Role of stearoyl-CoA desaturase in human metabolic disease

Bibliography

• Zivkovic AM, German JB, Sanyal AJ: Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am. J. Clin. Nutr. 86, 285–300 (2007)
   Google Scholar
• Isomaa B: A major health hazard: the metabolic syndrome. Life Sci. 73, 2395–2411 (2003)
   Google Scholar
• Grundy SM: Metabolic syndrome: a multiplex cardiovascular risk factor. J. Clin. Endocrinol. Metab. 92, 399–404 (2007)
   Google Scholar
• Sampath H, Ntambi JM: The fate and intermediary metabolism of stearic acid. Lipids 40, 1187–1191 (2005)
   Google Scholar
• Sampath H, Ntambi JM: Stearoylcoenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor- : independent and interactive roles in the regulation of lipid metabolism. Curr. Opin. Clin. Nutr. Metab. Care 9, 84–88 (2006).
   Google Scholar
• Concise review of the regulation of stearoyl-CoA desaturase (SCD) by the lipogenic transcription factor, sterol regulatory element binding protein-1c (SREBP-1c) and the potential role of SCD, SREBP-1c and PPAR-in lipid metabolism.
   Google Scholar
• Man WC, Miyazaki M, Chu K, Ntambi JM: Membrane topology of mouse stearoyl-CoA desaturase 1. J. Biol. Chem. 281, 1251–1260 (2006)
   Google Scholar
• Dobrzyn A, Ntambi JM: The role of stearoyl-CoA desaturase in the control of metabolism. Prostaglandins Leukot. Essent. Fatty Acids 73, 35–41 (2005).
   Google Scholar
• Comprehensive review of current understanding of the role of murine SCD in regulating whole body metabolism.
   Google Scholar
• Rudel LL, Haines J, Sawyer JK, Shah R, Wilson MS, Carr TP: Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat. J. Clin. Invest. 100, 74–83 (1997)
   Google Scholar
• Bell TA 3rd, Wilson MD, Kelley K, Sawyer JK, Rudel LL: Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice. J. Lipid Res. 48, 1122–1131 (2007)
   Google Scholar
• Ntambi JM, Miyazaki M, Dobrzyn A: Regulation of stearoyl-CoA desaturase expression. Lipids 39, 1061–1065 (2004)
   Google Scholar
• Miyazaki M, Ntambi JM: Role of stearoyl-coenzyme A desaturase in lipid metabolism. Prostaglandins Leukot. Essent. Fatty Acids 68, 113–121 (2003)
   Google Scholar
• Miyazaki M, Kim YC, Ntambi JM: A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res. 42, 1018–1024 (2001)
   Google Scholar
• Miyazaki M, Kim YC, Gray-Keller MP, Attie AD, Ntambi JM: The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J. Biol. Chem. 275, 30132–30138 (2000)
   Google Scholar
• Miyazaki M, Dobrzyn A, Man WC et al.: Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1cdependent and -independent mechanisms. J. Biol. Chem. 279, 25164–25171 (2004)
   Google Scholar
• Miyazaki M, Dobrzyn A, Elias PM, Ntambi JM: Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc. Natl Acad. Sci. USA 102, 12501–12506 (2005)
   Google Scholar
• Miyazaki M, Bruggink SM, Ntambi JM: Identification of mouse palmitoylcoenzyme A 9-desaturase. J. Lipid Res. 47, 700–704 (2006)
   Google Scholar
• Miyazaki M, Jacobson MJ, Man WC et al.: Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J. Biol. Chem. 278, 33904–33911 (2003)
   Google Scholar
• Sampath H, Ntambi JM: Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu. Rev. Nutr. 25, 317–340 (2005).
   Google Scholar
• Detailed review of regulators of gene transcription including the nuclear factors PPAR and liver X receptor and the lipogenic transcription factor SREBP-1c.
   Google Scholar
• Dobrzyn A, Dobrzyn P, Lee SH et al.: Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing -oxidation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 288, E599–E607 (2005)
   Google Scholar
• Ntambi JM, Miyazaki M, Stoehr JP et al.: Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl Acad. Sci. USA 99, 11482–11486 (2002)
   Google Scholar
• Dobrzyn P, Dobrzyn A, Miyazaki M et al.: Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl Acad. Sci. USA 101, 6409–6414 (2004)
   Google Scholar
• Miyazaki M, Flowers MT, Sampath H et al.: Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrateinduced adiposity and hepatic steatosis. Cell Metab. 6, 484–496 (2007). oo Demonstration of the critical role of hepatic SCD in mediating carbohydrateinduced adiposity.
