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Opinion

Implications of the obesity epidemic for lipid-lowering therapy: Non-HDL cholesterol should replace LDL cholesterol as the primary therapeutic target

Pages 143-156 | Published online: 28 Dec 2022

References

  • AbateNVegaGLGrundySMVariability in cholesterol content and physical properties of lipoproteins containing apolipoprotein B-100Atherosclerosis1993104159718141840
  • AlexanderCMLandsmanPBTeutschSMNCEP-Defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 Years and olderDiabetes20035212101412716754
  • AthyrosVGPapageorgiouAASymeonidisANNon-high density lipoprotein cholesterol and coronary events during long-term statin treatmentAtherosclerosis2003168397812801625
  • [ATPIII] Adult Treatment Panel IIIThird Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final reportCirculation2002106314342112485966
  • BallantyneCMAndrewsTCHsiaJACorrelation of non-high-density lipoprotein cholesterol with apolipoprotein B: effect of 5 hydroxymethylglutaryl coenzyme A reductase inhibitors on non-high-density lipoprotein cholesterol levelsAm J Cardiol200188265911472705
  • BarrELMZimmetPZWelbornTARisk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance. The Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)Circulation2007116151717576864
  • BarrettPHWattsGFKinetic studies of lipoprotein metabolism in the metabolic syndrome including effects of nutritional interventionsCurr Opin Lipidol20031461812544663
  • BarterPJBallantyneCMCarmenaRApo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panelJ Intern Med20062592475816476102
  • BennionLJGrundySMEffects of diabetes mellitus on cholesterol metabolism in manN Engl J Med1977296136571870827
  • BittnerVNon-high-density lipoprotein cholesterol: an alternate target for lipid-lowering therapyPrev Cardiol20047122615249764
  • BittnerVHardisonRKelseySFNon-high-density lipoprotein cholesterol levels predict five-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI)Circulation200210625374212427648
  • BonoraEThe metabolic syndrome and cardiovascular diseaseAnn Med200638648016448990
  • BonoraETargherGAlbericheMHomeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivityDiabetes Care200023576310857969
  • BosGDekkerJMNijpelsGA combination of high concentrations of serum triglyceride and non-high-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism--The Hoorn StudyDiabetologia2003469101612819906
  • BrionesERSteigerDLPalumboPJSterol excretion and cholesterol absorption in diabetics and nondiabetics with and without hyperlipidemiaAm J Clin Nutr198644353613751956
  • BrownellKDStunkardAJDifferential changes in plasma high-density lipoprotein-cholesterol levels in obese men and women during weight reductionArch Intern Med1981141114267259372
  • BrunoGMerlettiFBiggeriAEffect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato studyDiabetologia2006499374416525840
  • BurkeJPWilliamsKGaskillSPRapid rise in the incidence of type 2 diabetes from 1987 to 1996: results from the San Antonio Heart StudyArch Intern Med19991591450610399896
  • ButlerJRodondiNZhuYMetabolic syndrome and the risk of cardiovascular disease in older adultsJ Am Coll Cardiol200647159560216630996
  • CarrDBUtzschneiderKMHullRLIntra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndromeDiabetes20045320879415277390
  • CaseCCJacobsonTARobertsSManagement of persons with high risk of coronary heart disease but low serum low-density lipoprotein cholesterolAm J Cardiol2003911134612714165
  • ChanDCWattsGFBarrettPHRPlasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndromeObesity Res2003115916
  • ChienK-LHsuH-CSuT-CApolipoprotein B and non-high-density lipoprotein cholesterol and risk of coronary heart disease in ChineseJ Lipid Res200748249950517698856
  • CowieCCRustKFByrd-HoltDDPrevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health and Nutrition Examination Survey 1999-2002Diabetes Care2006291263816732006
  • CuiYBlumenthalRSFlawsJANon-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortalityArch Intern Med200116114131911386890
  • DavidsonMHMakiKCPearsonTAResults of the National Cholesterol Education (NCEP) Program Evaluation ProjecT Utilizing Novel E-Technology (NEPTUNE) II survey and implications for treatment under the recent NCEP Writing Group recommendationsAm J Cardiol2005965566316098311
