2,044
Views
2
CrossRef citations to date
0
Altmetric
Review

Telomere Length Analysis and Preterm Infant Health: The Importance of Assay Design in the Search for Novel Biomarkers

, , &
Pages 485-498 | Published online: 06 May 2014

References

  • Mangham LJ , PetrouS , DoyleLW , DraperES , MarlowN . The cost of preterm birth throughout childhood in England and Wales.Pediatrics123 ( 2 ), 312 – 327 ( 2009 ).
  • Costeloe KL , HennessyEM , HaiderS , StaceyF , MarlowN , DraperES . Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies).BMJ345 , e7976 ( 2012 ).
  • Uthaya S , ThomasEL , HamiltonG , DoreCJ , BellJ , ModiN . Altered adiposity after extremely preterm birth.Pediatr. Res.57 ( 2 ), 211 – 215 ( 2005 ).
  • Modi N , ThomasEL , UthayaSN , UmranikarS , BellJD , YajnikC . Whole body magnetic resonance imaging of healthy newborn infants demonstrates increased central adiposity in Asian Indians.Pediatr. Res.65 ( 5 ), 584 – 587 ( 2009 ).
  • Vasu V , ThomasEL , DurighelG , UthayaS , BellJD , ModiN . Lean body mass is reduced in preterm infants at term age . Presented at: Abstracts of the 50th Annual Meeting of the European Society for Paediatric Research . Hamburg, Germany , 9 – 12October 2009 .
  • Thomas EL , UthayaS , VasuVet al. Neonatal intrahepatocellular lipid. Arch. Dis. Child. 93 ( 5 ), 382 – 383 ( 2008 ).
  • Vasu V , ThomasE , DurighelG , HydeMJ , BellJ , ModiN . Early nutritional determinants of intrahepatocellular lipid deposition in preterm infants at term age.Int. J. Obesity37 ( 4 ), 500 – 504 ( 2013 ).
  • Bhat R , SalasAA , FosterC , CarloWA , AmbalavananN . Prospective analysis of pulmonary hypertension in extremely low birth weight infants.Pediatrics129 ( 3 ), 682 – 689 ( 2012 ).
  • Vandevoorde RG , MitsnefesMM . Neonatal hypertension . In: Kidney and Urinary Tract Diseases in the Newborn.ChishtiAS , AlamS , KiesslingSG (Eds). Springer Berlin Heidelberg , Berlin, Germany , 349 – 361 ( 2014 ).
  • Tinnion R , GilloneJ , CheethamT , EmbletonN . Preterm birth and subsequent insulin sensitivity: a systematic review.Arch. Dis. Child. doi:10.1136/archdischild-2013-304615 ( 2013 ) ( Epub ahead of print ).  
  • Thomas EL , ParkinsonJR , HydeMJet al. Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant. Pediatr. Res. 70 ( 5 ), 507 – 512 ( 2011 ).
  • De Jong F , MonuteauxMC , Van ElburgRM , GillmanMW , BelfortMB . Systematic review and meta-analysis of preterm birth and later systolic blood pressure.Hypertension59 ( 2 ), 226 – 234 ( 2012 ).
  • Parkinson JR , HydeMJ , GaleC , SanthakumaranS , ModiN . Preterm birth and the metabolic syndrome in adult life: a systematic review and meta-analysis.Pediatrics131 ( 4 ), 1240 – 1263 ( 2013 ).
  • Liu J , FoxCS , HicksonDAet al. Impact of abdominal visceral and subcutaneous adipose tissue on cardiometabolic risk factors: the Jackson Heart Study. J. Clin. Endocrinol. Metab. 95 ( 12 ), 5419 – 5426 ( 2010 ).
  • Matsuzawa Y , FunahashiT , NakamuraT . The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism.J. Atheroscler. Thromb.18 ( 8 ), 629 – 639 ( 2011 ).
  • Koster A , LeitzmannMF , SchatzkinAet al. Waist circumference and mortality. Am. J. Epidemiol. 167 ( 12 ), 1465 – 1475 ( 2008 ).
  • Jacobs EJ , NewtonCC , WangYet al. Waist circumference and all-cause mortality in a large US cohort. Arch. Intern. Med. 170 ( 15 ), 1293 – 1301 ( 2010 ).
