Micro-Rna335-5P Targeted Inhibition of SKLOTHO and Promoted Oxidative Stress–Mediated Aging of Endothelial Cells

References

• Mcaloon CJ , BoylanLM, HamborgTet al. The changing face of cardiovascular disease 2000–2012: an analysis of the World Health Organisation global health estimates data. Int. J. Cardiol.224, 256–264 (2016).
   PubMed Web of Science ®Google Scholar
• Benjamin EJ , BlahaMJ, ChiuveSEet al. Heart Disease and Stroke Statistics – 2017 Update: a report from the American Heart Association. Circulation135 (10), e146–e603 (2017).
   PubMed Web of Science ®Google Scholar
• Huang Q , QinL, DaiSet al. AIP1 suppresses atherosclerosis by limiting hyperlipidemia-induced inflammation and vascular endothelial dysfunction. Arterioscler. Thromb. Vasc. Biol.33 (4), 795–804 (2013).
   PubMed Web of Science ®Google Scholar
• Messner B , BernhardD. Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler. Thromb. Vasc. Biol.34 (3), 509–515 (2014).
   PubMed Web of Science ®Google Scholar
• Theodorou K , BoonRA. Endothelial cell metabolism in atherosclerosis. Front. Cell Dev. Biol.6, 82 (2018).
   PubMed Web of Science ®Google Scholar
• Wu B , MottolaG, SchallerM, UpchurchGRJr, ConteMS. Resolution of vascular injury: specialized lipid mediators and their evolving therapeutic implications. Mol. Aspects Med.58, 72–82 (2017).
   PubMed Web of Science ®Google Scholar
• Brennan E , WangB, McClellandAet al. Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis. Diabetes66 (8), 2266–2277 (2017).
   PubMed Web of Science ®Google Scholar
• Funamoto K , YoshinoD, MatsubaraKet al. Endothelial monolayer permeability under controlled oxygen tension. Integr. Biol.9 (6), 529–538 (2017).
   Google Scholar
• Kuro-O M , MatsumuraY, AizawaHet al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature390 (6655), 45–51 (1997).
   PubMed Web of Science ®Google Scholar
• Kurosu H , YamamotoM, ClarkJDet al. Suppression of aging in mice by the hormone Klotho. Science309 (5742), 1829–1833 (2005).
   PubMed Web of Science ®Google Scholar
• Imura A , IwanoA, TohyamaOet al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett.565 (1–3), 143–147 (2004).
   PubMed Web of Science ®Google Scholar
• Matsumura Y , AizawaH, Shiraki-IidaT, NagaiR, Kuro-OM, NabeshimaY. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem. Biophys. Res. Commun.242 (3), 626–630 (1998).
   PubMed Web of Science ®Google Scholar
• Liu Z , ZhangH, DingSet al. betaKlotho inhibits androgen/androgen receptor associated epithelial mesenchymal transition in prostate cancer through inactivation of ERK1/2 signaling. Oncol. Rep.40 (1), 217–225 (2018).
   PubMed Web of Science ®Google Scholar
• Wang Y , SunZ. Antiaging gene Klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats. J. Hypertens.32 (8), 1629–1636 ; discussion 1636 (2014).
   PubMed Web of Science ®Google Scholar
• Carracedo J , BuendiaP, MerinoAet al. Klotho modulates the stress response in human senescent endothelial cells. Mech. Ageing Dev.133 (11–12), 647–654 (2012).
   PubMed Web of Science ®Google Scholar
• Ikushima M , RakugiH, IshikawaKet al. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem. Biophys. Res. Commun.339 (3), 827–832 (2006).
   PubMed Web of Science ®Google Scholar
• Yang K , NieL, HuangYet al. Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein. Toxicol. Lett.215 (2), 77–83 (2012).
   PubMed Web of Science ®Google Scholar
• Richter B , HallerJ, HaffnerD, Leifheit-NestlerM. Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells. Pflugers Arch.468 (9), 1621–1635 (2016).
   PubMed Web of Science ®Google Scholar
• Harris TA , YamakuchiM, FerlitoM, MendellJT, LowensteinCJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc. Natl Acad. Sci. USA105 (5), 1516–1521 (2008).
   PubMed Web of Science ®Google Scholar
• Parmar KM , LarmanHB, DaiGHet al. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J. Clin. Invest.116 (1), 49–58 (2006).
   PubMed Web of Science ®Google Scholar
• Zhou J , WangKC, WuWet al. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc. Natl Acad. Sci. USA108 (25), 10355–10360 (2011).
   PubMed Web of Science ®Google Scholar
• Taganov KD , BoldinMP, ChangKJ, BaltimoreD. NF-kappa B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl Acad. Sci. USA103 (33), 12481–12486 (2006).
