The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation

References

• AckermannAFernandez-AlfonsoMSSanchezdRModulation of angiotensin-converting enzyme by nitric oxideBr J Pharmacol199812429189641545
   PubMed Web of Science ®Google Scholar
• AikawaMRabkinESugiyamaSAn HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitroCirculation20011032768311208689
   PubMed Web of Science ®Google Scholar
• AndersonTJMeredithITYeungACThe effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotionN Engl J Med1995332488937830729
   PubMed Web of Science ®Google Scholar
• BaldassarreDMoresNColliSPlatelet alpha 2-adrenergic receptors in hypercholesterolemia: relationship between binding studies and epinephrine-induced platelet aggregationClin Pharmacol Ther199761684919209252
   PubMed Web of Science ®Google Scholar
• BassellGSingerRHmRNA and cytoskeletal filamentsCurr Opin Cell Biol19979109159013679
   PubMed Web of Science ®Google Scholar
• BehrendtDGanzPEndothelial function. From vascular biology to clinical applicationsAm J Cardiol20029040L48L
   PubMed Web of Science ®Google Scholar
• BellostaSViaDCanavesiMHMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophagesArterioscler Thromb Vasc Biol199818167189812903
   PubMed Web of Science ®Google Scholar
• BernotDBenolielAMPeirettiFEffect of atorvastatin on adhesive phenotype of human endothelial cells activated by tumor necrosis factor alphaJ Cardiovasc Pharmacol2003413162412548094
   PubMed Web of Science ®Google Scholar
• BrownDALondonEStructure and function of sphingolipid- and cholesterol-rich membrane raftsJ Biol Chem200027517221410770957
   PubMed Web of Science ®Google Scholar
• BuchwaldHCamposCTBoenJRDisease-free intervals after partial ileal bypass in patients with coronary heart disease and hypercholesterolemia: report from the Program on the Surgical Control of the Hyperlipidemias (POSCH)J Am Coll Cardiol19952635177608434
   PubMed Web of Science ®Google Scholar
• CampbellDJHabenerJFAngiotensinogen gene is expressed and differentially regulated in multiple tissues of the ratJ Clin Invest1986783193013940
   PubMed Web of Science ®Google Scholar
• CarneadoJAlvarezdSPerez-GuerreroCSimvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effectJ Hypertens2002204293711875310
   PubMed Web of Science ®Google Scholar
• CelermajerDSSorensenKEGoochVMNon-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosisLancet19923401111151359209
   PubMed Web of Science ®Google Scholar
• ColliSEliginiSLalliMVastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosisArterioscler Thromb Vasc Biol199717265729081680
   PubMed Web of Science ®Google Scholar
• ColliSWerbaJPTremoliEStatins in atherothrombosisSemin Vasc Med200444071515861322
   PubMedGoogle Scholar
• CorsiniABellostaSBaettaRNew insights into the pharmacodynamic and pharmacokinetic properties of statinsPharmacol Ther1999844132810665838
   PubMed Web of Science ®Google Scholar
• CortellaroMCofrancescoEArbustiEAtorvastatin and thrombogenicity of the carotid atherosclerotic plaque: the ATROCAP studyThromb Haemost20028841712152675
   PubMed Web of Science ®Google Scholar
• CreagerMACookeJPMendelsohnMEImpaired vasodilation of forearm resistance vessels in hypercholesterolemic humansJ Clin Invest199086228342195060
   PubMed Web of Science ®Google Scholar
• DavignonJBeneficial cardiovascular pleiotropic effects of statinsCirculation2004109III394315198965
   PubMed Web of Science ®Google Scholar
• de SotomayorMAPerez-GuerreroCHerreraMDEffects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive ratsJ Hypertens1999177697610459874
   PubMed Web of Science ®Google Scholar
• de SotomayorMAPerez-GuerreroCHerrreraMDImprovement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathwaysBr J Pharmacol200514611303816231003
   PubMed Web of Science ®Google Scholar
• DimmelerSFlemingIFisslthalerBActivation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationNature1999399601510376603
   PubMed Web of Science ®Google Scholar
• DrexlerHHayozDMunzelTEndothelial function in chronic congestive heart failureAm J Cardiol19926915966011598876
   PubMed Web of Science ®Google Scholar
• DzauVJTheodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesisHypertension20013710475211304501
