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Review

The renin–angiotensin system and diabetes: An update

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Pages 787-803 | Published online: 24 Dec 2022

References

  • AbdallaSLotherHQuittererU2000AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestrationNature40794810993080
  • AgarwalR2003Proinflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockadeAm J Physiol Renal Physiol284F863912505865
  • AlbistonALMcDowallSGMatsacosD2001Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated ami nopeptidaseJ Biol Chem27648623611707427
  • AlbistonALPeckGRYeatmanHR2007Therapeutic targeting of insulin-regulated aminopeptidase: heads and tails?Pharmacol Ther1164172717900701
  • AlbistonALPedersonESBurnsP2004Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigmsBehav Brain Res1542394315302130
  • AndersonSJungFFIngelfingerJR1993Renal renin-angiotensin system in diabetes: functional immunohistochemical and molecular biological correlationsAm J Physiol265F4774868238377
  • BakerKMCherninMISchreiberT2004Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophyRegul Pept12051315177915
  • BedecsKElbazNSutremM1997Angiotensin II type 2 receptors mediate inhibition of mitogen activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphataseBiochem J325449549230127
  • BenterIFYousifMHDhaunsiGS2008Angiotensin (1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive ratsAm J Nephrol28253317890855
  • BjorkS1990The renin-angiotensin system in diabetes mellitus: a physiological and therapeutic studyScand J Urol Nephrol126150
  • BloemLJManatungaAKTewksburyDA1995The serum angio-tensinogen concentration and variants of the angiotensinogen gene in white and black childrenJ Clin Invest95948537883995
  • BojestigMNystromFHArnqvistHJ2000The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetesJ Renin Angiotensin Aldosterone Syst1353611967822
  • BraszkoJJWalesiukAWielgatP2006Cognitive effects attributed to angiotensin II may result from its conversion to angiotensin IVJ Renin Angiotensin Aldosterone Syst71687417094054
  • Braun-MenendezEFascioloJCLeloirLF1940The substance causing renal hypertensionJ Physiol (Lond)982839816995204
  • BrennerBMCooperMEde ZeeuwD2001Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyN Eng J Med3458619
  • BrewsterUCPerazellaMA2004The renin-angiotensin-aldosterone system and the kidney: effects on kidney diseaseAm J Med1162637214969655
  • BrosnihanKBLiPFerrarioCM1996Angiotensin-(1–7) dilates canine coronary arteries through kinins and nitric oxideHypertension2752388613197
  • BrosnihanKBNevesLAAntonL2004Enhanced expression of Ang (1–7) during pregnancyBraz J Med Biol Res3712556215273828
  • CaglayanEBlaschkeFTakataY2005Metabolic syndrome interdependence of the cardiovascular and metabolic pathwaysCurr Opin Pharmacol51354215780821
  • Campagnole-SantosMJDizDISantosRAS1989Cardiovascular effects of angiotensin-(1–7) injected into the dorsal medulla of ratsAm J Physiol257H32492750946
  • CampbellDJ2003The renin angiotensin and kallikrein kinin systemsInt J Biochem Cell Biol357849112676165
  • CardilloCPanzaJA1998Impaired endotelial regulation of vascular tone in patients with systemic arterial hypertensionVasc Med3138449796077
  • CareyRMSiragyHM2003aNewly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulationEndocr Rev2432617112788798
  • CareyRMSiragyHM2003bThe intrarenal renin-angiotensin system and diabetic nephropathyTrends Endocrinol Metab1462748112890592
  • CesariMRossiGPPessinaAC2002Biological properties of the angiotensin peptides other than angiotensin II: implications for hypertension and cardiovascular diseasesJ Hypertens20793912011628
  • ChappellMCModrallJGDizDI2004Novel aspects of the renal Renin-Angiotensin System: Angiotensin-(1–7), ACE2 and blood pressure regulationContrib Nephrol143778915248357
  • ChappellMC2007Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1–7)-Mas receptor axis: More than regulation of blood pressure?Hypertension50596917785634
  • ChaySRFernandoRPeckG2004The angiotensin IV/AT4 receptorCell Mol Life Sci6127283715549174
