Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers

References

• Abdel-WahabNWestonBSRobertsTConnective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophyJ Am Soc Nephrol20021324374512239232
   PubMed Web of Science ®Google Scholar
• AbreuJGKetpuraNIReversadeBConnective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-betaNat Cell Biol2002459960412134160
   PubMed Web of Science ®Google Scholar
• Abu El-AsrarAMVan den SteenPEAl-AmroSAExpression of angiogenic and fibrogenic factors in proliferative vitreoretinal disordersInt Ophthalmol200727112217375263
   PubMedGoogle Scholar
• AdlerSGKangSWFeldSGlomerular mRNAs in human type 1 diabetes: biochemical evidence for microalbuminuria as a manifestation of diabetic nephropathyKidney Int2001602330611737607
   PubMed Web of Science ®Google Scholar
• AlessiMCJuhan-VagueIContribution of PAI-1 in cardiovascular pathologyArch Mal Coeur Vaiss200497673815283042
   PubMedGoogle Scholar
• AllaFKearney-SchwartzARadauceanuAEarly changes in serum markers of cardiac extra-cellular matrix turnover in patients with uncomplicated hypertension and type II diabetesEur J Heart Fail200681475316198628
   PubMed Web of Science ®Google Scholar
• AndersenSvan NieuwenhovenFATarnowLReduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathyKidney Int2005672325915882275
   PubMed Web of Science ®Google Scholar
• AnguloPNonalcoholic fatty liver diseaseN Engl J Med200234612213111961152
   PubMed Web of Science ®Google Scholar
• ArkkilaPERonnemaaTKoskinenPJBiochemical markers of type III and I collagen: association with retinopathy and neuropathy in type 1 diabetic subjectsDiabet Med2001188162111678972
   PubMed Web of Science ®Google Scholar
• AzarSTSaltiIZantoutMSAlterations in plasma transforming growth factor beta in normoalbuminuric type 1 and type 2 diabetic patientsJ Clin Endocrinol Metab2000854680211134127
   PubMed Web of Science ®Google Scholar
• BabaTOsterbyRNeugebauer-BabaSNo nephropathy in Type 2 diabetic patient with POEMS syndrome with an elevated plasma VEGFDiabet Med200421292415008843
   PubMed Web of Science ®Google Scholar
• BaeldeHJEikmansMLappinDWReduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte lossKidney Int2007716374517264876
   PubMed Web of Science ®Google Scholar
• BatallerRSancho-BruPGinesPActivated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin IIGastroenterology20031251172512851877
   PubMed Web of Science ®Google Scholar
• BergTJSnorgaardOFaberJSerum levels of advanced glycation end products are associated with left ventricular diastolic function in patients with type 1 diabetesDiabetes Care19992211869010388987
   PubMed Web of Science ®Google Scholar
• BishopJELaurentGJCollagen turnover and its regulation in the normal and hypertrophying heartEur Heart J199516Suppl C38447556271
   PubMed Web of Science ®Google Scholar
• BlomIEvan DijkAJWietenLIn vitro evidence for differential involvement of CTGF, TGFbeta, and PDGF-BB in mesangial response to injuryNephrol Dial Transplant20011611394811390712
   PubMed Web of Science ®Google Scholar
• BorderWANobleNAInteractions of transforming growth factor-beta and angiotensin II in renal fibrosisHypertension19983118189453300
   PubMed Web of Science ®Google Scholar
• BrigstockDRRegulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61)Angiogenesis200251536512831056
   PubMedGoogle Scholar
• BrillaCGScheerCRuppHRenin-angiotensin system and myocardial collagen matrix: modulation of cardiac fibroblast function by angiotensin II type 1 receptor antagonismJ Hypertens Suppl199715S1399493122
   PubMedGoogle Scholar
• BrownleeMBiochemistry and molecular cell biology of diabetic complicationsNature20014148132011742414
   PubMed Web of Science ®Google Scholar
• BrownleeMSpiroRGBiochemistry of the basement membrane in diabetes mellitusAdv Exp Med Biol197912414156388998
   PubMedGoogle Scholar
• BrownleeMCeramiAVlassaraHAdvanced glycosylation end products in tissue and the biochemical basis of diabetic complicationsN Engl J Med19883181315213283558
   PubMed Web of Science ®Google Scholar
• BugianesiELeoneNVanniEExpanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinomaGastroenterology20021231344012105842
   PubMed Web of Science ®Google Scholar
• BursellSEClermontACOrenBThe in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic ratsInvest Ophthalmol Vis Sci1995365966077890491
   PubMed Web of Science ®Google Scholar
• CandidoRForbesJMThomasMCA breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changesCirc Res2003927859212623881
   PubMed Web of Science ®Google Scholar
• ChaDRKangYSHanSYRole of aldosterone in diabetic nephropathyNephrology (Carlton)200510SupplS37916174286
   PubMedGoogle Scholar
• ChakrabartiSGanXTMerryAAugmented retinal endothelin-1, endothelin-3, endothelin A and endothelin B gene expression in chronic diabetesCurr Eye Res19981730179543639
   PubMed Web of Science ®Google Scholar
• ChakravarthyUHayesRGStittAWEndothelin expression in ocular tissues of diabetic and insulin-treated ratsInvest Ophthalmol Vis Sci1997382144519331278
   PubMed Web of Science ®Google Scholar
• ChaqourBYangRShaQMechanical Stretch Modulates the Promoter Activity of the Profibrotic Factor CCN2 through Increased Actin Polymerization and NF-{kappa}B ActivationJ Biol Chem2006281206082216707502
   PubMed Web of Science ®Google Scholar
• CharltonMNonalcoholic fatty liver disease: a review of current understanding and future impactClin Gastroenterol Hepatol2004210485815625647
   PubMed Web of Science ®Google Scholar
• ChaturvediNFullerJHPokrasFCirculating plasma vascular endothelial growth factor and microvascular complications of type 1 diabetes mellitus: the influence of ACE inhibitionDiabet Med2001182889411437859
   PubMed Web of Science ®Google Scholar
• ChaturvediNSjolieAKStephensonJMEffect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes. The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes MellitusLancet199835128319433426
   PubMed Web of Science ®Google Scholar
• ChenSKhanZAKarmazynMRole of endothelin-1, sodium hydrogen exchanger-1 and mitogen activated protein kinase (MAPK) activation in glucose-induced cardiomyocyte hypertrophyDiabetes Metab Res Rev2007233566717024690
   PubMed Web of Science ®Google Scholar
• CichaIYilmazAKleinMConnective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitroArterioscler Thromb Vasc Biol20052510081315761189
   PubMed Web of Science ®Google Scholar
• CohenMPShearmanCWLautenslagerGTSerum type IV collagen in diabetic patients at risk for nephropathyDiabetes Care2001241324711473064
   PubMedGoogle Scholar
• CookerLAPetersonDRambowJTNF-{alpha}, but not IFN-{gamma}, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosisAm J Physiol Renal Physiol2007293F1576517376761
   PubMed Web of Science ®Google Scholar
• CreanJKFinlayDMurphyMThe role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cellsJ Biol Chem2002277441879412218048
   PubMed Web of Science ®Google Scholar