   PubMed Web of Science ®Google Scholar
• EgashiraKInouTHirookaYImpaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesionsJ Clin Invest19939129378423226
   PubMed Web of Science ®Google Scholar
• EtoMKozaiTCasentinoFStatin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathwaysCirculation20021051756911956113
   PubMed Web of Science ®Google Scholar
• FeganPGShoreACMawsonDMicrovascular endothelial function in subjects with Type 2 diabetes and the effect of lipid-lowering therapyDiabetes Care20052216706
   Google Scholar
• FeronODessyCDesagerJPHydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundanceCirculation20011031131811136695
   PubMed Web of Science ®Google Scholar
• FeronOSaldanaFMichelJBThe endothelial nitric-oxide synthase-caveolin regulatory cycleJ Biol Chem1998273312589452418
   PubMed Web of Science ®Google Scholar
• FichtlschererSRosenbergerGWalterDHElevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery diseaseCirculation20001021000610961964
   PubMed Web of Science ®Google Scholar
• FichtlschererSSchmidt-LuckeCBojungaSDifferential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for ‘pleiotropic’ functions of statin therapyEur Heart J20062711829016621868
   PubMed Web of Science ®Google Scholar
• FultonDGrattonJPMcCabeTJRegulation of endothelium-derived nitric oxide production by the protein kinase AktNature199939959760110376602
   PubMed Web of Science ®Google Scholar
• GanzPVitaJATesting endothelial vasomotor function: nitric oxide, a multipotent moleculeCirculation200310820495314581383
   PubMed Web of Science ®Google Scholar
• GargalovicPDoryLCaveolins and macrophage lipid metabolismJ Lipid Res200344112112518018
   PubMed Web of Science ®Google Scholar
• GauthierTWScaliaRMuroharaTNitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemiaArterioscler Thromb Vasc Biol199515165297583540
   PubMed Web of Science ®Google Scholar
• GertzKLaufsULindauerUWithdrawal of statin treatment abrogates stroke protection in miceStroke200334551712574574
   PubMed Web of Science ®Google Scholar
• HalcoxJPDeanfieldJEBeyond the laboratory: clinical implications for statin pleiotropyCirculation2004109II42815173062
   PubMed Web of Science ®Google Scholar
• HarrisonDGCellular and molecular mechanisms of endothelial cell dysfunctionJ Clin Invest1997100215379410891
   PubMed Web of Science ®Google Scholar
• HeeschenCHammCWLaufsUWithdrawal of statins increases event rates in patients with acute coronary syndromesCirculation200210514465211914253
   PubMed Web of Science ®Google Scholar
• HirataYEndothelin peptidesCurr Opin Nephrol Hypertens199651258834156
   PubMedGoogle Scholar
• IchikiTTakedaKTokunouTDownregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cellsArterioscler Thromb Vasc Biol200121189690111742861
   PubMed Web of Science ®Google Scholar
• JuHZouRVenemaVJDirect interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activityJ Biol Chem19972721852259228013
   PubMed Web of Science ®Google Scholar
• KansuiYFujiiKGotoKEffects of fluvastatin on endothelium-derived hyperpolarizing factor- and nitric oxide- mediated relaxations in arteries of hypertensive ratsClin Exp Pharmacol Physiol200431354915191411
   PubMed Web of Science ®Google Scholar
• KohKKEffects of statins on vascular wall: vasomotor function, inflammation, and plaque stabilityCardiovasc Res2000476485710974215
   PubMed Web of Science ®Google Scholar
• KohKKAhnJYChoiYMVascular effects of step I diet in hypercholesterolemic patients with coronary artery diseaseAm J Cardiol2003927081012972113
   PubMedGoogle Scholar
• KumarKVDasUNEffect of cis-unsaturated fatty acids, prostaglandins, and free radicals on angiotensin-converting enzyme activity in vitroProc Soc Exp Biol Med199721437499111529
   PubMed Web of Science ®Google Scholar
• LandsbergerMWolffBJantzenFCerivastatin reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cellsAtherosclerosis2007190435216529752
   PubMed Web of Science ®Google Scholar
• LaufsUEndresMCustodisFSuppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcriptionCirculation200010231041011120702
   PubMed Web of Science ®Google Scholar
• LaufsULa FataVPlutzkyJUpregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitorsCirculation1998971129359537338
