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Review

Impact of Anticholinergics on the Aging Brain: A Review and Practical Application

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Pages 311-320 | Published online: 02 Jun 2008

Bibliography

  • Vangala VR , TuethMJ: Chronic anticholinergic toxicity: identification and management in older patients.Geriatrics358, 36–37(2002).
  • Roe C , AndersonM, SpivackB: Use of anticholinergic medications by older adults with dementia.J. Am. Geriatr. Soc.50, 836–842(2002).
  • Flacker JM , VirginiaC, MachJR, BettinK, KielyDK, WeiJ: The association of serum anticholinergic activity with delirium in elderly medical patients.Am. J. Geriatr. Psychiatry6, 31–41(1998).
  • Blazer DG 2nd, Federspiel CF, Ray WA, Schaffner W: The risk of anticholinergic toxicity in the elderly: a study of prescribing practices in two populations. J. Gerontol.38, 31–35(1983).
  • Mulsant BH , PollockBG, KirshnerM, Shen C, Hiroko D, Ganguli M: Serum anticholinergic activity in a community-based sample of older adults. Arch. Gen. Psychiatry60, 198–203(2003).
  • Tune LE : Anticholinergic effects of medication in elderly patients.J. Clin. Psychiatry62(Suppl. 21), 11–14(2001).
  • Dyer CB , AshtonC, TeasdaleTA: Postoperative delirium: a review of 80 primary data-collection studies.Arch. Intern. Med.155(5), 461–465(1995).
  • American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (4th Edition). American Psychiatric Association, Washington, DC, USA (1994).
  • Boustani M , ButtarA: Delirium. In: Primary Care Geriatrics, a Case-Based Approach (5th Edition). Ham RJ, Sloane PD, Warshaw GA, Bernard MA, Flaherty E (Eds). Chapter 15, 210–218(2007).
  • Boustani M , HamRJ: Alzheimer disease and other dementias. In: Primary Care Geriatrics, a Case-Based Approach (5th Edition). Ham RJ, Sloane PD, Warshaw GA, Bernard MA, Flaherty E (Eds). Chapter 16, 219–236(2007).
  • Boustani M , SchubertC, SennourY: The challenge of supporting care for dementia in primary care.Clin. Interv. Aging2(4), 631–636(2007).
  • Boustani M , PetersonB, HansonLet al.: Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force.Ann. Intern. Med.138(11), 927–937(2003).
  • Boustani M , CallahanCM, UnverzagtFWet al.: Implementing a screening and diagnosis program for dementia in primary care.J. Gen. Intern. Med.20(7), 572–577(2005).
  • Ferri CP , PrinceM, BrayneCet al.: Alzheimer‘s disease international. Global prevalence of dementia: a Delphi consensus study.Lancet366(9503), 2112–2117(2005).
  • The Lewin Group: Saving lives. Saving money: dividends for Americans investing in Alzheimer research. Report of the Lewin Group to the Alzheimer‘s Association (2004).
  • DeKosky ST : Pathology and pathways of Alzheimer‘s disease with an update on new developments in treatment.J. Am. Geriatr. Soc.51(5 Suppl. Dementia), S314–S320 (2003).
  • Terry AV Jr, Buccafusco JJ: The cholinergic hypothesis of age and alzheimer‘s disease-related cognitive deficits: recent challenges and their implications for novel drug development. J. Pharmacol. Exp.Ther.306(3), 821–827(2003).
  • Sivaprakasam K : Towards a unifying hypothesis of Alzheimer‘s disease: cholinergic system linked to plaques, tangles and neuroinflammation.Curr. Med. Chem.13(18), 2179–2188(2006).
  • Cummings JL : Cholinesterase inhibitors: a new class of psychotropic compounds.Am. J. Psych.157(1), 4–15(2000).
  • Sperling R , GreveD, DaleAet al.: Functional MRI detection of pharmacologically induced memory impairment.Proc. Natl Acad. Sci. USA99, 455–460(2002).
  • Flicker C , SerbyM, FerrisSH: Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed.Psychopharmacology (Berl.)100, 243–250(1990).
