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Review

Prevention of Neutropenia-Related Events in Elderly Patients with Hematological Cancer

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Pages 829-842 | Published online: 22 Nov 2011

References

  • Lyman GH , KudererNM, BalducciL. Cancer care in the elderly: cost and quality-of-life considerations. Cancer Control5, 347–354(1998).
  • Sant M , AllemaniC, TereanuCet al. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the Haemacare project. Blood 116, 3724–3734(2010).
  • Menzin J , LangK, EarleKet al. The outcomes and costs of acute myeloid leukemia among the elderly. Arch. Intern. Med. 162, 1597 (2002).
  • Extermann M . Geriatric oncology: an overview of progresses and challenges. Cancer Res. Treat.42, 61–68(2010).
  • Balducci L , ExtermannM. Cancer and aging. An evolving panorama. Hematol. Oncol. Clin. North Am.14, 1–15(2000).
  • Gillison TL , ChattaGS. Cancer chemotherapy in the elderly patient. Oncology24, 76–92(2010).
  • Ferra C , MarcosP, MisisMet al. Outcome and prognostic factors in patients with hematologic malignancies admitted to the intensive care unit: a single-center experience. Int. J. Hematol. 85, 195–202(2007).
  • Norgaard M , LarssonH, PedersenGet al. Short-term mortality of bacteraemia in elderly patients with haematological malignancies. Br. J. Haematol. 32, 25–31(2005).
  • Baker SD , GrochowLB. Pharmacology of cancer chemotherapy in the older person. Clin. Geriatr. Med.13, 169–183(1997).
  • Baraldi-Junkins CA , BeckAC, RothsteinG. Hematopoiesis and cytokines. Relevance to cancer and aging. Hematol. Oncol. Clin. North Am.14, 45–61(2000).
  • Rothstein G . Disordered hematopoiesis and myelodysplasia in the elderly. J. Am. Geriatr. Soc.51(3 Suppl.), S22–S26 (2003).
  • Sawhney R , SehlM, NaeimA. Physiologic aspects of aging: impact on cancer management and decision making, part I. Cancer J.11, 449–460(2005).
  • Lyman GH , LymanCH, AgboolaO. Risk models for predicting chemotherapy-induced neutropenia. Oncologist10, 427–437(2005).
  • Lyman GH , KudererNM, BalducciL. Cost–benefit analysis of granulocyte colony-stimulating factor in the management of elderly cancer patients. Curr. Opin. Hematol.9, 207–214(2002).
  • Klastersky J , PaesmansM, RubensteinEBet al. The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J. Clin. Oncol. 18, 3038–3051(2000).
  • Lalami Y , PaesmansM, MuanzaFet al. Can we predict the duration of chemotherapy-induced neutropenia in febrile neutropenic patients, focusing on regimen-specific risk factors?. A retrospective analysis. Ann. Oncol. 17, 507–514(2006).
  • Gerlier L , LamotteM, AwadaAet al. The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin‘s lymphoma. BMC Cancer 10, 642 (2010).
  • Balducci L , HardyCL, LymanGH. Hematopoietic growth factors in the older cancer patient. Curr. Opin. Hematol.8, 170–187(2001).
  • Balducci L , LymanGH, OzerH. Patients aged ≥70 are at high risk for neutropenic infection and should receive hemopoietic growth factors when treated with moderately toxic chemotherapy. J. Clin. Oncol.19, 1583–1585(2001).
  • Freifeld A , BowEJ, SepkowitzKAet al. Clinical practice guidelines for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin. Infect. Dis. 52, e56–e93 (2011).
  • Repetto L , BiganzoliL, KoehneCHet al. EORTC Cancer in the Elderly Task Force guidelines for the use of colony-stimulating factors in elderly patients with cancer. Eur. J. Cancer 39, 2264–2272(2003).
  • Balducci L , Al-HalawaniH, CharuVet al. Elderly cancer patients receiving chemotherapy benefit from first-cycle pegfilgrastim. Oncologist 12, 1416–1424(2007).
  • Aapro MS , CameronDA, PettengellRet al. EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. Eur. J. Cancer 42, 2433–2453(2006).
  • Caimi PF , BarrP, BergerNAet al. Non Hodgkin‘s lymphoma in the elderly. Drugs Aging 27, 211–238(2010).
  • Sonneveld P , de Ridder M, Van der Lelie H et al. Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkin‘s lymphoma using CHOP versus CNOP chemotherapy. J. Clin. Oncol.13, 2530–2539(1995).
  • Tirelli U , ErranteD, Van Glabbeke M et al. CHOP is the standard regimen in patients ≥70 years of age with intermediate-grade and high-grade non-Hodgkin‘s lymphoma. Results of a randomized study of the European Organization for Research and Treatment Cancer Lymphoma Cooperative Study Group. J. Clin. Oncol.16, 27–34(1998).
  • Gomez H , HidalgoM, CasanovaLet al. Risk factors for treatment-related death in elderly patients with aggressive non-Hodgkin‘s lymphoma: results of a multivariate analysis. J. Clin. Oncol. 16, 2065–2069(1998).
