113
Views
0
CrossRef citations to date
0
Altmetric
Review

The Influenza Matrix Protein 2 as a Vaccine Target

Pages 167-178 | Published online: 29 Feb 2008

Bibliography

  • Wood JM , RobertsonJS: Reference viruses for seasonal and pandemic influenza vaccine preparation.Influenza Other Respir. Viruses1(1) , 5–9 (2007).
  • Min Jou W , VerhoeyenM, DevosR et al.: Complete structure of the hemagglutinin gene from the human influenza a/victoria/3/75 (H3N2) strain as determined from cloned DNA. Cell19(3) , 683–696 (1980).
  • Russell CJ , WebsterRG: The genesis of a pandemic influenza virus.Cell123(3) , 368–371 (2005).
  • Verhoeyen M , FangR, JouWM et al.: Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/aichi/2/68 and A/victoria/3/75. Nature286(5775) , 771–776 (1980).
  • Smith DJ , LapedesAS, de Jong JC et al.: Mapping the antigenic and genetic evolution of influenza virus. Science305(5682) , 371–376 (2004).
  • Treanor JD : Influenza – the goal of control.N. Engl. J. Med.357(14) , 1439–1441 (2007).
  • Nichol KL , TreanorJJ: Vaccines for seasonal and pandemic influenza.J. Infect. Dis.194(Suppl.) , 2S111–2S118 (2006).
  • Jefferson T , RivettiD, RivettiA et al.: Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet366(9492) , 1165–1174 (2005).
  • Jefferson T : Influenza vaccination: policy versus evidence.Br. Med. J.333(7574) , 912–915 (2006).
  • Nicholson KG , WoodJM, ZambonM: Influenza.Lancet362(9397) , 1733–1745 (2003).
  • Fouchier RA , MunsterV, WallenstenA et al.: Characterization of a novel Influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J. Virol.79(5) , 2814–2822 (2005).
  • Guan Y , PoonLL, CheungCY et al.: H5N1 influenza: a protean pandemic threat. Proc. Natl Acad. Sci. USA101(21) , 8156–8161 (2004).
  • Fang R , Min Jou W, Huylebroeck D et al.: Complete structure of A/duck/ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin. Cell25(2) , 315–323 (1981).
  • Gething MJ , ByeJ, SkehelJ et al.: Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus. Nature287(5780) , 301–306 (1980).
  • Scholtissek C , RohdeW, Von Hoyningen V et al.: On the origin of the human influenza virus subtypes H2N2 and H3N2. Virology87(1) , 13–20 (1978).
  • Taubenberger JK , ReidAH, LourensRM et al.: Characterization of the 1918 influenza virus polymerase genes. Nature437(7060) , 889–893 (2005).
  • Leroux-Roels I , BorkowskiA, VanwolleghemT et al.: Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial. Lancet370(9587) , 580–589 (2007).
  • Gerhard W , MozdzanowskaK, ZharikovaD: Prospects for universal influenza virus vaccine.Emerg. Infect. Dis.12(4) , 569–574 (2006).
  • Sakaguchi T , TuQ, PintoLH et al.: The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer. Proc. Natl Acad. Sci. USA94(10) , 5000–5005 (1997).
  • Venkataraman P , LambRA, PintoLH: Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of Influenza A virus.J. Biol. Chem.280(22) , 21463–21472 (2005).
  • Lamb RA , ZebedeeSL, RichardsonCD: Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface.Cell40(3) , 627–633 (1985).
  • Takeuchi K , LambRA: Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport.J. Virol.68(2) , 911–919 (1994).
  • Takeuchi K , ShaughnessyMA, LambRA: Influenza virus M2 protein ion channel activity is not required to maintain the equine-1 hemagglutinin in its native form in infected cells.Virology202(2) , 1007–1011 (1994).
  • Ciampor F , BayleyPM, NermutMV et al.: Evidence that the amantadine-induced, M2-mediated conversion of Influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment. Virology188(1) , 14–24 (1992).
  • Ohuchi M , CramerA, VeyM et al.: R escue of vector-expressed fowl plague virus hemagglutinin in biologically active form by acidotropic agents and coexpressed M2 protein. J. Virol.68(2) , 920–926 (1994).
  • Wang C , TakeuchiK, PintoLH et al.: Ion channel activity of Influenza A virus M2 protein: characterization of the amantadine block. J. Virol.67(9) , 5585–5594 (1993).
  • Simonsen L , ViboudC, GrenfellBT et al.: The genesis and spread of reassortment human Influenza A/H3N2 viruses conferring adamantane resistance. Mol. Biol. Evol.24(8) , 1811–1820 (2007).
  • Bright RA , MedinaMJ, XuX et al.: Incidence of adamantane resistance among Influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet366(9492) , 1175–1181 (2005).
  • Tobler K , KellyML, PintoLH et al.: Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of Influenza A virus. J. Virol.73(12) , 9695–9701 (1999).
  • McCown MF , PekoszA: The Influenza A virus M2 cytoplasmic tail is required for infectious virus production and efficient genome packaging.J. Virol.79(6) , 3595–3605 (2005).
  • Iwatsuki-Horimoto K , HorimotoT, NodaT et al.: The cytoplasmic tail of the Influenza A virus M2 protein plays a role in viral assembly. J. Virol.80(11) , 5233–5240 (2006).
  • Sharp PM : Origins of human virus diversity.Cell108(3) , 305–312 (2002).
  • Black RA , RotaPA, GorodkovaN et al.: Antibody response to the M2 protein of Influenza A virus expressed in insect cells. J. Gen. Virol.74(Pt 1) , 143–146 (1993).