  • Flicker C , FerrisSH, SerbyM: Hypersensitivity to scopolamine in the elderly.Psychopharmacology (Berl.)107, 437–441(1992).
  • Drachman DA , NoffsingerD, SahakianBJ, KurdzielS, FlemingP: Aging, memory, and the cholinergic system: a study of dichotic listening.Neurobiol. Aging1, 39–43(1980).
  • Chew ML , MusantBH, PollockBG: Serum anticholinergic activity and cognition in patients with moderate-to-severe dementia.Am. J. Geriatr. Psychiatry13, 5354–5538(2005).
  • Shepherd G , Klein-SchwartzW, EdwardsR: Donepezil overdose: a tenfold dosing error.Ann. Pharmacother.33, 812–815(1999).
  • Perry EK , KilfordL, LeesAJ, BurnDJ, PerryRH: Increased Alzheimer pathology in Parkinson‘s disease related to antimuscarinic drugs.Ann. Neurol.54, 235–238(2003).
  • Rudd KM , RaehlCL, BondCA, Abbruscato TJ, Stenhouse AC: Methods for assessing drug-related anticholinergic activity. Pharmacotherapy25, 1592–1601(2005).
  • Tollefson GD , Montague-ClouseJ: The relationship of serum anticholinergic activity to mental status performance in an elderly nursing home population.J. Neuropsychiatry Clin. Neurosci.3(3), 314–319(1991).
  • Tune L , CarrS, HoagE, CooperT: Anticholinergic effects of drugs commonly prescribed for the elderly: potential means for assessing risk of delirium.Am. J. Psychiatry149, 1393–1394(1992).
  • Schubert CC , BoustaniM, CallahanCMet al.: Comorbidity profile of dementia patients in primary care: are they sicker? J. Am. Geriatr. Soc.54(1), 104–109(2006).
  • Ancellin ML , ArteroS, PortetF, DupuyAM, TouchonJ, RithieK: Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study.Br. Med. J.332(7539), 455–459(2006).
  • Carnahan RM , LundBC, PerryPJ, Pollock BG, Culp KR: The anticholinergic drug scale as a measure of drug-related anticholinergic burden: association with serum anticholinergic activity. J. Clin. Pharmacol.46, 1481–1486(2006).
  • Tune L , CoyleJT: Serum levels of anticholinergic drugs in treatment of acute extrapyramidal side effects.Arch. Gen. Psychiatry37, 293–297(1980).
  • Moore AR , O‘KeeffeST: Drug-induced cognitive impairment in the elderly.Drugs Aging15, 15–28(1999).
  • Francis J : A half-century of delirium research: time to close the gap.J. Am. Geriatr. Soc.43, 585–586(1995).
  • Han L , McCuskerJ, ColeM, AbrahamowiczM, PrimeauF, ElieM: Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients.Arch. Intern. Med.161, 1099–1105(2001).
  • Fick DM , CooperJW, WadeWE, WallerJL, MacleanJR, BeersMH: Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts.Arch. Intern. Med.163, 2716–2724(2003).
  • Feinberg M : The problems of anticholinergic adverse effects in older patients.Drugs Aging3, 335–348(1993).
  • Basu R , DodgeH, StoehrGP, GanguliM: Sedative–hypnotic use of diphenhydramine in a rural, older adult, community-based cohort: effects on cognition.Am. J. Geriatr. Psychiatry11, 205–213(2003).
  • Tune L , CoyleJT: Acute extrapyramidal side effects: serum levels of neuroleptics and anticholinergics.Psychopharmacology75, 9–15(1981).
  • Boustani MA , LimbilT, CampbellN, Fox C, Maidment I: Anticholinergic burden: measurement and impact. J. Am. Geriatr. Soc.55, S52 (2007).
  • Bottigi KA , SalazarJC, YuLet al.: Long-term cognitive impact of anticholinergic medications in older adults.Am. J. Geriatr. Psychiatry14(11), 980–984(2006).
  • Lim CJ , TrevinoC, TampiRR: Can olanzapine cause delirium in the elderly?Ann. Pharmacother.40, 135–138(2006).
  • deLion J : Letter to the editor. Benztropine equivalents for antimuscarinic medication.Am. J. Psychiatry162, 627 (2005).
  • Rudolph JL , SallowMJ, AngeliniMC, McGlincheyRE: The anticholinergic risk scale and anticholinergic adverse effects in older adults.Arch. Intern. Med.168, 508–513(2008).

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