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Aging Health Volume 2, 2006 - Issue 6
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Perspective

Is Depression Different in Older Adults?

Emma Teper1 Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK Tel.: +44 191 445 5212; Fax: +44 191 403 6685; E-mail: [email protected]
&
Alan Thomas1 Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK Tel.: +44 191 445 5212; Fax: +44 191 403 6685; E-mail: [email protected]
Pages 905-915 | Published online: 14 Dec 2006

Bibliography

  • Simon G : Collaborative care for depression.BMJ332, 250–251(2006).
  • Snowdon J : The prevalence of depression in old age.Int. J. Geriatr. Psychiatry5, 141–144(1990).
  • Beekman A , CopelandJ, PrinceM: Review of Community prevalence of depression in later life.Br. J. Psychiatry174, 207–311(1999).
  • Bebbington P , DunnG, JenkinsR et al.: The influence of age and sex on the prevalence of depressive conditions: report from the National Survey of Psychiatric Morbidity. Psychol. Med.28, 9–19(1998).
  • Kasper S , de Swart H, Friis Andersen H: Escitalopram in the treatment of depressed elderly patients. Am. J. Geriatr. Pyschiatry.13, 884–891(2005).
  • Baldwin RC : Is there a distinct type of major depression in the elderly?J. Psychopharmacol.8, 177–184(1994).
  • Brodaty H , PetersK, BoycePet al.: Age and depression. J. Affect. Disord.23, 137–149(1991).
  • Brodaty H , LuscombeG, ParkerG et al.: Increased rate of psychosis and psychomotor change in depression with age. Psychol. Med.27, 1205–1213(1997).
  • Baldwin RC , TomensonB: Depression in later life. A comparison of symptoms and risk factors in early and late onset cases.Br. J. Psychiatry167, 649–652(1995).
  • Krishnan KR , HaysJC, TuplerLA, George LK, Blazer DG: Clinical and phenomenological comparisons of late-onset and early-onset depression. Am. J. Psychiatry152, 785–788(1995).
  • Austin MP , MitchellP, GoodwinGM: Cognitive deficits in depression: possible implications for functional neuropathology.Br. J. Psychiatry178, 200–206(2001).
  • Lockwood K , AlexopoulosG, van Gorp W: Executive dysfunction in geriatric depression. Am. J. Psychiatry159, 1119–1123(2002).
  • Jorm AF , van Duijn CM, Chandra V et al.: Psychiatric history and related exposures as risk factors for Alzheimer’s disease: a collaborative re-analysis of case–control studies. EURODEM Risk Factors Research Group. Int. J. Epidemiol.20, S43–S47 (1991).
  • Alexopoulos GS , Meyers,BS, YoungRC, MattisS, KakumaT: The course of geriatric depression with ‘reversible dementia‘: a controlled study.Am. J. Psychiatry150, 1693–1699(1993).
  • Barnes DE , AlexopoulosGS, LopezOL, WilliamsonJD, YaffeK: Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study.Arch. Gen. Psychiatry63, 273–279(2006).
  • O’Brien JT , LloydA, McKeithI, GholkarA, FerrierN: A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects.Am. J. Psychiatry,161, 2081–2090(2004).
  • Steffens DC , OteyE, AlexopoulosGS et al.: Perspectives on depression, mild cognitive impairment and cognitive decline. Arch. Gen. Psychiatry63, 130–138(2006).
  • Hopkinson G : A genetic study of affective illness in patients over 50.Br. J. Psychiatry110, 244–254(1964).
  • Mendlewicz J : The age factor in depressive illness: some genetic considerations.J. Gerontol.31, 300–303(1976).
  • Alexopoulos G : Depression in the elderly.Lancet365, 1961–1970(2005).
  • Steffens DC , SvensonI, MarchukDA et al.: Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression. Am. J. Geriatr. Psychiatry10, 185–192(2002).
  • Blazer DG , BurchettBG, FillenbaumGG: Apo E4 e4 and low cholesterol as risk factors in a biracial elderly community sample.Am. J. Geriatr. Psychiatry10, 515–520(2002).
  • Hickie I , ScottE, NaismithS et al.: Late onset depression: genetic, vascular and clinical contribution. Psychol. Med.31, 1403–1412(2001).
  • Murphy E , SmithR, LindesayJ, SlatteryJ: Increased mortality rates in late-life depression.Br. J. Psychiatry152, 347–353(1988).
