Safety and efficacy of alteplase in the treatment of acute ischemic stroke

References

• MolinaCASaverJLExtending reperfusion therapy for acute ischemic stroke: emerging pharmacological, mechanical, and imaging strategiesStroke2005362311232016179577
   PubMed Web of Science ®Google Scholar
• SiaoCJFernandezSRTsirkaSECell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injuryJ Neurosci20032332243242
   Web of Science ®Google Scholar
• NicoleODocagneFAliCThe proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signalingNat Med20017596411135617
   PubMed Web of Science ®Google Scholar
• YepesMRousselBDAliCVivienDTissue-type plasminogen activator in the ischemic brain: more than a thrombolyticTrends Neurosci2009321485518963068
   PubMed Web of Science ®Google Scholar
• YepesMLawrenceDATissue-type plasminogen ayctivator and neuroserpin: A well-balanced act in the nervous systemCardiovasc Med200414173180
   Google Scholar
• Fernandez-MonrealMLopez-AtalayaJPBenchenaneKIs tissue-type plasminogen activator a neuromodulatorMol Cell Neurosci20042559460115080889
   PubMed Web of Science ®Google Scholar
• BenchenaneKLopez-AtalayaJPFernandez-MonrealMTouzaniOVivienDEquivocal roles of tissue-type plasminogen activator in stroke-induced injuryTrends Neurosci20042715516015036881
   PubMed Web of Science ®Google Scholar
• CastelHRousselBDAliCTissue plasminogen activator (tPA)-dependent cleavage of the NMDA receptor NR1 subunit occurs in vivo: Relevance to strokeAtlanta, GAProceedings 36th Annual Meeting of the Society for NeuroscienceOctober 14–182006
   Google Scholar
• SumiiTLoEHInvolvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in ratsStroke20023383183611872911
   PubMed Web of Science ®Google Scholar
• PfefferkornTWiessnerCAllegriniPRKlossCUAHamannGFMRI predicts area of increased plasminogen activation in permanent focal cerebral ischemiaNeurol Res20022482282412500707
   PubMed Web of Science ®Google Scholar
• del ZoppoGJvon KummerRHamannGFIschemic damage of brain microvessels: inherent risks for thrombolytic treatment in strokeJ Neurol Neurosurg Psychiatry199865199667553
   PubMed Web of Science ®Google Scholar
• Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study GroupN Engl J Med1995333158115877477192
   PubMed Web of Science ®Google Scholar
• KwiatkowskiTGLibmanRBFrankelMTilleyBCMorgensternLBLuMEffects of tissue plasminogen activator for acute ischemic stroke at one yearN Engl J Med19993401781178710362821
   PubMed Web of Science ®Google Scholar
• Karolinska Stroke UpdateConsensus statement on thrombolysisNov. 13–14, 2006. Cited on Apr 16, 2009. Available from: http://www.strokeupdate.org/ALLCURRENT/Consensus/Consensus_2000/2000.htm
   Google Scholar
• AdamsHPJrAdamsRJBrottTGuidelines for the early management of patients with ischemic stroke: a scientific statement from the Stroke Council of the American Stroke AssociationStroke2003341056108312677087
   PubMed Web of Science ®Google Scholar
• The European Stroke Initiative Executive Committee and European Stroke Initiative Writing GroupEuropean stroke initiative recommendations for stroke management—update 2003Cerebrovasc Dis20031631133714584488
   PubMed Web of Science ®Google Scholar
• HackeWKasteMFieschiCIntravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric strokeJAMA1995274101710257563451
   PubMed Web of Science ®Google Scholar
• HackeWKasteMFieschiCRandomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study InvestigatorsLancet1998352124512519788453
   PubMed Web of Science ®Google Scholar
• ClarkWMWissmanSAlbersGWJhamandasJHMaddenKPHamiltonSRecombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset: the ATLANTIS study: a randomized controlled trialJAMA19992822019202610591384
   PubMed Web of Science ®Google Scholar
• HackeWDonnanGFieschiCAssociation of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trialsLancet200436376877415016487
   PubMed Web of Science ®Google Scholar