  • Tucci A , FerrariS, BottelliCet al. A comprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy. Cancer 115, 4547–4553(2009).
  • Ruan J , MartinP, ColemanMet al. Durable responses with the metronomic rituximab and thalidomide plus prednisone, etoposide, procarbazine, and cyclophosphamide regimen in elderly patients with recurrent mantle cell lymphoma. Cancer 116, 2655–2664(2010).
  • Kurzwelly D , GlasM, RothPet al. Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status. J. Neurooncol. 97, 389–392(2010).
  • Ösby E , HagbergH, TeerenhoviLet al. CHOP is superior to CNOP in elderly patients with aggressive lymphoma while outcome is unaffected by filgrastim treatment: results of a Nordic Lymphoma Group randomized trial. Blood 101, 3840–3848(2003).
  • Wingard JR , ElmongyM. Strategies for minimizing complications of neutropenia: prophylactic myeloid growth factors or antibiotics. Crit. Rev. Oncol. Hematol.72, 144–154(2009).
  • Klastersky J , AwadaA, PaesmansMet al. Febrile neutropenia: a critical review of the initial management. Crit. Rev. Oncol. Hematol. 78, 185–194(2011).
  • Coiffier B , LepageE, BrièreJet al. CHOP-chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 235–242(2002).
  • Pfreundschuh M , TrümperL, KloessMet al. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL. Blood 104, 634–641(2004).
  • Klastersky J , AwadaA. Prevention of febrile neutropenia in chemotherapy-treated cancer patients: pegylated versus standard myeloid colony stimulating factors. Do we have a choice?. Crit. Rev. Hematol. Oncol.78, 17–23(2011).
  • Wolf M , BentleyM, MarltonPet al. Pegfilgrastim to support CHOP-14 in elderly patients with non-Hodgkin‘s lymphoma. Leuk. Lymphoma 7, 2344–2350(2006).
  • Mey UJM , MaierA, Schmidt-WolfIGHet al. Pegfilgrastim as hematopoietic support for dose-dense chemoimmunotherapy with R-CHOP-14 as first-line therapy in elderly patients with diffuse large B cell lymphoma. Support. Care Cancer 15, 877–884(2007).
  • Rodon P , LinassierC, GauvainJBet al. Multiple myeloma in elderly patients. presenting features and outcome. Eur. J. Hematol. 66, 11–17(2001).
  • Musto P , D‘AuriaF, PietrantuonoGet al. First-line treatment of multiple myeloma in elderly patients. The GINEMA (Gruppo Italiano Malattie Ematologiche dell‘Adulto) Multiple Myeloma Working Party perspective. Curr. Drug Targets 10, 906–922(2009).
  • Wijermans P , SchaafsmaM, TermorshuizenFet al. Phase III study of the value of thalidomide added to melphalan plus prednisone in elderly patients with newly diagnosed multiple myeloma: the HOVON study. J. Clin. Oncol. 28, 3260–3166(2010).
  • Offidani M , LeoniP, CorvattaLet al. ThaDD plus high dose therapy and autologous stem cell transplantation does not appear superior to ThaDD plus maintenance in elderly patients with de novo multiple myeloma. Eur. J. Haematol. 84, 474–483(2010).
  • Mele G , GiannottaA, PinnaSet al. Frail elderly patients with relapsed–refractory multiple myeloma: efficacy and toxicity profile of the combination of bortezomib, high-dose dexamethasone, and low-dose oral cyclophosphamide. Leuk. Lymphoma 51, 937–940(2010).
  • Gozzetti A , FabbriA, OlivaSet al. Weekly bortezomib, pegylated liposomal doxorubicin, and dexamethasone is a safe and effective therapy for elderly patients with relapsed/refractory multiple myeloma. Clin. Lymphoma Myeloma Leuk. 10, 68–72(2010).
  • Dombret H , ChastangC, FenauxPet al. A controlled study of recombinant human granulocyte colony-stimulating factor in elderly patients after treatment for acute myelogenous leukemia. N. Engl. J. Med. 332, 1678–1683(1995).
  • Maslak PG , WeissMA, BermanEet al. Granulocyte colony-stimulating factor following chemotherapy in elderly patients with newly diagnosed acute myelogenous leukemia. Leukemia 10, 32–39(1996).
  • Stone RM , BergDT, GeorgeSLet al. Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia. N. Engl. J. Med. 332, 1671–1677(2010).
  • Rowe JM , AndersenJW, MazzaJJet al. A randomized placebo-controlled Phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (>55 to 70 years of age) with accute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490). Blood 86, 457–462(1995).
  • Löwenberg B , SuciuS, ArchimbaudEet al. Use of recombinant granulocyte-macrophage colony-stimulating factor during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia (AML): final report of AML-11, a Phase III randomized study of the Leukemia Cooperative Group of European Organisation for the Research and Treatment of Cancer (EORTC-LCG) and the Dutch Belgian Hematology-Oncology Cooperative Group (HOVON). Blood 90, 2952–2961(1997).