• D’ArmientoJMatrix metalloproteinase disruption of the extracellular matrix and cardiac dysfunctionTrends Cardiovasc Med2002129710112007733
   PubMed Web of Science ®Google Scholar
• DasAKDasJPChandrasekarSSpecific heart muscle disease in diabetes mellitus – a functional structural correlationInt J Cardiol1987172993023679609
   PubMed Web of Science ®Google Scholar
• de VrieseASTiltonRGElgerMAntibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetesJ Am Soc Nephrol200112993100011316858
   PubMed Web of Science ®Google Scholar
• DeathAKFisherEJMcGrathKCHigh glucose alters matrix metalloproteinase expression in two key vascular cells: potential impact on atherosclerosis in diabetesAtherosclerosis2003168263912801609
   PubMed Web of Science ®Google Scholar
• DegertekinBOzenirlerSElbegSThe Serum Endothelin-1 Level in Steatosis and NASH, and Its Relation with Severity of Liver FibrosisDig Dis Sci2007411
   Web of Science ®Google Scholar
• DerosaGCiceroAFScaliseFMetalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromesEndothelium200714455117364896
   PubMed Web of Science ®Google Scholar
• DerubertisFRCravenPAActivation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathyDiabetes199443188262306
   PubMed Web of Science ®Google Scholar
• DescampsFJMartensEKangaveDThe activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhageExp Eye Res200683401716643893
   PubMed Web of Science ®Google Scholar
• Di PaoloSGesualdoLRanieriEHigh glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cellsAm J Pathol199614920951068952542
   PubMed Web of Science ®Google Scholar
• DingYZouRJuddRLEndothelin-1 receptor blockade prevented the electrophysiological dysfunction in cardiac myocytes of streptozotocin-induced diabetic ratsEndocrine200630121717185800
   PubMed Web of Science ®Google Scholar
• DresowBDelbruckAThe isolation and activity of growth-stimulating factors from human plateletsJ Clin Chem Clin Biochem198422527336238121
   PubMedGoogle Scholar
• DuncanMRFrazierKSAbramsonSConnective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMPFaseb J19991317748610506580
   PubMed Web of Science ®Google Scholar
• EbiharaINakamuraTShimadaNIncreased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in noninsulin-dependent diabetes mellitusAm J Kidney Dis199832544509774113
   PubMed Web of Science ®Google Scholar
• EdwardsIJWagnerJDVogl-WillisCAArterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeysCardiovasc Diabetol20043615117408
   PubMed Web of Science ®Google Scholar
• EfratiSBermanSGoldfingerNEnhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertensionJ Hypertens20072510415217414669
   PubMed Web of Science ®Google Scholar
• EllisDForrestKYErbeyJUrinary measurement of transforming growth factor-beta and type IV collagen as new markers of renal injury: application in diabetic nephropathyClin Chem19984495069590367
   PubMed Web of Science ®Google Scholar
• EngeliSGorzelniakKKreutzRCo-expression of renin-angiotensin system genes in human adipose tissueJ Hypertens1999175556010404958
   PubMed Web of Science ®Google Scholar
• FactorSMOkunEMMinaseTCapillary microaneurysms in the human diabetic heartN Engl J Med198030238487351930
   PubMed Web of Science ®Google Scholar
• FarquharAMacDonaldMKIrelandJTThe role of fibrin deposition in diabetic glomerulosclerosis: a light, electron and immunofluorescence microscopy studyJ Clin Pathol197225657674561948
   PubMed Web of Science ®Google Scholar
• FinckenbergPInkinenKAhonenJAngiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathwaysAm J Pathol20031633556612819040
   PubMed Web of Science ®Google Scholar
• FiorettoPMauerMHistopathology of diabetic nephropathySemin Nephrol20072719520717418688
   PubMed Web of Science ®Google Scholar
• FisherEJMcLennanSVYueDKHigh glucose reduces generation of plasmin activity by mesangial cellsMicrovasc Res19975317389143550
   PubMed Web of Science ®Google Scholar
• FitzsimmonsPJForoughRLawrenceMEUrinary levels of matrix metalloproteinase 9 and 2 and tissue inhibitor of matrix metalloproteinase in patients with coronary artery diseaseAtherosclerosis2006828
   PubMedGoogle Scholar
• FleischmajerRPerlishJSTimplRCollagen fibrillogenesis in human skinAnn N Y Acad Sci1985460246573914229
   PubMed Web of Science ®Google Scholar
• FloresLNafSHernaezRTransforming growth factor beta at clinical onset of Type 1 diabetes mellitus. A pilot studyDiabet Med2004218182215270783
   PubMed Web of Science ®Google Scholar
• ForbesJMCooperMEThallasVReduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathyDiabetes20025132748212401719
   PubMed Web of Science ®Google Scholar
• FrazierKWilliamsSKothapalliDStimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factorJ Invest Dermatol1996107404118751978
   PubMed Web of Science ®Google Scholar
• FukudaGKhanZABarbinYPEndothelin-mediated remodeling in aortas of diabetic ratsDiabetes Metab Res Rev2005213677515580650
   PubMed Web of Science ®Google Scholar
• FukuiMNakamuraTEbiharaIECM gene expression and its modulation by insulin in diabetic ratsDiabetes199241152071280237
   PubMed Web of Science ®Google Scholar
• GeigerMBinderBRPlasminogen activation in diabetes mellitus. Kinetics of plasmin formation with tissue plasminogen activator and plasminogen from individual diabetic donors and with in vitro glucosylated plasminogenEnzyme198840149572971532
   PubMedGoogle Scholar
• GendaAMizunoSNunodaSClinical studies on diabetic myocardial disease using exercise testing with myocardial scintigraphy and endomyocardial biopsyClin Cardiol19869375823731563
   PubMed Web of Science ®Google Scholar
• GeorgeJTsutsumiMsiRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in ratsGene Ther20071479080317344905
   PubMed Web of Science ®Google Scholar
• GilbertREAkdenizAWeitzSUrinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathyDiabetes Care2003262632612941731
   PubMed Web of Science ®Google Scholar
• GilbertRECoxAWuLLExpression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibitionDiabetes199847414229519748
   PubMed Web of Science ®Google Scholar
• GlickADJacobsonHRHaralsonMAMesangial deposition of type I collagen in human glomerulosclerosisHum Pathol199223137391468774
   PubMed Web of Science ®Google Scholar
• GoldinABeckmanJASchmidtAMAdvanced glycation end products: sparking the development of diabetic vascular injuryCirculation200611459760516894049
   PubMed Web of Science ®Google Scholar
• GomezDEAlonsoDFYoshijiHTissue inhibitors of metalloproteinases: structure, regulation and biological functionsEur J Cell Biol199774111229352216
   PubMed Web of Science ®Google Scholar
• Gomez-GarreDRuiz-OrtegaMOrtegoMEffects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growthHypertension199627885928613264
   PubMed Web of Science ®Google Scholar
• Gonzalez-VilchezFAyuelaJAresMOxidative stress and fibrosis in incipient myocardial dysfunction in type 2 diabetic patientsInt J Cardiol200510153815860383
   PubMed Web of Science ®Google Scholar
• Gore-HyerEShegogueDMarkiewiczMTGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cellsAm J Physiol Renal Physiol2002283F7071612217862