• SaverJLNumber needed to treat estimates incorporating effects over the whole range of clinical outcomes: novel derivation method and application to thrombolytic therapy for acute strokeArch Neurol2004611066107015262737
   PubMed Web of Science ®Google Scholar
• IngallTJO’FallonWMAsplundKFindings from the reanalysis of the NINDS Tissue Plasminogen Activator for Acute Ischemic Stroke Treatment TrialStroke2004352418242415345796
   PubMed Web of Science ®Google Scholar
• WardlawJMZoppoGYamaguchiTBergeEThrombolysis for acute ischaemic strokeCochrane Database Syst Rev20033CD00021312917889
   PubMedGoogle Scholar
• WangDZRoseJAHoningsDSGarwackiDJMilbrandtJCTreating acute stroke patients with intravenous tPA: the OSF stroke network experienceStroke200031778110625719
   PubMed Web of Science ®Google Scholar
• AlbersGWBatesVEClarkWMBellRVerroPHamiltonSAIntravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) studyJAMA20002831145115010703776
   PubMed Web of Science ®Google Scholar
• ChiuDKriegerKVillar-CordovaCIntravenous tissue plasminogen activator for acute ischemic stroke: feasibility, safety and efficacy in the first year of clinical practiceStroke19982918229445322
   PubMed Web of Science ®Google Scholar
• GrondMStenzelCSchmullingSEarly intravenous thrombolysis for acute ischemic stroke in a community-based approachStroke199829154415499707190
   PubMed Web of Science ®Google Scholar
• TanneDBatesVEVerroPInitial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: a multicenter studyNeurology19995342442710430444
   PubMed Web of Science ®Google Scholar
• WahlgrenNAhmedNDávalosAThrombolysis with alteplase for acute ischemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational studyLancet200736927528217258667
   PubMed Web of Science ®Google Scholar
• HillMDBuchanAMThrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness StudyCMAJ20051721307131215883405
   PubMed Web of Science ®Google Scholar
• KatzanILFurlanAJLloydLEUse of tissue-type plasminogen activator for acute ischemic stroke: the Cleveland area experienceJAMA20002831151115810703777
   PubMed Web of Science ®Google Scholar
• LydenPDLeesKRDavisSMAlteplase for acute stroke revisited: the first 10 yearsLancet Neurol2006572272416914399
   PubMed Web of Science ®Google Scholar
• MarlerJRTilleyBCLuMEarly stroke treatment associated with better outcome: the NINDS rt-PA Stroke StudyNeurology2000551649165511113218
   PubMed Web of Science ®Google Scholar
• ClarkWMAlbersGWMaddenKPHamiltonSThe rt-PA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter studyStroke20003181181610753980
   PubMed Web of Science ®Google Scholar
• HackeWKasteMBluhmkiEECASS InvestigatorsThrombolysis with alteplase 3 to 4.5 hours after acute ischemic strokeN Engl J Med2008359131317132918815396
   PubMed Web of Science ®Google Scholar
• LansbergMGAlbersGWWijmanCASymptomatic intracerebral hemorrhage following thrombolytic therapy for acute ischemic stroke: a review of the risk factorsCerebrovasc Dis20072411017519538
   PubMed Web of Science ®Google Scholar
• SavitzSILewRBluhmkiEHackeWFisherMShift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS II trialsStroke2007383205321217975102
   PubMed Web of Science ®Google Scholar
• Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study GroupStroke199728210921189368550
   PubMed Web of Science ®Google Scholar
• WahlgrenNAhmedNDávalosASITS investigatorsThrombolysis with alteplase 3–4.5 h after acute ischemic stroke (SITS-ISTR): an observational studyLancet200837296461303130918790527
   PubMed Web of Science ®Google Scholar
• del ZoppoGJHigashidaRTFurlanAJPessinMSRowleyHAGentMPROACT: A phase II randomized trial of recombinant prourokinase by direct arterial delivery in acute middle cerebral artery stroke; PROACT investigators, prolyse in acute cerebral thromboembolismStroke1998294119445320
   PubMed Web of Science ®Google Scholar
• FurlanAHigashidaRWeschlerLIntra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral ThromboembolismJAMA19992822003201110591382