   Google Scholar
• Lin J, Yang R, Tarr PT et al.: Hyperlipidemic effects of dietary saturated fats mediated through PGC-1 coactivation of SREBP. Cell 120, 261–273 (2005)
   Google Scholar
• Sampath H, Miyazaki M, Dobrzyn A, Ntambi JM: Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J. Biol. Chem. 282, 2483–2493 (2007). oo Demonstrates a critical role for mouse SCD in mediating the lipogenic effects of saturated fats.
   Google Scholar
• Cohen P, Miyazaki M, Socci ND et al.: Role for stearoyl-CoA desaturase-1 in leptinmediated weight loss. Science 297, 240–243 (2002)
   Google Scholar
• Flowers JB, Rabaglia ME, Schueler KL et al.: Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56, 1228–1239 (2007)
   Google Scholar
• Savage DB, Petersen KF, Shulman GI: Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol. Rev. 87, 507–520 (2007)
   Google Scholar
• Petersen KF, Shulman GI: Etiology of insulin resistance. Am. J. Med. 119, S10–S16 (2006)
   Google Scholar
• Rahman SM, Dobrzyn A, Lee SH, Dobrzyn P, Miyazaki M, Ntambi JM: Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am. J. Physiol. Endocrinol. Metab. 288, E381–E387 (2005)
   Google Scholar
• Rahman SM, Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Ntambi JM: Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc. Natl Acad. Sci. USA 100, 11110–11115 (2003). oo Demonstrated increased insulin sensitivity in mouse skeletal muscle as a result of SCD1 deficiency.
   Google Scholar
• Dobrzyn P, Sampath H, Dobrzyn A, Miyazaki M, Ntambi JM: Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. Am. J. Physiol. Endocrinol. Metab. 294(2), E357–E364 (2008)
   Google Scholar
• Narayan SB, Rakheja D, Tan L, Pastor JV, Bennett MJ: CLN3P, the Batten’s disease protein, is a novel palmitoyl-protein -9 desaturase. Ann. Neurol. 60, 570–577 (2006)
   Google Scholar
• Georgel P, Crozat K, Lauth X et al.: A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect. Immun. 73, 4512–4521 (2005)
   Google Scholar
• Alfadley A, Al Hawsawi K, Al Aboud K: Ichthyosis follicularis: a case report and review of the literature. Pediatr. Dermatol. 20, 48–51 (2003)
   Google Scholar
• Melhus H, Riserus U, Warensjo E et al.: A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men. Osteoporos. Int. DOI:10.1007/s00198-007-0521-y (2007) (Epub ahead of print)
   Google Scholar
• Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 348, 1625–1638 (2003)
   Google Scholar
• Patel AV, Rodriguez C, Bernstein L, Chao A, Thun MJ, Calle EE: Obesity, recreational physical activity, and risk of pancreatic cancer in a large U.S. Cohort. Cancer Epidemiol. Biomarkers Prev. 14, 459–466 (2005)
   Google Scholar
• Rodriguez C, Freedland SJ, Deka A et al.: Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol. Biomarkers Prev. 16, 63–69 (2007)
   Google Scholar
• Ceschi M, Gutzwiller F, Moch H, Eichholzer M, Probst-Hensch NM: Epidemiology and pathophysiology of obesity as cause of cancer. Swiss Med. Wkly 137, 50–56 (2007)
   Google Scholar
• Scaglia N, Caviglia JM, Igal RA: High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim. Biophys. Acta 1687, 141–151 (2005)
   Google Scholar
• Scaglia N, Igal RA: Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. J. Biol. Chem. 280, 25339–25349 (2005)
   Google Scholar
• Morgan-Lappe SE, Tucker LA, Huang X et al.: Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res. 67, 4390–4398 (2007)
   Google Scholar
• Bene H, Lasky D, Ntambi JM: Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol. Biochem. Biophys. Res. Commun. 284, 1194–1198 (2001)
   Google Scholar
• Zhang L, Ge L, Tran T, Stenn K, Prouty SM: Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element. Biochem. J. 357, 183–193 (2001)
   Google Scholar
• Wang J, Yu L, Schmidt RE et al.: Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem. Biophys. Res. Commun. 332, 735–742 (2005).
   Google Scholar
• Identification of the second human isoform of SCD and tissue distribution of the two isoforms.