  • ChenSPatelJMBlockER2000Angiotensin IV-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium releaseAm J Physiol279L84956
  • CipolloneFFaziaMLMezzetiA2006Role of angiotensin II receptor blockers in atherosclerotic plaque stabilityExpert Opin Pharmacother72778516448322
  • ClarkMAGuillaumeGPierre-LouisHC2008Angiotensin II induces proliferation of cultured rat astrocytes through c-Jun N-terminal kinaseBrain Res Bull75101618158102
  • CooperMETikellisCThomasMC2006Preventing diabetes in patients with hypertension: one more reason to block the renin-angiotensin systemJ Hypertens Suppl24S576316601575
  • DahlofBDevereuxRBKjeldsenSE2002Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint Reduction in Hypertension Study (LIFE): a randomized trial against atenololLancet359995100311937178
  • DanserAH2003Local renin-angiotensin systems: the unanswered questionsInt J Biochem Cell Biol357596812676161
  • De GasparoMCattKJInagamiT2000International union of pharmacology. XXIII. The angiotensin II receptorsPharmacol Rev524157210977869
  • De MattiaGFerriCLaurentiO1996Circulating cathecolamines and metabolic effects of captopril in NIDDM patientsDiabetes Care19226308742566
  • DeckertT1994Nephropathy and coronary death: the fatal twins in diabetes mellitusNephrol Dial Transplant91069717800202
  • DeddishPAMarcicBJackmanHL1998N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1–7) and keto-ACEHypertension31912179535414
  • DonoghueMHsiehFBaronasE2000A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9Circ Res87E1910969042
  • DoriaAOnumaTWarramJH1997Synergistic effect of angiotensin II type 1 receptor genotype and poor glycaemic control on risk of nephropathy in IDDMDiabetologia401293999389421
  • FeiDTCoghlanJPFernleyRT1980Peripheral production of angiotensin II and III in sheepCirc Res46I13577379257
  • FerrarioCAbdelhamedAIMooreM2004Angiotensin II antagonists in hypertension, heart failure, and diabetic nephropathy: focus on losartanCurr Med Res Opin202799315025837
  • FerrarioCMJessupJGallagherPE2005Effects of renin-angiotensin system blockade on renal angiotensin-(1–7) forming enzymes and receptorsKidney Int6821899616221218
  • FerrarioCMMartellNYunisC1998Characterization of angiotensin-(1–7) in the urine of normal and essential hypertensive subjectsAm J Hypertens11137469524041
  • FolliFSaadMJVellosoL1999Crosstalk between insulin and angiotensin II signalling systemsExp Clin Endocrinol Diabetes107133910320054
  • Fraga-SilvaRAPinheiroSVGonçalvesAC2008The Antithrombotic Effect of Angiotensin-(1–7) Involves Mas-Mediated NO Release from PlateletsMol Med14283518026570
  • FreemanEJChisolmGMFerrarioCM1996Angiotensin (1–7) inhibits vascular smooth muscle cell growthHypertension2810488675248
  • FrossardMJoukhadarCSteffenG2000Paracrine effects of angiotensin-converting-enzyme-and angiotensin-II-receptor-inhibition on transcapillary glucose transport in humansLife Sci6614754
  • FuruhashiMUraNTakizawaH2004Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivityJ Hypertens2219778215361770
  • GallagherPETallantEA2004Inhibition of human lung cancer cell growth by angiotensin-(1–7)Carcinogenesis2520455215284177
  • GantenDMarquez-JulioAGrangerP1971Renin in dog brainAm J Physiol221173374330904
  • GiacchettiGSechiLARilliS2005The renin-angiotensin-aldosterone system, glucose metabolism and diabetesTrends Endocrinol Metab16120615808810
  • GlossmannHBaukalACattKJ1974Angiotensin II receptors in bovine adrenal cortex. Modification of angiotensin II binding by guanyl nucleotidesJ Biol Chem24966464358562
  • GrossCMPerrotAGeierC2007Recurrent in-stent restenosis is not associated with the angiotensin converting enzyme D/I, angiotensinogen Thr174Met and Met235Thr, and the angiotensin-II receptor 1 A1166C polymorphismJ Invasive Cardiol19261417541127
  • GumprechtJZychmaMJGrzeszczakW2000End-stage renal disease study group. Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: risk of chronic renal failureKidney Int585131910916074
