Plant Sterols as Dietary Adjuvants in the Reduction of Cardiovascular Risk: Theory and Evidence

References

• AndersonASCoxDNMcKellarSTake Five, a nutrition education intervention to increase fruit and vegetable intakes: impact on attitudes towards dietary changeBrit J Nutr199880133409828754
   PubMed Web of Science ®Google Scholar
• AnonymousRandomised trial of cholesterol-lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)Lancet1994344138397968073
   PubMed Web of Science ®Google Scholar
• [AIHW] Australian Institute of Health and WelfareNational Cardiovascular Disease Database2004Canberra 2005
   Google Scholar
• AyeshRWestrateJADrewittPNSafety evaluation of phytosterol esters. Part 5. Faecal short-chain fatty acid and microflora content, faecal bacteria enzyme activity and serum female sex hormones in healthy normolipidaemic volunteers consuming a controlled diet either with or without a phytosterol ester-enriched margarineFood Chem Toxocol199937112738
   PubMed Web of Science ®Google Scholar
• BakerVAHepburnPAKennedySJSafety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assaysFood Chem Toxocol1999371322
   PubMed Web of Science ®Google Scholar
• BujaLMDoes atherosclerosis have an infectious etiology?Circulation19969487238790018
   PubMed Web of Science ®Google Scholar
• CliftonPMNoakesMRossDHigh dietary intake of phytosterol esters decreases carotenoids and increases plasma plant sterol levels with no additional cholesterol-loweringJ Lipid Res2004451493915145979
   PubMed Web of Science ®Google Scholar
• CliftonPMNoakesMSullivanDCholesterol-lowering effects of plant sterol esters differ in milk, yoghurt, bread and cerealEur J Clin Nutr200458503914985690
   PubMed Web of Science ®Google Scholar
• GyllingHMiettinenTACholesterol reduction by different plant stanol mixtures ans with variable fat intakeMetabolism1999485758010337856
   PubMed Web of Science ®Google Scholar
• GyllingHRadhakrishanRMiettinenTAReduction of serum cholesterol in post menopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarineCirculation1997984226319416886
   PubMedGoogle Scholar
• HallikainenMSarkkinenESUusitupaMIEffects of low-fat stanol ester enriched margarines on concentrarions of serum carotenoids in subjects with elevated serum cholesterol concentrationsEur J Clin Nutr199953966910602355
   PubMed Web of Science ®Google Scholar
• HallikainenMASarkkinenESGyllingHComparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low fat dietEur J Clin Nutr2000547152511002384
   PubMed Web of Science ®Google Scholar
• HardingAAn insurance break for margarine2004New York, NY, USAMSNBC
   Google Scholar
• HaskellWLCardiovascular disease prevention and lifestyle interventions: effectiveness and efficacyJ Cardiovasc Nurs2003182455514518600
   PubMedGoogle Scholar
• HendriksHWestrateJAvan VlietTSpreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol-lowering in normocholesterolaemic and mildly hypercholesterolaemic subjectsEur J Clin Nutr1999533192710334658
   PubMed Web of Science ®Google Scholar
• HepburnPAHornerSASmithMSafety evaluation of phytosterol esters. Part 2. Sunchronic 90-day oral toxicity study on phytosterol esters – a novel functional foodFood Chem Toxocol19993752132
   PubMed Web of Science ®Google Scholar
• [IAS] International Atherosclerosis SocietyHarmonized clinical guidelines on the prevention of atherosclerotic vascular disease2003Hamburg, GermanyInternational Atherosclerosis Society128
   Google Scholar
• JandacekRJWebbMRMattsonFHEffect of an aqueous phase on the solubility of cholesterol in an oil phaseJ Lipid Res19771820310845502
   PubMed Web of Science ®Google Scholar
• JenkinsDJKendallCWMarchieADirect comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participantsAm J Clin Nutr200581380715699225