   Google Scholar
• Hulver MW, Berggren JR, Carper MJ et al.: Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2, 251–261 (2005). oo Reports increased SCD-1 expression in skeletal muscle from obese humans and its effect on decreasing lipid partitioning towards oxidation.
   Google Scholar
• Beiraghi S, Zhou M, Talmadge CB et al.: Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. Gene 309, 11–21 (2003)
   Google Scholar
• Zhang S, Yang Y, Shi Y: Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Biochem. J. 388, 135–142 (2005)
   Google Scholar
• Warensjo E, Riserus U, Vessby B: Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia 48, 1999–2005 (2005)
   Google Scholar
• Warensjo E, Ohrvall M, Vessby B: Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr. Metab. Cardiovasc. Dis. 16, 128–136 (2006)
   Google Scholar
• Warensjo E, Ingelsson E, Lundmark P et al.: Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity. Obesity (Silver Spring) 15, 1732–1740 (2007). oo Identifies four single nucleotide polymorphisms in the human SCD1 gene that decrease waist circumference and increase insulin sensitivity.
   Google Scholar
• Corpeleijn E, Feskens EJ, Jansen EH et al.: Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study. Diabetologia 49, 2392–2401 (2006)
   Google Scholar
• Stumvoll M: Control of glycaemia: from molecules to men. Minkowski Lecture 2003. Diabetologia 47, 770–781 (2004)
   Google Scholar
• Simon JA, Fong J, Bernert JT Jr: Serum fatty acids and blood pressure. Hypertension 27, 303–307 (1996)
   Google Scholar
• Attie AD, Krauss RM, Gray-Keller MP et al.: Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J. Lipid Res. 43, 1899–1907 (2002). oo Describes a positive correlation between serum desaturation ratio and hypertriglyceridemia, especially in the context of a high-carbohydrate diet.
   Google Scholar
• Paillard F, Catheline D, Duff FL et al.: Plasma palmitoleic acid, a product of stearoyl-CoA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity. Nutr. Metab. Cardiovasc. Dis. DOI: 10.1016/j.numecd.2007.02.017 (2007) (Epub ahead of print)
   Google Scholar
• Sjogren P, Sierra-Johnson J, Gertow K et al.: Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. Diabetologia 51(2), 328–335 (2008)
   Google Scholar
• Despres JP: Cardiovascular disease under the influence of excess visceral fat. Crit. Pathw. Cardiol. 6, 51–59 (2007)
   Google Scholar
• Kelley DE, Williams KV, Price JC, McKolanis TM, Goodpaster BH, Thaete FL: Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in Type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 86, 5412–5419 (2001)
   Google Scholar
• Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL: Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48, 839–847 (1999)
   Google Scholar
• Iannucci CV, Capoccia D, Calabria M, Leonetti F: Metabolic syndrome and adipose tissue: new clinical aspects and therapeutic targets. Curr. Pharm. Des. 13, 2148–2168 (2007)
   Google Scholar
• Tchernof A: Visceral adipocytes and the metabolic syndrome. Nutr. Rev. 65, S24–S29 (2007)
   Google Scholar
• Mangravite LM, Dawson K, Davis RR, Gregg JP, Krauss RM: Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response. Am. J. Clin. Nutr. 86, 759–767 (2007).
   Google Scholar
• Demonstrates that plasma triglyceride levels are positively correlated to adipose tissue SCD1 expression in humans.
   Google Scholar
• Schoonjans K, Peinado-Onsurbe J, Lefebvre AM et al.: PPAR and PPAR activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15, 5336–5348 (1996)
   Google Scholar
• Frohnert BI, Hui TY, Bernlohr DA: Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene. J. Biol. Chem. 274, 3970–3977 (1999)
   Google Scholar
• Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA: A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat. Med. 8, 1122–1128 (2002)
   Google Scholar
• Kim YC, Gomez FE, Fox BG, Ntambi JM: Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes. J. Lipid Res. 41, 1310–1316 (2000)
   Google Scholar
• Kakuma T, Lee Y, Unger RH: Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. Biochem. Biophys. Res. Commun. 297, 1259–1263 (2002)
   Google Scholar
• Toyama T, Kudo N, Hibino Y, Mitsumoto A, Nishikawa M, Kawashima Y: Effects of pioglitazone on stearoyl-CoA desaturase in obese Zucker fa/fa rats. J. Pharmacol. Sci. 104, 137–145 (2007)
   Google Scholar
• Way JM, Harrington WW, Brown KK et al.: Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 142, 1269–1277 (2001)
   Google Scholar
• Singh Ahuja H, Liu S, Crombie DL et al.: Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. Mol. Pharmacol. 59, 765–773 (2001)
   Google Scholar
• Riserus U, Tan GD, Fielding BA et al.: Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor- . Diabetes 54, 1379–1384 (2005). oo Reports an increase in plasma desaturation ratio to be associated with increased insulin sensitivity in response to rosiglitazone treatment.