   PubMed Web of Science ®Google Scholar
• GreeneDALattimerSASimaAASorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complicationsN Engl J Med19873165996063027558
   PubMed Web of Science ®Google Scholar
• GressnerOALahmeBDemirciIDifferential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytesJ Hepatol2007626
   Web of Science ®Google Scholar
• GrotendorstGROkochiHHayashiNA novel transforming growth factor beta response element controls the expression of the connective tissue growth factor geneCell Growth Differ19967469809052988
   PubMedGoogle Scholar
• GuhaMXuZGTungDSpecific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetesFASEB J20072133556817554073
   PubMed Web of Science ®Google Scholar
• HaffnerSMGreenbergASWestonWMEffect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitusCirculation20021066798412163427
   PubMed Web of Science ®Google Scholar
• HagiwaraHKaizuKUriuKExpression of type-1 plasminogen activator inhibitor in the kidney of diabetic rat modelsThromb Res2003111301914693179
   PubMed Web of Science ®Google Scholar
• HanSYJeeYHHanKHAn imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathyNephrol Dial Transplant20062124061616728425
   PubMed Web of Science ®Google Scholar
• HanefeldMMarxNPfutznerAAnti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: the PIOSTAT StudyJ Am Coll Cardiol200749290717239709
   PubMed Web of Science ®Google Scholar
• HannekenAde JuanEJrLuttyGAAltered distribution of basic fibroblast growth factor in diabetic retinopathyArch Ophthalmol19911091005112064554
   PubMedGoogle Scholar
• HargroveGMDufresneJWhitesideCDiabetes mellitus increases endothelin-1 gene transcription in rat kidneyKidney Int20005815344511012888
   PubMed Web of Science ®Google Scholar
• HashimotoGInokiIFujiiYMatrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165J Biol Chem2002277362889512114504
   PubMed Web of Science ®Google Scholar
• HaydenMRSowersJRTyagiSCThe central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloadedCardiovasc Diabetol20054915985157
   PubMed Web of Science ®Google Scholar
• Heart Outcomes Prevention Evaluation Study InvestigatorsEffects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudyLancet2000355253910675071
   PubMed Web of Science ®Google Scholar
• HintonDRSpeeCHeSAccumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathyDiabetes Care2004277586414988298
   PubMed Web of Science ®Google Scholar
• HishikawaKOemarBSTannerFCOverexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cellsCirculation199910021081210562268
   PubMed Web of Science ®Google Scholar
• HocherBSchwarzAReinbacherDEffects of endothelin receptor antagonists on the progression of diabetic nephropathyNephron200187161911244312
   PubMed Web of Science ®Google Scholar
• HoekstraTGeleijnseJMSchoutenEGPlasminogen activator inhibitor-type 1: its plasma determinants and relation with cardiovascular riskThromb Haemost2004918617215116245
   PubMed Web of Science ®Google Scholar
• HorstrupJHGehrmannMSchneiderBElevation of serum and urine levels of TIMP-1 and tenascin in patients with renal diseaseNephrol Dial Transplant20021710051312032189
   PubMed Web of Science ®Google Scholar
• HosodaYOkadaMMatsumuraMEpiretinal membrane of proliferative diabetic retinopathy: an immunohistochemical studyOphthalmic Res199325289948259261
   PubMed Web of Science ®Google Scholar
• HoulihanCAAkdenizATsalamandrisCUrinary transforming growth factor-beta excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate: effects of angiotensin receptor blockade and sodium restrictionDiabetes Care2002251072712032117
   PubMed Web of Science ®Google Scholar
• HuaHGoldbergHJFantusIGHigh glucose-enhanced mesangial cell extracellular signal-regulated protein kinase activation and alpha1(IV) collagen expression in response to endothelin-1: role of specific protein kinase C isozymesDiabetes20015023768311574422
   PubMed Web of Science ®Google Scholar
• HueberAWiedemannPEsserPBasic fibroblast growth factor mRNA, bFGF peptide and FGF receptor in epiretinal membranes of intraocular proliferative disorders (PVR and PDR)Int Ophthalmol199620345509237137
   PubMed Web of Science ®Google Scholar
• HughesJMKuiperEJKlaassenIAdvanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retinaDiabetologia20075010899817333105
   PubMed Web of Science ®Google Scholar
• HughesAKStricklettPKPadillaEEffect of reactive oxygen species on endothelin-1 production by human mesangial cellsKidney Int19964918198770966
   PubMed Web of Science ®Google Scholar
• HuntJVSmithCCWolffSPAutoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucoseDiabetes199039142042227114
   PubMed Web of Science ®Google Scholar
• HyogoHYamagishiSIwamotoKElevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitisJ Gastroenterol Hepatol2007221112917559366
   PubMed Web of Science ®Google Scholar
• IgarashiAOkochiHBradhamDMRegulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repairMol Biol Cell19934637458374172
   PubMed Web of Science ®Google Scholar
• IkedaSMakinoHHaramotoTChanges in glomerular extracellular matrices components in diabetic nephropathyJ Diabet Complications1991518681770041
   PubMedGoogle Scholar
• InukaiTFujiwaraYTayamaKSerum levels of carboxy-terminal propeptide of human type I procollagen are an indicator for the progression of diabetic nephropathy in patients with type 2 diabetes mellitusDiabetes Res Clin Pract20004823810704696
   PubMed Web of Science ®Google Scholar
• IoachimEStefaniotouMGorezisSImmunohistochemical study of extracellular matrix components in epiretinal membranes of vitreoproliferative retinopathy and proliferative diabetic retinopathyEur J Ophthalmol2005153849115945009
   PubMed Web of Science ®Google Scholar
• IshimuraENishizawaYShojiSSerum type III, IV collagens and TIMP in patients with type II diabetes mellitusLife Sci199658133178614290
   PubMed Web of Science ®Google Scholar
• JacqueminetSBen AbdesselamOChapmanMJElevated circulating levels of matrix metalloproteinase-9 in type 1 diabetic patients with and without retinopathyClin Chim Acta2006367103716426593
   PubMed Web of Science ®Google Scholar
• JensenLTHorslev-PetersenKToftPSerum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarctionCirculation1990815272297848
   PubMed Web of Science ®Google Scholar
• JerdanJAGlaserBMRetinal microvessel extracellular matrix: an immunofluorescent studyInvest Ophthalmol Vis Sci1986271942033510998
   PubMed Web of Science ®Google Scholar
• KagamiSBorderWAMillerDEAngiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cellsJ Clin Invest199493243178200978
   PubMed Web of Science ®Google Scholar
• KakizawaHItohMItohYThe relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patientsMetabolism200453550515131756
   PubMed Web of Science ®Google Scholar
• KanauchiMNishiokaHNakashimaYRole of tissue inhibitors of metalloproteinase in diabetic nephropathyNippon Jinzo Gakkai Shi19963812488721333
   PubMedGoogle Scholar