   PubMed Web of Science ®Google Scholar
• LaufsULiaoJKPost-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPaseJ Biol Chem199827324266719727051
   PubMed Web of Science ®Google Scholar
• LaufsULiaoJKDirect vascular effects of HMG-CoA reductase inhibitorsTrends Cardiovasc Med200010143811239793
   PubMed Web of Science ®Google Scholar
• LaufsUWassmannSHilgersSRapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic menAm J Cardiol2001881306711728362
   PubMed Web of Science ®Google Scholar
• LiaoJKBeyond lipid lowering: the role of statins in vascular protectionInt J Cardiol20028651812243846
   PubMed Web of Science ®Google Scholar
• LiJJLiYSChenJRebound phenomenon of inflammatory response may be a major mechanism responsible for increased cardiovascular events after abrupt cessation of statin therapyMed Hypotheses200666119920416413682
   PubMed Web of Science ®Google Scholar
• LibbyPRidkerPMMaseriAInflammation and atherosclerosisCirculation200210511354311877368
   PubMed Web of Science ®Google Scholar
• LochDLevickSHoeyARosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive ratsJ Cardiovasc Pharmacol20064739640416633082
   PubMed Web of Science ®Google Scholar
• MansouratiJNewmanLGRomanSHLipid lowering does not improve endothelial function in subjects with poorly controlled diabetesDiabetes Care2001242152311723099
   PubMed Web of Science ®Google Scholar
• MaruiNOffermannMKSwerlickRVascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cellsJ Clin Invest1993921866747691889
   PubMed Web of Science ®Google Scholar
• MatsuoTIwadeKHirataNImprovement of arterial stiffness by the antioxidant and anti-inflammatory effects of short-term statin therapy in patients with hypercholesterolemiaHeart Vessels20052081215700196
   PubMed Web of Science ®Google Scholar
• MollnauHWendtMSzocsKEffects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signalingCirc Res200290E586511884382
   PubMed Web of Science ®Google Scholar
• NakamuraTSaitoYOhyamaYEffect of cerivastatin on endothelial dysfunction and aortic CD36 expression in diabetic hyperlipidemic ratsHypertens Res2004275899815492479
   PubMed Web of Science ®Google Scholar
• NasmythKJansenRPThe cytoskeleton in mRNA localization and cell differentiationCurr Opin Cell Biol199793964009159073
   PubMed Web of Science ®Google Scholar
• NawawiHOsmanNSYusoffKReduction in serum levels of adhesion molecules, interleukin-6 and C-reactive protein following short-term low-dose atorvastatin treatment in patients with non-familial hypercholesterolemiaHorm Metab Res2003354798512953165
   PubMed Web of Science ®Google Scholar
• NiWEgashiraKKataokaCAntiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesisCirc Res2001894152111532902
   PubMed Web of Science ®Google Scholar
• NickenigGBaumerATTemurYStatin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic menCirculation19991002131410571970
   PubMed Web of Science ®Google Scholar
• NickenigGSachinidisAMichaelsenFUpregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cellsCirculation19979547389008466
   PubMed Web of Science ®Google Scholar
• NishimatsuHSuzukiESatonakaHEndothelial dysfunction and hypercontractility of vascular myocytes are ameliorated by fluvastatin in obese Zucker ratsAm J Physiol Renal Physiol2005288H17706
   Web of Science ®Google Scholar
• NobesCDHallARho GTPases control polarity, protrusion, and adhesion during cell movementJ Cell Biol199914412354410087266
   PubMed Web of Science ®Google Scholar
• NotarbartoloADaviGAvernaMInhibition of thromboxane biosynthesis and platelet function by simvastatin in type IIa hypercholesterolemiaArterioscler Thromb Vasc Biol199515247517749833
   PubMed Web of Science ®Google Scholar
• O’DriscollGGreenDTaylorRRSimvastatin, an HMG-Coenzyme A reductase inhibitor, improves endothelial function within 1 monthCirculation1997951126319054840
   PubMed Web of Science ®Google Scholar
• OpperCClementCSchwarzHIncreased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterolAtherosclerosis1995113211177605360
   PubMed Web of Science ®Google Scholar
• OsamahHMiraRSorinaSReduced platelet aggregation after fluvastatin therapy is associated with altered platelet lipid composition and drug binding to the plateletsBr J Clin Pharmacol19974477839241100