  • HallJEBrandsMWHenegarJR1999Angiotensin II and long term arterial pressure regulation: the overriding dominance of the kidneyJ Am Soc Nephrol10S2586510201880
  • HallJE1991The renin-angiotensin system: renal actions and blood pressure regulationCompr Ther178171879129
  • HandaRK1999Angiotensin-(1–7) can interact with the rat proximal tubule AT(4) receptor systemAm J Physiol277F75F8310409300
  • [HOPE] Heart Outcomes Prevention Evaluation Study Investigators2000Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudyLancet355253910675071
  • HerathCBWarnerFJLubelJS2007Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and Angiotensin-(1–7) levels in experimental billiary fibrosisJ Hepatol473879517532087
  • HsuehWAQuiñonesMJ2003Role of endothelial dysfunction in insulin resistanceAm J Card9210J17J
  • HunyadyLCattKJ2006Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin IIMol Endocrinol209537016141358
  • IchikawaIHarrisRC1991Angiotensin actions in the kidney. Renewed insight into the old hormoneKidney Int40583961745006
  • JackmanHLMassadMGSekosanM2002Angiotensin 1–9 and 1–7 release in human heart: role of cathepsin AHypertension399768112019279
  • JacquesDAbdel MalakNASaderS2003Angiotensin II and its receptors in human endocardial endothelial cells : role in modulating intracellular calciumCan J Physiol Pharmacol812596612733824
  • JamersonKANesbittSDAmerenaJV1996Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effectsHypertension2785488613260
  • Jandeleit-DahmKATikellisCReidCM2005Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetesJ Hypertens234637315716683
  • JankowskiVVanholderRvan der GietM2007Mass-spectrometric identification of a novel angiotensin peptide in human plasmaArterioscler Thromb Vasc Biol2729730217138938
  • JanssonPA2007Endothelial dysfunction in insulin resistance and type 2 diabetesJ Intern Med2621738317645585
  • KagamiSBorderWAMillerDE1994Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in the rat glomerular mesangial cellsJ Clin Invest93243178200978
  • KalantariniaKOkusaMD2006The renin-angiotensin system and its blockade in diabetic renal and cardiovascular diseaseCurr Diab Rep681616522275
  • KambayashiYBardhanSTakahashiK1993Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibitionJ Biol Chem2682454368227011
  • KangD-HKanellisJHugoC2002Role of the microvascular endothelium in progressive renal diseaseJ Am Soc Nephrol138061611856789
  • Karwowska-PoleckaWKulakowskaAWisniewskiK1997Losartan influences behavioral effects of angiotensin II (3–7) in ratsPharmacol Res36275839425616
  • KohlstedtKBrandesRPMuller-EsterlW2004Angiotensin-converting enzyme is involved in outsidein signaling in endothelial cellsCirc Res9460714615289
  • KostenisEMilliganGChristopoulosA2005G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptorCirculation11118061315809376
  • KucharewiczIPawlakRMatysT2002Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1–7)Hypertension40774912411476
  • LauTCarlssonPOLeungPS2004Evidence for a local angiotensin-generating system and dose dependent inhibition of glucose stimulated insulin release by angiotensin II in isolated pancreatic isletsDiabetologia47240814722647
  • LavoieJLSigmundCD2003Minireview: overview of the renin-angiotensin system-an endocrine and paracrine systemEndocrinology14421798312746271
  • LewisEJHunsickerLGClarkWRfor The Collaborative Study Group2001Renoprotective effect of the angiotensin receptor antagonist irbersartan in patients with nephropathy due to type 2 diabetesN Engl J Med3458516011565517
  • LiMLiuKMichalicekJ2004Involvement of chymase-mediated angiotensin II generation in blood pressure regulationJ Clin Invest1141122015232618
  • LiXCCampbellDJOhishiM2006AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in ratsAm J Physiol290F102433
  • LiebWGrafJGotzA2006Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudyJ Mol Med84889616283142
  • LindholmLHIbsenHDahlofB2002Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE). A randomized trial against atenololLancet35910041011937179
  • LupiRDel GuerraSBuglianiM2006The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic isletsEur J Endocrinol1543556116452552
