445
Views
0
CrossRef citations to date
0
Altmetric
Research Report

Warfarin and Cytochrome P450 2C9 Genotype: Possible Ethnic Variation in Warfarin Sensitivity

, , , , , , & show all
Pages 217-225 | Published online: 27 Feb 2007

Bibliography

  • Adcock DM , KoftanC, CrisanD, Kiechle FL: Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation. Arch. Pathol. Lab. Med.128(12) , 1360–1363 (2004).
  • Douketis JD , LaneA, MilneJ, GinsbergJS: Accuracy of a portable international normalization ratio monitor in outpatients receiving long-term oral anticoagulant therapy: comparison with a laboratory reference standard using clinically relevant criteria for agreement.Thromb. Res.92(1) , 11–17 (1998).
  • Beyth RJ : Management of haemorrhagic complications associated with oral anticoagulant treatment.Expert Opin. Drug Saf.1(2) , 129–136 (2002).
  • Ansell J , HirshJ, DalenJ et al.: Managing oral anticoagulant therapy. Chest119(Suppl. 1) , S22–S38 (2001).
  • Wadelius M , SorlinK, WallermanO et al.: Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors. Pharmacogenomics J.4(1) , 40–48 (2004).
  • Hirsh J , DalenJE, DeykinD, PollerL: Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range.Chest102(Suppl. 4) , S312–S326 (1992).
  • Haber LT , MaierA, GentryPR, ClewellHJ, DoursonML: Genetic polymorphisms in assessing interindividual variability in delivered dose.Regul. Toxicol. Pharmacol.35(2 Pt 1) , 177–197 (2002).
  • Kaminsky LS , ZhangZY: Human P450 metabolism of warfarin.Pharmacol. Ther.73(1) , 67–74 (1997).
  • Kirchheiner J , BrockmollerJ: Clinical consequences of cytochrome P450 2C9 polymorphisms.Clin. Pharmacol. Ther.77(1) , 1–16 (2005).
  • Haining RL , HunterAP, VeroneseME, TragerWF, RettieAE: Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.Arch. Biochem. Biophys.333(2) , 447–458 (1996).
  • Sullivan-Klose TH , GhanayemBI, BellDA et al.: The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics6(4) , 341–349 (1996).
  • Kaminsky LS , de Morais SM, Faletto MB, Dunbar DA, Goldstein JA: Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe. Mol Pharmacol.43(2) , 234–239 (1993).
  • Crespi CL , MillerVP: The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH: cytochrome P450 oxidoreductase.Pharmacogenetics7(3) , 203–210 (1997).
  • Margaglione M , ColaizzoD, D‘AndreaG et al.: Genetic modulation of oral anticoagulation with warfarin. Thromb. Haemost.84(5) , 775–778 (2000).
  • Aithal GP , DayCP, KestevenPJ, DalyAK: Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications.Lancet353(9154) , 717–719 (1999).
  • Tabrizi AR , ZehnbauerBA, BoreckiIB, McGrathSD, BuchmanTG, FreemanBD: The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin.J. Am. Coll. Surg.194(3) , 267–273 (2002).
  • Taube J , HalsallD, BaglinT: Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment.Blood96(5) , 1816–1819 (2000).
  • Gage BF , EbyC, MilliganPE, BanetGA, DuncanJR, McLeodHL: Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin.Thromb. Haemost.91(1) , 87–94 (2004).
  • Rieder MJ , ReinerAP, GageBF et al.: Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N. Engl. J. Med.352(22) , 2285–2293 (2005).
  • Walker AH , NajarianD, WhiteDL, Jaffe JF, Kanetsky PA, Rebbeck TR: Collection of genomic DNA by buccal swabs for polymerase chain reaction-based biomarker assays. Environ. Health Perspect.107(7) , 517–520 (1999).
  • Barbaux S , KluijtmansLA, Whitehead AS: Accurate and rapid ‘multiplex heteroduplexing‘ method for genotyping key enzymes involved in folate/homocysteine metabolism. Clin. Chem.46(7) , 907–912 (2000).
  • Yasar U , EliassonE, DahlML, Johansson I, Ingelman-Sundberg M, Sjoqvist F: Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population. Biochem. Biophys. Res. Commun.254(3) , 628–631 (1999).
  • Higashi MK , VeenstraDL, KondoLM et al.: Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA287(13) , 1690–1698 (2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.