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Review

PROactive 07: pioglitazone in the treatment of type 2 diabetes: results of the PROactive study

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Pages 355-370 | Published online: 24 Dec 2022

References

  • BhattDLStegPGOhmanEMREACH Registry InvestigatorsInternational prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosisJAMA2006295180916403930
  • BrownLCJohnsonJAMajumdarSREvidence of suboptimal management of cardiovascular risk in patients with type 2 diabetes mellitus and symptomatic atherosclerosisCMAJ200417111899215534311
  • BuseJBTanMHPrinceMJThe effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetesDiabetes Obes Metab200461335614746579
  • CharbonnelBDormandyJErdmannEPROactive Study GroupThe prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patientsDiabetes Care20042716475315220241
  • CharbonnelBScheenAPioglitazone in triple oral therapy: long-term glycaemic results from PROactive [abstract]Diabetes200655Suppl 1A106
  • CharbonnelBHMatthewsDRSchernthanerGQUARTET Study GroupA long-term comparison of pioglitazone and gliclazide in patients with Type 2 diabetes mellitus: a randomized, double-blind, parallel-group comparison trialDiabet Med2005a2239940515787663
  • CharbonnelBSchernthanerGBrunettiPLong-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetesDiabetologia2005b48109310415889234
  • ChiassonJLJosseRGGomisRSTOP-NIDDM Trial Research GroupAcarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trialJAMA20032904869412876091
  • ChoiDKimSKChoiSHPreventative effects of rosiglitazone on restenosis after coronary stent implantation in patients with type 2 diabetesDiabetes Care20042726546015505001
  • ColhounHMBetteridgeDJDurringtonPNCARDS investigatorsPrimary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomized placebo-controlled trialLancet20043646859615325833
  • The Diabetes Control and Complications Trial Research GroupThe effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitusN Engl J Med1993329977868366922
  • DerosaGCiceroAFDangeloAThiazolidinedione effects on blood pressure in diabetic patients with metabolic syndrome treated with glimepirideHypertens Res2005a289172416555581
  • DerosaGCiceroAFGaddiAA comparison of the effects of pioglitazone and rosiglitazone combined with glimepiride on prothrombotic state in type 2 diabetic patients with the metabolic syndromeDiabetes Res Clin Pract2005b6951315955382
  • DormandyJon behalf of the PROactive Writing CommitteePROactive study [letter]Lancet2006367267
  • DormandyJACharbonnelBEcklandDJPROactive investigatorsSecondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trialLancet200536612798916214598
  • The DREAM (Diabetes Reduction Assessment with ramipril and rosiglitazone Medication) Trial InvestigatorsEffect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomized controlled trialLancet2006368109610516997664
  • EmbersonJRWhincupPHLawlorDACoronary heart disease prevention in clinical practice: are patients with diabetes special? Evidence from two studies of older men and womenHeart200591451515772196
  • ErdmannEDormandyJACharbonnelBon behalf of the PROactive investigatorsThe effect of pioglitazone on recurrent myocardial infarction in 2445 patients with type 2 diabetes and previous myocardial infarction – Results from PROactive (PROactive 05)J Am Coll Cardiol20074917728017466227
  • ErdmannEDormandyJAKupferSMorbidity after reports of serious heart failure in type 2 diabetes patients with underlying cardiovascular disease: results from PROactive [abstract]Circulation2006114Suppl 11848
  • European Diabetes Policy Group. 1998–1999A Desktop Guide to Type 2 Diabetes Mellitus Accessed 17 September 2006. URL: http://www.staff.ncl.ac.uk/philip.home/t2dgw97r.doc
  • GaedePParvingHHPedersenOPROactive studyLancet200636723416399142
  • GaedePVedelPLarsenNMultifactorial intervention and cardiovascular disease in patients with type 2 diabetesN Engl J Med20033483839312556541
  • GoldbergRBKendallDMDeegMAGLAI Study InvestigatorsA comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemiaDiabetes Care20052815475415983299
  • GoldbergRBMelliesMJSacksFMfor the Care InvestigatorsCardiovascular events and their reduction with pravastatin in diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels. Subgroup analyses in the cholesterol and recurrent events (CARE) trialCirculation199898251399843456
  • HaffnerSMLehtoSRönnemaaTMortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarctionN Engl J Med1998339229349673301
  • HanefeldMBrunettiPSchernthanerGHQUARTET Study GroupOne-year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetesDiabetes Care200427141714693980