   PubMed Web of Science ®Google Scholar
• JenkinsDJAKendallCWCMarchieAEffects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and c-reactive proteinJAMA2003290502912876093
   PubMed Web of Science ®Google Scholar
• JonesPHDavidsonMHSteinEAComparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR Trial)Am J Cardiol2003921526012860216
   PubMed Web of Science ®Google Scholar
• JonesPJRaeini-SarjazMNtaniosFmodulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol estersJ Lipid Res20004169770510787430
   PubMed Web of Science ®Google Scholar
• KatanMBGrundySMJonesPEfficacy and safety of plant stanols and sterols in the management of blood cholesterol levelsMayo Clin Proc2003789657812911045
   PubMed Web of Science ®Google Scholar
• KeysAAndersonJTGrandeFPrediction of serum cholesterol responses of man to changes in fat in the dietLancet1957ii9596613482259
   PubMedGoogle Scholar
• KochharSInfluence of processing on sterols of edible vegetable oilsProg Lipid Res198322161886356149
   PubMed Web of Science ®Google Scholar
• KuhlmannKLindtnerOBauchASimulation of prospective phytosterol intake in Germany by novel functional foodsBrit J Nutr2005933778515877878
   PubMed Web of Science ®Google Scholar
• KwiterovichPJThe effect of dietary fat, antioxidants, and pro-oxidants on blood lipids, lipoproteins, and atherosclerosisJ Am Diet Assoc199797S31419216565
   PubMedGoogle Scholar
• MensinkRPEbbingSLindhoutMEffects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrationsAtherosclerosis20021602051311755939
   PubMed Web of Science ®Google Scholar
• MiettinenTARailoMLepantaloMPlant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarterectomyJ Am Coll Cardiol200545179480115936608
   PubMed Web of Science ®Google Scholar
• MiettinenTAStrandbergTEGyllingHNoncholesterol sterols and cholesterol-lowering by long-term simvastatin treatment in coronary patients: Relation to basal serum cholesterolArterioscler Thromb Vasc Biol2000201340610807752
   PubMed Web of Science ®Google Scholar
• [NCEP] Expert panel on detection evaluation and treatment of high blood cholesterol in adultsExecutive summary of the third report of the National Cholesterol Education Program (NCEP) (Adult Treatment Panel III)JAMA200128524869711368702
   PubMed Web of Science ®Google Scholar
• NeilVAMeijerGWRoeLRandomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spreadAtherosclerosis20011563293711395029
   PubMed Web of Science ®Google Scholar
• [NHF] National Heart FoundationLipid management guidelines – 2001Med J Aust2001175S136
   Web of Science ®Google Scholar
• NoakesMCliftonPNtaniosFAn increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrationsAm J Clin Nutr200275798611756063
   PubMed Web of Science ®Google Scholar
• NorménLHolmesDFrohlichJPlant sterols and their role in combined use with statins for lipid loweringCurr Opin Investig Drugs2005630716
   PubMedGoogle Scholar
• PatchCSTapsellLCWilliamsPGPlant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practiceJ Am Diet Assoc2005105465315635344
   PubMed Web of Science ®Google Scholar
• PoveyRWellensBConnerMAttitudes towards meat, vegetarian and vegan diets: an examination of the role of ambivalenceAppetite200137152611562154
   PubMed Web of Science ®Google Scholar
• RamsayLEYeoWWJacksonPRDietary reduction of serum cholesterol concentration: time to think againBMJ199130395371954418
   PubMedGoogle Scholar
• RaulioSNurtillaAMannonenLAdding phytosterols and -stanols to food – modelling the amount received by Finnish adultsPub Nat Food Agency200110322
   Google Scholar
• RossRThe pathogenesis of atherosclerosisN Eng J Med198631448894
   PubMed Web of Science ®Google Scholar
