142
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Osteoprotegerin and Osteopontin Levels, But Not Gene Polymorphisms, Predict Mortality in Cardiovascular Diseases

, , , , , , , & show all
Pages 751-760 | Received 05 Dec 2018, Accepted 12 Apr 2019, Published online: 03 Jun 2019

References

  • Venuraju SM , YerramasuA, CorderR, LahiriA. Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity. J. Am. Coll. Cardiol.55(19), 2049–2061 (2010).
  • Lieb W , GonaP, LarsonMGet al. Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality. Arterioscler. Thromb. Vasc. Biol.30(9), 1849–1854 (2010).
  • Pedersen ER , UelandT, SeifertRet al. Serum osteoprotegerin levels and long-term prognosis in patients with stable angina pectoris. Atherosclerosis212(2), 644–649 (2010).
  • Yang Q , LuS, ChenYet al. Plasma osteoprotegerin levels and long-term prognosis in patients with intermediate coronary artery lesions. Clin. Cardiol.34(7), 447–453 (2011).
  • Esteghamati A , AflatoonianM, RadMVet al. Association of osteoprotegerin with peripheral artery disease in patients with Type 2 diabetes. Arch. Cardiovasc. Dis.108(8–9), 412–419 (2015).
  • Gravallese EM . Osteopontin: a bridge between bone and the immune system. J. Clin. Invest.112(2), 147–149 (2003).
  • Gadeau AP , CampanM, MilletD, CandresseT, DesgrangesC. Osteopontin overexpression is associated with arterial smooth muscle cell proliferation in vitro. Arterioscler. Thromb.13(1), 120–125 (1993).
  • Scatena M , LiawL, GiachelliCM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler. Thromb. Vasc. Biol.27(11), 2302–2309 (2007).
  • Wolak T . Osteopontin – a multi-modal marker and mediator in atherosclerotic vascular disease. Atherosclerosis236(2), 327–337 (2014).
  • Bjerre M , PedersenSH, MøgelvangRet al. High osteopontin levels predict long-term outcome after STEMI and primary percutaneous coronary intervention. Eur. J. Prev. Cardiol.20(6), 922–929 (2013).
  • Kato R , MomiyamaY, OhmoriRet al. Prognostic significance of plasma osteopontin levels in patients undergoing percutaneous coronary intervention. Circ. J.73(1), 152–157 (2009).
  • Georgiadou P , IliodromitisEK, KolokathisFet al. Osteopontin as a novel prognostic marker in stable ischaemic heart disease: a 3-year follow-up study. Eur. J. Clin. Invest.40(4), 288–293 (2010).
  • Ueland T , WilsonSG, AmirulIslam FMet al. A cohort study of the effects of serum osteoprotegerin and osteoprotegerin gene polymorphisms on cardiovascular mortality in elderly women. Clin. Endocrinol. (Oxf).71(6), 828–833 (2009).
  • Genre F , López-MejíasR, García-BermúdezMet al. Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis. PLoS ONE9(9), e106823 (2014).
  • Song DH , ZhouPZ, XiuXL, ZhouGH, SunYX, SongC. Relationships of OPG genetic polymorphisms with susceptibility to cardiovascular disease: a meta-analysis. Med. Sci. Monit.22, 1223–1231 (2016).
  • Jing M , LiB, HouXet al. OPN gene polymorphism and the serum OPN levels confer the susceptibility and prognosis of ischemic stroke in Chinese patients. Cell. Physiol. Biochem.32(6), 1798–1807 (2013).
  • Lin JF , WuS, JuangJJet al. IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease. Atherosclerosis257, 71–77 (2017).
  • Tousoulis D , SiasosG, ManiatisKet al. Novel biomarkers assessing the calcium deposition in coronary artery disease. Curr. Med. Chem.19(6), 901–920 (2012).
  • Tousoulis D , SiasosG, ManiatisKet al. Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease. Int. J. Cardiol.167(5), 1924–1928 (2013).
  • Røysland R , BonacaMP, OmlandTet al. Osteoprotegerin and cardiovascular mortality in patients with non-ST elevation acute coronary syndromes. Heart98(10), 786–791 (2012).
  • Koshikawa M , AizawaK, KasaiHet al. Elevated osteopontin levels in patients with peripheral arterial disease. Angiology60(1), 42–45 (2009).
  • Niu Y , ZhangW, YangZet al. Association of plasma osteoprotegerin levels with the severity of lower extremity arterial disease in patients with Type 2 diabetes. BMC. Cardiovasc. Disord.15(1), 86 (2015).
  • Liu W , GeS, LiuYet al. Polymorphisms in three genes are associated with hemorrhagic stroke. Brain. Behav.5(11), e00395 (2015).
