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Future Virology Volume 2, 2007 - Issue 6
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Review

Novel and Unexpected Role for the Tumor Suppressor ARF in Viral Infection Surveillance

Maria Angel Garciaa Centro Nacional de Biotecnología CSIC,Campus Universidad Autónoma,Madrid28049,Spain. Tel.: +34 915 854 560; Fax: +34 915 854 506; [email protected]
,
Cesar Muñoz-Fontelab Mount Sinai School of Medicine,Dept of Oncological Sciences,One Gustave L. Levy Place. Box 1130,NY10029,USA. Tel.: +1 212 659 5578; Fax: +1 212 987 2240; [email protected]
,
Manuel Colladoc Spanish National Cancer Centre (CNIO),3 Melchor Fernández Almagro,Madrid28029,Spain. Tel.: +34 917 328 036; Fax: +34 917 328 028; [email protected]
,
Laura Marcos-Villard Universidad Complutense de Madrid,Departamento de Microbiología II,Plaza Ramón y Cajal s/n,Madrid28040,Spain. Tel.: +34 913 941 746; Fax: +34 913 941 745; [email protected]
,
Mariano Estebane Centro Nacional de Biotecnología,CSIC,Campus Universidad Autónoma,Madrid28049,Spain. Tel.: +34 915 854 560; Fax: +34 915 854 506; [email protected]
&
Carmen RivasCorrespondence[email protected]
Pages 625-629 | Published online: 31 Oct 2007