  • Witz F , SadounA, PerrinMCet al. A placebo-controlled study of recombinant human granulocyte-macrophage colony-stimulating factor administered during and after induction treatment for de novo acute myelogenous leukemia in elderly patients. Blood 91, 2722–2730(1998).
  • Woronoff-Lemsi MC , WitzF, ArveuxPet al. [Intérêt thérapeutique et économique du GM-CSF dans le traitement des leucémies aiguës myéloblastiques du sujet âgé: protocole GOELAM Sa3] [Article in French]. Thérapie 56, 131–133(2001).
  • Ritchie EK , RobozGJ. Levels of care: defining best supportive care in elderly patients with acute myeloid leukemia. Curr. Hematol. Malig. Rep.5, 95–100(2010).
  • Pagel JM , GooleyTA, RajendranJet al. Allogeneic hematopoietic cell transplantation after conditioning with 131I-anti-CD45 antibody plus fludarabine and low-dose total body irradiation for elderly patients with advanced acute myeloid leukemia or high-risk myelodysplastic syndrome. Blood 114, 5444–5453(2009).
  • Suzushima H , WadaN, Yamasaki et al. Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor for elderly patients with previously untreated acute myeloid leukemia. Leuk. Res.34, 610–614(2010).
  • Dombret H , RaffouxE, GardinC. New insights in the management of elderly patients with acute myeloid leukemia. Curr. Opin. Oncol.21, 589–593(2009).
  • Ria NR , MoschettaM, RealeAet al. Managing myelodysplastic symptoms in elderly patients. Clin. Interv. Aging 4, 413–423(2009).
  • Pomeroy C , OkenMM, RydellRE, FiliceGA. Infection in the myelodysplastic syndromes. Am. J. Med.90, 338–344(1991).
  • National Comprehensive Cancer Network. NCCN practice guidelines for the myelodysplastic syndromes. Oncology12, 53–80(1998).
  • Walsh TJ , AnaissieEJ, DenningDWet al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin. Infect. Dis. 46, 327–360(2008).
  • Robak T . Acute lymphoblastic leukaemia in elderly patients: biological characteristics and therapeutic approaches. Drugs Aging21, 779–791(2004).
  • Morrison VA . Infectious complications of chronic lymphocytic leukemia: pathogenesis, spectrum of infection, preventive approaches. Best Pract. Res. Clin. Haematol.23, 145–153(2010).
  • Goede V , HallekM. Optimal pharmacotherapeutic management of chronic lymphocytic leukemia. Considerations in the elderly. Drugs Aging28, 163–176(2011).
  • Casac S , LemerySJ, ShenYLet al. US Food and Drug Administration Approval. Rituximab in combination with fludarabine and cyclophosphamide for the treatment of patients with chronic lymphocytic leukemia. Oncologist 16, 97–104(2011).
  • Flinn IW , NeubergDS, GreverMRet al. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia. US Intergroup Trial E2997. J. Clin. Oncol. 25, 793–798(2007).
  • O‘Brien S , KeatingMJ, MocarskiES. Updated guidelines on the management of cytomegalovirus reactivation inpatients with chronic lymphocytic leukemia treated with alemtuzumab. Clin. Lymphoma Myeloma7, 125–130(2006).
  • Terrosi C , Di Genova G, Martorelli B et al. Short report. Humoral immunity to respiratory syncytial virus in young and elderly adults. Epidemiol. Infect.137, 1684–1686(2009).
  • Michel JP . Updated vaccine guidelines for aging and aged citizens of Europe. Expert Rev. Vaccines9, 7–10(2010).
  • Klastersky J , MommenP, CantraineFet al. Placebo controlled pneumococcal immunization in patients with bronchogenic carcinoma. Eur. J. Cancer Clin. Oncol. 22, 807–813(1986).
  • Bron D . Bone marrow transplantation. In: Supportive Care in Cancer. Klastersky J, Schimpff SC, Senn HJ (Eds). Marcel Dekker, Inc., New York, NY, USA, 191–212(1999).
  • Fishman JA , GonzalezRG, BrandaJA. Case records of the Massachussetts General Hospital: a 45-year old man with changes in mental status after liver transplantation. N. Engl. J. Med.358, 1604–1613(2008).
  • Klastersky J , AounM. Infection in the immunodeficient patient. In: Clinical Infectious Diseases: Clinical Approaches. Stamm W, Waldvogel F, Carey L (Eds). Oxford University Press, Oxford, UK, 809–819(1999).
  • Pickering LK , BakerCJ, FreedGLet al. Immunization programs for infants, children, adolescents and adults: clinical practice guidelines by the Infectious Diseases Society of America. Clin. Infect. Dis. 49, 817–840(2009).
  • Yahav D , Gafter-GviliA, MuchtarEet al. Antiviral prophylaxis in haematological patients: systematic review and meta-analysis. Eur. J. Cancer 45, 3131–3148(2009).
  • Maertens JA , FrereP, Lass-FlorlC, HeinzW, CornelyOA. Primary antifungal prophylaxis in leukemia patients. Eur. J. Cancer Suppl.5, 43–48(2007).

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