  • Emmerson JP , BurvillPW, Finlay-JonesR, HallW: Life events, life difficulties and confiding relationships in the depressed elderly.Br. J. Psychiatry155, 787–792(1989).
  • Prince MJ , HarwoodRH, BlizardRA, ThomasA, MannAH: Social support deficits, loneliness and life events as risk factors for depression in old age. The Gospel Oak Project VI.Psychol. Med.27, 323–332(1997).
  • O’Brien J , AmesD, SchweitzerI: HPA axis function in depression and dementia: a review.Int. J. Geriatr. Psychiatry8, 887–898(1993).
  • Sapolsky RM , PlotskyPM: Hypercortisolism and its possible neural bases.Biol. Psychiatry27, 937–952(1990).
  • Sapolsky RM : Glucocorticoids and hippocampal atrophy in neuropsychiatric disoders.Arch. Gen. Psychiatry57, 925–935(2000).
  • Pohjasvaara T , LeppavuoriA, SiiraI, Vataja R, Kaste M, Erkinjuntti T: Frequency and clinical determinants of poststroke depression. Stroke29, 2311–2317(1998).
  • Ballard C , HolmesC, McKeithI et al: Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer’s disease. Am. J. Psychiatry156, 1039–1045(1999).
  • Ballard C , NeillD, O’BrienJ, McKeithIG, InceP, PerryR: Anxiety, depression and psychosis in vascular dementia: prevalence and associations.J. Affect. Disord.59, 97–106(2000).
  • Cummings JL : Depression and Parkinson’s disease: a review.Am. J. Psychiatry149, 443–454(1992).
  • Frasure-Smith N , LesperanceF, TalajicM: Depression following myocardial infarction. Impact on 6-month survival.JAMA270, 1819–1825(1993).
  • Hance M , CarneyRM, FreedlandKE, Skala J: Depression in patients with coronary heart disease. A 12-month follow-up. Gen. Hosp. Psychiatry18, 61–65(1996).
  • Hippisley-Cox J , FieldingK, PringleM: Depression as a risk factor for ischaemic heart disease in men: population based case–control study.BMJ316, 1714–1719(1998).
  • Pratt LA , FordDE, CrumRM, Armenian HK, Gallo JJ, Eaton WW: Depression, psychotropic medication, and risk of myocardial infarction. Prospective data from the Baltimore ECA follow-up. Circulation94, 3123–3129(1996).
  • Ford DE , MeadLA, ChangPP, Cooper-PatrickL, WangNY, KlagMJ: Depression is a risk factor for coronary artery disease in men: the precursors study.Arch. Intern. Med.158, 1422–1426(1998).
  • Ariyo AA , HaanM, TangenCMet al.: Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Cardiovascular Health Study Collaborative Research Group. Circulation102, 1773–1779(2000).
  • Penninx BW , GeerlingsSW, DeegDJ, van EijkJT, van Tilburg W, Beekman AT: Minor and major depression and the risk of death in older persons. Arch. Gen. Psychiatry56, 889–895(1999).
  • Frasure-Smith N , LesperanceF, TalajicM: Depression and 18-month prognosis after myocardial infarction.Circulation91, 999–1005(1995).
  • Goodyer I (Ed.): Unipolar depression, a lifespan perspective. Oxford University Press, Oxford, UK, 151–155(2003).
  • Breslau N , PetersonEL, SchultzLR, ChilcoatHD, AndreskiP: Major depression and stages of smoking. A longitudinal investigation.Arch. Gen. Psychiatry55, 161–166(1998).
  • Musselman DL , TomerA, ManatungaAKet al.: Exaggerated platelet reactivity in major depression. Am. J. Psychiatry153, 1313–1317(1996).
  • Laghrissi-Thode F , WagnerWR, Pollock BG, Johnson PC, Finkel MS: Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease. Biol. Psychiatry42, 290–295(1997).
  • Connor TJ , LeonardBE: Depression, stress and immunological activation: the role of cytokines in depressive disorders.Life Sciences62, 583–606(1998).
  • Musselman DL , EvansDL, NemeroffCB: The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment.Arch. Gen. Psychiatry55, 580–592(1998).
  • Carney RM , SaundersRD, FreedlandKE, SteinP, RichMW, JaffeAS: Association of depression with reduced heart rate variability in coronary artery disease.Am. J. Cardiology76, 562–564(1995).
  • Sauer WH , MandaniMM, WellsPS, WilliamsSE: Selective serotonin reuptake inhibitors and myocardial infarction.Circulation104, 1894–1898(2001).