  • LuqueMMartinPMartellN1996Effects of captopril related to increased levels of prostacyclin and angiotensin-(1–7) in essential hypertensionJ Hypertens147998058793704
  • MaiaLGRamosMCFernandesL2004Angiotensin – (1–7) antagonist A-779 attenuates the potentiation of bradykinin by captopril in ratsJ Cardiovasc Pharmacol436859115071356
  • MatayoshiTKamideKTakiuchiS2007Relationship between insulin resistance and the renin-angiotensin system: analysis for patients with essential and renovascular hypertensionClin Exp Hypertens294798718041161
  • MeigsJB2003The metabolic syndromeBr Med J32761212855493
  • MerrilDCKarolyMChenK2002Angiotensin–(1–7) in normal and pre-elamptic pregnancyEndocrine182394512450315
  • MervaalaEMMullerDNParkJK1999Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertensionHypertension33389959931135
  • MiyazakiMTakaiS2006Tissue angiotensin II generating system by angiotensin-converting enzyme and chymaseJ Pharmacol Sci100391716799256
  • MogensenCE1984Microalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetesN Eng J Med31035660
  • MogielnickiAKramkowskiKChabielskaE2003Angiotensin 1–9 influences hemodynamics and hemostatics parameters in ratsPol J Pharmacol555034
  • MukaiYShimokawaHHigashiM2002Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging ratsArterioscler Thromb Vasc Biol2214455012231564
  • MukoyamaMNakajimaMHoriuchiM1993Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptorsJ Biol Chem26824539428227010
  • MullerMFaschingPSchmidR1997Inhibition of paracrine angiotensin-converting enzyme in vivo: effects on interstitial glucose and lactate concentrations in human skeletal muscleEur J Clin Invest27825309373760
  • MurphyTJAlexanderRWGriendlingKK1991Isolation of a cDNA encoding the vascular type-1 angiotensin II receptorNature35123362041570
  • NaberCKSiffertW2004Genetics of human arterial hypertensionMinerva Med953475615467511
  • NagataSKatoJSasakiK2006Isolation and identification of pro-angiotensin-12, a possible component of the renin-angiotensin systemBiochem Biophys Res Comm35010263117045572
  • NakagawaTSegalMCrokerB2007A breakthrough in diabetic nephropathy: the role of endothelial dysfunctionNephrol Dial Transplant222775717595179
  • NakashimaHSuzukiHOhtsuH2006Angiotensin II regulates vascular and endothelial dysfunction: recent topics of Angiotensin II type-1 receptor signaling in the vasculatureCurr Vasc Pharmacol4677816472178
  • NavarLGHarrisonBLImigJD2000Renal responses to AT(1) receptor blockadeAm J Hypertens13S4554
  • NavarLGNishiyamaA2004Why are angiotensin concentrations so high in the kidney?Curr Opin Nephrol Hypertens131071515090867
  • NguyenGDelarueFBurckleC2002Pivotal role of the renin/pro-renin receptor in angiotensin II production and cellular responses to reninJ Clin Invest10914172712045255
  • NielsenAHSchauserKHPoulsenK2000Current topic: the uteropla cental renin-angiotensin systemPlacenta214687710940196
  • NogueiraAISantosRASSimões e SilvaAC2007The pregnancy-induced increase of plasma angiotensin-(1–7) is blunted in gestational diabetesRegul Pep1415560
  • NouetSNahmiasC2000Signal transduction from the Angiotensin II AT2 receptorTrends Endocrinol Metab111610652498
  • OrcaranzaMPGodoyIJalilJE2006Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted ratHypertension48572816908757
  • PadiaSHHowellNLSiragyHM2006Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked ratHypertension475374416380540
  • PadiaSHKempBAHowellNL2007Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked ratsHypertension496253017190872
  • PaizisGTikellisCCooperME2005Chronic liver injury in rat and man upregulates the novel enzyme angiotensin converting enzyme IIGut541790616166274
  • ParvingHHLehnertHBrochner-MortensenJfor the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group2001The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetesN Engl J Med345870811565519
  • PatelJMMartensJRLiYD1998Angiotensin IV receptor-mediated activation of lung endothelial NOS is associated with vasorelaxationAm J Physiol275L106189843842