  • DenkeMASemposCTGrundySMExcess body weight. An underrecognized contributor to high blood cholesterol levels in white American menArch Intern Med199315310931038481076
  • DenkeMASemposCTGrundySMExcess body weight. An under-recognized contributor to dyslipidemia in white American womenArch Intern Med1994154401108117172
  • El HarchaouiKvan der SteegWAStroesESValue of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC–Norfolk Prospective Population StudyJ Am Coll Cardiol2007495475317276177
  • FlegalKMCarrollMDOgdenCLPrevalence and trends in obesity among US adults 1999-2000JAMA20022881723712365955
  • FollickMJAbramsDBSmithTWContrasting short- and long-term effects of weight loss on lipoprotein levelsArch Intern Med1984144157146466014
  • FordESGilesWHMokdadAHIncreasing prevalence of the metabolic syndrome among U.S. adultsDiabetes Care2004272444915451914
  • FordESMokdadAHGilesWHTrends in waist circumference among U.S. adultsObesity Res200311122331
  • FosterCJWeinsierRLBirchRObesity and serum lipids: an evaluation of the relative contribution of body fat and fat distribution to lipid levelsInt J Obes198711151613610468
  • FoxCSCoadySSorliePDIncreasing cardiovascular disease burden due to diabetes mellitus: The Framingham Heart StudyCirculation200711515445017353438
  • FoxCSMassaroJMHoffmannUAbdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart StudyCirculation2007116394817576866
  • FoxCSPencinaMJMeigsJBTrends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: The Framingham Heart StudyCirculation200611329141816785337
  • FriedlandONemetDGorodnitskyNObesity and lipid profiles in children and adolescentsJ Pediatr Endocrinol Metab20021510111612199328
  • FrostPHDavisBRBurlandoAJSerum Lipids and incidence of coronary heart disease: Findings from the Systolic Hypertension in the Elderly Program (SHEP)Circulation199694238188921777
  • GardnerCDWinklebyMAFortmannSPPopulation frequency distribution of non-high-density lipoprotein cholesterol (Third National Health and Nutrition Examination Survey [NHANES III], 1988-1994)Am J Cardiol20008629930410922437
  • GenestJFrohlichJFodorGRecommendations for the management of dyslipidemia and the prevention of cardiovascular disease: summary of the 2003 updateCMAJ2003169921414581310
  • GordonDJProbstfieldJLGarrisonRJHigh-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studiesCirculation1989798152642759
  • GrundySMA constellation of complications: The metabolic syndromeClin Cornerstone20057364516473259
  • GrundySMMetabolic syndrome: connecting and reconciling cardiovascular and diabetes worldsJ Am Coll Cardiol200647109310016545636
  • GrundySMCleemanJIDanielsSRDiagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific StatementCirculation200511227355216157765
  • GrundySMCleemanJIMerzCNImplications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelinesCirculation20041102273915249516
  • GyllingHMiettinenTACholesterol absorption, synthesis, and LDL metabolism in NIDDMDiabetes Care1997209059028702
  • HaffnerSMLehtoSRonnemaaTMortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarctionN Engl J Med1998339229349673301
  • HoenigMRKostnerKMReadSJImplications of the obesity epidemic for statin therapy: shifting cholesterol metabolism to a high synthesis and low dietary absorption stateEndocr Metab Immune Disord Drug Targets200771536617897042
  • HowardBVBestLGGallowayJMCoronary heart disease risk equivalence in diabetes depends on concomitant risk factorsDiabetes Care200629391716443893
  • HowardBVRobbinsDCSieversMLLDL cholesterol as a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: The Strong Heart StudyArterioscler Thromb Vasc Biol200020830510712410
  • HsiaSHNon-HDL Cholesterol: Into the SpotlightDiabetes Care200326240212502688
  • HultheJBokemarkLWikstrandJThe metabolic syndrome, LDL particle size, and atherosclerosis: The Atherosclerosis and Insulin Resistance (AIR) StudyArterioscler Thromb Vasc Biol2000202140710978261
  • IngelssonESchaeferEJContoisJHClinical utility of different lipid measures for prediction of coronary heart disease in men and womenJAMA20072987768517699011
  • JacobsDRJrBurkeGLLiuKRelationships of low density lipoprotein cholesterol with age and other factors: a cross-sectional analysis of the CARDIA studyAnn Clin Res1988203283261566
  • JiangRSchulzeMBLiTNon-HDL cholesterol and apolipoprotein B predict cardiovascular disease events among men with type 2 diabetesDiabetes Care2004271991715277429