   PubMed Web of Science ®Google Scholar
• PalmerRMFerrigeAGMoncadaSNitric oxide release accounts for the biological activity of endothelium-derived relaxing factorNature198732752463495737
   PubMed Web of Science ®Google Scholar
• ParkJKMullerDNMervaalaEMCerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effectsKidney Int20005814203011012877
   PubMed Web of Science ®Google Scholar
• PasceriVWillersonJTYehETDirect proinflammatory effect of C-reactive protein on human endothelial cellsCirculation20001022165811056086
   PubMed Web of Science ®Google Scholar
• Perez-GuerreroCAlvarezdSJimenezLEffects of simvastatin on endothelial function after chronic inhibition of nitric oxide synthase by L-NAMEJ Cardiovasc Pharmacol2003422041012883323
   PubMed Web of Science ®Google Scholar
• RadomskiMWReesDDDutraAS-nitroso-glutathione inhibits platelet activation in vitro and in vivoBr J Pharmacol199210774591335336
   PubMed Web of Science ®Google Scholar
• RidkerPMHigh-sensitivity C-reactive protein and cardiovascular risk: rationale for screening and primary preventionAm J Cardiol20039217K22K
   PubMed Web of Science ®Google Scholar
• RidleyAJRho-related proteins: actin cytoskeleton and cell cycleCurr Opin Genet Dev1995524307749321
   PubMed Web of Science ®Google Scholar
• RikitakeYKimHHHuangZInhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protectionStroke2005362251716141422
   PubMed Web of Science ®Google Scholar
• RobbieLABoothNABrownAJInhibitors of fibrinolysis are elevated in atherosclerotic plaqueArterioscler Thromb Vasc Biol199616539458624776
   PubMed Web of Science ®Google Scholar
• RomanoMDiomedeLSironiMInhibition of monocyte chemotactic protein-1 synthesis by statinsLab Invest2000801095110010908155
   PubMed Web of Science ®Google Scholar
• RomanoMMezzettiAMarulliCFluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients: role of nitric oxideJ Investig Med2000481839
   PubMed Web of Science ®Google Scholar
• SalernoJCHarrisDEIrizarryKAn autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthaseJ Biol Chem199727229769779368047
   PubMed Web of Science ®Google Scholar
• ScaliaRGooszenMEJonesSPSimvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient miceCirculation2001103259860311382730
   PubMed Web of Science ®Google Scholar
• SearlesCDIdeLDavisMEActin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growthCirc Res2004954889515256481
   PubMed Web of Science ®Google Scholar
• SimonsKEhehaltRCholesterol, lipid rafts, and diseaseJ Clin Invest200211059760312208858
   PubMed Web of Science ®Google Scholar
• Skaletz-RorowskiALutchmanMKureishiYHMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cellsCardiovasc Res2003572536412504836
   PubMed Web of Science ®Google Scholar
• SmartEJGrafGAMcNivenMACaveolins, liquid-ordered domains, and signal transductionMol Cell Biol199919728930410523618
   PubMed Web of Science ®Google Scholar
• SomlyoAVNew roads leading to Ca2+ sensitizationCirc Res20029183412142337
   PubMed Web of Science ®Google Scholar
• SowersJREndothelial vasodilation effects of statins in type 2 diabetic patients: response to van Venrooij et alDiabetes Care2002251242312087027
   PubMedGoogle Scholar
• StalkerTJLeferAMScaliaRA new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acidBr J Pharmacol20011334061211375257
   PubMed Web of Science ®Google Scholar
• SugiyamaMOhashiMTakaseHEffects of atorvastatin on inflammation and oxidative stressHeart Vessels200520133616025360
   PubMed Web of Science ®Google Scholar
• TakemotoMEgashiraKUsuiMImportant role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in ratsJ Clin Invest199799278879005996
   PubMed Web of Science ®Google Scholar
• TakemotoMLiaoJKPleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitorsArterioscler Thromb Vasc Biol20012117121911701455
   PubMed Web of Science ®Google Scholar
• TamaiOMatsuokaHItabeHSingle LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humansCirculation19979576828994420
   PubMed Web of Science ®Google Scholar
• TanKCChowWSTamSCAtorvastatin lowers C-reactive protein and improves endothelium-dependent vasodilation in type 2 diabetes mellitusJ Clin Endocrinol Metab200287563811836286
   PubMed Web of Science ®Google Scholar