  • HanssonLZanchettiACarruthersSGfor the HOT Study GroupEffects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study GroupLancet19983511755629635947
  • Heart Outcomes Prevention Evaluation (HOPE) Study InvestigatorsEffects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudyLancet2000355253910675071
  • Heart Protection Study Collaborative GroupMRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trialLancet200336120051612814710
  • HeineRSchindhelmRDiamantMLong-term pioglitazone treatment improves markers of liver function: results from PROactive [Abstract]Diabetes200655Suppl 1A115
  • HollenbergNKConsiderations for management of fluid dynamic issues associated with thiazolidinedionesAm J Med2003115Suppl 8A111S5S14678876
  • HomePDPocockSJBeck-NielsenHRosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (RECORD): study design and protocolDiabetologia20054817263516025252
  • HorioTSuzukiMSuzukiKPioglitazone improves left ventricular diastolic function in patients with essential hypertensionAm J Hypertens2005189495716053992
  • IdrisIThomsonGASharmaJCDiabetes mellitus and strokeInt J Clin Pract200660485616409428
  • JuutilainenALehtoSRönnemaaTType 2 diabetes as a “coronary heart disease equivalent”: an 18-year prospective population-based study in Finnish subjectsDiabetes Care2005282901716306552
  • KarterAJAhmedATLiuJPioglitazone initiation and subsequent hospitalization for congestive heart failureDiabet Med2005229869316026362
  • KeechASimesRJBarterPFIELD study investigatorsEffects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trialLancet200536618496116310551
  • KoDTMamdaniMAlterDALipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradoxJAMA200429118647015100205
  • LangenfeldMRForstTHohbergCPioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized studyCirculation200511125253115883215
  • LawrenceJMReidJTaylorGJFavorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetesDiabetes Care20042741614693964
  • The Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study GroupPrevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levelsN Engl J Med19983391349579841303
  • MarxNWohrleJNusserTPioglitazone reduces neointima volume after coronary stent implantation: a randomized, placebo-controlled, double-blind trial in nondiabetic patientsCirculation20051122792816246947
  • Massi-BenedettiMScheenACharbonnelBPioglitazone delays the need for permanent insulin use: results from PROactive [abstract]Diabetes200655Suppl 1A124
  • MeinertCLKnatterudGLProutTEA study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality resultsDiabetes197019Suppl7898304926376
  • MiettinenHLehtoSSalomaaVImpact of diabetes on mortality after the first myocardial infarction. The FINMONICA Myocardial Infarction Register Study GroupDiabetes Care19982169759538972
  • MiyazakiYMahankaliAMatsudaMEffect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patientsJ Clin Endocrinol Metab20028727849112050251
  • MiyazakiYMahankaliAWajcbergEEffect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patientsJ Clin Endocrinol Metab2004894312915356026
  • MukamalKJNestoRWCohenMCImpact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarctionDiabetes Care2001241422711473080
  • NathanDMClearyPABacklundJYDiabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research GroupIntensive diabetes treatment and cardiovascular disease in patients with type 1 diabetesN Engl J Med200535326435316371630
  • NathanDMLachinJClearyPDiabetes Control and Complications Trial; Epidemiology of Diabetes Interventions and Complications Research GroupIntensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitusN Engl J Med2003348229430312788993
  • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final reportCirculation2002106314342112485966
  • NigroJOsmanNDartAMInsulin resistance and atherosclerosisEndocr Rev2006272425916492903
  • NikolaidisLALevineTBPeroxisome proliferator activator receptors (PPAR), insulin resistance, and cardiomyopathy: friends or foes for the diabetic patient with heart failure?Cardiol Rev2004121587015078585
  • PavoIJermendyGVarkonyiTTEffect of pioglitazone compared with metformin on glycemic control and indicators of insulin sensitivity in recently diagnosed patients with type 2 diabetesJ Clin Endocrinol Metab20038816374512679450
  • PerezAKhanMJohnsonTPioglitazone plus a sulphonylurea or metformin is associated with increased lipoprotein particle size in patients with type 2 diabetesDiab Vasc Dis Res20041445016305056
  • PfutznerAMarxNLubbenGImprovement of cardiovascular risk markers by pioglitazone is independent from glycemic control: results from the pioneer studyJ Am Coll Cardiol20054519253115963388
