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Perspective

LDL lowering in peripheral arterial disease:are there benefits beyond reducing cardiovascular morbidity and mortality?

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Pages 141-149 | Published online: 18 Jan 2017

References

  • Weitz JI, Byrne J, Clagett GP et al. Diagnosis and treatment of chronic arterial insufficiency of the lower extremities: a critical review. Circulation 94, 3026-3049 (1996).
  • Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey. Circulation 110, 738-743 (2004).
  • Diehm C, Allenberg JR, Pittrow D et al. Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral arterial disease. Circulation 120, 2053-2061 (2009).
  • McDermott MM, Mehta S, Greenland P. Exertional leg symptoms other than intermittent claudication are common in peripheral arterial disease. Arch. Intern. Med. 159, 387-392 (1999).
  • McDermott MM, Liu K, Greenland P et al. Functional decline in peripheral arterial disease: associations with ankle brachial index and leg symptoms. JAMA 292, 453-461 (2004).
  • Dumville JC, Lee AJ, Smith FB, Fowkes FGR. The health related quality of life of people with peripheral arterial disease in the community: the Edinburgh Artery Study. Br. J. Gen. Pract. 54(508), 639-642 (2004).
  • Catalano M. Epidemiology of critical limb ischemia: northern Italian data. Eur. J. Med. 2, 11-14 (1993).
  • American Diabetes Association. Peripheral arterial disease in people with diabetes. Diabetes Care 26, 3333-3341 (2003).
  • Muluk SC, Muluk VS, Kelley ME et al. Outcome events in patients with claudication: a 15 year study in 2777 patients. J. Vasc. Surg. 33(2), 251-258 (2001).
  • Heart Protection Study Collaborative Group. Randomized trial of the effects of cholesterol-lowering with simvastatin on peripheral vascular and other major vascular outcomes in 20,536 people with peripheral arterial disease and other high-risk conditions. J. Vasc. Surg. 45, 645-654 (2007).
  • Aung PP, Maxwell H, Jepson RG, Price J, Leng GC. Lipid-lowering for peripheral arterial disease of the lower limb. Cochrane Database Syst. Rev. 4, CD000123 (2007).
  • Feringa HH, Karagiannis SE, van Waning VH et al. The effect of lipid-lowering therapy on long-term prognosis in patients with peripheral arterial disease. J. Vasc. Surg. 45, 936-943 (2007).
  • Sastry P, Kaski JC. Atherosclerotic plaque regression - the role of statin therapy. Drugs Today (Barc.) 46(8), 601-608 (2010).
  • Youssef F, Seifalian AM, Jagroop IA et al. The early effect of lipid lowering treatment on carotid and femoral intima media thickness (IMT). Eur. J. Vasc. Endovasc. Surg. 23(4), 358-364 (2002).
  • West AM, Anderson JD, Meyer CH et al. The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline. Atherosclerosis 218, 156-162 (2012).
  • Kastelein JJ, Akdim F, Stroes ES et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N. Engl. J. Med. 358, 1431-1443 (2008).
  • Taylor AJ, Villines TC, Stanek EJ et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N. Engl. J. Med. 361, 2113-2122 (2009).
  • Pedersen T, Kjekshus J, Berg K et al. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344, 1383-1389 (1994).
  • Pedersen TR, Kjekshus J, Pyorala K et al. Effect of simvastatin on ischemic signs and symptoms in the Scandinavian Simvastatin Survival Study. Am. J. Cardiol. 81(3), 333-335 (1998).
  • Aronow WS, Nayak D, Woodworth S, Ahn C. Effect of simvastatin versus placebo on treadmill exercise time until the onset of intermittent claudication in older patients with peripheral arterial disease at 6 months and one year after treatment. Am. J. Cardiol. 92(6), 711-712 (2003).
  • Mondillo S, Ballo P, Barbati R et al. Effects of simvastatin on walking performance and symptoms of intermittent claudication in hypercholesterolemic patients with peripheral vascular disease. Am. J. Med. 114(5), 359-364 (2003).
  • Mohler ER 3rd, Hiatt WR, Creager MA. Cholesterol reduction with atorvastatin improves walking distance in patients with peripheral arterial disease. Circulation 108, 1481-1486 (2003).
  • McDermott MM, Guralnik JM, Greenland P et al. Statin use and leg functioning in patients with and without lower-extremity peripheral arterial disease. Circulation 107, 757-761 (2003).
  • Giri J, McDermott MM, Greenland P et al. Statin use and functional decline in patients with and without peripheral arterial disease. J. Am. Coll. Cardiol. 47, 998-1004 (2006).
  • West AM, Anderson JD, Epstein FH et al. Low-density lipoprotein lowering does not improve calf muscle perfusion, energetic or exercise performance in peripheral arterial disease. J. Am. Coll. Cardiol. 58, 1068-1076 (2012).
