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Review

Atorvastatin in stroke: a review of SPARCL and subgroup analysis

, &
Pages 229-236 | Published online: 30 Mar 2010

References

  • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)Lancet1994344138313897968073
  • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study GroupPrevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levelsN Engl J Med1998339134913579841303
  • PlehnJFDavisBRSacksFMReduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) studyCirculation1999992162239892586
  • SeverPSDahlofBPoulterNRPrevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial – Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trialLancet20033611149115812686036
  • Heart Protection Collaborative Study GroupMRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trialLancet200236072212114036
  • AmarencoPLabreucheJLavalléePTouboulPJStatins in stroke prevention and carotid atherosclerosis: systematic review and metaanalysisStroke2004352902290915514180
  • The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) InvestigatorsHigh-dose atorvastatin after stroke or transient ischemic attackN Engl J Med200635554955916899775
  • LiaoJKEffects of statins on 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition beyond low-density lipoprotein cholesterolAm J Cardiol200596Suppl24F33F
  • ZhangLZhangZGLiuXSHozeska-SolgotAChoppMThe PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the ratArterioscler Thromb Vasc Bio2007272470247517717296
  • ChenJLZhangZGLiYStatins induce angiogenesis, neurogenesis, and synaptogenesis after strokeAnn Neurol20035374375112783420
  • KawashimaSYamashitaTMiwaYHMG-CoA reductase inhibitor has protective effects against stroke events in stroke-prone spontaneously hypertensive ratsStroke20033415716312511768
  • LuDQuCGoussevAStatins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injuryJ Neurotrauma2007241132114617610353
  • BoselJGandorFHarmsCNeuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neuronesJ Neurochem2005921386139815748157
  • LaufsUGertzKHuangPAtorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic miceStroke2000312442244911022078
  • SandercockPGubitzGFoleyPCounsellCAntiplatelet therapy for acute ischaemic strokeCochrane Database Syst Rev20032CD00002912804384
  • IsoHJacobsDRJWentworthDNeatonJDCohenJDSerum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trialN Engl J Med19893209049102619783
  • YanoKReedDMMacLeanCJSerum cholesterol and hemorrhagic stroke in the Honolulu heart programStroke198920146014652815179
  • EbrahimSSungJSongYMFerrerRLLawlorDADavey SmithGSerum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort studyBMJ2006333222816757495
  • LeppalaJMVirtamoJFogelholmRAlbanesDHeinonenOPDifferent risk factors for different stroke subtypes: association of blood pressure, cholesterol, and antioxidantsStroke1999302535254010582974
  • GoldsteinLBAmarencoPSzarekMon behalf of the SPARCL InvestigatorsHemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels studyNeurology702364237018077795
  • AmarencoPGoldsteinLBSzarekMSPARCL InvestigatorsEffects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) TrialStroke2007383198320417962589
  • AmarencoPGoldsteinLBCallahanA3rdSPARCL InvestigatorsBaseline blood pressure, low- and high-density lipoproteins, and triglycerides and the risk of vascular events in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trialAtherosclerosis200920451552018962621
  • AmarencoPGoldsteinLBMessigMSPARCL InvestigatorsRelative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trialStroke2009402486249219461031
  • BaigentCKeechAKearneyPMCholesterol Treatment Trialists’ (CTT) CollaboratorsEfficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statinsLancet20053661267127816214597
  • RothwellPMCoullAJSilverLEPopulation-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study)Lancet20053661773178316298214
  • JemalAWardEHaoYThunMTrends in the leading causes of death in the United States, 1970–2002JAMA20052941255125916160134
  • SeverPADahlofBPoulterNRPrevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trialLancet20033611149115812686036
  • ShepherdJBlauwGJMurphyMBPravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trialLancet20023601623163012457784
  • LewisSJMoyeLASacksFMEffect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average rangeAnn Intern Med19981296816899841599
  • KoDTMamdaniMAlterDALipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradoxJAMA20042911864187015100205
  • BennerJSGlynnRJMogunHNeumannPJWeinsteinMCAvornJLong-term persistence in use of statin therapy in elderly patientsJAMA200228845546112132975
  • ChaturvediSZivinJABreaznaAfor the SPARCL investigatorsEffect of atorvastatin in elderly patients with a recent stroke or transient ischemic attackNeurology20097268869418768917
  • GoldsteinLBAmarencoPLaMonteMRelative effects of statin therapy on stroke and cardiovascular events in men and women: Secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) StudyStroke2008392444244818617654
  • AmarencoPBenaventeOGoldsteinLBResults of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial by stroke subtypesStroke2009401405140919228842
  • SillesenHAmarencoPHennericiMGStroke Prevention by Aggressive Reduction in Cholesterol Levels InvestigatorsAtorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trialStroke2008393297330218845807
  • Executive Committee for the Asymptomatic Carotid Atherosclerosis StudyEndarterectomy for asymptomatic carotid stenosisJAMA1995273142114287723155
  • HallidayAMansfieldAMarroJMRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative GroupPrevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomized controlled trialLancet20043631491150215135594
  • GoldsteinLBAmarencoPZivinJStatin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) TrialStroke2009403526353119745172
  • MoonisMKaneKSchwiderskiUSandageBWFisherMHMG-CoA reductase inhibitors improve acute ischemic stroke outcomeStroke2005361298130015879346
  • ElkindMSFlintACSciaccaRRSaccoRLLipid-lowering agent use at ischemic stroke onset is associated with decreased mortalityNeurology20056525325816043795
  • AslanyanSWeirCJMcInnesGTReidJLWaltersMRLeesKRStatin administration prior to ischaemic stroke onset and survival: exploratory evidence from matched treatment-control studyEur J Neurol20051249349815958087
  • ReevesMJGarganoJWLuoZMullardAJJacobsBSMajidAEffect of pretreatment with statins on ischemic stroke outcomesStroke2008391779178518369173
  • KarkiKKnightRAHanYSimvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhageStroke2009403384338919644071
  • LapchakPAHanMKThe 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbitsBrain Res200915130314415019781532
  • FitzMauriceEWendellLSniderREffect of statins on intracerebral hemorrhage outcome and recurrenceStroke2008392151215418436876
  • LekerRRKhourySTRafaeliGShwartzREichelRTanneDNASIS InvestigatorsPrior use of statins improves outcome in patients with intracerebral hemorrhage: prospective data from the National Acute Stroke Israeli Surveys (NASIS)Stroke2009402581258419407227
  • AmarencoPGoldsteinLBSillesenHStroke Prevention by Aggressive Reduction in Cholesterol Levels InvestigatorsCoronary heart disease risk in patients with stroke or transient ischemic attack and no known coronary heart disease: findings from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trialStroke20104142643020110538
  • FitchettDHGoodmanSGLangerAIschemic stroke: A cardiovascular risk equivalent? Lessons learned from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trialCan J Cardiol20082470570818787721
  • AmarencoPStegPGStroke is a coronary heart disease risk equivalent: implications for future clinical trials in secondary stroke preventionEur Heart J2008291605160718523057