  • PyöräläKPedersenTRKjekshusJfor the Scandinavian Simvastatin Survival Study (4S) GroupCholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)Diabetes Care199720614209096989
  • RodenMLaaksoMJohnsDLong-term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitusDiabet Med2005221101616026380
  • RoperNABilousRWKellyWFExcess mortality in a population with diabetes and the impact of material deprivation: longitudinal population based studyBMJ200132213899311397742
  • RydénLThráinsdóttirISwedbergKAdjudication of serious heart failure in patients from PROactive [letter]Lancet200736818990
  • SatohNOgawaYUsuiTAntiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effectDiabetes Care2003262493912941708
  • SchaumbergDAGlynnRJJenkinsAJEffect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trialCirculation200511124465315867184
  • ScheenACharbonnelBReduced insulin requirements and improved glycaemic control with pioglitazone in insulin-treated patients with type 2 diabetes: results from PROactive [abstract]Diabetes200655Suppl 1A134
  • SchernthanerGMatthewsDRCharbonnelBQuartet Study GroupEfficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: a double-blind, randomized trialJ Clin Endocrinol Metab20048960687615579760
  • ShepherdJBlauwGJMurphyMBPROSPER study groupPROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trialLancet200236016233012457784
  • ShiomiTTsutsuiHHayashidaniSPioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarctionCirculation200210631263212473562
  • SobelBEFryeRDetreKMBypass Angioplasty Revascularization Investigation 2 Diabetes Trial. Burgeoning dilemmas in the management of diabetes and cardiovascular disease: rationale for the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) TrialCirculation20031076364212566379
  • StrattonIMAdlerAINeilAWon behalf of the UK Prospective Diabetes Study GroupAssociation of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational studyBMJ20003214051210938048
  • St John SuttonMRendellMDandonaPA comparison of the effects of rosiglitazone and glyburide on cardiovascular function and glycemic control in patients with type 2 diabetesDiabetes Care20022520586412401757
  • TakagiTAkasakaTYamamuroATroglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: a serial intravascular ultrasound studyJ Am Coll Cardiol20003615293511079654
  • TakagiTYamamuroATamitaKPioglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with type 2 diabetes mellitus: an intravascular ultrasound scanning studyAm Heart J2003146E512891212
  • TanMHGlazerNBJohnsDJPioglitazone as monotherapy or in combination with sulfonylurea or metformin enhances insulin sensitivity (HOMA-S or QUICKI) in patients with type 2 diabetesCurr Med Res Opin2004a20723815140339
  • TanMHJohnsDJGonzalez GalvezGGLAD Study GroupEffects of pioglitazone and glimepiride on glycemic control and insulin sensitivity in Mexican patients with type 2 diabetes mellitus: A multicenter, randomized, double-blind, parallel-group trialClin Ther2004b266809315220012
  • TanMHJohnsDJStrandJGLAC Study GroupSustained effects of pioglitazone vs. glibenclamide on insulin sensitivity, glycaemic control, and lipid profiles in patients with Type 2 diabetesDiabet Med2004c218596615270789
  • TaskinenMRDiabetic dyslipidaemia: from basic research to clinical practiceDiabetologia2003467334912774165
  • UK Prospective Diabetes Study (UKPDS) GroupIntensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)Lancet1998352837539742976
  • UK Prospective Diabetes Study (UKPDS) GroupEffect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)Lancet1998352854659742977
  • UK Prospective Diabetes Study GroupTight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38BMJ1998317703139732337
  • WilcoxRBousserM-GPiragVPROactive 04: Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke – results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular EventsStroke2007388657317290029
  • WilcoxRKupferSEffects of pioglitazone on major adverse cardiovascular events (MACE) and myocardial infarction: results from PROactive [abstract]Diabetes200655Suppl 1A74
  • WynneAMMocanuMMYellonDMPioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPKJ Cardiovasc Pharmacol2005468172216306807
  • Yki-JärvinenHThiazolidinedionesN Engl J Med200435111061815356308
  • Yki-JärvinenHThe PROactive study: some answers, many questions [commentary]Lancet20053661241216214581
  • ZuanettiGLatiniRMaggioniAPEffect of the ACE inhibitor lisinopril on mortality in diabetic patients with acute myocardial infarction. Data from the GISSI-3 studyCirculation1997964239459416888