• KanedaHHashimotoEYatsujiSHyaluronic acid levels can predict severe fibrosis and platelet counts can predict cirrhosis in patients with nonalcoholic fatty liver diseaseJ Gastroenterol Hepatol20062114596516911693
   PubMed Web of Science ®Google Scholar
• KatavetinPEiam-OngSSuwanwalaikornSPioglitazone reduces urinary protein and urinary transforming growth factor-beta excretion in patients with type 2 diabetes and overt nephropathyJ Med Assoc Thai200689170716579002
   PubMedGoogle Scholar
• KawasakiDKosugiKWakiHRole of activated renin-angiotensin system in myocardial fibrosis and left ventricular diastolic dysfunction in diabetic patients – reversal by chronic angiotensin II type 1A receptor blockadeCirc J200771524917384453
   PubMed Web of Science ®Google Scholar
• KhanZAChakrabartiSEndothelins in chronic diabetic complicationsCan J Physiol Pharmacol2003816223412839273
   PubMed Web of Science ®Google Scholar
• KimNHKimKBKimDLPlasma and urinary vascular endothelial growth factor and diabetic nephropathy in Type 2 diabetes mellitusDiabet Med2004215455115154937
   PubMed Web of Science ®Google Scholar
• KimYKleppelMMButkowskiRDifferential expression of basement membrane collagen chains in diabetic nephropathyAm J Pathol1991138413201992766
   PubMed Web of Science ®Google Scholar
• KiryuKMoritaHFujitaYPhenotypic expressions of type I, III, IV, V, and VI collagens in patients with diabetic nephropathy: immunohistochemical comparison between HD and non-HD patientsNippon Jinzo Gakkai Shi199436365738022109
   PubMedGoogle Scholar
• KobayashiTInoueTOkadaHConnective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucoseClin Exp Nephrol200591142115980944
   PubMedGoogle Scholar
• KohnoMHorioTIkedaMAngiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cellsKidney Int19924286061333547
   PubMed Web of Science ®Google Scholar
• KohnoMIkedaMJohchiMInteraction of PDGF and natriuretic peptides on mesangial cell proliferation and endothelin secretionAm J Physiol1993265E67398238492
   PubMedGoogle Scholar
• KoitabashiNAraiMKogureSIncreased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosisHypertension2007491120717372041
   PubMed Web of Science ®Google Scholar
• KolmVSauerUOlgemoollerBHigh glucose-induced TGF-beta 1 regulates mesangial production of heparan sulfate proteoglycanAm J Physiol1996270F812218928843
   PubMedGoogle Scholar
• KotajimaNKandaTYuukiNType IV collagen serum and vitreous fluid levels in patients with diabetic retinopathyJ Int Med Res200129292611675902
   PubMed Web of Science ®Google Scholar
• KotajimaNKimuraTKandaTType IV collagen as an early marker for diabetic nephropathy in non-insulin-dependent diabetes mellitusJ Diabetes Complications20001413710925061
   PubMed Web of Science ®Google Scholar
• KuiperEJWitmerANKlaassenIDifferential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retinaBr J Ophthalmol2004881082715258030
   PubMed Web of Science ®Google Scholar
• LamSvan der GeestRNVerhagenNASecretion of collagen type IV by human renal fibroblasts is increased by high glucose via a TGF-beta-independent pathwayNephrol Dial Transplant200419169470115150349
   PubMed Web of Science ®Google Scholar
• LamSvan der GeestRNVerhagenNAConnective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucoseDiabetes20035229758314633859
   PubMed Web of Science ®Google Scholar
• LaviadesCVaroNFernandezJAbnormalities of the extracellular degradation of collagen type I in essential hypertensionCirculation199898535409714110
   PubMed Web of Science ®Google Scholar
• LeeHBHaHPlasminogen activator inhibitor-1 and diabetic nephropathyNephrology (Carlton)200510SupplS11316174279
   PubMedGoogle Scholar
• LeeSWSongKEShinDSAlterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetesDiabetes Res Clin Pract200569175916005367
   PubMed Web of Science ®Google Scholar
• LeeTSSaltsmanKAOhashiHActivation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complicationsProc Natl Acad Sci, USA198986514152740348
   PubMed Web of Science ®Google Scholar
• LembachKJInduction of human fibroblast proliferation by epidermal growth factor (EGF): enhancement by an EGF-binding arginine esterase and by ascorbateProc Natl Acad Sci, USA19767318371061114
   PubMed Web of Science ®Google Scholar
• LiMChenYZhangZInhibition of mesangial cell proliferation by antisense oligodeoxynucleotide targeting preproendothelin-1 mRNA in vitroChin Med J (Engl)1999112790311717946
   PubMed Web of Science ®Google Scholar
• LiYYFeldmanAMSunYDifferential expression of tissue inhibitors of metalloproteinases in the failing human heartCirculation1998981728349788826
   PubMed Web of Science ®Google Scholar
• LindsayMMMaxwellPDunnFGTIMP-1: a marker of left ventricular diastolic dysfunction and fibrosis in hypertensionHypertension2002401364112154103
   PubMed Web of Science ®Google Scholar
• LipPLBelgoreFBlannADPlasma VEGF and soluble VEGF receptor FLT-1 in proliferative retinopathy: relationship to endothelial dysfunction and laser treatmentInvest Ophthalmol Vis Sci2000412115910892852
   PubMed Web of Science ®Google Scholar
• LipPLChatterjeeSCaineGJPlasma vascular endothelial growth factor, angiopoietin-2, and soluble angiopoietin receptor tie-2 in diabetic retinopathy: effects of laser photocoagulation and angiotensin receptor blockadeBr J Ophthalmol2004881543615548809
   PubMed Web of Science ®Google Scholar
• Li-Saw-HeeFLEdmundsEBlannADMatrix metalloproteinase-9 and tissue inhibitor metalloproteinase-1 levels in essential hypertension. Relationship to left ventricular mass and anti-hypertensive therapyInt J Cardiol20007543711054505
   PubMed Web of Science ®Google Scholar
• LiuXLuoFPanKHigh glucose upregulates connective tissue growth factor expression in human vascular smooth muscle cellsBMC Cell Biol20078117224075
   PubMedGoogle Scholar
• LiuYWangZYinWSevere insulin resistance and moderate glomerulosclerosis in a minipig model induced by high-fat/ high-sucrose/ high-cholesterol dietExp Anim200756112017283886
   PubMed Web of Science ®Google Scholar
• LjubimovAVBurgesonREButkowskiRJBasement membrane abnormalities in human eyes with diabetic retinopathyJ Histochem Cytochem1996441469798985139
   PubMed Web of Science ®Google Scholar
• LorenziMGerhardingerCEarly cellular and molecular changes induced by diabetes in the retinaDiabetologia20014479180411508263
   PubMed Web of Science ®Google Scholar
• LuCHLuJXHuaGPEffects of antisense RNA of connective tissue growth factor expressing plasmid on rat liver fibrosisZhonghua Gan Zang Bing Za Zhi2007151182117362637
   PubMedGoogle Scholar
• MakinoHKashiharaNSugiyamaHPhenotypic changes of the mesangium in diabetic nephropathyJ Diabetes Complications1995928248573747
   PubMed Web of Science ®Google Scholar
• MakinoHShikataKWieslanderJLocalization of fibril/microfibril and basement membrane collagens in diabetic glomerulosclerosis in type 2 diabetesDiabet Med199411304118033531
   PubMed Web of Science ®Google Scholar
• MakinoHYamasakiYHaramotoTUltrastructural changes of extracellular matrices in diabetic nephropathy revealed by high resolution scanning and immunoelectron microscopyLab Invest19936845558423676