  • Moyzis RK , BuckinghamJM , CramLSet al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl Acad. Sci. USA 85 ( 18 ), 6622 – 6626 ( 1988 ).
  • De Lange T . Shelterin: the protein complex that shapes and safeguards human telomeres.Genes Dev.19 ( 18 ), 2100 – 2110 ( 2005 ).
  • McClintock B . The behavior in successive nuclear divisions of a chromosome broken at meiosis.Proc. Natl Acad. Sci. USA25 ( 8 ), 405 – 416 ( 1939 ).
  • Muller H . The remaking of chromosomes.Collecting Net.13 ( 198 ), 181 – 195 ( 1938 ).
  • Griffith JD , ComeauL , RosenfieldSet al. Mammalian telomeres end in a large duplex loop. Cell 97 ( 4 ), 503 – 514 ( 1999 ).
  • Olovnikov AM . A theory of marginotomy.J. Theoret. Biol.41 ( 1 ), 181 – 190 ( 1973 ).
  • Jiang H , JuZ , RudolphK . Telomere shortening and ageing.Z. Gerontol. Geriatr.40 ( 5 ), 314 – 324 ( 2007 ).
  • Allsopp RC , VaziriH , PattersonCet al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl Acad. Sci. USA 89 ( 21 ), 10114 – 10118 ( 1992 ).
  • Harley CB , FutcherAB , GreiderCW . Telomeres shorten during ageing of human fibroblasts.Nature345 ( 6274 ), 458 – 460 ( 1990 ).
  • Londoño-Vallejo JA . Telomere instability and cancer.Biochimie90 ( 1 ), 73 – 82 ( 2008 ).
  • Shay JW , WrightWE . Role of telomeres and telomerase in cancer.Sem. Cancer Biol.21 ( 6 ), 349 – 353 ( 2011 ).
  • Wang YY , ChenAF , WangHZ , XieLY , SuiKX , ZhangQY . Association of shorter mean telomere length with large artery stiffness in patients with coronary heart disease.Aging Male14 ( 1 ), 27 – 32 ( 2011 ).
  • Salpea KD , HumphriesSE . Telomere length in atherosclerosis and diabetes.Atherosclerosis209 ( 1 ), 35 – 38 ( 2010 ).
  • Salpea KD , TalmudPJ , CooperJAet al. Association of telomere length with Type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis 209 ( 1 ), 42 – 50 ( 2010 ).
  • Al-Attas OS , Al-DaghriNM , AlokailMSet al. Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin. Eur. J. Endocrinol. 163 ( 4 ), 601 – 607 ( 2010 ).
  • Calado RT , YoungNS . Telomere diseases.N. Engl. J. Med.361 ( 24 ), 2353 – 2365 ( 2009 ).
  • Friedrich U , SchwabM , GrieseEU , FritzP , KlotzU . Telomeres in neonates: new insights in fetal hematopoiesis.Pediatr. Res.49 ( 2 ), 252 – 256 ( 2001 ).
  • Holmes DK , BellantuonoI , WalkinshawSAet al. Telomere length dynamics differ in foetal and early post-natal human leukocytes in a longitudinal study. Biogerontology 10 ( 3 ), 279 – 284 ( 2009 ).
  • Menon R , YuJ , Basanta-HenryPet al. Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes. PLoS ONE 7 ( 2 ), e31136 ( 2012 ).
  • Kajantie E , PietiläinenKH , WehkalampiKet al. No association between body size at birth and leucocyte telomere length in adult life – evidence from three cohort studies. Int. J. Epidemiol. 41 ( 5 ), 1400 – 1408 ( 2012 ).
  • Henckel E , BroströmEB , HedlinG , RoosG , BohlinK . Prematurity and lung function in relation to telomere length and inflammation in 10-year old children.Pediatr. Res.70 , 136 ( 2011 ).
  • Allshire RC , DempsterM , HastieND . Human telomeres contain at least three types of G–rich repeat distributed non-randomly.Nucleic Acids Res.17 ( 12 ), 4611 – 4627 ( 1989 ).
  • Müezzinler A , ZaineddinAK , BrennerH . A systematic review of leukocyte telomere length and age in adults.Ageing Res. Rev.12 ( 2 ), 509 – 519 ( 2013 ).