   PubMed Web of Science ®Google Scholar
• SuarezJISunshineJLTarrRPredictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thrombolysis for acute ischemic strokeStroke1999302094210010512912
   PubMed Web of Science ®Google Scholar
• The IMS Study InvestigatorsCombined intravenous and intra-arterial recanalization for acute ischemic stroke: The interventional management of stroke studyStroke20043590491215017018
   PubMed Web of Science ®Google Scholar
• LewandowskiCFrankelMTomsickTCombined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging TrialStroke1999302598260510582984
   PubMed Web of Science ®Google Scholar
• ZaidatOOWelterELoveTECombined intravenous and intra-arterial versus intra-arterial recombinant tissue plasminogen activator in acute ischemic stroke patients: Propensity score analysis [abstract]J Neurosurg2004100A181
   Web of Science ®Google Scholar
• ErnstRPancioliATomsickTCombined intravenous and intra-arterial recombinant tissue plasminogen activator in acute ischemic strokeStroke2000312552255711062274
   PubMed Web of Science ®Google Scholar
• ZaidatOOSuarezJISantillanCIntra-arterial and combined intravenous and intra-arterial thrombolytic therapy for distal carotid artery occlusionStroke2002331828183312105361
   PubMed Web of Science ®Google Scholar
• SuarezJIZaidatOOSunshineJLTarrRSelmanWRLandisDMEndovascular administration after intravenous infusion of thrombolytic agents for the treatment of patients with acute ischemic strokesNeurosurgery20025025126011844259
   PubMed Web of Science ®Google Scholar
• JansenOvon KummerRForstingMThrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcationAJNR Am J Neuroradiol199516197719868585483
   PubMed Web of Science ®Google Scholar
• TheronJCourtheouxPCasascoALocal intraarterial fibrinolysis in the carotid territoryAJNR Am J Neuroradiol1989107537652505504
   PubMed Web of Science ®Google Scholar
• UedaTSakakiSKumonYOhtaSMultivariable analysis of predictive factors related to outcome at 6 months after intra-arterial thrombolysis for acute ischemic strokeStroke1999302360236510548671
   PubMed Web of Science ®Google Scholar
• JahanRDuckwilerGRKidwellCSIntraarterial thrombolysis for treatment of acute stroke: experience in 26 patients with long-term follow-upAJNR Am J Neuroradiol1999201291129910472989
   PubMed Web of Science ®Google Scholar
• WolpertSMBruckmannHGreenleeRWechslerLPessinMSdel ZoppoGJNeuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator. The rt-PA Acute Stroke Study GroupAJNR Am J Neuroradiol1993143138427107
   PubMed Web of Science ®Google Scholar
• BruckmannHFerbertAdel ZoppoGJAcute basilar thrombosis: angiologic-clinical comparison and therapeutic implicationsActa Radiol Suppl198636938422980502
   PubMedGoogle Scholar
• ArcherCRHorensteinSBasilar artery occlusion: clinical and radiological correlationStroke19778383390860293
   PubMed Web of Science ®Google Scholar
• ZeumerHFreitagHJGrzyskaUNeunzigHPLocal intraarterial fibrinolysis in acute vertebrobasilar occlusion. Technical developments and recent resultsNeuroradiology1989313363402797426
   PubMed Web of Science ®Google Scholar
• RosaAGautierJThrombolytic agents in cerebral infarctionsRev Neurol199147991102028156
   PubMedGoogle Scholar
• KubicCAdamsROcclusion of the basilar artery: a clinical and pathological studyBrain19466973121
   PubMed Web of Science ®Google Scholar
• FerbertABruckmannHDrummenRClinical features of proven basilar artery occlusionStroke199021113511422389292
   PubMed Web of Science ®Google Scholar
• BogousslavskyJRegliFMaederPMeuliRNaderJThe etiology of posterior circulation infarcts: a prospective study using magnetic resonance imaging and magnetic resonance angiographyNeurology199343152815338351006
   PubMed Web of Science ®Google Scholar
• HackeWZeumerHFerbertABrückmannHdel ZoppoGJIntra-arterial thrombolytic therapy improves outcome in patients with acute vertebrobasilar diseaseStroke198819121612223176080
   PubMed Web of Science ®Google Scholar