• SacksFMPfefferMAMoyeLAThe effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levelsN Eng J Med199633510019
   PubMed Web of Science ®Google Scholar
• SchaeferEJLipoproteins, nutrition, and heart diseaseAm J Clin Nutr20027519121211815309
   PubMed Web of Science ®Google Scholar
• [SCF] Scientific Committee on FoodGeneral view of the scientific committee on food on the long-term effects of the intake of elevated levels of phytosterols from multiple dietary sources, with particular attention to the effects of β-carotene2002Brussels, BelgiumCommission E
   Google Scholar
• SimojokiMLuotoRUutelaAConsistency of use of plant stanol ester margarine in FinlandPub Health Nutr2004763814972073
   PubMed Web of Science ®Google Scholar
• SimojokiMLuotoRUutelaAUse of plant stanol ester margarine among persons with and without cardiovascular disease: Early phases of the adoption of a functional food in FinlandNutr J2005414752891
   Web of Science ®Google Scholar
• SimonsLAAdditive effect of plant sterol-ester margarine and cerivastatin in lowering low-density lipoprotein cholesterol in primary hypercholesterolemiaAm J Cardiol2002907374012356387
   PubMed Web of Science ®Google Scholar
• SteinbergDParthasarathySCarewTEBeyond cholesterol – modifications of low-density lipoprotein that increase its atherogenicityN Eng J Med198932091520
   PubMed Web of Science ®Google Scholar
• TangJLArmitageJMLancasterTSystematic review of dietary intervention trials to lower blood total cholesterol in free living subjectsBMJ19983161213209552999
   PubMed Web of Science ®Google Scholar
• ThompsonGRO'NeillFSeedMWhy some patients respond poorly to statins and how this might be remediedEur Heart J200223200611792134
   PubMed Web of Science ®Google Scholar
• ThomsenABHansenHBChristiansenCEffect of free plant sterols in low-fat milk on serum lipid profile in hypercholesterolemic subjectsEur J Clin Nutr2004588607015164106
   PubMed Web of Science ®Google Scholar
• UlbrichtTLVSouthgateDATCoronary heart disease: seven dietary factorsLancet199133898581681350
   PubMed Web of Science ®Google Scholar
• VanhanenHCholesterol malabsorption caused by sitosterol ester feeding and meomycin in pravastatin-treated hypercholesterolaemic patientsEur J Pharmacol19944716976
   Web of Science ®Google Scholar
• VolpeRNiittynenLKorpelaREffects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemiaBrit J Nutr200186233911502237
   PubMed Web of Science ®Google Scholar
• von BaeyerHHopfenmullerWRiedelEAtherosclerosis: current concepts of pathophysiology and pharmacological intervention based on trial outcomesClin Nephrol200360S314812940532
   PubMed Web of Science ®Google Scholar
• Waalkens-BerendsenDHWolterbeekAPWijnandsMVSafety evaluation of phytosterol esters. Part 3. Two-generation reproduction study in rats with phytosterol esters - a novel functional foodFood Chem Toxocol19993768396
   PubMed Web of Science ®Google Scholar
• WestrateJAAyeshRBauer-PlankCSafety evaluation of phytosterol esters. Part 4. Faecal concentrations of bile acids and neutral sterols in healthy normolipidaemic volunteers consuming a controlled diet either with or without a phytosterol ester-enriched margarineFood Chem Toxocol199937106371
   PubMed Web of Science ®Google Scholar
• WilundKRYuLXuFNo association between plasma levels of plant sterols and atherosclerosis in mice and menArterioscler Thromb Vasc Biol20042423263215514206
   PubMed Web of Science ®Google Scholar
• [WHO] World Health OrganizationGlobal strategy on diet, physical activity and health [online]2005 Accessed 1 November 2005 URL: http://www.who.int/dietphysicalactivity/publications/facts/cvd/en
   Google Scholar
• ZemanFJClinical nutrition and dietetics1991New York, USAMacmillan
   Google Scholar