  • KathiresanSOtvosJDSullivanLMIncreased small low-density lipoprotein particle number: A prominent feature of the metabolic syndrome in the Framingham Heart StudyCirculation200611320916380547
  • KempenHGlatzJGevers LeuvenJSerum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humansJ Lipid Res1988291149553183524
  • KeysAKarvonenMJPunsarSHDL serum cholesterol and 24-year mortality of men in FinlandInt J Epidemiol198413428356519880
  • LakkaH-MLaaksonenDELakkaTAThe metabolic syndrome and total and cardiovascular disease mortality in middle-aged menJAMA200228827091612460094
  • Lamon-FavaSWilsonPWFSchaeferEJImpact of body mass index on coronary heart disease risk factors in men and women: The Framingham Offspring StudyArterioscler Thromb Vasc Biol1996161509158977456
  • LehtoSRonnemaaTHaffnerSMDyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDMDiabetes199746135499231662
  • LiberopoulosENMikhailidisDPElisafMSDiagnosis and management of the metabolic syndrome in obesityObes Rev200562839616246214
  • LiuJSemposCDonahueRPJoint distribution of non-HDL and LDL cholesterol and coronary heart disease risk prediction among individuals with and without diabetesDiabetes Care20052819162116043732
  • LiuJSemposCTDonahueRPNon-high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart diseaseAm J Cardiol2006981363817134630
  • [LRC] Lipid Research ClinicsPlasma lipid distributions in selected North American populations: the Lipid Research Clinics Program Prevalence Study. The Lipid Research Clinics Program Epidemiology CommitteeCirculation19796042739312704
  • [LRC] Lipid Research ClinicsThe Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart diseaseJAMA1984a25135164
  • [LRC] Lipid Research ClinicsThe Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol loweringJAMA1984b25136574
  • LuWResnickHEJablonskiKANon-HDL cholesterol as a predictor of cardiovascular disease in type 2 diabetes: The Strong Heart StudyDiabetes Care200326162312502653
  • MackWJKraussRMHodisHNLipoprotein subclasses in the monitored Atherosclerosis Regression Study (MARS): Treatment effects and relation to coronary angiographic progressionArterioscler Thromb Vasc Biol1996166977048963728
  • MalikSWongNDFranklinSSImpact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adultsCirculation200411012455015326067
  • McNamaraDJKolbRParkerTSHeterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantityJ Clin Invest1987791729393584466
  • MeilahnENKullerLHSteinEACharacteristics associated with apoprotein and lipoprotein lipid levels in middle-aged womenArteriosclerosis19888515203142451
  • MenottiASpagnoloAScangaMMultivariate prediction of coronary deaths in a 10 year follow-up of an Italian occupational male cohortActa Cardiol199247311201523912
  • MiettinenTACholesterol production in obesityCirculation197144842505115077
  • NathanDMClearyPABacklundJYIntensive diabetes treatment and cardiovascular disease in patients with type 1 diabetesN Engl J Med200535326435316371630
  • NestelPJWhyteHMGoodmanDSDistribution and turnover of cholesterol in humansJ Clin Invest196948982915771198
  • NievesDJCnopMRetzlaffBThe atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fatDiabetes200352172912502509
  • NigamABourassaMGFortierAThe metabolic syndrome and its components and the long-term risk of death in patients with coronary heart diseaseAm Heart J20061515142116442923
  • OgdenCLCarrollMDCurtinLRPrevalence of overweight and obesity in the United States, 1999-2004JAMA200629515495516595758
  • PedersenTROlssonAGFærgemanOLipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S)Circulation1998971453609576425
  • PhillipsNWatersDHavelRPlasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical eventsCirculation1993882762708252689
  • PischonTGirmanCJSacksFMNon-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in menCirculation200511233758316316964
  • PladevallMSingalBWilliamsLKA single factor underlies the metabolic syndrome: A confirmatory factor analysisDiabetes Care2006291132216373906
  • PocockSJShaperAGPhillipsANHigh density lipoprotein cholesterol is not a major risk factor for ischaemic heart disease in British menBr Med J (Clin Res Ed)198629251519
  • RallidisLSPitsavosCPanagiotakosDBNon-high density lipoprotein cholesterol is the best discriminator of myocardial infarction in young individualsAtherosclerosis2005179305915777546