  • Feng J , ZhangM, MozdzanowskaK et al.: Influenza A virus infection engenders a poor antibody response against the ectodomain of matrix protein 2. Virol. J.3 , 102 (2006).
  • Kitikoon P , StraitEL, ThackerEL: The antibody responses to swine influenza virus (SIV) recombinant matrix 1 (rM1), matrix 2 (M2), and hemagglutinin (HA) proteins in pigs with different SIV exposure.Vet. Microbiol.126(1-3) , 51–62 (2007).
  • Liu W , LiH, ChenYH: N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication.FEMS Immunol. Med. Microbiol.35(2) , 141–146 (2003).
  • Mozdzanowska K , FengJ, EidM et al.: Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2. Vaccine21(19–20) , 2616–2626 (2003).
  • Bui HH , PetersB, AssarssonE et al.: Ab and T cell epitopes of Influenza A virus, knowledge and opportunities. Proc. Natl Acad. Sci. USA104(1) , 246–251 (2007).
  • Jameson J , CruzJ, EnnisFA: Human cytotoxic T-lymphocyte repertoire to Influenza A viruses.J. Virol.72(11) , 8682–8689 (1998).
  • Jameson J , CruzJ, TerajimaM et al.: Human CC8+ and CD4+ T lymphocyte memory to Influenza A viruses of swine and avian species. J. Immunol.162(12) , 7578–7583 (1999).
  • Park EK , CastrucciMR, PortnerA et al.: The M2 ectodomain is important for its incorporation into Influenza A virions. J. Virol.72(3) , 2449–2455 (1998).
  • Kovacova A , Ruttkay-NedeckyG, Haverlik IK et al.: Sequence similarities and evolutionary relationships of influenza virus A hemagglutinins. Virus Genes24(1) , 57–63 (2002).
  • Zebedee SL , LambRA: Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions.J. Virol.62(8) , 2762–2772 (1988).
  • Hughey PG , RobertsPC, HolsingerLJ et al.: Effects of antibody to the Influenza A virus M2 protein on M2 surface expression and virus assembly. Virology212(2) , 411–421 (1995).
  • Treanor JJ , TierneyEL, ZebedeeSL et al.: Passively transferred monoclonal antibody to the M2 protein inhibits Influenza A virus replication in mice. J. Virol.64(3) , 1375–1377 (1990).
  • Slepushkin VA , KatzJM, BlackRA et al.: Protection of mice against Influenza A virus challenge by vaccination with baculovirus-expressed M2 protein. Vaccine13(15) , 1399–1402 (1995).
  • Neirynck S , DerooT, SaelensX et al.: A universal Influenza A vaccine based on the extracellular domain of the M2 protein. Nat. Med.5(10) , 1157–1163 (1999).
  • Noad R , RoyP: Virus-like particles as immunogens.Trends Microbiol.11(9) , 438–444 (2003).
  • De Filette M , Min Jou W, Birkett A et al.: Universal Influenza A vaccine: optimization of M2-based constructs. Virology337(1) , 149–161 (2005).
  • Eriksson AM , SchonKM, LyckeNY: The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues.J. Immunol.173(5) , 3310–3319 (2004).
  • De Filette M , FiersW, MartensW et al.: Improved design and intranasal delivery of an M2e-based human Influenza A vaccine. Vaccine24(44–46) , 6597–6601 (2006).
  • De Filette M , RamneA, BirkettA et al.: The universal influenza vaccine M2e–HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection. Vaccine24(5) , 544–551 (2006).
  • Frace AM , KlimovAI, RoweT et al.: Modified M2 proteins produce heterotypic immunity against Influenza A virus. Vaccine17(18) , 2237–2244 (1999).
  • Jegerlehner A , TissotA, LechnerF et al.: A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses. Vaccine20(25–26) , 3104–3112 (2002).
  • Liu W , PengZ, LiuZ et al.: High epitope density in a single recombinant protein molecule of the extracellular domain of Influenza A virus M2 protein significantly enhances protective immunity. Vaccine23(3) , 366–371 (2004).
  • Ernst WA , KimHJ, TumpeyTM et al.: Protection against H1, H5, H6 and H9 Influenza A infection with liposomal matrix 2 epitope vaccines. Vaccine24(24) , 5158–5168 (2006).
  • Fan J , LiangX, HortonMS et al.: Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys. Vaccine22(23–24) , 2993–3003 (2004).
  • Tompkins SM , ZhaoZS, LoCY et al.: Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1. Emerg. Infect. Dis.13(3) , 426–435 (2007).
  • Brown EG , LiuH, KitLC et al.: Pattern of mutation in the genome of Influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes. Proc. Natl Acad. Sci. USA98(12) , 6883–6888 (2001).
  • Heinen PP , RijsewijkFA, de Boer-Luijtze EA et al.: Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge with Influenza A virus. J. Gen. Virol.83(Pt 8) , 1851–1859 (2002).
  • Jegerlehner A , SchmitzN, StorniT et al.: Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity. J. Immunol.172(9) , 5598–5605 (2004).
  • Zebedee SL , LambRA: Growth restriction of Influenza A virus by M2 protein antibody is genetically linked to the M1 protein.Proc. Natl Acad. Sci. USA86(3) , 1061–1065 (1989).
  • Zharikova D , MozdzanowskaK, FengJ et al.: Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2. J. Virol.79(11) , 6644–6654 (2005).
  • Nishimura K , KimS, ZhangL et al.: The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR. Biochemistry41(44) , 13170–13177 (2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.