• TanevaEBoruckiKWiensLEarly effects on endothelial function of atorvastatin 40 mg twice daily and its withdrawalAm J Cardiol2006971002616563905
   PubMed Web of Science ®Google Scholar
• ThomasMMannJIncreased thrombotic vascular events after change of statinLancet1998352183019851392
   PubMed Web of Science ®Google Scholar
• TomitaHEgashiraKKubo-InoueMInhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vesselsArterioscler Thromb Vasc Biol1998181456649743235
   PubMed Web of Science ®Google Scholar
• TousoulisDAntoniadesCBosinakouEEffects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failureAtherosclerosis20051783596315694946
   PubMed Web of Science ®Google Scholar
• TreasureCBKleinJLWeintraubWSBeneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery diseaseN Engl J Med199533248177830728
   PubMed Web of Science ®Google Scholar
• TsunekawaTHayashiTKanoHCerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 daysCirculation2001104376911468195
   PubMed Web of Science ®Google Scholar
• van der HarstPWagenaarLJBuikemaHEffect of intensive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery diseaseAm J Cardiol2005961361416275178
   PubMed Web of Science ®Google Scholar
• van EttenRWde KoningEJHoningMLIntensive lipid lowering by statin therapy does not improve vasoreactivity in patients with type 2 diabetesArterioscler Thromb Vasc Biol20022279980412006393
   PubMed Web of Science ®Google Scholar
• van VenrooijFVvan de ReeMABotsMLAggressive lipid lowering does not improve endothelial function in type 2 diabetes: the Diabetes Atorvastatin Lipid Intervention (DALI) Study: a randomized, double-blind, placebo-controlled trialDiabetes Care20022512111612087021
   PubMed Web of Science ®Google Scholar
• VergnaniLHatrikSRicciFEffect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production : key role of L-arginine availabilityCirculation20001011261610725285
   PubMed Web of Science ®Google Scholar
• WangHRLiJJHuangCXFluvastatin inhibits the expression of tumor necrosis factor-alpha and activation of nuclear factor-kappaB in human endothelial cells stimulated by C-reactive proteinClin Chim Acta2005353536015698590
   PubMed Web of Science ®Google Scholar
• WassmannSLaufsUBaumerATInhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPaseMol Pharmacol2001596465411179461
   PubMed Web of Science ®Google Scholar
• WeberCErlWWeberKSHMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemiaJ Am Coll Cardiol1997301212179350917
   PubMed Web of Science ®Google Scholar
• Weitz-SchmidtGWelzenbachKBrinkmannVStatins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin siteNat Med200176879211385505
   PubMed Web of Science ®Google Scholar
• WidlanskyMEGokceNKeaneyJFJrThe clinical implications of endothelial dysfunctionJ Am Coll Cardiol20034211496014522472
   PubMed Web of Science ®Google Scholar
• WolfrumSJensenKSLiaoJKEndothelium-dependent effects of statinsArterioscler Thromb Vasc Biol2003237293612615672
   PubMed Web of Science ®Google Scholar
• WOSCOPS Study GroupInfluence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS)Circulation199897144059576423
   PubMed Web of Science ®Google Scholar
• WuLGirouardHde ChamplainJInvolvement of the cyclic GMP pathway in the superoxide-induced IP3 formation in vascular smooth muscle cellsJ Hypertens20001810576410953997
   PubMed Web of Science ®Google Scholar
• XingYChenHHuDYEffects of withdrawal of statins on nitric oxide production in vascular endothelial cellsZhonghua Nei Ke Za Zhi20054422415769392
   PubMedGoogle Scholar
• YamakuchiMGreerJJCameronSJHMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct sizeCirc Res20059611859215905463
   PubMed Web of Science ®Google Scholar
• Zapolska-DownarDSiennickaAKaczmarczykMSimvastatin modulates TNFalpha-induced adhesion molecules expression in human endothelial cellsLife Sci200475128730215234187
   PubMed Web of Science ®Google Scholar
• ZeiherAMFisslthalerBSchray-UtzBNitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cellsCirc Res19957698067758169
   PubMed Web of Science ®Google Scholar
• ZundelWSwierszLMGiacciaACaveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramideMol Cell Biol20002015071410669728
   PubMed Web of Science ®Google Scholar