• BeckerKJMonseinLHUlatowskiJMirskiMWilliamsMHanleyDFIntraarterial thrombolysis in vertebrobasilar occlusionAJNR Am J Neuroradiol1996172552628938295
   PubMed Web of Science ®Google Scholar
• IMS II Trial InvestigatorsThe Interventional Management of Stroke (IMS) II StudyStroke2007382127213517525387
   PubMed Web of Science ®Google Scholar
• WolfeTSuarezJITarrRWComparison of combined venous and arterial thrombolysis with primary arterial therapy using recombinant tissue plasminogen activator in acute ischemic strokeJ Stroke Cerebrovasc Dis200817312112818436152
   PubMedGoogle Scholar
• ReevesMJAroraSBroderickJPAcute stroke care in the US: results from the 4 pilot prototypes of the Paul Coverdell National Acute Stroke RegistryStroke2005361232124015890989
   PubMed Web of Science ®Google Scholar
• CaplanLRStroke thrombolysis: slow progressCirculation200611418719016847163
   PubMed Web of Science ®Google Scholar
• del ZoppoGJZeumerHHarkerLAThrombolytic therapy in stroke: possibilities and hazardsStroke198675956073526644
   PubMedGoogle Scholar
• RosenbergGAEstradaEYDencoffJEMatrix metalloproteinases and TIMPS are associated with blood brain barrier opening after reperfusion in rat brainStroke199829218921959756602
   PubMed Web of Science ®Google Scholar
• AsahiMWangXMoriTEffects of matrix metalloproteinase-9 gene knockout on the proteolysis of blood–brain barrier and white matter components after cerebral ischemiaJ Neurosci2001217724773211567062
   PubMed Web of Science ®Google Scholar
• SumiiTLoEHInvolvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in ratsStroke20023383183611872911
   PubMed Web of Science ®Google Scholar
• RomanicAMWhiteRFArlethAJOhlsteinEHBaroneFCMatrix metalloproteinase expression increases after cerebral focal ischemia in rats. Inhibition of matrix metalloproteinase-9 reduces infarct sizeStroke199829102010309596253
   PubMed Web of Science ®Google Scholar
• GautierSPetraultOGelePInvolvement of thrombolysis in recombinant tissue plasminogen activator-induced cerebral hemorrhages and effect on infarct volume and postischemic endothelial functionStroke2003342975297914615621
   PubMed Web of Science ®Google Scholar
• MontanerJAlvarez-SabinJMolinaCMatrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairmentStroke2001321759176611486102
   PubMed Web of Science ®Google Scholar
• MontanerJMolinaCAMonasterioJMatrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human strokeCirculation200310759860312566373
   PubMed Web of Science ®Google Scholar
• CastellanosMLeiraRSerenaJPlasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic strokeStroke200334404612511748
   PubMed Web of Science ®Google Scholar
• LapchakPAChapmanDFZivinJAMetalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic strokeStroke2000313034304011108768
   PubMed Web of Science ®Google Scholar
• CastellanosMLeiraRSerenaJPlasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic strokeStroke2004351671167615166391
   PubMed Web of Science ®Google Scholar
• RiboMMontanerJMolinaCAAdmission fibrinolytic profile is associated with symptomatic hemorrhagic transformation in stroke patients treated with tissue plasminogen activatorStroke2004352123212715243150
   PubMed Web of Science ®Google Scholar
• DerexLHermierMAdeleinePClinical and imaging predictors of intracerebral hemorrhage in stroke patients treated with intravenous tissue plasminogen activatorJ Neurol Neurosurg Psychiatry200576707515607998
   PubMed Web of Science ®Google Scholar
• LarrueVvon KummerRdel ZoppoGBluhmkiEHemorrhagic transformation in acute ischemic stroke. Potential contributing factors in the European Cooperative Acute Stroke StudyStroke1997289579609158632
   PubMed Web of Science ®Google Scholar
• LarrueVvon KummerRMüllerABluhmkiERisk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator. A secondary analysis of the European-Australasian Acute Stroke Study (ECASS II)Stroke20013243844111157179
   PubMed Web of Science ®Google Scholar
