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Review

Androgen therapy and atherosclerotic cardiovascular disease

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Pages 11-21 | Published online: 28 Dec 2022

References

  • AdamsMRWilliamsJKKaplanJREffects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsivenessArterioscler Thromb Vasc Biol199515562707749870
  • AlexandersenPHaarboJByrjalsenINatural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbitsCirc Res1999848131910205149
  • AnderssonBMattssonLAHahnLEstrogen replacement therapy decreases hyperandrogenicity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin-dependent diabetes mellitusJ Clin Endocrinol Metab199782638439024268
  • AradYBadimonJJBadimonLDehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbitsArteriosclerosis19899159652522296
  • Barrett-ConnorEKhawKTEndogenous sex hormones and cardiovascular disease in men. A prospective population-based studyCirculation198878539453409497
  • BentonWPMGuoZKruckenJWunderlichFRapid effects of androgens in macrophagesSteroids2004695859015288774
  • BjorntorpPHyperandrogenicity in women-a prediabetic condition?J Intern Med1993234579838258749
  • Bonithon-KoppCScarabinPYBaraLRelationship between sex hormones and haemostatic factors in healthy middle-aged menAtherosclerosis1988717163377881
  • BruckBBrehmeUGugelNGender-specific differences in the effects of testosterone and estrogen on the development of atherosclerosis in rabbitsArterioscler Thromb Vasc Biol199717219299351389
  • ChenSJLiHBDurandJEstrogen reduces myointimal proliferation after balloon injury of rat carotid arteryCirculation199693577848565178
  • ContoreggiCSBlackmanMRAndresRPlasma levels of estradiol, testosterone, and DHEAS do not predict risk of coronary artery disease in menJ Androl199011460702147671
  • CooperBCGokinaNIOsolGTestosterone replacement increases vasodilatory reserve in androgen-deficient female ratsFertility and Sterility200787422517081525
  • DavisonSLBellRAndrogen physiologySeminars in Reproductive Medicine20062471716633980
  • DeathAKMcGrathKCYSaderMADihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-(B-dependent pathwayEndocrinology200414518899714684616
  • EichDMNestlerJEJohnsonDEInhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantationCirculation19938726158419015
  • ElhageRArnalJFPieraggiMT17(-estradiol prevents fatty streak formation in apolipoprotein E-deficient miceArterioscler Thromb Vasc Biol1997172679849409242
  • EnglishKMMandourOSteedsRPMen with coronary artery disease have lower levels of androgens than men with normal coronary angiogramsEur Heart J200021890410806012
  • EnglishKMSteedsRPJonesTHLow-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled studyCirculation200010219061111034937
  • FogelbergMBIDicsfalusyUHenrikssonPStanozolol and experimental atherosclerosis: atherosclerosis development and blood lipids during anabolic steroid therapy of New Zealand white rabbitsScand J Clin Lan Invest199050693700
  • FriedlRBrunnerMMoeslingerTTestosterone inhibits expression of inducible nitric oxide synthase in murine macrophagesLife Sci2000684172911205891
  • FujimotoRMorimotoIMoritaEAndrogen receptors, 5(-reductase activity and androgen-dependent proliferation of vascular smooth muscle cellsJ Steroid Biochem Mol Biol199450169748049146
  • GioeliDFicarroSBKwiekJJAndrogen receptor phosphorylation. Regulation and identification of the phosphorylation sitesJournal of Biological Chemistry2002277293041412015328
  • GordonGBBushDEWeismanHFReduction of atherosclerosis by administration of dehydroepiandrosterone: a study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injuryJ Clin Invest1988825864
  • GordonTCastelliWPHjortlandMCHigh density lipoprotein as a protective factor against coronary artery disease: the Framingham StudyAm J Med19976270714193398
  • GrinoPBGriffinJEWilsonJDTestosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosteroneEndocrinology19901261165722298157
  • HaddadRMKennedyCCCaplesSMTestosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled studiesMayo Clinic Proc2007822939
  • HaffnerSMShatenJSternMPLow levels of sex hormone binding globulin and testosterone predict the development of non insulin dependent diabetes mellitus in menAmerican Journal of Epidemiology1996143889978610702
  • HakAEWittemanJCde JongFHLow levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam studyJ Clin Endocrinol Metab2002873632912161487
