77
Views
19
CrossRef citations to date
0
Altmetric
Review

Pleiotropic effects of statins in atrial fibrillation patients: the evidence

, , &
Pages 533-551 | Published online: 17 Jun 2009

References

  • MihmMJYuFCarnesCAImpaired myofibrillar energetics and oxidative injury during human atrial fibrillationCirculation200110417418011447082
  • CarnesCAChungMKNakayamaTAscorbate attenuates atrial pacing–induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillationCirc Res200189e32e3811557745
  • AvilesRJMartinDOApperson-HansenCInflammation as a risk factor for atrial fibrillationCirculation20031083006301014623805
  • GaudinoMAndreottiFZamparelliRThe −174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation. Is atrial fibrillation an inflammatory complication?Circulation2003108Suppl 1II195II19912970232
  • EngelmannMDSvendsenJHInflammation in the genesis and perpetuation of atrial fibrillationEur Heart J2005262083209215975993
  • BoosCJAndersonRALipGYIs atrial fibrillation an inflammatory disorderEur Heart J20062713614916278230
  • EhrlichJRHohnloserSHNattelSRole of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidenceEur Heart J20062751251816311236
  • ChanAWBhattDLChewDPRelation of inflammation and benefit of statins after percutaneous coronary interventionsCirculation20031071750175612665489
  • HorneBDMuhlesteinJBCarlquistJFStatin therapy interacts with cytomegalovirus seropositivity and high C-reactive protein in reducing mortality among patients with angiographically significant coronary diseaseCirculation200310725826312538425
  • ShishehborMHBrennanMLAvilesRJStatins promote potent systemic antioxidant effects through specific inflammatory pathwaysCirculation200310842643112860913
  • Young-XuYJabbourSGoldbergRUsefulness of statin drugs in protecting against atrial fibrillation in patients with coronary artery diseaseAm J Cardiol2003921379198314675569
  • SiuCWLauCPTseHFPrevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversionAm J Cardiol2003921343134514636918
  • MarínFPascualDARoldánVStatins and postoperative risk of atrial fibrillation following coronary artery bypass graftingAm J Cardiol2006971556016377284
  • SpachMSDolberPCRelating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle: evidence for electrical uncoupling of side-to-side fiber connections with increasing ageCardiovasc Res198658356371
  • SchottenUAusmaJStellbrinkCHanrathPAllessieMACellular mechanisms of depressed atrial contractility in patients with chronic atrial fibrillationCirculation200110369169811156881
  • KuceraJPRudyYMechanistic insights into very slow conduction in branching cardiac tissue: a model studyCirc Res20018979980611679410
  • KostinSKleinGSzalayZStructural correlate of atrial fibrillation in human patientsCardiovasc Res20025436137912062341
  • BoldtAWetzelULauschkeJFibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve diseaseHeart20049040040515020515
  • FrustaciAChimentiCBellocciFHistological substrate of atrial biopsies in patients with lone atrial fibrillationCirculation199796118011849286947
  • TsaiCTLaiLPKuoKTAngiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodelingCirculation2008b117334435518172037
  • ChelloMSpadaccioCPattiGSimvastatin reduces platelet-endocardium adhesion in atrial fibrillationAtherosclerosis2008197258859517904146
  • NeumanRBBloomHLShukrullahIOxidative stress markers are associated with persistent atrial fibrillationClin Chem20075391652165717599958
  • SpodickDHArrhythmias during acute pericarditis: a prospective study of 100 consecutive casesJAMA19762353941945999
  • MorgeraTDi LenardaADreasLElectrocardiography of myocarditis revisited: clinical and prognostic significance of electrocardiographic changesAm Heart J19921244554671636589
  • BruinsPVelthuisHYazdanbakhshAPActivation of the complement system during and after cardiopulmonary bypass surgery: post surgery activation involves C-reactive protein and is associated with postoperative arrhythmiaCirculation199796354235489396453
  • MaixentJMPaganelliFScaglioneJAntibodies against myosin in sera of patients with idiopathic paroxysmal atrial fibrillationJ Cardiovasc Electrophysiol199896126179654226
  • ChungMKMartinDOSprecherDC-Reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillationCirculation20011042886289111739301
  • Shiroshita-TakeshitaASchramGLavoieJEffect of Simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrialtachycardia remodeling in dogsCirculation20041102313231915477401
  • KorantzopoulosPKolettisTMKountourisEOral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammationInt J Cardiol2005a10232132615982504