   Google Scholar
• Boden G, Lebed B, Schatz M, Homko C, Lemieux S: Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50, 1612–1617 (2001)
   Google Scholar
• Bachmann OP, Dahl DB, Brechtel K et al.: Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 50, 2579–2584 (2001)
   Google Scholar
• Goodpaster BH, Thaete FL, Kelley DE: Thigh adipose tissue distribution is associated with insulin resistance in obesity and in Type 2 diabetes mellitus. Am. J. Clin. Nutr. 71, 885–892 (2000)
   Google Scholar
• Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE: Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46, 1579–1585 (1997)
   Google Scholar
• Krssak M, Falk Petersen K, Dresner A et al.: Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42, 113–116 (1999)
   Google Scholar
• Yu C, Chen Y, Cline GW et al.: Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277, 50230–50236 (2002)
   Google Scholar
• Chavez JA, Summers SA: Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch. Biochem. Biophys. 419, 101–109 (2003)
   Google Scholar
• Itani SI, Ruderman NB, Schmieder F, Boden G: Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I B- . Diabetes 51, 2005–2011 (2002)
   Google Scholar
• Ropelle ER, Pauli JR, Prada PO et al.: Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J. Physiol. 577, 997–1007 (2006)
   Google Scholar
• Hirosumi J, Tuncman G, Chang L et al.: A central role for JNK in obesity and insulin resistance. Nature 420, 333–336 (2002)
   Google Scholar
• Yuan M, Konstantopoulos N, Lee J et al.: Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikk . Science 293, 1673–1677 (2001)
   Google Scholar
• Goodpaster BH, He J, Watkins S, Kelley DE: Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86, 5755–5761 (2001).
   Google Scholar
• Describes the ‘paradox’ of increased skeletal muscle lipid accumulation and insulin sensitivity after exercise training in athletes.
   Google Scholar
• Schenk S, Horowitz JF: Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J. Clin. Invest. 117, 1690–1698 (2007).
   Google Scholar
• Demonstrates that increased muscle triglyceride accumulation and insulin sensitivity as well as lipogenic gene expression occurs rapidly after even a single bout of exercise.
   Google Scholar
• Richter EA, Mikines KJ, Galbo H, Kiens B: Effect of exercise on insulin action in human skeletal muscle. J. Appl. Physiol. 66, 876–885 (1989)
   Google Scholar
• Perseghin G, Price TB, Petersen KF et al.: Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N. Engl. J. Med. 335, 1357–1362 (1996)
   Google Scholar
• Devlin JT, Horton ES: Effects of prior highintensity exercise on glucose metabolism in normal and insulin-resistant men. Diabetes 34, 973–979 (1985)
   Google Scholar
• Pinnamaneni SK, Southgate RJ, Febbraio MA, Watt MJ: Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro. Diabetologia 49, 3027–3037 (2006)
   Google Scholar
• Gutierrez-Juarez R, Pocai A, Mulas C et al.: Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest. 116, 1686–1695 (2006). oo Utilized an antisense oligonucleotidemediated method to knockdown hepatic SCD1 expression in rats and demonstrated increased insulin sensitivity as a consequence of hepatic SCD1 deficiency.
   Google Scholar
• Le KA, Faeh D, Stettler R et al.: Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 34, 82–85 (2008)
   Google Scholar
• Puigserver P: Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1- . Int. J. Obes. (Lond.) 29(Suppl. 1), S5–S9 (2005).
   Google Scholar
• Concise review of the role of the coactivator PGC-1 in skeletal muscle fiber type switching.
   Google Scholar
• Petersson H, Basu S, Cederholm T, Riserus U: Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men. Br. J. Nutr. 6, 1–4 (2007). oo Provides evidence of increased serum C-reactive protein levels being associated with increased SCD activity in humans, establishing a link between SCD and systemic inflammation.
   Google Scholar
• Ndumele CE, Pradhan AD, Ridker PM: Interrelationships between inflammation, C-reactive protein, and insulin resistance. J. Cardiometab. Syndr. 1, 190–196 (2006).
   Google Scholar