   PubMed Web of Science ®Google Scholar
• Cheng HS , SivachandranN, LauAet al. MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol. Med.5 (7), 1017–1034 (2013).
   PubMed Web of Science ®Google Scholar
• Rau CS , YangJCS, ChenYCet al. Lipopolysaccharide-induced microRNA-146a targets CARD10 and regulates angiogenesis in human umbilical vein endothelial cells. Toxicol. Sci.140 (2), 315–326 (2014).
   PubMed Web of Science ®Google Scholar
• Asgeirsdottir SA , Van SolingenC, KurniatiNFet al. MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am. J. Physiol-Renal.302 (12), F1630–F1639 (2012).
   PubMed Web of Science ®Google Scholar
• Wu W , XiaoH, Laguna-FernandezAet al. Flow-dependent regulation of Kruppel-like factor 2 is mediated by microRNA-92a. Circulation124 (5), 633–641 (2011).
   PubMed Web of Science ®Google Scholar
• Wang Y , LeeCGL. MicroRNA and cancer: focus on apoptosis. J. Cell Mol. Med.13 (1), 12–23 (2009).
   PubMed Web of Science ®Google Scholar
• Liu D , ZhangXL, YanCHet al. MicroRNA-495 regulates the proliferation and apoptosis of human umbilical vein endothelial cells by targeting chemokine CCL2. Thromb. Res.135 (1), 146–154 (2015).
   PubMed Web of Science ®Google Scholar
• Tome M , SepulvedaJC, DelgadoMet al. miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity. Stem Cells32 (8), 2229–2244 (2014).
   PubMed Web of Science ®Google Scholar
• Raihan O , BrishtiA, MollaMRet al. The age-dependent elevation of miR-335-3p leads to reduced cholesterol and impaired memory in brain. Neuroscience390, 160–173 (2018).
   PubMed Web of Science ®Google Scholar
• Bai XY , MaY, DingR, FuB, ShiS, ChenXM. miR-335 and miR-34a promote renal senescence by suppressing mitochondrial antioxidative enzymes. J. Am. Soc. Nephrol.22 (7), 1252–1261 (2011).
   PubMed Web of Science ®Google Scholar
• Sun Z , ZhangZ, LiuZ, QiuB, LiuK, DongG. MicroRNA-335 inhibits invasion and metastasis of colorectal cancer by targeting ZEB2. Med. Oncol.31 (6), 982 (2014).
   PubMed Web of Science ®Google Scholar
• Lynch J , MeehanMH, CreanJ, CopelandJ, StallingsRL, BrayIM. Metastasis suppressor microRNA-335 targets the formin family of actin nucleators. PLoS ONE8 (11), e78428 (2013).
   PubMed Web of Science ®Google Scholar
• Jiang F , LiJ, WuGet al. Upregulation of microRNA335 and microRNA584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase. Mol. Med. Rep.12 (4), 5383–5390 (2015).
   PubMed Web of Science ®Google Scholar
• Zhang JB , ZhuXN, CuiJ, ChenP, WangSM, WangJS. Differential expressions of microRNA between young and senescent endothelial cells. Zhonghua Yi Xue Za Zhi92 (31), 2205–2209 (2012).
   PubMedGoogle Scholar
• Sui XQ , XuZM, XieMB, PeiDA. Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. J. Atheroscler. Thromb.21 (2), 108–118 (2014).
   PubMed Web of Science ®Google Scholar
• Harries LW . MicroRNAs as mediators of the ageing process. Genes (Basel)5 (3), 656–670 (2014).
   PubMed Web of Science ®Google Scholar
• Wadley AJ , Van ZantenJJCSV, AldredS. The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad. Age35 (3), 705–718 (2013).
   PubMedGoogle Scholar
• Cevenini E , CarusoC, CandoreGet al. Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr. Pharm. Des.16 (6), 609–618 (2010).
   PubMed Web of Science ®Google Scholar
• Forstermann U , XiaN, LiH. Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis. Circ. Res.120 (4), 713–735 (2017).
   PubMed Web of Science ®Google Scholar
• Tousoulis D , SimopoulouC, PapageorgiouNet al. Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches. Pharmacol. Ther.144 (3), 253–267 (2014).
   PubMed Web of Science ®Google Scholar
• Mudau M , GenisA, LochnerA, StrijdomH. Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc. J. Afr.23 (4), 222–231 (2012).
   PubMed Web of Science ®Google Scholar
• Sun S , ChengB, SunPG, WuXH, WuQQ, HeP. RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation. Exp. Biol. Med. (Maywood)240 (12), 1606–1613 (2015).
   PubMed Web of Science ®Google Scholar