Bibliography
- Smas CM, Sul HS: Pref1, a protein containing EGFlike repeats, inhibits adipocyte differentiation. Cell 73, 725–734 (1993). First report that demonstrates Pref-1 inhibition of adipocyte differentiation.
- Lee YL, Helman L, Hoffman T, Laborda J: dlk, pG2 and Pref‑1 mRNAs encode similar proteins belonging to the EGFlike superfamily. Identification of polymorphic variants of this RNA. Biochim. Biophys. Acta 1261, 223–232 (1995).
- Laborda J, Sausville EA, Hoffman T, Notario V: dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J. Biol. Chem. 268, 3817–3820 (1993).
- Jensen CH, Teisner B, Hojrup P et al.: Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenalspecific cDNA, pG2. Hum. Reprod. 8, 635–641 (1993).
- Carlsson C, Tornehave D, Lindberg K et al.: Growth hormone and prolactin stimulate the expression of rat preadipocyte factor1/ Deltalike protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas. Endocrinology 138, 3940–3948 (1997).
- Kaneta M, Osawa M, Sudo K, Nakauchi H, Farr AG, Takahama Y: A role for pref1 and HES1 in thymocyte development. J. Immunol. 164, 256–264 (2000).
- Halder SK, Takemori H, Hatano O, Nonaka Y, Wada A, Okamoto M: Cloning of a membranespanning protein with epidermal growth factorlike repeat motifs from adrenal glomerulosa cells. Endocrinology 139, 3316–3328 (1998).
- Floridon C, Jensen CH, Thorsen P et al.: Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation. Differentiation 66, 49–59 (2000).
- Schmidt JV, Matteson PG, Jones BK, Guan XJ, Tilghman SM: The Dlk1 and Gtl2 genes are linked and reciprocally imprinted. Genes Dev. 14, 1997–2002 (2000).
- Takada S, Tevendale M, Baker J et al.: Deltalike and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Curr. Biol. 10, 1135–1138 (2000).
- Wylie AA, Murphy SK, Orton TC, Jirtle RL: Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 10, 1711–1718 (2000).
- Murphy SK, Freking BA, Smith TP et al.: Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep. Mamm. Genome 16, 171–183 (2005).
- Smas CM, Green D, Sul HS: Structural characterization and alternate splicing of the gene encoding the preadipocyte EGFlike protein pref1. Biochemistry 33, 9257–9265 (1994).
- Smas CM, Chen L, Sul HS: Cleavage of membraneassociated pref1 generates a soluble inhibitor of adipocyte differentiation. Mol. Cell. Biol. 17, 977–988 (1997). Transmembrane form of Pref-1 is cleaved to generate a soluble Pref-1 to inhibit adipocyte differentiation.
- Wang Y, Sul HS: Pref1 regulates mesenchymal cell commitment and differentiation through Sox9. Cell Metab. 9, 287–302 (2009). Downregulation of Sox9 is required for adipocyte differentiation and Pref-1 inhibits adipocyte differentiation by preventing downregulation of Sox9. Sox9 directly binds to promoter regions of C/EBP-b and C/EBP-d to suppress their transcription.
- Abdallah BM, Jensen CH, Gutierrez G, Leslie RG, Jensen TG, Kassem M: Regulation of human skeletal stem cells differentiation by Dlk1/Pref1. J. Bone Miner. Res. 19, 841–852 (2004).
- Ohno N, Izawa A, Hattori M, Kageyama R, Sudo T: dlk inhibits stem cell factorinduced colony formation of murine hematopoietic progenitors: Hes1independent effect. Stem Cells 19, 71–79 (2001).
- Raghunandan R, RuizHidalgo M, Jia Y et al.: Dlk1 influences differentiation and function of B lymphocytes. Stem Cells Dev. 17, 495–507 (2008).
- Yin D, Xie D, Sakajiri S et al.: DLK1: increased expression in gliomas and associated with oncogenic activities. Oncogene 25, 1852–1861 (2006).
- Huang J, Zhang X, Zhang M et al.: Upregulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis 28, 1094–1103 (2007).
- Mei B, Zhao L, Chen L, Sul HS: Only the large soluble form of preadipocyte factor1 (Pref1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing. Biochem. J. 364, 137–144 (2002).
- Deiuliis JA, Li B, LyversPeffer PA, Moeller SJ, Lee K: Alternative splicing of Deltalike 1 homolog (DLK1) in the pig and human. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 145, 50–59 (2006).