   PubMed Web of Science ®Google Scholar
• MarxNFroehlichJSiamLAntidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery diseaseArterioscler Thromb Vasc Biol200323283812588772
   PubMed Web of Science ®Google Scholar
• MasonRMWahabNAExtracellular matrix metabolism in diabetic nephropathyJ Am Soc Nephrol20031413587312707406
   PubMed Web of Science ®Google Scholar
• MathewsMKMergesCMcLeodDSVascular endothelial growth factor and vascular permeability changes in human diabetic retinopathyInvest Ophthalmol Vis Sci1997382729419418725
   PubMed Web of Science ®Google Scholar
• MatosJPde Lourdes RodriguesMIsmerimVLEffects of dual blockade of the renin angiotensin system in hypertensive type 2 diabetic patients with nephropathyClin Nephrol200564180916175942
   PubMed Web of Science ®Google Scholar
• MaxwellPRTimmsPMChandranSPeripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with type 1 diabetesDiabet Med2001187778011678966
   PubMed Web of Science ®Google Scholar
• McClainDAPatersonAJRoosMDGlucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cellsProc Natl Acad Sci, USA199289815041518840
   PubMed Web of Science ®Google Scholar
• McLennanSVFisherEMartellSYEffects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: possible role in diabetic nephropathyKidney Int Suppl200077S81710997695
   PubMedGoogle Scholar
• McLennanSVWangXYMorenoVConnective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathyEndocrinology200414556465515345671
   PubMed Web of Science ®Google Scholar
• McLennanSVYueDKTurtleJREffect of glucose on matrix metalloproteinase activity in mesangial cellsNephron19987929389678429
   PubMed Web of Science ®Google Scholar
• MigdalisINKalogeropoulouKZachariadisDSerum levels of type III procollagen peptide and peripheral vascular disease in diabetic patientsDiabetes Res Clin Pract199423179827924878
   PubMed Web of Science ®Google Scholar
• MorganKWhartonJWebbJCCo-expression of renin-angiotensin system component genes in human atrial tissueJ Hypertens Suppl199412S1197965269
   PubMedGoogle Scholar
• MoriyaTGroppoliTJKimYQuantitative immunoelectron microscopy of type VI collagen in glomeruli in type I diabetic patientsKidney Int2001593172311135085
   PubMed Web of Science ®Google Scholar
• MurphyMGodsonCCannonSSuppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cellsJ Biol Chem19992745830410026205
   PubMed Web of Science ®Google Scholar
• NaftilanAJPrattREDzauVJInduction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cellsJ Clin Invest1989831419242649516
   PubMed Web of Science ®Google Scholar
• NahmanNSJrLeonhartKLCosioFGEffects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cellsKidney Int1992413964021552712
   PubMed Web of Science ®Google Scholar
• NakamuraTFukuiMEbiharaIAbnormal gene expression of matrix metalloproteinases and their inhibitor in glomeruli from diabetic ratsRen Physiol Biochem199417316257533311
   PubMedGoogle Scholar
• NakamuraTMatsudaTSuzukiYEffects of low-density lipoprotein apheresis on plasma matrix metalloproteinase-9 and serum tissue inhibitor of metalloproteinase-1 levels in diabetic hemodialysis patients with arteriosclerosis obliteransAsaio J200349430412918586
   PubMed Web of Science ®Google Scholar
• NakamuraTUshiyamaCSuzukiSUrinary excretion of podocytes in patients with diabetic nephropathyNephrol Dial Transplant20001513798310978394
   PubMed Web of Science ®Google Scholar
• NakashimaYFujiiHSumiyoshiSEarly human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltrationArterioscler Thromb Vasc Biol20072711596517303781
   PubMed Web of Science ®Google Scholar
• NerlichASchleicherEImmunohistochemical localization of extracellular matrix components in human diabetic glomerular lesionsAm J Pathol1991139889991928305
   PubMed Web of Science ®Google Scholar
• NguyenTQTarnowLAndersenSUrinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathyDiabetes Care20062983816373901
   PubMed Web of Science ®Google Scholar
• NieuwdorpMHollemanFde GrootEPerturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosisDiabetologia20075012889317415544
   PubMed Web of Science ®Google Scholar
• NojiYKajinamiKKawashiriMACirculating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosisClin Chem Lab Med200139380411434385
   PubMed Web of Science ®Google Scholar
• NunodaSGendaASugiharaNQuantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitusHeart Vessels198514374093355
   PubMedGoogle Scholar
• OberhammerFAPavelkaMSharmaSInduction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1Proc Natl Acad Sci, USA1992895408121608949
   PubMed Web of Science ®Google Scholar
• OkazakiRMatsuokaKHoriuchiAAssays of serum laminin and type III procollagen peptide for monitoring the clinical course of diabetic microangiopathyDiabetes Res Clin Pract19885163703219988
   PubMed Web of Science ®Google Scholar
• OlgemollerBSchleicherEAlterations of glomerular matrix proteins in the pathogenesis of diabetic nephropathyClin Investig199371S139
   PubMedGoogle Scholar
• OtaniATakagiHOhHAngiotensin II-stimulated vascular endothelial growth factor expression in bovine retinal pericytesInvest Ophthalmol Vis Sci2000411192910752960
   PubMed Web of Science ®Google Scholar
• PandolfiACetrulloDPolishuckRPlasminogen activator inhibitor type 1 is increased in the arterial wall of type II diabetic subjectsArterioscler Thromb Vasc Biol20012113788211498469
   PubMed Web of Science ®Google Scholar
• ParadisVPerlemuterGBonvoustFHigh glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitisHepatology2001347384411584370
   PubMed Web of Science ®Google Scholar
• ParkISKiyomotoHAbboudSLExpression of transforming growth factor-beta and type IV collagen in early streptozotocin-induced diabetesDiabetes199746473809032105
   PubMed Web of Science ®Google Scholar
• ParkJYTakaharaNGabrieleAInduction of endothelin-1 expression by glucose: an effect of protein kinase C activationDiabetes20004912394810909984
   PubMed Web of Science ®Google Scholar
• PaueksakonPReveloMPMaLJMicroangiopathic injury and augmented PAI-1 in human diabetic nephropathyKidney Int2002612142812028454
   PubMed Web of Science ®Google Scholar
• PaulMWagnerJDzauVJGene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reactionJ Clin Invest1993912058648387539
   PubMed Web of Science ®Google Scholar
• PfeifferAMiddelberg-BispingKDrewesCElevated plasma levels of transforming growth factor-beta 1 in NIDDMDiabetes Care199619111378886558
   PubMed Web of Science ®Google Scholar
• PragaMAndradeCFLunoJAntiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: a double-blind, randomized clinical trialNephrol Dial Transplant20031818061312937228
   PubMed Web of Science ®Google Scholar
• QiWTwiggSChenXIntegrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosisAm J Physiol Renal Physiol2005288F800915536170
   PubMed Web of Science ®Google Scholar
• QuerejetaRLopezBGonzalezAIncreased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosisCirculation20041101263815313958
