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Editorials

More than skin deep: dyslipidemia in skin diseases

Pages 533-536 | Published online: 18 Jan 2017

  • Gelfand JM, Dommasch ED, Shin DB et al.: The risk of stroke in patients with psoriasis. J. Invest. Dermatol. DOI: 10.1038/ jid.2009.112 (2009) (Epub ahead of print).
  • Cohort study that examined the risk of stroke in psoriasis patients and demonstrated in a well-planned study an excess risk.
  • Prodanovich S, Kirsner RS, Kravetz JD et al.: Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality. Arch. Dermatol. 145(6), 700–703 (2009).
  • Kaye JA, Li L, Jick SS: Incidence of risk factors for myocardial infarction and other vascular diseases in patients with psoriasis. Br. J. Derm. 159(4), 895–902 (2008).
  • Kimball AB, Robinson D, Wu Y et al.: Cardiovascular disease and risk factors among psoriasis patients in two US healthcare databases, 2001–2002. Dermatology 217(1), 27–37 (2008).
  • Gelfand JM, Neimann AL, Shin DB et al.: Risk of myocardial infarction in patients with psoriasis. JAMA 296(14), 1735–1741 (2006).
  • Well-designed cohort study. This study was among the first to demonstrate an excess risk of myocardial infarction in psoriasis patients.
  • Christophers E: Comorbidities in psoriasis. J. Eur. Acad. Dermatol. Venereol. 20 (Suppl.), 52–55 (2006).
  • Wakkee M, Thio HB, Prens EP, Sijbrands EJ, Neumann HA: Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients. Atherosclerosis 190(1), 1–9 (2007).
  • Mallbris L, Granath F, Hamsten A, Ståhle M: Psoriasis is associated with lipid abnormalities at the onset of skin disease. J. Am. Acad. Dermatol. 54(4), 614–621 (2006).
  • Case–control study, that is one of the first to show an increased prevalence of dyslipidemia (and specific lipid abnormalities) in psoriasis patients.
  • Naldi L, Chatenoud L, Linder D et al.: Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case–control study. J. Invest. Dermatol. 125(1), 61–67 (2005).
  • Neimann AL, Shin DB, Wang X et al.: Prevalence of cardiovascular risk factors in patients with psoriasis. J. Am. Acad. Dermatol. 55(5), 829–835 (2006).
  • Sommer DM, Jenisch S, Suchan M, Christophers E, Weichental M: Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch. Dermatol. Res. 298(7), 321–328 (2006).
  • Späh F: Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. Br. J. Derm. 159 (Suppl. 2), 10–17 (2008).
  • Excellent review that summarizes the common inflammatory pathways in psoriasis and atherosclerosis.
  • Wu Y, Mills D, Bala M: Psoriasis: cardiovascular risk factors and other disease comorbidities. J. Drug. Dermatol. 7(4), 373–377 (2008).
  • Pietrzak A, Lecewicz-Torun B: Activity of serum lipase (EC 3.1.1.3) and the diversity of serum lipid profile in psoriasis. Med. Sci. Monit. 8(1), CR9–CR13 (2002).
  • Tekin NS, Tekin IO, Barut F, Sipahi EY: Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients. Mediators Inflamm. 78454 (2007).
  • Pearce DJ, Morrison AE, Higgins KB et al.: The comorbid state of psoriasis patients in a university dermatology practice. J. Derm. Treat. 16(5–6), 319–332 (2005).
  • Cohen AD, Dreiher J, Shapiro Y et al.: Psoriasis and diabetes: a population-based cross-sectional study. J. Eur. Acad. Dermatol. Venereol. 22(5), 585–589 (2008).
  • Cohen AD, Gilutz H, Henkin Y et al.: Psoriasis and the metabolic syndrome. Acta Derm. Venereol. 87(6), 506–509 (2007).
  • Cohen AD, Sherf M, Vidavsky L et al.: Between psoriasis and the metabolic syndrome: a cross-sectional study. Dermatology 216(2), 152–155 (2008)
  • Dreiher J, Shapiro J, Cohen AD: Lichen planus and dyslipidemia: a case–control study. Br. J. Derm. 161(3), 626–629 (2009).
  • da Cunha DF, da Cunha SF, Montero JP et al.: Nutritional evaluation of pemphigus foliaceus patients on long term glucocorticoid therapy. Rev. Inst. Med. Trop. Sao Paulo 42(1), 23–26 (2000).
  • da Cunha SF, dos Santos VM, Montero JP et al.: Serum lipids of pemphigus foliaceus patients on long term glucocorticoid therapy. Rev. Soc. Bras. Med. Trop. 36 (1), 1–4 (2003).
  • Wohl Y, Dreiher J, Cohen AD: Pemphigus and dyslipidemia: a case–control study. Br. J. Derm. DOI: 10.1111/j.1365-2133.2009.09474.x (2009) (Epub ahead of print).
  • Azfar RS, Gelfand JM: Psoriasis and metabolic disease: epidemiology and pathophysiology. Curr. Opin. Rheumatol. 20(4), 416–422 (2008) Excellent review that summarizes the various explanations for the association between psoriasis and the metabolic syndrome.
  • Gottlieb A, Dann F, Menter A: Psoriasis and the metabolic syndrome. J. Drugs Dermatol. 7(6), 53–72 (2008).
  • Good review regarding the association between psoriasis and the metabolic syndrome.
  • Farshichian M, Zamanian A, Farshichian M, Monsef AR, Mahjub A: Serum lipid levels in Iranian patients with psoriasis. J. Eur. Assoc. Deramatol. Venereol. 21(6), 802–805 (2007).
  • Sezer E, Ozugurlu F, Ozyurt H, Sahin S, Etikan I: Lipid peroxidation and antioxidant status in lichen planus. Clin. Exp. Dermatol. 32(4), 430–434 (2007).
  • Grossmann SMC, de Aguiar MCF, Teixeira R, do Carmo MAV: Oral lichen planus and chronic hepatitis C: a controversial association. Am. J. Clin. Pathol. 127(5), 800–804 (2007).
  • Meller S, Gilliet M, Homey B: Chemokines in the pathogenesis of lichenoid tissue reactions. J. Invest. Dermatol. 129(2), 315–319 (2009).
  • Nijsten T, Wakkee M: Complexity of the association between psoriasis and comorbidities. J. Invest. Derm. 129(7), 1601–1603 (2009).
  • Thought-provoking editorial that summarizes the methodological pitfalls in epidemiological studies of comorbidities in psoriasis.
  • Namazi MR: Statins: novel additions to the dermatologic arsenal? Exp. Dermatol. 13(6), 337–339 (2004).
  • Shirinsky IV, Shirinsky VS: Efficacy of simvastatin in plaque psoriasis: a pilot study. J. Am. Acad. Derm. 37(3), 529–531 (2007)
  • Only study published to date that tested the utility of statins in psoriasis.

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