  • Levy MZ , AllsoppRC , FutcherAB , GreiderCW , HarleyCB . Telomere end-replication problem and cell aging.J. Mol. Biol.225 ( 4 ), 951 – 960 ( 1992 ).
  • Mefford HC , TraskBJ . The complex structure and dynamic evolution of human subtelomeres.Nature Rev. Genet.3 ( 2 ), 91 – 102 ( 2002 ).
  • Baird DM , JeffreysAJ , RoyleNJ . Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere.EMBO J.14 ( 21 ), 5433 – 5443 ( 1995 ).
  • Riethman H , AmbrosiniA , PaulS . Human subtelomere structure and variation.Chromosome Res.13 ( 5 ), 505 – 515 ( 2005 ).
  • Kimura M , StoneRC , HuntSCet al. Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths. Nat. Protoc. 5 ( 9 ), 1596 – 1607 ( 2010 ).
  • Bryant JE , HutchingsKG , MoyzisRK , GriffithJK . Measurement of telomeric DNA content in human tissues.Biotechniques23 ( 3 ), 476 – 478 , 480, 482, passim ( 1997 ).
  • Norwood D , DimitrovDS . Sensitive method for measuring telomere lengths by quantifying telomeric DNA content of whole cells.Biotechniques25 ( 6 ), 1040 – 1045 ( 1998 ).
  • Cawthon RM . Telomere measurement by quantitative PCR.Nucleic Acids Res.30 ( 10 ), e47 ( 2002 ).
  • Cawthon RM . Telomere length measurement by a novel monochrome multiplex quantitative PCR method.Nucleic Acids Res.37 ( 3 ), e21 ( 2009 ).
  • Treff NR , SuJ , TaylorD , ScottRTJr . Telomere DNA deficiency is associated with development of human embryonic aneuploidy.PLoS Genet.7 ( 6 ), e1002161 ( 2011 ).
  • O’Callaghan NJ , FenechM . A quantitative PCR method for measuring absolute telomere length.Biol. Proced. Online13 , 3 ( 2011 ).
  • Baird DM , RowsonJ , Wynford-ThomasD , KiplingD . Extensive allelic variation and ultrashort telomeres in senescent human cells.Nat. Genet.33 ( 2 ), 203 – 207 ( 2003 ).
  • Britt-Compton B , RowsonJ , LockeM , MackenzieI , KiplingD , BairdDM . Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans.Hum. Mol. Genet.15 ( 5 ), 725 – 733 ( 2006 ).
  • Xing J , AjaniJA , ChenMet al. Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev. Res. 2 ( 5 ), 459 – 465 ( 2009 ).
  • Bendix L , HornPB , JensenUB , RubeljI , KolvraaS . The load of short telomeres, estimated by a new method, Universal STELA, correlates with number of senescent cells.Aging Cell9 ( 3 ), 383 – 397 ( 2010 ).
  • Brown WR , MacKinnonPJ , VillasantéA , SpurrN , BuckleVJ , DobsonMJ . Structure and polymorphism of human telomere-associated DNA.Cell63 ( 1 ), 119 – 132 ( 1990 ).
  • Ijdo JW , LindsayEA , WellsRA , BaldiniA . Multiple variants in subtelomeric regions of normal karyotypes.Genomics14 ( 4 ), 1019 – 1025 ( 1992 ).
  • Riethman H . Human subtelomeric copy number variations.Cytogenet. Genome Res.123 ( 1–4 ), 244 – 252 ( 2009 ).
  • Rudd MK . Human and primate subtelomeres . In: Subtelomeres . LouisEJ , BeckerMM (Eds). Springer Berlin Heidelberg , Berlin, Germany , 153 – 164 ( 2014 ).
  • Lansdorp PM , VerwoerdNP , VanDe Rijke FMet al. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5 ( 5 ), 685 – 691 ( 1996 ).
  • De Pauw E , VerwoerdN , DuinkerkenNet al. Assessment of telomere length in hematopoietic interphase cells using in situ hybridization and digital fluorescence microscopy. Cytometry 32 ( 3 ), 163 – 169 ( 1998 ).