  • HartgensFRietjensGKeizerHAEffects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a)Br J Sports Med200438253915155420
  • HashimuraKSudhirKNigroJAndrogens stimulate human vascular smooth muscle cell proteoglycan biosynthesis and increases lipoprotein bindingEndocrinology200514620859015661861
  • HatakeyamaHNishizawaMNakagawaATestosterone inhibits tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cellsFEBS Letters20025301293212387879
  • HawkTZhangYQRajakumarGTestosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male ratsBrain Res199879629689689481
  • HolmangASvedbergJJennischeEEffects of testosterone on muscle insulin sensitivity and morphology in female ratsAm J Physiol1990259E555602221057
  • HougakuHFlegJLNajjarSSRelationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurementsAm J Physiol Endocrinol Metab2006290E2344216159908
  • IsidoriAMGiannettaEPozzaCAndrogens, cardiovascular disease and osteoporosisJournal of Endocrinological Investigation20052873916550728
  • JeanesHNewbyDGrayGACardiovascular risk in women: the impact of hormone replacement therapy and prospects for new therapeutic approachesExpert Opinion on Pharmacotherapy200782798817266463
  • JenkinsCSalisburyRElyDCastration lowers and testosterone restores blood pressure in several rat strains on high sodium dietClin Exp Hypertens199416611257951166
  • KalinMFZumoffBSex hormones and coronary disease: a review of the clinical studiesSteroids199955330522237942
  • KhawKTBarrett-ConnorELower endogenous androgens predict central adiposity in menAnn Epidemiol19922675821342319
  • KorytkowskiMTKrugEIDalyMADoes androgen excess contribute to the cardiovascular risk profile in postmenopausal women with type 2 diabetes?Metabolism Clinical and Experimental20055416263116311096
  • KrentzAJvon MuhlenDBarrett-ConnorESearching for polycystic ovary syndrome in postmenopausal women: evidence of a dose-effect association with prevalent cardiovascular diseaseMenopause2007142849217245231
  • KrongradAWilsonCMWilsonJDAndrogens increase androgen receptor protein while decreasing receptor mRNA in LNCaP cellsMolecular and Cellular Endocrinology19917679881820979
  • KupelianVPageSTAraujoABLow sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese menJ Clin Endocrinol and Metab2006918435016394089
  • LangerCGanszBGoepfertCTestosterone up-regulates scavenger receptor B1 and stimulates cholesterol efflux from macrophagesBiochem Biophys Res Commun20022961051712207878
  • LarsenBANordestgaardBGStenderSEffect of T on atherogenesis in cholesterol-fed rabbits with similar plasma cholesterol levelsAtherosclerosis19939979868461063
  • LeeHJChangCRecent advances in androgen receptor actionCellular and Molecular Life Sciences20026016132214504652
  • LingSDaiADilleyRJEndogenous estrogen deficiency reduces proliferation and enhances apoptosis-related death in vascular smooth muscle cells: insights from the aromatase knock-out mouseCirculation200453943
  • LiuPYDeathAKHandelsmanDJAndrogens and Cardiovascular diseaseEndocrine Reviews2003243134012788802
  • MalkinCJPughPJJonesTHChannerKSTestosterone for secondary prevention in men with ischaemic heart diseaseQuart J Med2003965219
  • MalkinCJJonesRDJonesTHChannerKSEffect of testosterone on ex vivo vascular reactivity in manClin Sci20061112657416722820
  • MalkinCJPughPJWestJNTestosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trialEur Heart J200627576416093267
  • MarinPHolmangSJonssonLThe effects of testosterone treatment on body composition and metabolism in middle-aged obese menInt J Obes Relat Metab Disord19921699171335979
  • MaronBJShiraniJPoliacLCSudden death in young competitive athletes Clinical, demographic and pathological profilesJAMA19962761992048667563
  • MeriggiolaMCMarcovinaSPaulsenCATestosterone enanthate at a dose of 200 mg/week decreases HDL-cholesterol levels in healthy menInt J Androl199518237428567093
  • MukherjeeTKDinhHChaudhuriGTestosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosisPNAS20029940556011904449
  • MullerMvan den BeldAWBotsMLEndogenous sex hormones and progression of carotid atherosclerosis in elderly menCirculation20041092074915096452
  • NathanLShiWDinhHTestosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromataseProc Natl Acad Sci USA20019835899311248122
  • NgMQuinnCMMcCrohonJAAndrogens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosisJ Am Coll Cardiol20034213061314522500