   PubMed Web of Science ®Google Scholar
• QuerejetaRVaroNLopezBSerum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart diseaseCirculation200010117293510758057
   PubMed Web of Science ®Google Scholar
• RachfalAWBrigstockDRConnective tissue growth factor (CTGF/CCN2) in hepatic fibrosisHepatol Res2003261912787797
   PubMed Web of Science ®Google Scholar
• RatziuVBonyhayLDi MartinoVSurvival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosisHepatology20023514859312029634
   PubMed Web of Science ®Google Scholar
• RatziuVGiralPCharlotteFLiver fibrosis in overweight patientsGastroenterology200011811172310833486
   PubMed Web of Science ®Google Scholar
• RazzaqueMSKojiTHaradaTIdentification of type VI collagen synthesizing cells in human diabetic glomerulosclerosis using renal biopsy sectionsAnal Cell Pathol199715175819497854
   PubMed Web of Science ®Google Scholar
• RazzaqueMSKojiTTaguchiTIn situ localization of type III and type IV collagen-expressing cells in human diabetic nephropathyJ Pathol199417413187965408
   PubMed Web of Science ®Google Scholar
• ReganTJLyonsMMAhmedSSEvidence for cardiomyopathy in familial diabetes mellitusJ Clin Invest19776088499893679
   PubMed Web of Science ®Google Scholar
• RiserBLCortesPDeNichiloMUrinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary reportKidney Int200364451812846740
   PubMed Web of Science ®Google Scholar
• RiserBLCortesPYeeJMechanical strain- and high glucose-induced alterations in mesangial cell collagen metabolism: role of TGF-betaJ Am Soc Nephrol19989827369596080
   PubMed Web of Science ®Google Scholar
• RiserBLDenichiloMCortesPRegulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosisJ Am Soc Nephrol200011253810616837
   PubMed Web of Science ®Google Scholar
• RisteliJRisteliLAnalysing connective tissue metabolites in human serum. Biochemical, physiological and methodological aspectsJ Hepatol19952277817665854
   PubMed Web of Science ®Google Scholar
• RobertsABSpornMBAssoianRKTransforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroProc Natl Acad Sci, USA1986834167712424019
   PubMed Web of Science ®Google Scholar
• RoestenbergPvan NieuwenhovenFAJolesJATemporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in miceAm J Physiol Renal Physiol2006290F13445416380465
   PubMed Web of Science ®Google Scholar
• RoestenbergPvan NieuwenhovenFAWietenLConnective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathyDiabetes Care20042711647015111539
   PubMed Web of Science ®Google Scholar
• RothSMichelKGressnerAM(Latent) transforming growth factor beta in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cellsHepatology1998271003129537440
   PubMed Web of Science ®Google Scholar
• RoySMaielloMLorenziMIncreased expression of basement membrane collagen in human diabetic retinopathyJ Clin Invest199493438428282817
   PubMed Web of Science ®Google Scholar
• RoySSalaRCaglieroEOverexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memoryProc Natl Acad Sci, USA19908740482296596
   PubMed Web of Science ®Google Scholar
• RoySSatoTParyaniGDownregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed ratsDiabetes20035212293412716757
   PubMed Web of Science ®Google Scholar
• Ruiz-OrtegaMBustosCHernandez-PresaMAAngiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesisJ Immunol199816143099647253
   PubMed Web of Science ®Google Scholar
• Ruiz-OrtegaMGomez-GarreDAlcazarRInvolvement of angiotensin II and endothelin in matrix protein production and renal sclerosisJ Hypertens Suppl199412S5187965275
   PubMedGoogle Scholar
• Ruiz-OrtegaMGonzalezSSeronDACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritisKidney Int1995481778918587237
   PubMed Web of Science ®Google Scholar
• Ruiz-RuizFJRuiz-LaiglesiaFJSamperiz-LegarrePPropeptide of procollagen type I (PIP) and outcomes in decompensated heart failureEur J Intern Med2007181293417338965
   PubMed Web of Science ®Google Scholar
• RuperezMLorenzoOBlanco-ColioLMConnective tissue growth factor is a mediator of angiotensin II-induced fibrosisCirculation2003a108149950512952842
   PubMed Web of Science ®Google Scholar
• RuperezMRuiz-OrtegaMEstebanVAngiotensin II increases connective tissue growth factor in the kidneyAm J Pathol2003b16319374714578193
   PubMed Web of Science ®Google Scholar
• RutschowSLiJSchultheissHPMyocardial proteases and matrix remodeling in inflammatory heart diseaseCardiovasc Res2006696465616417902
   PubMed Web of Science ®Google Scholar
• SakugawaHNakayoshiTKobashigawaKClinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver diseaseWorld J Gastroenterol200511255915633226
   PubMed Web of Science ®Google Scholar
• SanyalAJAGA technical review on nonalcoholic fatty liver diseaseGastroenterology200212317052512404245
   PubMedGoogle Scholar
• SatoAHayashiKNaruseMEffectiveness of aldosterone blockade in patients with diabetic nephropathyHypertension20034164812511531
   PubMed Web of Science ®Google Scholar
• SchaeferLRaslikIGroneHJSmall proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulinFaseb J2001155596111259366
   PubMed Web of Science ®Google Scholar
• ScheinmanJIFishAJMichaelAFThe immunohistopathology of glomerular antigens. The glomerular basement membrane, collagen, and actomyosin antigens in normal and diseased kidneysJ Clin Invest1974541144544138529
   PubMed Web of Science ®Google Scholar
• SchjoedtKJRossingKJuhlTRBeneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathyKidney Int2006705364216775595
   PubMed Web of Science ®Google Scholar
• SchneebergerSAHjelmelandLMTuckerRPVascular endothelial growth factor and fibroblast growth factor 5 are colocalized in vascular and avascular epiretinal membranesAm J Ophthalmol1997124447549323936
   PubMed Web of Science ®Google Scholar
• SchwartzkopffBFassbachMPelzerBElevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathyEur J Heart Fail20024439412167381
   PubMed Web of Science ®Google Scholar
• ShanklandSJLyHThaiKGlomerular expression of tissue inhibitor of metalloproteinase (TIMP-1) in normal and diabetic ratsJ Am Soc Nephrol19967971048808115
   PubMed Web of Science ®Google Scholar
• SharmaKEltayebBOMcGowanTACaptopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patientsAm J Kidney Dis1999348182310561136
   PubMed Web of Science ®Google Scholar
• SharmaKJinYGuoJNeutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic miceDiabetes199645522308603776
   PubMed Web of Science ®Google Scholar
• SharmaKZiyadehFNHyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediatorDiabetes1995441139467556948
   PubMed Web of Science ®Google Scholar
• SharmaKZiyadehFNAlzahabiBIncreased renal production of transforming growth factor-beta1 in patients with type II diabetesDiabetes19974685499133555
   PubMed Web of Science ®Google Scholar
• SheetzMJKingGLMolecular understanding of hyperglycemia’s adverse effects for diabetic complicationsJama200228825798812444865
   PubMed Web of Science ®Google Scholar
• ShimizuMUmedaKSugiharaNCollagen remodelling in myocardia of patients with diabetesJ Clin Pathol1993463267679418