• BergerCFiorelliMSteinerTHemorrhagic transformation of ischemic brain tissue. Asymptomatic or symptomaticStroke2001321330133511387495
   PubMed Web of Science ®Google Scholar
• FiorelliMBastianelloSvon KummerRHemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohortStroke1999302280228410548658
   PubMed Web of Science ®Google Scholar
• CochoDBorrellMMarti-FabregasJPretreatment hemostatic markers of symptomatic intracerebral hemorrhage in patients treated with tissue plasminogen activatorStroke20063799699916497981
   PubMed Web of Science ®Google Scholar
• LevyDBrottTHaleyECJrFactors related to intracranial hematoma formation in patients receiving tissue-type plasminogen activator for acute ischemic strokeStroke1994252912978303734
   PubMed Web of Science ®Google Scholar
• TanneDKasnerSEDemchukAMMarkers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator for acute ischemic stroke in clinical practice: the Multicenter rt-PA Acute Stroke SurveyCirculation20021051679168511940547
   PubMed Web of Science ®Google Scholar
• GurwitzJHGoreJMGoldbergRJRisk for intracranial hemorrhage after tissue plasminogen activator treatment for acute myocardial infarction. Participants in the National Registry of Myocardial Infarction 2Ann Intern Med19981295976049786806
   PubMed Web of Science ®Google Scholar
• ItohYYamadaMHayakawaMOtomoEMiyatakeTCerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar hemorrhage in the elderlyJ Neurol Sci19931161351418336159
   PubMed Web of Science ®Google Scholar
• HeuschmannPUKolominsky-RabasPLRoetherJPredictors of in-hospital mortality in patients with acute ischemic stroke treated with thrombolytic therapyJAMA20042921831183815494580
   PubMed Web of Science ®Google Scholar
• TanneDGormanMJBatesVEIntravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and older: the tPA stroke survey experienceStroke20003137037510657408
   PubMed Web of Science ®Google Scholar
• BerrouschotJRötherJGlahnJKucinskiTFiehlerJThomallaGOutcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (> or =80 years) stroke patientsStroke2005362421242516210554
   PubMed Web of Science ®Google Scholar
• SylajaPNCoteRBuchanAMHillMDCanadian Alteplase for Stroke Effectiveness Study (CASES) InvestigatorsThrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness StudyJ Neurol Neurosurg Psychiatry20067782682916505004
   PubMed Web of Science ®Google Scholar
• WardlawJMDormanPJCaldeliseLSignoriniDFThe influence of baseline prognostic variables on outcome after thrombolysis. MAST-Italy Collaborative groupJ Neurol19992461059106210631638
   PubMed Web of Science ®Google Scholar
• CapesSEHuntDMalmbergKPathakPGersteinHCStress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overviewStroke2001322426243211588337
   PubMed Web of Science ®Google Scholar
• WeirCJMurrayGDDykerAGLeesKRIs hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up studyBMJ1997314130313069158464
   PubMed Web of Science ®Google Scholar
• JorgensenHNakayamaHRaaschouHOOlsenTSStroke in patients with diabetes. The Copenhagen Stroke StudyStroke199425197719848091441
   PubMed Web of Science ®Google Scholar
• van KootenFHoogerbrugeNNaardingPKoudstaalPJHyperglycemia in the acute phase of stroke is not caused by stressStroke199324112911328342185
   PubMed Web of Science ®Google Scholar
• MurrosKFogelholmRKettunenSVuorelaALValveJBlood glucose, glycosylated haemoglobin, and outcome of ischemic brain infarctionJ Neurol Sci199211159641402998
   PubMed Web of Science ®Google Scholar
• MurrosKFogelholmdRDiabetes and stress hyperglycaemia in strokeJ Neurol Neurosurg Psychiatry1993564288482972
   PubMed Web of Science ®Google Scholar
• WooEMaJTRobinsonJDYuYLHyperglycemia is a stress response in acute strokeStroke198819135913643188121
   PubMed Web of Science ®Google Scholar
• DemchukAMMorgensternLBKriegerDWSerum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic strokeStroke19993034399880385
   PubMed Web of Science ®Google Scholar