  • Poon SS , MartensUM , WardRK , LansdorpPM . Telomere length measurements using digital fluorescence microscopy.Cytometry36 ( 4 ), 267 – 278 ( 1999 ).
  • Erdmann N , LiuY , HarringtonL . Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice.Proc. Natl Acad. Sci. USA101 ( 16 ), 6080 – 6085 ( 2004 ).
  • Wong HP , SlijepcevicP . Telomere length measurement in mouse chromosomes by a modified Q-FISH method.Cytogenet. Genome Res.105 ( 2–4 ), 464 – 470 ( 2004 ).
  • Zijlmans JM , MartensUM , PoonSSet al. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl Acad. Sci. USA 94 ( 14 ), 7423 – 7428 ( 1997 ).
  • Ourliac-Garnier I , Londoño-VallejoA . Telomere length analysis by quantitative fluorescent in situ hybridization (Q-FISH).Methods Mol. Biol.735 , 21 – 31 ( 2011 ).
  • Baerlocher GM , VultoI , DeJong G , LansdorpPM . Flow cytometry and FISH to measure the average length of telomeres (flow FISH).Nat. Protoc.1 ( 5 ), 2365 – 2376 ( 2006 ).
  • Baerlocher GM , LansdorpPM . Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH.Cytometry Part A55 ( 1 ), 1 – 6 ( 2003 ).
  • Wieser M , StadlerG , BöhmEet al. Nuclear flow FISH: isolation of cell nuclei improves the determination of telomere lengths. Exp. Gerontol. 41 ( 2 ), 230 – 235 ( 2006 ).
  • Alter BP , BaerlocherGM , SavageSAet al. Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood 110 ( 5 ), 1439 – 1447 ( 2007 ).
  • Aviv A , ValdesAM , SpectorTD . Human telomere biology: pitfalls of moving from the laboratory to epidemiology.Int. J. Epidemiol.35 ( 6 ), 1424 – 1429 ( 2006 ).
  • Shiels PG . Improving precision in investigating aging: why telomeres can cause problems.J. Gerontol. A Biol. Sci. Med. Sci.65 ( 8 ), 789 – 791 ( 2010 ).
  • Baird DM . New developments in telomere length analysis.Exp. Gerontol.40 ( 5 ), 363 – 368 ( 2005 ).
  • Koppelstaetter C , SchratzbergerG , PercoPet al. Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation. Aging Cell 7 ( 4 ), 491 – 497 ( 2008 ).
  • Gingell-Littlejohn M , McGuinnessD , McGlynnLMet al. Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. PLoS ONE 8 ( 7 ), e68133 ( 2013 ).
  • Pathai S , GilbertCE , LawnSDet al. Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. Mech. Ageing Dev. 134 ( 7–8 ) 338 – 345 ( 2013 ).
  • Young RC , KitayskyAS , HaussmannMFet al. Age, sex, and telomere dynamics in a long-lived seabird with male-biased parental care. PLoS ONE 8 ( 9 ), e74931 ( 2013 ).
  • Aubert G , HillsM , LansdorpPM. Telomere length measurement – caveats and a critical assessment of the available technologies and tools . Mutat. Res.730 ( 1 ), 59 – 67 ( 2012 ).
  • Heaphy CM , BisoffiM , JosteNE , BaumgartnerKB , BaumgartnerRN , GriffithJK . Genomic instability demonstrates similarity between DCIS and invasive carcinomas.Breast Cancer Res. Treat.117 ( 1 ), 17 – 24 ( 2009 ).
  • Heaphy CM , BaumgartnerKB , BisoffiM , BaumgartnerRN , GriffithJK . Telomere DNA content predicts breast cancer-free survival interval.Clin. Cancer Res.13 ( 23 ), 7037 – 7043 ( 2007 ).
  • Treat EG , HeaphyCM , MassieLWet al. Telomere DNA content in prostate biopsies predicts early rise in prostate-specific antigen after radical prostatectomy for prostate cancer. Urology 75 ( 3 ), 724 – 729 ( 2010 ).
  • Isokawa O , SudaT , AoyagiYet al. Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: convenient evaluation by slot-blot analysis. Hepatology 30 ( 2 ), 408 – 412 ( 1999 ).