   PubMed Web of Science ®Google Scholar
• ShirkRAParthasarathyNSan AntonioJDAltered dermatan sulfate structure and reduced heparin cofactor II-stimulating activity of biglycan and decorin from human atherosclerotic plaqueJ Biol Chem2000275180859210749870
   PubMed Web of Science ®Google Scholar
• SinghRAlaviNSinghAKRole of angiotensin II in glucose-induced inhibition of mesangial matrix degradationDiabetes19994820667310512375
   PubMed Web of Science ®Google Scholar
• SipersteinMDUngerRHMadisonLLStudies of muscle capillary basement membranes in normal subjects diabetic, and prediabetic patientsJ Clin Invest1968471973995675423
   PubMed Web of Science ®Google Scholar
• SongJHChaSHLeeHJEffect of low-dose dual blockade of renin-angiotensin system on urinary TGF-beta in type 2 diabetic patients with advanced kidney diseaseNephrol Dial Transplant200621683916330466
   PubMed Web of Science ®Google Scholar
• SongWErgulAType-2 diabetes-induced changes in vascular extracellular matrix gene expression: relation to vessel sizeCardiovasc Diabetol20065316503991
   PubMed Web of Science ®Google Scholar
• SpirinKSSaghizadehMLewinSLBasement membrane and growth factor gene expression in normal and diabetic human retinasCurr Eye Res199918490910435836
   PubMed Web of Science ®Google Scholar
• StokesMBHollerSCuiYExpression of decorin, biglycan, and collagen type I in human renal fibrosing diseaseKidney Int2000574879810652025
   PubMed Web of Science ®Google Scholar
• SugimotoKTsuruokaSFujimuraARenal protective effect of YM598, a selective endothelin ET(A) receptor antagonist, against diabetic nephropathy in OLETF ratsEur J Pharmacol2002450183912206857
   PubMed Web of Science ®Google Scholar
• SugimotoREnjojiMKohjimaMHigh glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinaseLiver Int20052510182616162162
   PubMed Web of Science ®Google Scholar
• SundstromJEvansJCBenjaminEJRelations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart studyEur Heart J20042515091615342170
   PubMed Web of Science ®Google Scholar
• SungSHZiyadehFNWangABlockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in miceJ Am Soc Nephrol200617309310416988063
   PubMed Web of Science ®Google Scholar
• SvennevigKKolsetSOBangstadHJIncreased syndecan-1 in serum is related to early nephropathy in type 1 diabetes mellitus patientsDiabetologia2006492214616832664
   PubMed Web of Science ®Google Scholar
• TakagiCBursellSELinYWRegulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1Invest Ophthalmol Vis Sci1996372504188933767
   PubMed Web of Science ®Google Scholar
• TakahashiMIncreased urinary fibronectin excretion in type II diabetic patients with microalbuminuriaNippon Jinzo Gakkai Shi199537336427666599
   PubMedGoogle Scholar
• TashiroHShimokawaHSadamatuKPrognostic significance of plasma concentrations of transforming growth factor-beta in patients with coronary artery diseaseCoron Artery Dis2002131394312131016
   PubMed Web of Science ®Google Scholar
• TashiroHShimokawaHYamamotoKAltered plasma levels of cytokines in patients with ischemic heart diseaseCoron Artery Dis1997814379237023
   PubMed Web of Science ®Google Scholar
• TashiroKKoyanagiIOharaILevels of urinary matrix metalloproteinase-9 (MMP-9) and renal injuries in patients with type 2 diabetic nephropathyJ Clin Lab Anal2004182061015103687
   PubMed Web of Science ®Google Scholar
• TayebjeeMHLimHSMacFadyenRJMatrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 in type 2 diabetes: effect of 1 year’s cardiovascular risk reduction therapyDiabetes Care20042720495115277439
   PubMed Web of Science ®Google Scholar
• TayebjeeMHLimHSNadarSTissue inhibitor of metalloproteinse-1 is a marker of diastolic dysfunction using tissue doppler in patients with type 2 diabetes and hypertensionEur J Clin Invest2005a3581215638813
   PubMed Web of Science ®Google Scholar
• TayebjeeMHLipGYTanKTPlasma matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-2, and CD40 ligand levels in patients with stable coronary artery diseaseAm J Cardiol2005b963394516054454
   PubMed Web of Science ®Google Scholar
• The Diabetes Control and Complications Trial Research GroupThe effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitusN Engl J Med1993329977868366922
   PubMed Web of Science ®Google Scholar
• The EUCLID Study GroupRandomised placebo-controlled trial of lisinopril in normotensive patients with insulin-dependent diabetes and normoalbuminuria or microalbuminuriaLancet19973491787929269212
   PubMed Web of Science ®Google Scholar
• ThomsonSMcLennanSVKirwanPRenal connective tissue growth factor (CTGF) correlates with glomerular basement membrane thickness and prospective microalbuminuria in a non-human primate model of diabetes: Possible predictive marker for diabetic nephropathyJ Diab Complic2007in press
   Google Scholar
• ThrailkillKMBunnRCMoreauCSMMP-2 dysregulation in Type 1 Diabetes MellitusDiabetes Care2007302321617563344
   PubMed Web of Science ®Google Scholar
• TikellisCCooperMETwiggSMConnective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibitionEndocrinology2004145860614592956
   PubMed Web of Science ®Google Scholar
• TimmsPMWrightAMaxwellPPlasma tissue inhibitor of metalloproteinase-1 levels are elevated in essential hypertension and related to left ventricular hypertrophyAm J Hypertens2002152697211939619
   PubMed Web of Science ®Google Scholar
• TranPKAgardhHETran-LundmarkKReduced perlecan expression and accumulation in human carotid atherosclerotic lesionsAtherosclerosis20071902647016620836
   PubMed Web of Science ®Google Scholar
• TsengSCSavionNSternRFibroblast growth factor modulates synthesis of collagen in cultured vascular endothelial cellsEur J Biochem1982122355606460622
   PubMedGoogle Scholar
• TsilibaryECMicrovascular basement membranes in diabetes mellitusJ Pathol20032005374612845621
   PubMed Web of Science ®Google Scholar
• TsutsuiHMatsushimaSKinugawaSAngiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heartHypertens Res2007304394917587756
   PubMed Web of Science ®Google Scholar
• TwiggSMCooperMEThe time has come to target connective tissue growth factor in diabetic complicationsDiabetologia200447965815168021
   PubMed Web of Science ®Google Scholar
• TwiggSMCaoZSVMCRenal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidineEndocrinology2002b14349071512446618
   PubMed Web of Science ®Google Scholar
• TwiggSMChenMMJolyAHAdvanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitusEndocrinology20011421760911316739
   PubMed Web of Science ®Google Scholar
• TwiggSMJolyAHChenMMConnective tissue growth factor/IGF-binding protein-related protein-2 is a mediator in the induction of fibronectin by advanced glycosylation end-products in human dermal fibroblastsEndocrinology2002a1431260911897682
   PubMed Web of Science ®Google Scholar
• TyagiSCKumarSGBanksJCo-expression of tissue inhibitor and matrix metalloproteinase in myocardiumJ Mol Cell Cardiol1995272177898576934
   PubMed Web of Science ®Google Scholar