  • Biscetti F , GiovanniniS, StrafaceGet al. RANK/RANKL/OPG pathway: genetic association with history of ischemic stroke in Italian population. Eur. Rev. Med. Pharmacol. Sci.20(21), 4574–4580 (2016).
  • Celczyńska Bajew L , HorstSikorska W, BychowiecB, WykrętowiczA, WesołyJ, MichalakM. The effects of osteoprotegerin (OPG) gene polymorphism in patients with ischaemic heart disease on the morphology of coronary arteries and bone mineral density. Kardiol. Pol.69(6), 573–578 (2011).
  • Song DH , ZhouPZ, XiuXL, ZhouGH, SunYX, SongC. Relationships of OPG genetic polymorphisms with susceptibility to cardiovascular disease: a meta-analysis. Med. Sci. Monit.22, 1223–1231 (2016).
  • Mu G , WangH, CaiZ, JiH. OPN -443C>T genetic polymorphism and tumor OPN expression are associated with the risk and clinical features of papillary thyroid cancer in a Chinese cohort. Cell. Physiol. Biochem.32(1), 171–179 (2013).
  • Mi Y , RenK, DaiF, ZhuL, FengN. OPN gene polymorphisms, rs17524488 GG/G, rs11730582 T/C, and rs9138 C/A, and cancer risk in a Chinese population. Sci. Rep.5, 14164 (2015).
  • Hou X , HuZ, HuangXet al. Serum osteopontin, but not OPN gene polymorphism, is associated with LVH in essential hypertensive patients. J. Mol. Med. (Berl).92(5), 487–495 (2014).
  • Kim JG , KimJH, KimJYet al. Association between osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) gene polymorphisms and circulating OPG, soluble RANKL levels, and bone mineral density in Korean postmenopausal women. Menopause14(5), 913–918 (2007).
  • Omar HS , ShakerOG, NassarYH, MarzoukSA, ElMarzoukyMS. The association between RANKL and osteoprotegerin gene polymorphisms with breast cancer. Mol. Cell. Biochem.403(1–2), 219–229 (2015).
  • Xue JB , ZhanXL, WangWJ, YanYG, LiuC. OPG rs2073617 polymorphism is associated with upregulated OPG protein expression and an increased risk of intervertebral disc degeneration. Exp. Ther. Med.12(2), 702–710 (2016).
  • Jono S , IkariY, ShioiAet al. Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease. Circulation106(10), 1192–1194 (2002).
  • Toffoli B , PickeringRJ, TsorotesDet al. Osteoprotegerin promotes vascular fibrosis via a TGF-β1 autocrine loop. Atherosclerosis218(1), 61–68 (2011).
  • Lawrie A , WatermanE, SouthwoodMet al. Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension. Am. J. Pathol.172(1), 256–264 (2008).
  • Mosheimer BA , KaneiderNC, FeistritzerCet al. Syndecan-1 is involved in osteoprotegerin-induced chemotaxis in human peripheral blood monocytes. J. Clin. Endocrinol. Metab.90(5), 2964–2971 (2005).
  • Zauli G , CoralliniF, BossiFet al. Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo. Blood110(2), 536–543 (2007).
  • Ueland T , YndestadA, ØieEet al. Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure. Circulation111(19), 2461–2468 (2005).
  • Arnlöv J , EvansJC, BenjaminEJet al. Clinical and echocardiographic correlates of plasma osteopontin in the community: the Framingham Heart Study. Heart92(10), 1514–1515 (2006).
  • Carbone F , MontecuccoF. Novel cardiovascular risk biomarkers in carotid atherogenesis. Biomark. Med.12(10), 1065–1067 (2018).
  • Parker DM , BrownJR. Biomarkers for the prediction of cardiac readmission. Biomark. Med.13(2), 55–58 (2019).
  • Serra R , IelapiN, BarbettaA, AndreucciM, de FranciscisS. Novel biomarkers for cardiovascular risk. Biomark. Med.12(9), 1015–1024 (2018).
  • Oikonomou E , VogiatziG, TsalamandrisSet al. Non-natriuretic peptide biomarkers in heart failure with preserved and reduced ejection fraction. Biomark. Med.12(7), 783–797 (2018).
  • Chiba S , OkamotoH, KonSet al. Development of atherosclerosis in osteopontin transgenic mice. Heart. Vessels.16(3), 111–117 (2002).
  • Bruemmer D , CollinsAR, NohGet al. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J. Clin. Invest.112(9), 1318–1331 (2003).
  • Liu J , RenY, KangL, ZhangL. Oxidized low-density lipoprotein increases the proliferation and migration of human coronary artery smooth muscle cells through the upregulation of osteopontin. Int. J. Mol. Med.33(5), 1341–1347 (2014).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.