  • ObasanjoIOClarksonTBWeaverDSEffects of the anabolic steroid nandrolone decanoate on plasma lipids and coronary arteries of female cynomolgus macaquesMetabolism19964546388609832
  • PageSTAmoryJKBowmanFDExogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum TJ Clin Endocrinol Metab20059015021015572415
  • ParadisiGSteinbergHOHempflingAPolycystic ovary syndrome is associated with endothelial dysfunctionCirculation200110314101511245645
  • PoldermanKHGoorenLJAsschemanHInduction of insulin resistance by androgens and estrogensJ Clin Endocrinol Metab199479265718027240
  • PughPJJonesTHChannerKSAcute haemodynamic effects of testosterone in men with chronic heart failureEur Heart J2003249091512714022
  • QuigleyCADeBellisAMarschkeKBAndrogen receptor defects: historical, clinical and molecular perspectivesEndocrinology Reviews199516271321
  • ReckelhoffJFSex steroids, cardiovascular disease and hypertensionHypertension200545170415583070
  • RosanoGMLeonardoFPagnottaPAcute anti-ischemic effect of testosterone in men with coronary artery diseaseCirculation19909916667010190874
  • RossRAtherosclerosis- an inflammatory diseaseN Engl J Med1999340115269887164
  • RossouwJEPrenticeRLMansonJEWuLPostmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopauseJAMA200729714657717405972
  • SeyrekMYildizOUlusoyHBYildrimVTestosterone relaxes isolated human radial artery by potassium channel opening actionJ Pharmocological Sciences200710330916
  • SnyderPJPeacheyHBerlinJAEffect of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of ageAm J Med20011112556011566454
  • StellatoRKFeldmanHAHambyOTestosterone, sex hormone binding globulin and the development of type 2 diabetes in middle aged menDiabetes Care200023490410857940
  • SvartbergJvon MuhlenDSchirmerHAssociation of endogenous testosterone with blood pressure and left ventricular mass in men: the Tromso StudyEur J Endocrinol2004150657114713281
  • TchernofALabrieFBelangerARelationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variablesAtherosclerosis1997133235449298684
  • ThomasHDadgarNAphaleAAndrogen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to an expanded glutamine tractsJournal of Biological Chemistry200427983899514670946
  • TodaTTodaYChoBHUltrastructural changes in the comb and aorta of chicks fed excess testosteroneArteriosclerosis1984514753
  • TracyRESex differences in coronary disease: two opposing viewsJ Chronic Dis1966191245515966017
  • TrapmanJRis-StalpersCvan der KorputJAThe androgen receptor: functional structure and expression in transplanted human prostate tumors and prostate tumor cell linesJournal of Steroid Biochemistry and Molecular Biology199037837422285596
  • van KesterenPAsschemenHMegensJAJMortality and morbidity in transsexual subjects treated with cross-sex hormonesClin Endocrinol19974733742
  • VermeulenAKaufmanJMDiagnosis of hypogonadism in the aging maleAging Male200252706
  • von DehnGvon DehnOVolkerWAtherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormonesHorm Metab Res200133110411294492
  • WebbCMAdamsonDLde ZeiglerDEffect of acute testosterone on myocardial ischemia in men with coronary artery diseaseAm J Cardiol199983437910072236
  • WhitselEABoykoEJMatsumotoAMIntramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysisAm J Med2001111261911566455
  • WiermanMESex steroid effects at target tissues: mechanisms of actionAdvances in Physiology Education200731263317327579
  • WoodardTLBurghenGAKitabchiAEWilimasJAGlucose intolerance and insulin resistance in aplastic anemia treated with oxymetholoneJ Clin Endocrinol Metab19815390587026595
  • WuFCFarleyTMPeregoudovAWaitesGMEffects of testosterone enanthate in normal men: experience from a multicenter contraceptive efficacy study. World Health Organization Task Force on Methods for the Regulation of Male FertilityFertil Steril199665626368774299
  • WuFCvon EckardsteinAAndrogens and coronary artery diseaseEndocrine Reviews20032418321712700179
  • YeapBBKruegerRGLeedmanPJDifferential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cellsEndocrinology199914032829110385425
  • ZhouZXKemppainenJAWilsonEMIdentification of three proline-directed phosphorylation sites in the human androgen receptorMolecular Endocrinology19959605157565807
  • ZmudaJMCauleyJAKriskaALongitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participantsAm J Epidemiol1997146609179345114