- Jensen CH, Krogh TN, Hojrup P et al.: Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermalgrowth factorlike protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. Eur. J. Biochem. 225, 83–92 (1994).
- Wang Y, Sul HS: Ectodomain shedding of preadipocyte factor 1 (Pref1) by tumor necrosis factora converting enzyme (TACE) and inhibition of adipocyte differentiation. Mol. Cell. Biol. 26, 5421–5435 (2006).
- Smas CM, Kachinskas D, Liu CM, Xie X, Dircks LK, Sul HS: Transcriptional control of the pref‑1 gene in 3T3L1 adipocyte differentiation. Sequence requirement for differentiationdependent suppression. J. Biol. Chem. 273, 31751–31758 (1998).
- Kim KA, Kim JH, Wang Y, Sul HS: Pref1 (preadipocyte factor 1) activates the MEK/ extracellular signalregulated kinase pathway to inhibit adipocyte differentiation. Mol. Cell. Biol. 27, 2294–2308 (2007).
- Moon YS, Smas CM, Lee K et al.: Mice lacking paternally expressed Pref1/Dlk1 display growth retardation and accelerated adiposity. Mol. Cell. Biol. 22, 5585–5592 (2002). Pref-1 null mice show enhanced adipogenesis and accelerated adiposity.
- Lee K, Villena JA, Moon YS et al.: Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor1 (Pref1). J. Clin. Invest. 111, 453–461 (2003). Pref-1 overexpressing mice show impaired adipogenesis with lean phenotype.
- Villena JA, Choi CS, Wang Y et al.: Resistance to highfat dietinduced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor1 (Pref1): a new model of partial lipodystrophy. Diabetes 57, 3258–3266 (2008).
- Wermter AK, Scherag A, Meyre D et al.: Preferential reciprocal transfer of paternal/ maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. Eur. J. Hum. Genet. 16, 1126–1134 (2008).
- Zhang H, Noohr J, Jensen CH et al.: Insulinlike growth factor1/insulin bypasses Pref1/FA1mediated inhibition of adipocyte differentiation. J. Biol. Chem. 278, 20906–20914 (2003).
- RuizHidalgo MJ, Gubina E, Tull L, Baladron V, Laborda J: dlk modulates mitogenactivated protein kinase signaling to allow or prevent differentiation. Exp. Cell. Res. 274, 178–188 (2002).
- Nueda ML, GarciaRamirez JJ, Laborda J, Baladron V: dlk1 specifically interacts with insulinlike growth factor binding protein 1 to modulate adipogenesis of 3T3L1 cells. J. Mol. Biol. 379, 428–442 (2008).
- Ross DA, Rao PK, Kadesch T: Dual roles for the Notch target gene Hes‑1 in the differentiation of 3T3L1 preadipocytes. Mol. Cell. Biol. 24, 3505–3513 (2004).
- Garces C, RuizHidalgo MJ, Font de Mora J et al.: Notch1 controls the expression of fatty acidactivated transcription factors and is required for adipogenesis. J. Biol. Chem. 272, 29729–29734 (1997).
- Nichols AM, Pan Y, Herreman A et al.: Notch pathway is dispensable for adipocyte specification. Genesis 40, 40–44 (2004).
- Fleming RJ, Scottgale TN, Diederich RJ, ArtavanisTsakonas S: The gene Serrate encodes a putative EGFlike transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 4, 2188–2201 (1990).
- Kopczynski CC, Alton AK, Fechtel K, Kooh PJ, Muskavitch MA: Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. Genes Dev. 2, 1723–1735 (1988).
- Tax FE, Yeargers JJ, Thomas JH: Sequence of C. elegans lag2 reveals a cellsignalling domain shared with Delta and Serrate of Drosophila. Nature 368, 150–154 (1994).
- Baladron V, RuizHidalgo MJ, Nueda ML et al.: dlk acts as a negative regulator of Notch1 activation through interactions with specific EGFlike repeats. Exp. Cell. Res. 303, 343–359 (2005).
- Bray SJ, Takada S, Harrison E, Shen SC, FergusonSmith AC: The atypical mammalian ligand Deltalike homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev. Biol. 8, 11 (2008).
- Nueda ML, Baladron V, SanchezSolana B, Ballesteros MA, Laborda J: The EGFlike protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells. J. Mol. Biol. 367, 1281–1293 (2007).