Bibliography

  • Garcia MA , GilJ, VentosoIet al.: Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol. Mol. Biol. Rev.70, 1032–1060 (2006).
  • Regad T , Chelbi-AlixMK: Role and fate of PML nuclear bodies in response to interferon and viral infections.Oncogene20, 7274–7286 (2001).
  • Bernardi R , PandolfiPP: Role of PML and the PML-nuclear body in the control of programmed cell death.Oncogene22, 9048–9057 (2003).
  • Munoz-Fontela C , Angel GarciaM, Garcia-CaoIet al.: Resistance to viral infection of super p53 mice. Oncogene24, 3059–3062 (2005).
  • Takaoka A , HayakawaS, YanaiHet al.: Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature424, 516–523 (2003).
  • Munoz-Fontela C , GarciaMA, ColladoMet al.: Control of virus infection by tumour suppressors. Carcinogenesis28, 1140–1144 (2007).
  • Chelbi-Alix MK , PelicanoL, QuignonFet al.: Induction of the PML protein by interferons in normal and APL cells. Leukemia9, 2027–2033 (1995).
  • Johnson JA , HochkeppelHK, GangemiJD: IFN-tau exhibits potent suppression of human papillomavirus E6/E7 oncoprotein expression.J. Interferon Cytokine Res.19, 1107–1116 (1999).
  • Stadler M , Chelbi-AlixMK, KokenMHet al.: Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene11, 2565–2573 (1995).
  • Ruas M , PetersG: The p16INK4a/ CDKN2A tumor suppressor and its relatives.Biochim. Biophys. Acta1378, F115–F177 (1998).
  • Sharpless NE , DePinhoRA: The INK4A/ARF locus and its two gene products.Curr. Opin. Genet. Dev.9, 22–30 (1999).
  • Serrano M , HannonGJ, BeachD: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.Nature366, 704–707 (1993).
  • Quelle DE , AshmunRA, HannonGJet al.: Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene11, 635–645 (1995).
  • Stott FJ , BatesS, JamesMCet al.: The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J.17, 5001–5014 (1998).
  • Pomerantz J , Schreiber-AgusN, LiegeoisNJet al.: The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2s inhibition of p53. Cell92, 713–723 (1998).
  • Zhang Y , XiongY, YarbroughWG: ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.Cell92, 725–734 (1998).
  • Kamijo T , WeberJD, ZambettiGet al.: Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl Acad. Sci. USA95, 8292–8297 (1998).
  • Sherr CJ : Tumor surveillance via the ARF–p53 pathway.Genes Dev.12, 2984–2991 (1998).
  • Sherr CJ : Divorcing ARF and p53: an unsettled case.Nat. Rev. Cancer6, 663–673 (2006).
  • Zindy F , EischenCM, RandleDHet al.: Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev.12, 2424–2433 (1998).
  • de Stanchina E , McCurrachME, ZindyFet al.: E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev.12, 2434–2442 (1998).
  • Radfar A , UnnikrishnanI, LeeHWet al.: p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. Proc. Natl Acad. Sci. USA95, 13194–13199 (1998).
  • Bates S , PhillipsAC, ClarkPAet al.: p14ARF links the tumour suppressors RB and p53. Nature395, 124–125 (1998).
  • Kamijo T , ZindyF, RousselMFet al.: Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell91, 649–659 (1997).
  • Sandoval R , XueJ, PilkintonMet al.: Different requirements for the cytostatic and apoptotic effects of type I interferons. Induction of apoptosis requires ARF but not p53 in osteosarcoma cell lines. J. Biol. Chem.279, 32275–32280 (2004).
  • Kashuba E , MattsonK, PokrovskajaKet al.: EBV-encoded ENBA-5 associates with p14ARF in extranucleolar inclusions and prolongs the survival of p14ARF-expressing cells.Int. J. Cancer105, 644–653 (2003).
  • Ries SJ , BrandtsCH, ChungASet al.: Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).Nat. Med.6, 1128–1133 (2000).
  • Yang CT , YouL, UematsuKet al.: p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53. Cancer Res.61, 5959–5963 (2001).
  • Garcia MA , ColladoM, Munoz-FontelaCet al.: Antiviral action of the tumor suppressor ARF. EMBO J.25, 4284–4292 (2006).
  • Pollice A , NastiV, RoncaRet al.: Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1. J. Biol. Chem.279, 6345–6353 (2004).
  • Lomax M , FriedM: Polyomavirus disrupts ARF signaling to p53.Oncogene20, 4951–4960 (2001).
  • Lowe SW , RuleyHE: Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.Genes Dev.7, 535–545 (1993).
  • Bertwistle D , SugimotoM, SherrCJ: Physical and functional interactions of the ARF tumor suppressor protein with nucleophosmin/B23.Mol. Cell Biol.24, 985–996 (2004).
  • Brady SN , YuY, MaggiLBet al.: ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol. Cell Biol.24, 9327–9338 (2004).
  • Itahana K , BhatKP, JinAet al.: Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol. Cell12, 1151–1164 (2003).
  • Korgaonkar C , HagenJ, TompkinsVet al.: Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol. Cell Biol.25, 1258–1271 (2005).
  • Hiscox JA : The nucleolus–a gateway to viral infection?Arch. Virol.147, 1077–1089 (2002).
  • Okuwaki M , IwamatsuA, TsujimotoMet al.: Identification of nucleophosmin/B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins. J. Mol. Biol.311, 41–55 (2001).
  • Pang Q , ChristiansonTA, KoretskyTet al.: Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR. J. Biol. Chem.278, 41709–41717 (2003).
  • Carnero A , HudsonJD, PriceCMet al.: p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Nat. Cell Biol.2, 148–155 (2000).
  • Eischen CM , WeberJD, RousselMFet al.: Disruption of the ARF–Mdm2–p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev.13, 2658–2669 (1999).
  • Weber JD , JeffersJR, RehgJEet al.: p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev.14, 2358–2365 (2000).
  • Moore L , VenkatachalamS, VogelHet al.: Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis. Oncogene22, 7831–7837 (2003).
  • Sugimoto M , KuoML, RousselMFet al.: Nucleolar ARF tumor suppressor inhibits ribosomal RNA processing. Mol. Cell11, 415–424 (2003).
  • Ayrault O , AndriqueL, LarsenCJet al.: Human ARF tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes. Oncogene23, 8097–8104 (2004).
  • Kuo ML , DuncavageEJ, MathewRet al.: ARF induces p53-dependent and -independent antiproliferative genes. Cancer Res.63, 1046–1053 (2003).
  • Martelli F , HamiltonT, SilverDPet al.: p19ARF targets certain E2F species for degradation.Proc. Natl Acad. Sci. USA98, 4455–4460 (2001).
  • Eymin B , KarayanL, SeitePet al.: Human ARF binds E2F1 and inhibits its transcriptional activity.Oncogene20, 1033–1041 (2001).
  • Datta A , NagA, RaychaudhuriP: Differential regulation of E2F1, DP1, and the E2F1/DP1 complex by ARF.Mol. Cell Biol.22, 8398–8408 (2002).
  • Aslanian A , IaquintaPJ, VeronaRet al.: Repression of the ARF tumor suppressor by E2F3 is required for normal cell cycle kinetics.Genes Dev.18, 1413–1422 (2004).
  • Qi Y , GregoryMA, LiZet al.: p19ARF directly and differentially controls the functions of c-Myc independently of p53.Nature431, 712–717 (2004).
  • Datta A , NagA, PanWet al.: Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.J. Biol. Chem.279, 36698–36707 (2004).
  • Rocha S , CampbellKJ, PerkinsND: p53- and Mdm2-independent repression of NF-κB transactivation by the ARF tumor suppressor.Mol. Cell12, 15–25 (2003).
  • Tago K , ChioccaS, SherrCJ: Sumoylation induced by the Arf tumor suppressor: a p53-independent function.Proc. Natl Acad. Sci. USA102, 7689–7694 (2005).

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