  • PaulMMehrAPKreutzR2006Physiology of local renin-angiotensin systemsPhysiol Rev8674780316816138
  • PaulaRDLimaCVKhoslaMC1995Angiotensin -(1–7) potentiates the hypotensive effect of bradykinin in conscious ratsHypertension26115497498987
  • PechánováOSimkoF2007The role of nitric oxide in the maintenance of vasoactive balancePhysiol Res56Suppl 2S71617824812
  • PereiraRMSantosRASTeixeiraMM2007The renin-angiotensin system in a rat model of hepatic fibrosis: Evidence for a protective role of angiotensin-(1–7)J Hepatol466748117188388
  • PlovsingRRWambergCSandgaardNC2003Effects of truncated angiotensins in humans after double blockade of the renin systemAm J Physiol285R98191
  • PorstiIBaraATBusseR1994Release of nitric oxide by angiotensin-(1–7) from porcine coronary endothelium: implications for a novel angiotensin receptorBr J Pharmacol11165248019744
  • PriceDADe’OliveiraJMFisherND1999The state and responsiveness of the renin-angiotensin system in patients with type II diabetes mellitusAm J Hypertens123485510232494
  • ReRN2003Intracellular renin and the nature of intracrine enzymesHypertension421172212860832
  • RiceGIThomasDAGrantPJ2004Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolismBiochem J383455115283675
  • RicheyJMAderMMooreD1999Angiotensin II induces insulin resistance independent of changes in interstitial insulinAm J Physiol2779206
  • RodriguezAFortuñoAGómez-AmbrosiJ2007The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smoth muscle cells is mediated via a nitric oxide-dependent mechanismEndocrinology1483243117038553
  • RomeoGRMoultonKSKazlauskasA2007Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouseCirc Res1013283017702977
  • Ruiz-OrtegaMLorenzoOEgidoJ2000Angiotensin III increases MCP-1 and activates NF-kappaB and AP-1 in cultured mesangial and mononuclear cellsKidney Int5722859810844599
  • RydénMArnerP2007Tumour necrosis factor-alpha in human adipose tissue – from signaling mechanisms to clinical implicationsJ Intern Med262431817875179
  • SampaioWOHenrique de CastroCSantosRA2007aAngiotensin-(1–7) counterregulates angiotensin II signaling in human endothelial cellsHypertension501093817984366
  • SampaioWOSouza dos SantosRAFaria-SilvaR2007bAngiotensin-(1–7) through receptor Mas mediates endothelial nitric oxide synthese activation via Akt-dependent pathwaysHypertension491859217116756
  • SantosRASBrosnihanKBChappellMC1988Converting enzyme activity and angiotensin metabolism in the dog brainstemHypertension1115373277912
  • SantosRASFerreiraAJ2005Cardiovascular actions of Angiotensin-(1–7)Braz J Med Biol Res3849950715962175
  • SantosRASFerreiraAJ2007Angiotensin-(1–7) and the reninangiotensin systemCurr Opin Nephrol Hypertens16122817293687
  • SantosRASSimões e SilvaACMaricC2003Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor MasProc Natl Acad Sci USA10082586312829792
  • SantosSHFernandesLRMarioEG2008Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolismDiabetes57340718025412
  • SarzaniRMarcucciPSalviP2008Angiotensin II stimulates and atrial natriuretic peptide inhibits human visceral adipocyte growthInt J Obes3225967
  • SasakiKYamanoYBardhanS1991Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptorNature35123032041569
  • SavoiaCSchiffrinEL2007Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventionsClin Sci1123758417324119
  • SchiavoneMTSantosRASBrosnihanKB1988Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1–7) heptapeptideProc Natl Acad Sci USA85409583375255
  • SchmiederREHilgersKFSchlaichPM2007Renin-angiotensin system and cardiovascular riskLancet36912081917416265
  • SerniaC2001A critical appraisal of the intrinsic pancreatic angiotensin-generating systemJOP250511862023
  • ShahDM2005Role of the renin-angiotensin system in the pathogenesis of preeclampsiaAm J Physiol Renal Physiol288F6142515753325
  • Simões e SilvaACDinizJSPereiraRM2006bCirculating renin angiotensin system in childhood chronic renal failure: Marked increase of angiotensin-(1–7) in end-stage renal diseasePediatr Res607349