  • Jeyapalan JN , Mendez-BermudezA , ZaffaroniN , DubrovaYE , RoyleNJ . Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies.Int. J. Cancer122 ( 11 ), 2414 – 2421 ( 2008 ).
  • Harbo M , DelaisseJ , Kjaersgaard-AndersenP , SoerensenF , KoelvraaS , BendixL . The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis.Mech. Ageing Dev.134 ( 9 ), 367 – 372 ( 2013 ).
  • Liu X , BaoG , HuoT , WangZ , HeX , DongG . Constitutive telomere length and gastric cancer risk: case–control analysis in Chinese Han population.Cancer Sci.100 ( 7 ), 1300 – 1305 ( 2009 ).
  • Harris SE , Martin-RuizC , Von ZglinickiT , StarrJM , DearyIJ . Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936.Neurobiol. Aging33 ( 7 ), 1486.e3 – 1486.e8 ( 2012 ).
  • Criscuolo F , BizeP , NasirLet al. Real-time quantitative PCR assay for measurement of avian telomeres. J. Avian Biol. 40 ( 3 ), 342 – 347 ( 2009 ).
  • Wang F , PanX , KalmbachKet al. Robust measurement of telomere length in single cells. Proc. Natl Acad. Sci. USA 110 ( 21 ), 1906 – 1912 ( 2013 ).
  • Aviv A , HuntSC , LinJ , CaoX , KimuraM , BlackburnE . Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR.Nucleic Acids Res.39 ( 20 ), e134 ( 2011 ).
  • Ferlicot S , YoussefN , FeneuxD , DelhommeauF , ParadisV , BedossaP . Measurement of telomere length on tissue sections using quantitative fluorescence in situ hybridization (Q-FISH).J. Pathol.200 ( 5 ), 661 – 666 ( 2003 ).
  • Vera E , BlascoMA . Beyond average potential for measurement of short telomeres.Aging (Albany NY)4 ( 6 ), 379 – 392 ( 2012 ).
  • O’Sullivan JN , FinleyJC , RisquesRAet al. Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms. Cytometry Part A 58 ( 2 ), 120 – 131 ( 2004 ).
  • Nakamura KI , IshikawaN , IzumiyamaNet al. Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH. Gene 533 ( 1 ), 199 – 207 ( 2014 ).
  • Sputova K , GarbeJC , PelissierFA , ChangE , StampferMR , LabargeMA . Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length.Genome Integr.4 ( 1 ), 1 – 8 ( 2013 ).
  • Shen J , TerryMB , GurvichI , LiaoY , SenieRT , SantellaRM . Short telomere length and breast cancer risk: a study in sister sets.Cancer Res.67 ( 11 ), 5538 – 5544 ( 2007 ).
  • Cunningham JM , JohnsonRA , LitzelmanKet al. Telomere length varies by DNA extraction method: implications for epidemiologic research. Cancer Epidemiol. Biomarkers Prev. 22 ( 11 ), 2047 – 2054 ( 2013 ).
  • Zanet DL , SaberiS , OliveiraL , SatthaB , GadawskiI , CôtéHC . Blood and dried blood spot telomere length measurement by qPCR: assay considerations.PLoS ONE8 ( 2 ), e57787 ( 2013 ).
  • Spyridopoulos I , ErbenY , BrummendorfTHet al. Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 28 ( 5 ), 968 – 974 ( 2008 ).
  • Hoffmann J , ErbenY , ZeiherAM , DimmelerS , SpyridopoulosI . Telomere length-heterogeneity among myeloid cells is a predictor for chronological ageing.Exp. Gerontol.44 ( 5 ), 363 – 366 ( 2009 ).
  • Zeichner SL , PalumboP , FengYet al. Rapid telomere shortening in children. Blood 93 ( 9 ), 2824 – 2830 ( 1999 ).
  • Frenck RW Jr , BlackburnEH , ShannonKM . The rate of telomere sequence loss in human leukocytes varies with age.Proc. Natl Acad. Sci. USA95 ( 10 ), 5607 – 5610 ( 1998 ).
  • Okuda K , BardeguezA , GardnerJPet al. Telomere length in the newborn. Pediatr. Res. 52 ( 3 ), 377 – 381 ( 2002 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.