  • ReedDBenfanteRLipid and lipoprotein predictors of coronary heart disease in elderly men in the Honolulu Heart ProgramAnn Epidemiol1992229341342261
  • RidkerPMRifaiNCookNRNon-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in womenJAMA20052943263316030277
  • RobinsonJGSmithBMaheshwariNPleiotropic effects of statins: benefit beyond cholesterol reduction? A meta-regression analysisJ Am Coll Cardiol20054618556216286171
  • RossouwJELewisBRifkindBMThe value of lowering cholesterol after myocardial infarctionN Engl J Med19903231112192215579
  • SacksFMAlaupovicPMoyeLAVLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) TrialCirculation200010218869211034934
  • SattarNWilliamsKSnidermanADComparison of the associations of apolipoprotein B and non-high-density lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the Insulin Resistance Atherosclerosis StudyCirculation200411026879315492304
  • SchaeferEJLamon-FavaSJohnsonSEffects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring StudyArterioscler Thromb1994141105138018666
  • SchulzeMBShaiIMansonJEJoint role of non-HDL cholesterol and glycated haemoglobin in predicting future coronary heart disease events among women with type 2 diabetesDiabetologia20044721293615662553
  • ShepherdJDoes statin monotherapy address the multiple lipid abnormalities in type 2 diabetes?Atheroscler Suppl20056151916046280
  • SimonenPGyllingHHowardANIntroducing a new component of the metabolic syndrome: low cholesterol absorptionAm J Clin Nutr20007282810871565
  • SimonenPPGyllingHKMiettinenTADiabetes contributes to cholesterol metabolism regardless of obesityDiabetes Care20022515111512196419
  • SnidermanADFurbergCDKeechAApolipoproteins versus lipids as indices of coronary risk and as targets for statin treatmentLancet20033617778012620753
  • SnidermanADSt-PierreACCantinBConcordance/discordance between plasma apolipoprotein B levels and the cholesterol indexes of atherosclerotic riskAm J Cardiol2003911173712745098
  • SrinivasanSRFrontiniMGXuJUtility of childhood non-high-density lipoprotein cholesterol levels in predicting adult dyslipidemia and other cardiovascular risks: The Bogalusa Heart StudyPediatrics2006118201616818566
  • SrinivasanSRMyersLBerensonGSDistribution and correlates of non-high-density lipoprotein cholesterol in children: The Bogalusa Heart StudyPediatrics2002110e2912205279
  • StamlerJStamlerRBrownWSerum cholesterol. Doing the right thingCirculation1993881954608403343
  • StamlerJWentworthDNeatonJDIs relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)JAMA1986256282383773199
  • St-PierreACCantinBDagenaisGRApolipoprotein-B, low-density lipoprotein cholesterol, and the long-term risk of coronary heart disease in menAm J Cardiol200697997100116563904
  • St-PierreACCantinBDagenaisGRLow-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Quebec Cardiovascular StudyArterioscler Thromb Vasc Biol200525553915618542
  • St-PierreACRuelILCantinBComparison of various electrophoretic characteristics of ldl particles and their relationship to the risk of ischemic heart diseaseCirculation20011042295911696468
  • VaccaroOStamlerJNeatonJDSixteen-year coronary mortality in black and white men with diabetes screened for the Multiple Risk Factor Intervention Trial (MRFIT)Int J Epidemiol199827636419758118
  • WalldiusGJungnerIHolmeIHigh apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective studyLancet200135820263311755609
  • WilsonPWD’AgostinoRBLevyDPrediction of coronary heart disease using risk factor categoriesCirculation1998971837479603539
  • WolfRGrundySInfluence of weight reduction on plasma lipoproteins in obese patientsArterioscler Thromb Vasc Biol1983a31609
  • WolfRNGrundySMInfluence of weight reduction on plasma lipoproteins in obese patientsArteriosclerosis1983b316096573161
  • WongNDWilsonPWKannelWBSerum cholesterol as a prognostic factor after myocardial infarction: the Framingham StudyAnn Intern Med1991115687931929036
  • WoodPDStefanickMLDreonDMChanges in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exerciseN Engl J Med1988319117393173455
  • YusufSHawkenSOunpuuSObesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control studyLancet20053661640916271645
  • ZimmetPMaglianoDMatsuzawaYThe metabolic syndrome: a global public health problem and a new definitionJ Atheroscler Thromb20051229530016394610