  • Glassman AH , O’ConnorCM, CaliffRM et al.: Sertraline treatment of major depression in patients with acute MI or unstable angina JAMA288, 701–709(2002).
  • Taylor CB , YoungbloodME, CatellierD et al.: Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch. Gen. Psychiatry62, 792–798(2005).
  • Robinson RG , StarrLB, KubosKL, Price TR:A two-year longitudinal study of post-stroke mood disorders: findings during the initial evaluation. Stroke14, 736–741(1983).
  • Morris PL , RobinsonRG, RaphaelB: Prevalence and course of depressive disorders in hospitalized stroke patients.Int. J. Psychiatry Med.20, 349–364(1990).
  • House A , DennisM, MogridgeL, Warlow C, Hawton K, Jones L: Mood disorders in the year after first stroke. Br. J. Psychiatry158, 83–92(1991).
  • Andersen G , VestergaardK, RiisJ, Lauritzen L: Incidence of post-stroke depression during the first year in a large unselected stroke population determined using a valid standardized rating scale. Acta Psychiatr. Scand.90, 190–195(1994).
  • Burvill PW , JohnsonGA, JamrozikKD, AndersonCS, Stewart-WynneEG, Chakera TM: Prevalence of depression after stroke: the Perth Community Stroke Study. Br. J. Psychiatry166, 320–327(1995).
  • House A : Depression associated with stroke.J. Neuropsychiatry Clin. Neurosci.8, 453–457(1996).
  • Rao R : Cerebrovascular disease and late life depression: an age old association revisited.Int. J. Geriatr. Psychiatry15, 419–433(2000).
  • Colantonio A , KasiSV, OstfeldAM: Depressive symptoms and other psychosocial factors as predictors of stroke in the elderly.Am. J. Epidemiol.136, 884–894(1992).
  • Everson SA , RobertsRE, GoldbergDE, KaplanGA: Depressive symptoms and increased risk of stroke mortality over a 29-year period.Arch. Intern. Med.158, 1133–1138(1998).
  • Jonas BS , MussolinoME: Symptoms of depression as a prospective risk factor for stroke.Psychosom. Med.62, 463–471(2000).
  • Simonsick EM , WallaceRB, BlazerDG, BerkmanLF: Depressive symptomatology and hypertension-associated morbidity and mortality in older adults.Psychosom. Med.57, 427–435(1995).
  • Wassertheil-Smoller S , ApplegateWB, Berge K et al: Change in depression as a precursor of cardiovascular events. SHEP Cooperative Research Group (Systolic Hypertension in the elderly). Arch. Intern. Med.156, 553–561(1996).
  • Carson AJ , MacHaleS, AllenKet al.: Depression after stroke and lesion location: a systematic review. Lancet356, 122–126(2000).
  • Robinson RG , SzetelaB: Mood change following left hemispheric brain injury.Ann. Neurol.9, 447–453(1981).
  • MacHale SM , O’RourkeSJ, WardlawJM, DennisMS: Depression and its relation to lesion location after stroke.J. Neurol. Neurosurg. Psychiatr.64, 371–374(1998).
  • Cummings JL , MillerB, HillMA, Neshkes R: Neuropsychiatric aspects of multi-infarct dementia and dementia of the Alzheimer type. Arch. Neurol.44, 389–393(1987).
  • Reding M , HaycoxJ, BlassJ: Depression in patients referred to a dementia clinic. A three-year prospective study.Arch. Neurol.42, 894–896(1985).
  • Reichman WE , CoyneAC: Depressive symptoms in Alzheimer’s disease and multi-infarct dementia.J. Geriatr. Psychiatry Neurol.8, 96–99(1995).
  • Rabkin JG , CharlesE, KassF: Hypertension and DSM-III depression in psychiatric outpatients.Am. J. Psychiatry140, 1072–1074(1983).
  • Paterniti S , Verdier-TailleferMH, Geneste C, Bisserbe JC, Alperovitch A: Low blood pressure and risk of depression in the elderly. A prospective community-based study. Br. J. Psychiatry176, 464–467(2000).
  • Gavard JA , LustmanPJ, ClouseRE: Prevalence of depression in adults with diabetes. An epidemiological evaluation.Diabetes Care16, 1167–1178(1993).
  • Eaton WW , ArmenianH, GalloJ, PrattL, FordDE: Depression and risk for onset of type II diabetes. A prospective population-based study.Diabetes Care19, 1097–1102(1996).