• UK Prospective Diabetes Study (UKPDS) GroupIntensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)Lancet1998352837539742976
   PubMed Web of Science ®Google Scholar
• UmezonoTToyodaMKatoMGlomerular expression of CTGF, TGF-beta 1 and type IV collagen in diabetic nephropathyJ Nephrol200619751717173248
   PubMed Web of Science ®Google Scholar
• van den MeirackerAHBaggenRGPauliSSpironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal functionJ Hypertens20062422859217053552
   PubMed Web of Science ®Google Scholar
• van HoevenKHFactorSMA comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart diseaseCirculation199082848552394006
   PubMed Web of Science ®Google Scholar
• VaughanDEPAI-1 and atherothrombosisJ Thromb Haemost2005318798316102055
   PubMed Web of Science ®Google Scholar
• VranesDCooperMEDilleyRJCellular mechanisms of diabetic vascular hypertrophyMicrovasc Res1999578189882558
   PubMed Web of Science ®Google Scholar
• WagnerJJan DanserAHDerkxFHDemonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin systemBr J Ophthalmol199680159638814748
   PubMed Web of Science ®Google Scholar
• WahabNAHarperKMasonRMExpression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemiaBiochem J1996316Pt 3985928670179
   PubMedGoogle Scholar
• WahabNASchaeferLWestonBSGlomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuliDiabetologia20054826506016270194
   PubMed Web of Science ®Google Scholar
• WahabNAYevdokimovaNWestonBSRole of connective tissue growth factor in the pathogenesis of diabetic nephropathyBiochem J2001359778711563971
   PubMed Web of Science ®Google Scholar
• WatanabeHSanadaHShigetomiSUrinary excretion of type IV collagen as a specific indicator of the progression of diabetic nephropathyNephron200086273510971150
   PubMed Web of Science ®Google Scholar
• WatanabeTNegishiKKatayamaSSerum or urinary concentration of type IV collagen in diabeticsJ Diabet Complications1991519121770043
   PubMedGoogle Scholar
• WeberKTExtracellular matrix remodeling in heart failure: a role for de novo angiotensin II generationCirculation1997964065829403633
   PubMed Web of Science ®Google Scholar
• WellsJAMurthyRChibberRLevels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisationBr J Ophthalmol19968036368703891
   PubMed Web of Science ®Google Scholar
• WestermannDRutschowSJagerSContributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonismDiabetes200756641617327431
   PubMed Web of Science ®Google Scholar
• WestonBSWahabNAMasonRMCTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cellsJ Am Soc Nephrol2003146011012595495
   PubMed Web of Science ®Google Scholar
• WilliamsonJRChangKFrangosMHyperglycemic pseudohypoxia and diabetic complicationsDiabetes199342801138495803
   PubMed Web of Science ®Google Scholar
• WolkartGStesselHSaadZCardioprotective effects of atrasentan, an endothelin-A receptor antagonist, but not of nitric oxide in diabetic mice with myocyte-specific overexpression of endothelial nitric oxide synthaseBr J Pharmacol20061486718116702986
   PubMed Web of Science ®Google Scholar
• WooVNiLSHakDEffects of losartan on urinary secretion of extracellular matrix and their modulators in type 2 diabetes mellitus patients with microalbuminuriaClin Invest Med2006293657217330452
   PubMed Web of Science ®Google Scholar
• WuLLCoxARoeCJTransforming growth factor beta 1 and renal injury following subtotal nephrectomy in the rat: role of the renin-angiotensin systemKidney Int1997511553679150473
   PubMed Web of Science ®Google Scholar
• XuXWuZZhouQThe role of determining the levels of serum collagen type IV in diagnosing early diabetic nephropathyRen Fail2002247475312472197
   PubMed Web of Science ®Google Scholar
• YagameMKimYZhuDDifferential distribution of type IV collagen chains in patients with diabetic nephropathy in non-insulin-dependent diabetes mellitusNephron1995704287617116
   PubMed Web of Science ®Google Scholar
• YamamotoTNakamuraTNobleNAExpression of transforming growth factor beta is elevated in human and experimental diabetic nephropathyProc Natl Acad Sci, USA199390181487680480
   PubMed Web of Science ®Google Scholar
• YangCPatelKHardingPRegulation of TGF-beta1/MAPK-mediated PAI-1 gene expression by the actin cytoskeleton in human mesangial cellsExp Cell Res200731312405017328891
   PubMed Web of Science ®Google Scholar
• YanoYUraHGabazzaECCirculating levels of 7 S domain of type IV collagen and atrial natriuretic peptide in normotensive type 2 diabetic patients with or without retinopathyHorm Metab Res19983010379543694
   PubMed Web of Science ®Google Scholar
• YanoYUraHSumidaYSerum 7S domain of type IV collagen levels in essential hypertension and hypertensive type 2 diabetic patientsDiabet Med199714466719212312
   PubMed Web of Science ®Google Scholar
• YokotaTMaRCParkJYRole of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytesDiabetes2003528384512606528
   PubMed Web of Science ®Google Scholar
• YonedaMMawatariHFujitaKType IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stageJ Gastroenterol2007423758117530362
   PubMed Web of Science ®Google Scholar
• ZannadFAllaFDoussetBLimitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales InvestigatorsCirculation20001022700611094035
   PubMed Web of Science ®Google Scholar
• ZaouiPCantinJFAlimardani-BessetteMRole of metalloproteases and inhibitors in the occurrence and progression of diabetic renal lesionsDiabetes Metab200026Suppl 425910922970
   PubMedGoogle Scholar
• ZhangBBCaiWMWengHLDiagnostic value of platelet derived growth factor-BB, transforming growth factor-beta1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosisWorld J Gastroenterol200392490614606082
   PubMed Web of Science ®Google Scholar
• ZhouGLiCCaiLAdvanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathwayAm J Pathol200416520334315579446
   PubMed Web of Science ®Google Scholar
• ZhuDKimYSteffesMWGlomerular distribution of type IV collagen in diabetes by high resolution quantitative immunochemistryKidney Int199445425338164429
   PubMed Web of Science ®Google Scholar
• ZimmetPGlobalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted?J Intern Med20002473011010762445
   PubMed Web of Science ®Google Scholar
• ZiyadehFNHanDCCohenJAGlycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: involvement of the transforming growth factor-beta systemKidney Int19985363189507208
   PubMed Web of Science ®Google Scholar
• ZiyadehFNHoffmanBBHanDCLong-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic miceProc Natl Acad Sci, USA20009780152010859350
   PubMed Web of Science ®Google Scholar
• ZiyadehFNSharmaKEricksenMStimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-betaJ Clin Invest199493536428113392
   PubMed Web of Science ®Google Scholar
• ZojaCOrisioSPericoNConstitutive expression of endothelin gene in cultured human mesangial cells and its modulation by transforming growth factor-beta, thrombin, and a thromboxane A2 analogueLab Invest19916416201703585
   PubMed Web of Science ®Google Scholar