  • KorantzopoulosPKolettisTMKountourisEVariation of inflammatory indexes after electrical cardioversion of persistent atrial fibrillation: Is there an association with early recurrence ratesInt J Clin Pract2005b5988188516033606
  • DudleySCJrHochNEMcCannLAAtrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidasesCirculation20051121266127316129811
  • KaplanMHVolanakisJEInteraction of C-reactive protein complexes with the complement system. I Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelinJ Immunol1974112213521474151108
  • VolanakisJEWirtzKWInteraction of C-reactive protein with artificial phosphatidylcholine bilayersNature1979281155157471064
  • DernellisJPanaretouMC-reactive protein and paroxysmal atrial fibrillation: evidence of the implication of an inflammatory process in paroxysmal atrial fibrillationActa Cardiol20015637538011791805
  • BlakeGJRidkerPMC-reactive protein and other inflammatory risk markers in acute coronary syndromesJ Am Coll Cardiol200341Suppl 437S42S12644339
  • ConwayDSBugginsPHughesEPredictive value of indexes of inflammation and hypercoagulability on success of cardioversion of persistent atrial fibrillationAm J Cardiol2004a4508510
  • ConwayDSBugginsPHughesERelationship of interleukin-6 and C-reactive protein to the prothrombotic state in chronic atrial fibrillationJ Am Coll Cardiol2004b432075208215172416
  • SataNHamadaNHorinouchiTC-reactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillationJpn Heart J20044544144515240964
  • PsychariSNApostolouTSSinosLRelation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillationAm J Cardiol20059576476715757607
  • AsselbergsFWvan den BergMPDiercksGFC-reactive protein and microalbuminuria are associated with atrial fibrillationInt J Cardiol200598737715676170
  • WatanabeTTakeishiYHironoOC-reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillationHeart Vessels200520454915772777
  • AndersonJLAllen MaycockCALappeDLIntermountain Heart Collaborative Study Group. Frequency of elevation of C-reactive protein in atrial fibrillationAm J Cardiol2004941255125915541240
  • DernellisJPanaretouMRelationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillationEur Heart J2004251100110715231367
  • OralHKnightBPOzaydinMClinical significance of early recurrences of atrial fibrillation after pulmonary vein isolationJ Am Coll Cardiol20024010010412103262
  • DernellisJPanaretouMEffect of C-reactive protein reduction on paroxysmal atrial fibrillationAm Heart J200550106416290998
  • NakaTNishimotoNKishimotoTThe paradigm of IL-6: from basic science to medicineArthritis Res20024Suppl 3S233S24212110143
  • MarcusGMWhooleyMAGliddenDVInterleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul StudyAm Heart J2008155230330918215601
  • AbdelhadiRHGurmHSVan WagonerDRRelation of an exaggerated rise in white blood cells after coronary bypass or cardiac valve surgery to development of atrial fibrillation postoperativelyAm J Cardiol2004931176117815110218
  • LaufsUEndresMCustodisFSuppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcriptionCirculation20001023104311011120702
  • AlbertMADanielsonERifaiNEffect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort studyJAMA2001286647011434828
  • AmarDZhangHHeerdtPMStatin use is associated with a reduction in atrial fibrillation after noncardiac thoracic surgery independent of C-reactive proteinChest20051283421342716304294
  • HadiHACarrCSAl SuwaidiJEndothelial dysfunction: cardiovascular risk factors, therapy, and outcomeVasc Health Risk Manag20051318319817319104
  • PlengeJKHernandezTLWeilKMSimvastatin lowers C-reactive protein within 14 days: an effect independent of cholesterol reductionCirculation20021061447145212234946
  • Blanco-ColioLMTunonJMartin-VenturaJLAnti-inflammatory and immunomodulatory effects of statinsKidney Int200363122312472764
  • GoetteAHoneycuttCLangbergJJElectrical remodeling in atrial fibrillation. Time course and mechanismsCirculation199694296829748941128
  • TielemanRGDe LangenCVan GelderICVerapamil reduces tachycardia-induced electrical remodeling of the atriaCirculation199795194519539107184
  • LeeSHYuWCChengJJEffect of verapamil on long-term tachycardia-induced atrial electrical remodelingCirculation200010120020610637209
  • Van NoordTVan GelderICTielemanRGVERDICT: the Verapamil versus Digoxin Cardioversion Trial: a randomized study on the role of calcium lowering for maintenance of sinus rhythm after cardioversion of persistent atrial fibrillationJ Cardiovasc Electrophysiol20011276676911469424
  • KumagaiKNakashimaHSakuKThe HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis modelCardiovasc Res20046210511115023557
