318703479
  • KereiakesDJTeirsteinPSSarembockIJThe truth and consequences of the COURAGE trialJ Am Coll Cardiol2007501598160317936161
  • MaronDJBodenWEO’RourkeRAfor the COURAGE Trial Research GroupIntensive multifactorial intervention for stable coronary artery disease. Optimal medical therapy in the COURAGE trialJ Amer Col Cardiol2010551313481358
  • O’GaraPTThe COURAGE trial: can we deliver on its promise?J Am Coll Cardiol201055131359136120338497
  • CicconeMMAquilinoACorteseFFeasibility and effectiveness of a disease and care management model in the primary health care system for patients with heart failure and diabetes (Project Leonardo)Vasc Health Risk Manag2010629730520479952
  • SchömigAMehilliJde WahaASeyfarthMPacheJKastratiAA meta-analysis of 17 randomized trials of a percutaneous coronary intervention-based strategy in patients with stable coronary artery diseaseJ Am Coll Cardiol20085289490418772058
  • O’RourkeRAOptimal medical therapy is a proven option for chronic stable anginaJ Am Coll Cardiol20085290590718772059
  • MariePYDanchinNDurandJFLong-term prediction of major ischemic events by exercise thallium-201 single-photon emission computed tomography. Incremental prognostic value compared with clinical, exercise testing, catheterization and radionuclideangiographic dataJ Am Coll Cardiol1995268798867560612
  • JahnkeCNagelEGebkerRPrognostic value of cardiac magnetic resonance stress tests: adenosine stress perfusion and dobutamine stress wall motion imagingCirculation20071151769177617353441
  • MinJKShawLJDevereuxRBPrognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortalityJ Am Coll Cardiol2007501161117017868808
  • DaviesRFGoldbergADFormanSAsymptomatic Cardiac Ischemia Pilot (ACIP) study two-year follow-up: outcomes of patients randomized to initial strategies of medical therapy versus revascularizationCirculation199795203720439133513
  • KatritsisDGMeierBPercutaneous coronary intervention for stable coronary artery diseaseJ Am Coll Cardiol20085288989318772057
  • CaliffRMArmstrongPWCarverJRTask Force 5. Stratification of patients into high-, medium-, and low-risk subgroups for purposes of risk factor managementJ Am Coll Cardiol19962796410478609362
  • BramlagePMesserCBitterlichNThe effect of optimal medical therapy on 1-year mortality after acute myocardial infarctionHeart20109660460920353936
  • CavenderMAAlexanderKPBroderickSLong-term morbidity and mortality among medically managed patients with angina and multivessel coronary artery diseaseAm Heart J2009158693394019958859
  • HannanELRaczMJGoldJAdherence of catheterization laboratory cardiologists to American College of Cardiology/American Heart Association guidelines for percutaneous coronary interventions and coronary artery bypass graft surgery: what happens in actual practiceCirculation200912126727520048207
  • PatelMRDehmerGJHirshfeldJWSmithPKSpertusJAACCF/SCAI/STS/AATS/AHA/ASNC 2009 Appropriateness Criteria for Coronary Revascularization American College of Cardiology Foundation Appropriateness Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association and the American Society of Nuclear Cardiology American Society of Echocardiography, the Heart Failure Society of America, and the Society of Cardiovascular Computed TomographyJ Am Coll Cardiol20095353055319195618
  • Executive Summary. Comparative effectiveness of percutaneous coronary interventions and coronary artery bypass grafting for coronary artery disease. Agency for Healthcare Research and Quality Pub. No. 08-EHC002-1. 2007 Oct 15. Available at: www.effectivehealthcare.ahrq.gov/reports/final.cfm. Accessed May 1, 2010.
  • KingSBIIIMarshallJJTummalaPERevascularization for coronary artery disease: stents versus bypass surgeryAnnu Rev Med20106119921319824825