  • Simões e SilvaACDinizJSRegueira-FilhoA2004The renin angiotensin system in childhood hypertension: Selective increase of angiotensin-(1–7) in essential hypertensionJ Pediatr14593815238914
  • Simões e SilvaACPinheiroSVBPereiraRM2006aThe therapeutic potential of Angiotensin-(1–7) as a novel Renin Angiotensin System mediatorMini Rev Med Chem66039
  • Simões e SilvaAC2006cPathophysiology of arterial hypertension: Insights from pediatric studiesCurr Pediatr Rev220923
  • SinghRAlaviNSinghAK1999Role of angiotensin II in glucose-induced inhibition of mesangial matrix degradationDiabetes4820667310512375
  • SkeggsLTJrKahnJRShumwayNP1956The preparation and function of the hypertensin-converting enzymeJ Exp Med103295913295487
  • SlinkerBKWuYBrennanAJ1999Angiotensin IV has mixed effects on left ventricle systolic function and speeds relaxationCardiovasc Res42660910533606
  • SpätAHunyadyL2004Control of aldosterone secretion: a model for convergence in cellular signaling pathwaysPhysiol Rev8448953915044681
  • SpillertCRSunSMillerMA1994Hypertension-related coronary thrombosis: prothrombic role of angiotensin IIJ Natl Med Assoc8668687966432
  • StaessenJALiYRichartT2006Oral renin inhibitorsLancet36814495617055947
  • SuzukiSDoiYAoiW1984Effect of angiotensin III on blood pressure, renin-angiotensin-aldosterone system in normal and hypertensive subjectsJpn Heart J2575856376863
  • TallantEAFerrarioCMGallagherPE2005Angiotensin-(1–7) inhibits growth of cardiac myocytes through activation of the mas receptorAm J Physiol289H15606
  • TikellisCJohnstonCIForbesJM2003Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathyHypertension41392712623933
  • TipnisSRHooperNMHydeR2000A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidaseJ Biol Chem275332384310924499
  • TouyzRMSchiffrinEL2000Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cellsPharmacol Rev526397211121512
  • VellosoLAFolliFPeregoL2006The multi-faceted crosstalk between the insulin and angiotensin II signaling systemsDiabetes Metab Res Rev229810716389635
  • VickersCHalesPKaushikV2002Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidaseJ Biol Chem277148384311815627
  • VijayaraghavanKDeedwaniaPC2005The renin angiotensin system as a therapeutic target to prevent diabetes and its complicationsCardiol Clin231658315694745
  • VincentMAMontagnaniMQuonMJ2003Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulinAm J Physiol285E12330
  • WarnerFJLubelJSMcCaughanGW2007Liver fibrosis: a balance of ACEs?Clin Sci (Lond)11310818
  • WatanabeTBarkerTABerkBC2005Angiotensin II and the endothelium: Diverse signals and effectsHypertension45163915630047
  • WeberKT2001Aldosterone in congestive heart failureN Engl J Med34516899711759649
  • WeirMR2007Effects of renin-angiotensin system inhibition end-organ protection: can we do better?Clin Ther2918032418035185
  • WijpkemaJSvan HaelstPLMonraatsPS2006Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1Pharmacogenet Genomics16331716609364
  • WinkelmannBRRussAPNauckM1999Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular diseaseAm Heart J13769870510097233
  • WolfGZiyadehFN1997The role of angiotensin II in diabetic nephropathy: enphasis on non-hemodynamic mechanismsAm J Kidney Dis29153669002545
  • YangWHuangWSuS2007Association study of angiotensin I converting enzyme 2 gene polymorphisms with coronary heart disease and myocardial infarction in Chinese Han populationClin Sci (Lond)1113334016822235
  • Yki-JarvinenH2003Non-glycemic effects of insulinClin Cornerstone, Suppl4S612
  • YusufSGersteinHHoogwerfB2001Ramipril and the development of diabetesJAMA28618828511597291
  • ZamanMAOparilSCalhoumDA2002Drugs targeting the renin-angiotensin aldosterone systemNature162136
  • ZhongJYanZLiuD2006Association of angiotensin converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chi nese patients with metabolic syndromeJ Lab Clin Med14791516459167
  • ZismanLSKellerRSWeaverB2003Increased angiotensin-(1–7)-forming activity in failing human heart ventricles: evidence for up regulation of the angiotensin-converting enzyme homologue ACE2Circulation10817071214504186