  • SavelievaICammJStatins and polyunsaturated fatty acids for treatment of atrial fibrillationNat Clin Pract Cardiovasc Med20085304118094671
  • PliquettRUCornishKGPeulerJDSimvastatin normalizes autonomic neural control in experimental heart failureCirculation20031072493249812695293
  • GaoLWangWLiYLSimvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD (P) H oxidaseCirculation20051121763177016157767
  • TziakasDNChalikiasGKStakosDAEffect of statins on collagen type I degradation in patients with coronary artery disease and atrial fibrillationAm J Cardiol2008101219920218178406
  • JacobsonJStatins in endothelial signaling and activationAntioxid Redox Signal2008922 [Epub ahead of print]
  • OkazakiHMinaminoTWakenoMStatin prevents structural and electrical atrial remodeling in rat hypertensive heart failure induced by chronic inhibition of NO synthesisCirculation2007116Suppl II140
  • Shiroshita-TakeshitaABrundelBJBursteinBEffects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failureCardiovasc Res2007741758417270161
  • LiuTLiLKorantzopoulosPStatin use and development of atrial fibrillation: A systematic review and meta-analysis of randomized clinical trials and observational studiesInt J Cardiol2008126216017018031847
  • FauchierLPierreBde LabriolleAAntiarrhythmic effect of statin therapy and atrial fibrillation a meta-analysis of randomized controlled trialsJ Am Coll Cardiol200851882883518294568
  • PatelAAWhiteCMShahSAThe relationship between statin use and atrial fibrillationCurr Med Res Opin2007231177118517519085
  • McLeanDSRavidSBlazingMEffect of statin dose on incidence of atrial fibrillation: data from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) and Aggrastat to Zocor (A to Z) trialsAm Heart J2008155229830218215600
  • AdabagASNelsonDBBloomfieldHEEffects of statin therapy on preventing atrial fibrillation in coronary disease and heart failureAm Heart J20071541140114518035087
  • HannaIRDudleySCJrKing-HagemanDLipid-lowering therapy reduces the prevalence of atrial fibrillation (Abstract)New Orleans, LA2005 Heart Rhythm Society Scientific SessionsMay 4–72005134
  • RamaniGZahidMGoodCBComparison of frequency of new-onset atrial fibrillation or flutter in patients on statins versus not on statins presenting with suspected acute coronary syndromeAm J Cardiol2007100340440517659917
  • TveitAGrundtvigMGundersenTAnalysis of pravastatin to prevent recurrence of atrial fibrillation after electrical cardioversionAm J Cardiol200493678078215019894
  • WatanabeEArakawaTUchiyamaTHigh sensitivity C-reactive protein is predictive of successful cardioversion for atrial fibrillation and maintenance of sinus rhythm after conversionInt J Cardiol2006108334635315964643
  • HumphriesKHLeeMSheldonRCARAF InvestigatorsStatin use and recurrence of atrial fibrillation after successful cardioversionAm Heart J2007154590891317967597
  • LoricchioMLCianfroccaCPasceriVRelation of C-reactive protein to long-term risk of recurrence of atrial fibrillation after electrical cardioversionAm J Cardiol200799101421142417493472
  • OzaydinMVarolEAslanSMEffect of atorvastatin on the recurrence rates of atrial fibrillation after electrical cardioversionAm J Cardiol2006971490149316679090
  • Al ChekakieMOAkarJGWangFThe effects of statins and renin-angiotensin system blockers on atrial fibrillation recurrence following antral pulmonary vein isolationJ Cardiovasc Electrophysiol200718994294617593228
  • RichterBDerntlMMarxMTherapy with angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and statins: no effect on ablation outcome after ablation of atrial fibrillationAm Heart J2007153111311917174648
  • GillisAMMorckMExnerDVBeneficial effects of statin therapy for prevention of atrial fibrillation following DDDR pacemaker implantationEur Heart J2008291873188018477727
  • TsaiCTLaiLPHwangJJAtorvastatin prevents atrial fibrillation in patients with brady-arrhythmias and implantation of an atrial-based or dual-chamber pacemaker: a prospective randomized trialAm Heart J2008a1561657018585498
  • AmitGKatzABar-OnSAssociation of statin therapy and the risk of atrial fibrillation in patients with a permanent pacemakerClin Cardiol200629624925216796074
  • BhavnaniSPColemanCIWhiteCMAssociation between statin therapy and reductions in atrial fibrillation or flutter and inappropriate shock therapyEuropace200810785485918495672
  • KorantzopoulosPGalarisDPapaioannidesDC-reactive protein and oxidative stress in atrial fibrillationInt J Cardiol2003b8810310412659994
  • KorantzopoulosPKolettisTMGalarisDThe role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillationInt J Cardiol200711513514316764958