• LindsbergPJSoinneLRoineROCommunity-based thrombolytic therapy of acute ischemic stroke in HelsinkiStroke2003341443144912738891
   PubMed Web of Science ®Google Scholar
• KaseCSFurlanAJWechslerLRCerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: the PROACT II trialNeurology20015791603161011706099
   PubMed Web of Science ®Google Scholar
• HamannGFdel ZoppoGJvon KummerRHemorrhagic transformation of cerebral infarction: possible mechanismsThromb Haemost199982929410695495
   PubMedGoogle Scholar
• von KummerREarly major ischemic changes on computed tomography should preclude use of tissue plasminogen activatorStroke20033482082112624316
   PubMed Web of Science ®Google Scholar
• LydenPEarly major ischemic changes on computed tomography should not preclude use of tissue plasminogen activatorStroke20033482182212624317
   PubMed Web of Science ®Google Scholar
• RobertsHCDillonWPFurlanAJComputed tomographic findings in patients undergoing intra-arterial thrombolysis for acute ischemic stroke due to middle cerebral artery occlusion: results from the PROACT II trialStroke2002331565156712532957
   PubMed Web of Science ®Google Scholar
• BarberPADemchukAMZhangJValidity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT ScoreLancet20003551670167410905241
   PubMed Web of Science ®Google Scholar
• Neumann-HaefelinTHoeligSBerkefeldJLeukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute strokeStroke2006372463246616931786
   PubMed Web of Science ®Google Scholar
• NighoghossianNHermierMAdeleinePOld microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke. A gradient-echo T2*-weighted brain MRI studyStroke20023373574211872897
   PubMed Web of Science ®Google Scholar
• FanYHZhangLLamWWMCerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic strokeStroke2003342459246212958325
   PubMed Web of Science ®Google Scholar
• ChalelaJAKangDWWarachSMultiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone stateJ Neuroimaging200414545714748209
   PubMed Web of Science ®Google Scholar
• DerexLNighoghossianNHermierMThrombolysis for ischemic stroke in patients with old microbleeds on pretreatment MRICerebrovasc Dis20041723824114718753
   PubMed Web of Science ®Google Scholar
• KakudaWThijsVNLansbergMGClinical importance of microbleeds in patients receiving IV thrombolysisNeurology2005651175117816247042
   PubMed Web of Science ®Google Scholar
• FiehlerJAlbersGWBoulangerJMBleeding risk analysis in stroke imaging before thromboLysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patientsStroke2007382738274417717319
   PubMed Web of Science ®Google Scholar
• ThomallaGSobeskyJKöhrmannMTwo tales: hemorrhagic transformation but not parenchymal hemorrhage after thrombolysis is related to severity and duration of ischemia. MRI study of acute stroke patients treated with intravenous tissue plasminogen activator within 6 hoursStroke20073831331817204683
   PubMed Web of Science ®Google Scholar
• TrouillasPDerexLPhilippeauFEarly fibrinogen degradation coagulopathy is predictive of parenchymal hematomas in cerebral rt-PA thrombolysis. A study in 157 casesStroke2004351323132815105521
   PubMed Web of Science ®Google Scholar
• ThomallaGSchwarkCSobeskyJOutcome and symptomatic bleeding complications of intravenous thrombolysis within 6 hours in MRI-selected stroke patients. Comparison of a German multicenter study with the pooled data of ATLANTIS, ECASS, and NINDS tPA trialsStroke20063785285816439696
   PubMed Web of Science ®Google Scholar
• KöhrmannMJuttlerEFiebachJBMRI versus CT-based thrombolysis treatment within and beyond the 3 h time window after stroke onset: a cohort studyLancet Neurol2006566166716857571
   PubMed Web of Science ®Google Scholar
• KhatriPHillMDPaleschYYMethodology of the Interventional Management of Stroke III TrialInt J Stroke2008313013718706007
   PubMed Web of Science ®Google Scholar
• Lopez-AtalayaJPRousselBDLevratDToward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicityJ Cereb Blood Flow Metab2008281212122118334994
   PubMed Web of Science ®Google Scholar