  • Soares JC , MannJJ: The anatomy of mood disorders – review of structural neuroimaging studies.Biol. Psychiatry41, 86–106(1997).
  • Coffey CE , FigielGS, DjangWT, Weiner RD: Subcortical hyperintensity on magnetic resonance imaging: a comparison of normal and depressed elderly subjects. Am. J. Psychiatry147, 187–189(1990).
  • Greenwald BS , Kramer-GinsbergE, KrishnanKR, AshtariM, AuerbachC, Patel M: Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression. Stroke29, 613–617(1998).
  • Greenwald BS , Kramer-GinsbergE, KrishnanRR, AshtariM, AupperlePM, PatelM: MRI signal hyperintensities in geriatric depression.Am. J. Psychiatry153, 1212–1215(1996).
  • O’Brien J , DesmondP, AmesD, Schweitzer I, Harrigan S, Tress B: A magnetic resonance imaging study of white matter lesions in depression and Alzheimer’s disease. Br. J. Psychiatry168, 477–485(1996).
  • Coffey CE , WilkinsonWE, WeinerRDet al.: Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch. Gen. Psychiatry50, 7–16(1993).
  • Steffens DC , HelmsMJ, KrishnanKR, BurkeGL: Cerebrovascular disease and depression symptoms in the cardiovascular health study.Stroke30, 2159–2166(1999).
  • Groot JC , de Leeuw F, Oudkirk M, Hofman A, Jolles J, Breteler MB: Cerebral white matter lesions and depressive symptoms in elderly adults. Arch. Gen. Psychiatry57, 1071–1076(2000).
  • Hickie I , ScottE, MitchellP, WilhelmK, AustinMP, BennettB: Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression.Biol. Psychiatry37, 151–160(1995).
  • Hickie I , ScottE, WilhelmK, BrodatyH: Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression-a longitudinal evaluation.Biol. Psychiatry42, 367–374(1996).
  • Taylor WD , MacFallJR, PayneME et al.: Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am. J. Psychiatry,161, 1293–1296(2004).
  • Awata S , ItoH, KonnoM et al: Regional cerebral blood flow abnormalities in late-life depression: relation to refractoriness and chronification. Psychiatry Clin. Neurosci.52, 97–105(1998).
  • Bench CJ , FristonKJ, BrownRG, FrackowiakRS, DolanRJ: Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions.Psychol. Med.23, 579–590(1993).
  • Halloran E , PrenticeN, MurrayCLet al.: Follow-up study of depression in the elderly. Clinical and SPECT data. Br. J. Psychiatry175, 252–258(1999).
  • Tutus A , SimsekA, SofuogluSet al.: Changes in regional cerebral blood flow demonstrated by single photon emission computed tomography in depressive disorders: comparison of unipolar vs. bipolar subtypes. Psychiatry Res.83, 169–177(1998).
  • Bench CJ , FrackowiakRS, DolanRJ: Changes in regional cerebral blood flow on recovery from depression.Psychol. Med.25, 247–261(1995).
  • Salloway S , MalloyP, KohnR et al.: MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology,46, 1567–1574(1996).
  • Alexopoulos GS , MeyersBS, YoungRC, CampbellS, SilbersweigD, CharlsonM: ’Vascular depression’ hypothesis.Arch. Gen. Psychiatry54, 915–922(1997a).
  • Thomas AJ , FerrierIN, KalariaRNet al.: Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex. Am. J. Psychiatry157, 1682–1684(2000).
  • Thomas AJ , O’BrienJT, DavisS et al.: Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study. Arch. Gen. Psychiatry59, 785–792(2002).
  • Butters MA , WhyteEM, NebesRD et al.: The nature and determinants of neuropsychological functioning in late-life depression. Arch. Gen. Psychiatry61, 587–595(2004).
  • Abas MA , SahakianBJ, LevyR: Neuropsychological deficits and CT scan changes in elderly depressives.Psychol. Med.20, 507–520(1990).
  • Beats BC , SahakianBJ, LevyR: Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed.Psychol. Med.26, 591–603(1996).
  • Dahabra S , AshtonCH, BahrainianMet al.: Structural and functional abnormalities in elderly patients clinically recovered from early- and late-onset depression. Biol. Psychiatry44, 34–46(1998).
  • Starkman MN , GebarskiSS, BerentS, SchteingartDE: Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with cushing’s syndrome.Biol. Psychiatry32, 756–765(1992).
  • Starkman MN , GiordaniB, GebarskiSS, BerentS, SchorkMA, SchteingartDE: Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease.Biol. Psychiatry46, 1595–1602(1999).