  • KorantzopoulosPGalarisDPapaioannidesDThe possible role of oxidative stress in heart failure and the potential of antioxidant interventionMed Sci Monit2003a9RA12012512824962
  • LiuTLiGLiLAssociation between C-reactive protein and recurrence of atrial fibrillation after successful electrical cardioversion: a meta-analysisJ Am Coll Cardiol2007491642164817433956
  • MuscoSConwayELKoweyPRDrug therapy for atrial fibrillationMed Clin North Am20089212114118061001
  • ShanesJGMinadeoKNMoretAStatin therapy in heart failure: prognostic effects and potential mechanismsAm Heart J200715461762317892981
  • TousoulisDCharakidaMStefanadiEStatins in heart failure. Beyond the lipid lowering effectInt J Cardiol200711514415017175040
  • KorantzopoulosPKokkorisSThe antioxidant effects of statins may extend beyond atherosclerosis: potential benefits for atrial fibrillation and heart failureAtherosclerosis2004175118715186966
  • HadiHASuwaidiJAEndothelial dysfunction in diabetes mellitusVasc Health Risk Manag20073685387618200806
  • KostapanosMSLiberopoulosENGoudevenosJADo statins have an antiarrhythmic activityCardiovasc Res200775102017383620
  • HannaIRHeekeBBushHLipid-lowering drug use is associated with reduced prevalence of atrial fibrillation in patients with left ventricular systolic dysfunctionHeart Rhythm2006388188616876733
  • DickinsonMGHellkampASIpJHStatin therapy was associated with reduced atrial fibrillation and flutter in heart failure patients in SCD-HEFTHeart Rhythm20063SupplS49
  • ColettaAPCullingtonDClarkALClinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HFEur J Heart Fail200810121264126719008149
  • SpachMSDolberPCHeidlageJFInfluence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagationCirc Res1988628118322450697
  • AllessieMABoydenPACammAJPathophysiology and prevention of atrial fibrillationCirculation20011037697711156892
  • BruinsPVelthuisHYazdanbakhshAPActivation of the complement system during and after cardiopulmonary bypass surgery: post surgery activation involves C-reactive protein and is associated with postoperative arrhythmiaCirculation199796354235489396453
  • AmarDFleisherMZhangHElevated C-reactive protein but not troponin is associated with postoperative atrial fibrillationAnesth Analg200294S67
  • LiuTLiGPHuangTGAnti-inflammatory therapies in atrial fibrillationInt J Cardiol200510435936016087254
  • KnayzerBAbramovDNataliaBAtrial fibrillation and plasma troponin I elevation after cardiac surgery: relation to inflammation-associated parametersJ Card Surg200722211712317338744
  • KourliourosADe SouzaARobertsNDose-related effect of statins on atrial fibrillation after cardiac surgeryAnn Thorac Surg20088551515152018442529
  • SubramaniamKKochCGBashourAPreoperative statin intake and morbid events after isolated coronary artery bypass graftingJ Clin Anesth200820141118346602
  • MariscalcoGLorussoRKlersyCObservational study on the beneficial effect of preoperative statins in reducing atrial fibrillation after coronary surgeryAnn Thorac Surg20078441158116417888963
  • LertsburapaKWhiteCMKlugerJPreoperative statins for the prevention of atrial fibrillation after cardiothoracic surgeryJ Thorac Cardiovasc Surg2008135240541118242276
  • OzaydinMDoganAVarolEStatin use before by-pass surgery decreases the incidence and shortens the duration of postoperative atrial fibrillationCardiology2007107211712116864965
  • LiakopoulosOJChoiYHHaldenwangPLImpact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30,000 patientsEur Heart J200829121548155918506053
  • PattiGChelloMCanduraDRandomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery: results of the ARMYDA-3 (Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery) studyCirculation20061141455146117000910
  • SongYBOnYKKimJHThe effects of atorvastatin on the occurrence of postoperative atrial fibrillation after off-pump coronary artery bypass grafting surgeryAm Heart J20081562373,e9e1618657672
  • IshiiYSchuesslerRBGaynorSLInflammation of atrium after cardiac surgery is associated with in homogeneity of atrial conduction and atrial fibrillationCirculation20051112881288815927979
  • TselentakisEVWoodfordEChandyJInflammation effects on the electrical properties of atrial tissue and inducibility of postoperative atrial fibrillationJ Surg Res2006135687516650868
  • LammGAuerJWeberTPost-operative white blood cell count predicts atrial fibrillation after cardiac surgeryJ Cardiothorac Vasc Anesth200620515616458214
  • ViraniSSNambiVRazaviMPreoperative statin therapy is not associated with a decrease in the incidence of postoperative atrial fibrillation in patients undergoing cardiac surgeryAm Heart J2008155354154618294494