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Editorial

Are adipocytes nutritive or attractive for lymphocytes?

Pages 673-676 | Published online: 18 Jan 2017

  • Caspar-Bauguil S, Cousin B, André M et al.: Weight-dependent changes of immune system in adipose tissue: importance of leptin. Exp. Cell Res. 312, 2195-2202 (2006).
  • Wood S, Trayhurn P: Adipokines and the signaling role of adipose tissue in inflammation and obesity. Future Lipidol. 1, 81-89 (2006). o List of adipose tissue products that act as inflammatory mediators.
  • Lord GM, Matarese G, Howard JK et al.: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897-901 (1998).
  • Lord GM: Leptin as a proinflammatory cytokine. Contrib. Nephrol. 151, 151-164 (2006).
  • Wellen KE, Hotamisligil GS: Inflammation, stress, and diabetes. J. Clin. Invest. 115, 1111-1119 (2005). oo Review reporting how metabolism and immunity are closely linked. Accumulating evidence for endoplasmic reticulum stress in adipocytes and macrophages during inflammation and insulin resistance 6. Cousin B, Munoz O, André M et al.: A role for preadipocytes as macrophagelike cells. FASEB J. 13, 305-312 (1999).
  • Weisberg S, McCann D, Desai M et al.: Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808 (2003).
  • Cinti S, Mitchell G, Barbatelli G et al.: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46, 2347-2355 (2005). o Excellent visualization by light and electron microscopy of the macrophages surrounding hypertrophic or degenerating adipocytes.
  • Xu H, Barnes GT, Yang Q et al.: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830 (2003). o Pioneering demonstration of macrophage infiltration in adipose tissue of murine models of obesity, mainly by gene expression profiling.
  • Cancello R, Hengar C, Viguerie N et al.: Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obeses subjects after surgery-induced weight loss. Diabetes 54, 2277-2286 (2005).
  • Bouloumié A, Curat CA, Sengenés C et al.: Role of macrophage tissue infiltration in metabolic diseases. Curr. Opin. Clin. Nutr. Metab. Care 8, 347-354 (2005). o Comprehensive review on the role of macrophages in the growth of the fat mass and in the obesity-associated pathologies.
  • Pond CM: Adipose tissue and the immune system. Prostaglandins Leukot. Essent. Fatty Acids 73, 17-30 (2005).
  • Pond CM: Paracrine relationships between adipose and lymphoid tissues: implications for the mechanism of HIV-associated adipose redistribution syndrome. Trends Immunol. 24, 13-18 (2003). o Role of adipocytes in supplying immune cells with precursors of lipid mediators.
  • Sbarbati A, Osculati F, Silvagni D et al.: Obesity and inflammation: evidence for an elementary lesion. Pediatrics 117, 220-223 (2006).
  • Palming J, Gabrielsson BG, Jennische E et al.: Plasma cells and Fc receptors in human adipose tissue - lipogenic and antiinflammatory effects of immunoglobulins on adipocytes. Biochem. Biophys. Res. Comm. 343, 43-48 (2006).
  • Caspar-Bauguil S, Cousin B, Galinier A et al.: Adipose tissues as ancestral immune organ: site-specific change in obesity. FEBS Lett. 579, 3487-3492 (2005).

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