  • Simpson S , BaldwinRC, JacksonA, Burns AS: Is subcortical disease associated with a poor response to antidepressants? Neurological, neuropsychological and neuroradiological findings in late-life depression. Psychol. Med.28, 1015–1026(1998).
  • Alexopoulos GS , MeyersBS, YoungRC, KakumaT, SilbersweigD, CharlsonM: Clinically defined vascular depression.Am. J. Psychiatry154, 562–565(1997).
  • O’Brien J , AmesD, SchweitzerI: White matter changes in depression and Alzheimers disease: a review of magnetic resonance imaging studies.Int. J. Geriatr. Psychiatry11, 681–694(1996).
  • Cole MG , BellavanceF, MansourA: Prognosis of depression in elderly community and primary care populations: a systematic review and meta-analysis.Am. J. Psychiatry156, 1182–1189(1999).
  • Cole MG , BellavanceF: Depression in elderly medical inpatients: a meta-analysis of outcomes.CMAJ157, 1055–1060(1997).
  • Cole MG , BellavanceF: The prognosis of depression in old age.Am. J. Geriatr. Psychiatry5, 4–14(1997).
  • Sharma VK , CopelandJR, DeweyME, LoweD, DavidsonI: Outcome of the depressed elderly living in the community in Liverpool: a 5-year follow-up.Psychol. Med.28, 1329–1337(1998).
  • Wilson K , MottramP, SivanranthanA, NightingaleA: Antidepressant versus placebo for depressed elderly.Cochrane Database Syst. Rev.2, CD000561 (2001).
  • Mottram P , WilsonK, StroblJ: Antidepressants for the depressed elderly.Cochrane Database Syst. Rev.1, CD003491 (2006).
  • National Collaborating Centre for Mental Health: Management of depression in primary and secondary care. National Institute for Clinical Excellence, London, UK (2004).
  • Roose SP , SackeimmHA, KrishnanKR et al., Old-Old Depression Study Group: Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial Am. J. Psychiatry,161, 2050–2059(2004).
  • Tew JD Jr., Mulsant BH, Haskett RF et al.: Acute efficacy of ECT in the treatment of major depression in the old-old. Am. J. Psychiatry156, 1865–1870(1999).
  • O’Conner K , KnappR, HusanM et al.: The influence of age on the response of major depression to electroconvulsive therapy. A C.O.R.E report. Am. J. Geriatr. Psychiatry9, 382–390(2001).
  • Reynolds CF , FrankE, KupferDJet al.: Treatment outcome in recurrent major depression: a post hoc comparison of elderly (‘young old’) and midlife patients. Am. J. Psychiatry153, 1288–1292(1996).
  • Reynolds C , DewM, PollockB: Maintenance treatment of major depression in old age.N. Engl. J. Med.354, 1130–1138(2006).
  • Llewellyn-Jones RH , BaikieKA, Smithers H, Cohen J, Snowdon J, Tennant CC: Multifaceted shared care intervention for late life depression in residential care: randomised controlled trial. BMJ319, 676–682(1999).
  • Unutzer J , KatonW, CallahanCM et al., for the IMPACT Investigators: Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial JAMA288, 2836–2845(2002).
  • Sirey JA , BruceML, AlexopoulosGS: The treatment initiation program: an intervention to improve depression outcomes in older adults.Am. J. Psychiatry,162, 184–186(2005).
  • Roose S , SchatzbergA: The efficacy of antidepressants in the treatment of late life depression.J. Clin. Psychopharmacol.25(S1), S1–S7 (2005).
  • O’Brien J , AmesD, ChiuE, SchweitzerI, DesmondP, TressB: Severe deep white matter lesions and outcome in elderly patients with major depressive disorder: follow up study.BMJ317, 982–984(1998).
  • Alexopoulos GS , MeyersBS, YoungRCet al.: Executive dysfunction and long-term outcomes of geriatric depression. Arch. Gen. Psychiatry57, 285–290(2000).
  • Alexopoulos GS , KiossesDN, HeoM, MurphyCF, ShanmughamB, Gunning-DixonF: Executive dysfunction and the course of geriatric depression.Biol. Psychiatry58, 204–210(2005).
  • Butters MA , BhallaRK, MulsantBH et al.: Executive functioning, illness course and relapse/recurrence in the continuation and maintenance of late life depression, is there a relationship? Am. J. Geriatr. Psychiatry12, 387–394(2004).

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