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Signals from the adipose tissue alter systemic metabolism

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Pages 13-16 | Published online: 18 Jan 2017

Bibliography

  • Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS: Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134(6), 933–944 (2008)
  • Maeda K, Cao H, Kono K et al.: Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell. Metab. 1(2), 107–119 (2005).
  • Combined knockout of fatty acid-binding proteins (FABP)4 and 5 shows substantial protection against the metabolic syndrome.
  • Cao H, Maeda K, Gorgun CZ et al.: Regulation of metabolic responses by adipocyte/macrophage fatty acid-binding proteins in leptin-deficient mice. Diabetes 55(7), 1915–1922 (2006)
  • Ntambi JM, Miyazaki M: Regulation of stearoyl-CoA desaturases and role in metabolism. Prog. Lipid Res. 43(2), 91–104 (2004)
  • Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS: Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J. Clin. Invest. 118(7), 2640–2650 (2008)
  • Hotamisligil GS: Inflammation and metabolic disorders. Nature 444(7121), 860–867 (2006)
  • Furuhashi M, Tuncman G, Görgün CZ et al.: Treatment of diabetes and atherosclerosis by inhibiting fatty-acidbinding protein aP2. Nature 447(7147), 959–965 (2007).
  • Demonstration that targeting FABP4 with small-molecule inhibitors is possible and can lead to a new class of powerful therapeutic agents to prevent and treat metabolic diseases such as Type 2 diabetes and atherosclerosis. 8 Smith AJ, Sanders MA, Juhlmann BE, Hertzel AV, Bernlohr DA: Mapping of the hormone-sensitive lipase binding site on the adipocyte fatty acid-binding protein (AFABP): identification of the charge quartet on the AFABP/aP2 helix–turn–helix domain. J. Biol. Chem. 283(48), 33536–33543 (2008).
  • Shows the specific residues that interact with hormone-sensitive lipase. 9 Layne MD, Patel A, Chen YH et al.: Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 15(14), 2733–2735 (2001)
  • Haunerland NH, Spener F: Fatty acid-binding proteins insights from genetic manipulations. Prog. Lipid Res. 43(4), 328–349 (2004)
  • Hiraoka-Yamamoto J, Ikeda K, Negishi H et al.: Serum lipid effects of a monounsaturated (palmitoleic) fatty acid-rich diet based on macadamia nuts in healthy, young Japanese women. Clin. Exp. Pharmacol. Physiol. 31(Suppl. 2), S37–S38 (2004).

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