Biomarkers in Frontotemporal Dementia

References

• Seelaar H , RohrerJD , PijnenburgYA , FoxNC , van SwietenJC. Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review.J. Neurol. Neurosurg. Psychiatry82 ( 5 ), 476–486 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Rohrer JD , WarrenJD. Phenotypic signatures of genetic frontotemporal dementia.Curr. Opin. Neurol.24 ( 6 ), 542–549 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Rohrer JD , RosenH. Neuroimaging of frontotemporal dementia . Int. Rev. Psychiatry25 ( 2 ), 221 – 229 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Rohrer JD , RidgwayGR , ModatMet al. Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations. Neuroimage 53 ( 3 ), 1070 – 1076 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Rohrer JD , LashleyT , SchottJMet al. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Brain 134 ( 9 ), 2565 – 2581 ( 2011 ).
   PubMedGoogle Scholar
• Whitwell JL , WeigandSD , BoeveBFet al. Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics. Brain 135 ( Pt 3 ), 794 – 806 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• McMillan CT , IrwinDJ , AvantsBBet al. White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration. J. Neurol. Neurosurg. Psychiatry 84 ( 9 ), 949 – 955 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Knopman DS , KramerJH , BoeveBFet al. Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. Brain 131 ( Pt 11 ), 2957 – 2968 ( 2008 ).
   PubMedGoogle Scholar
• Gordon E , RohrerJD , KimLGet al. Measuring disease progression in frontotemporal lobar degeneration: a clinical and MRI study. Neurology 74 ( 8 ), 666 – 673 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Rohrer JD , ClarksonMJ , KittusRet al. Rates of hemispheric and lobar atrophy in the language variants of frontotemporal lobar degeneration . J. Alzheimers Dis.30 ( 2 ), 407 – 411 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Ghidoni R , StoppaniE , RossiGet al. Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian study. Neurodegener. Dis. 9 ( 3 ), 121 – 127 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Bian H , Van SwietenJC , LeightSet al. CSF biomarkers in frontotemporal lobar degeneration with known pathology. Neurology 70 ( 19 Pt 2 ), 1827 – 1835 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Rosso SM , van HerpenE , PijnenburgYAet al. Total tau and phosphorylated tau 181 levels in the cerebrospinal fluid of patients with frontotemporal dementia due to P301L and G272V tau mutations. Arch Neurol. 60 ( 9 ), 1209 – 1213 ( 2003 ).
   PubMedGoogle Scholar
• Foulds PG , DavidsonY , MishraM. Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration . Acta Neuropathol.118 ( 5 ), 647 – 658 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Suárez-Calvet M , Dols-IcardoO , LladóA. Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation . J. Neurol. Neurosurg. Psychiatry   doi:10.1136/jnnp-2013–305972 ( 2013 ) ( Epub ahead of print ).
   PubMed Web of Science ®Google Scholar
• Landqvist Waldö M , FrizellSantillo A , PassantUet al. Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia. BMC Neurol. 13 , 54 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Hu WT , Chen-PlotkinA, GrossmanMet al. Novel CSF biomarkers for frontotemporal lobar degenerations. Neurology 75 ( 23 ), 2079 – 2086 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Hu WT , WattsK , GrossmanMet al. Reduced CSF p-tau181 to tau ratio is a biomarker for FTLD–TDP . Neurology81 ( 22 ), 1945 – 1952 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Scherling CS , HallT , BerishaF. Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration . Ann Neurol.   doi:10.1002/ana.24052 ( 2013 ) ( Epub ahead of print ).
   Web of Science ®Google Scholar
• Martens LH , ZhangJ , BarmadaSJet al. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J. Clin. Invest. 122 ( 11 ), 3955 – 3959 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Lant SB , RobinsonAC , ThompsonJC. Patterns of microglial cell activation in frontotemporal lobar degeneration . Neuropathol. Appl. Neurobiol.   doi:10.1111/nan.12092 ( 2013 ) ( Epub ahead of print ).
   Web of Science ®Google Scholar
• Bossù P , SalaniF , AlbericiAet al. Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients. J. Neuroinflammation 8 , 65 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Miller ZA , RankinKP , Graff-RadfordNR. TDP-43 frontotemporal lobar degeneration and autoimmune disease . J. Neurol. Neurosurg. Psychiatry84 ( 9 ),  956–962 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Chien DT , BahriS , SzardeningsAKet al. Early clinical PET imaging results with the novel PHF-tauradioligand [F-18]-T807. J. Alzheimers Dis. 34 ( 2 ), 457 – 468 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Bateman RJ , XiongC , BenzingerTLDominantlyInherited Alzheimer Networket al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367 ( 9 ), 795 – 804 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Rohrer JD , WarrenJD , FoxNC , RossorMN. Presymptomatic studies in genetic frontotemporal dementia.Rev. Neurol. (Paris)169 ( 10 ), 820 – 824 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Borroni B , AlbericiA , CercignaniMet al. Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD . Neurobiol. Aging33 ( 10 ), 2506 – 2520 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Dopper EG , RomboutsSA , JiskootLCet al. Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia. Neurology 80 ( 9 ), 814 – 823 ( 2013 ).
   PubMed Web of Science ®Google Scholar