  • Hiatt WR, Hirsch AT, Creager MA et al. Effect of niacin ER/lovastatin on claudication symptoms in patients with peripheral arterial disease. J. Vasc. Med. 15, 171-179 (2010).
  • Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG; TASC II Working Group. Inter-Society Consensus for the Management of Peripheral Arterial Disease. J. Vasc. Surg. 45(1 Suppl.), S5-S67 (2007).
  • Rooke TW, Hirsch AT, Misra S et al.
  • ACCF/AHA Focused Update of the Guideline for the Management of Patients With Peripheral Arterial Disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 124, 2020-2045 (2012).
  • Tendera M, Aboyans V, Bartelink ML et al. ESC guidelines on the diagnosis and treatment of peripheral arterial diseases: document covering atherosclerotic disease of the extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology. Eur. Heart J. 32(22), 2723-2724 (2012).
  • Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler. Thromb. Vasc. Biol. 21, 1712-1719 (2001).
  • Wolfrum S, Jensen KS, Liao JK. Endothelium-dependent effects of statins. Arterioscler. Thromb. Vasc. Biol. 23, 729-736 (2003).
  • Stroes ES, Koomans HA, de Bruin TW, Rabelink TJ. Vascular function in the forearm of hypercholesterolemic patients off and on lipid-lowering medication. Lancet 326, 467-471 (1995).
  • Laufs U, La F, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 97, 1129-1135 (1998).
  • Creager MA, Cooke JP, Mendelsohn ME et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J. Clin. Invest. 86, 228-234 (1990).
  • Kinlay S, Plutzky J. Effect of lipid-lowering therapy on vasomotor and endothelial function. Curr. Cardiol. Rep. 1(3), 238-243 (1999).
  • Brevetti G, Silvestro A, Schiano V et al. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle brachial pressure index. Circulation 108, 2093-2098 (2003).
  • Maldonado FJ, Miralles Jde H, Aguilar EM, Gonzalez AF, García JR, García FA. Relationship between noninvasively measured endothelial function and peripheral arterial disease. Angiology 60, 725-731 (2009).
  • Payvandi L, Dyer A, McPherson D et al. Physical activity during daily life and brachial artery flow-mediated dilation in peripheral arterial disease. Vasc. Med. 14, 193-201 (2009).
  • Balk EM, Karas RH, Jordan HS, Kupelnick B, Chew P, Lau J. Effects of statins on vascular structure and function: a systematic review. Am. J. Med. 117, 775-790 (2004).
  • Coutinho T, Rooke TW, Kullo IJ. Arterial dysfunction and functional performance in patients with peripheral arterial disease: a review. Vasc. Med. 16, 203-211 (2012). n Excellent overview of the current means of assessing arterial dysfunction in PAD and a review of therapies aimed at improving arterial function and exercise performance.
  • Vainas T, Stassen FR, de Graaf R et al. C-reactive protein in peripheral arterial disease: relation to the severity of disease and to future cardiovascular events. J. Vasc. Surg. 42(2), 243-251 (2005).
  • Schillinger M, Exner M, Mlekusch W et al. Statin therapy improves cardiovascular outcome of patients with peripheral arterial disease. Eur. Heart J. 25, 742-748 (2004).
  • Vasa M, Fichtlscherer S, Adler K et al. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103, 2885-2890 (2001).
  • Van Belle E, Rivard A, Chen D et al. Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Circulation 96, 2667-2674 (1997).
  • Rosenson RS, Tagney CC. Antiatherothrombotic properties of statins. JAMA 279, 1643-1650 (1998).
  • Pipinos II, Judge AR, Selsby JT et al. The myopathy of peripheral arterial occlusive disease: Part 1. Functional and histomorphologic changes and evidence for mitochrondrial dysfunction. Vasc. Endovasc. Surg. 42(6), 481-489 (2008).
  • Pipinos II, Judge AR, Zhu Z et al. Basic science review: the myopathy of peripheral arterial occlusive disease: Part 2. Oxidative stress, neuropathy and shift in muscle fiber type. Vasc. Endovasc. Surg. 42, 101-112 (2008).
  • Lindner JR, Womack L, Barrett EJ et al. Limb stress-rest perfusion imaging with contrast ultrasound for the assessment of peripheral arterial disease severity. JACC Cardiovasc. Imag. 1(3), 343-350 (2008).
  • Isbell DC, Epstein FH, Zhong Z et al. Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. J. Magn. Reson. Imaging 25(5), 1013-1020 (2007).
  • Anderson JD, Epstein FH, Meyer CH et al. Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolism. J. Am. Coll. Cardiol. 54, 628-635 (2009).
  • Rizzo M, Pernice V, Frasheri A, Berneis K. Atherogenic lipoprotein phenotype and LDL size and subclasses in patients with peripheral arterial disease. Atherosclerosis 197, 237-241 (2008).
  • Meade T, Zuhrie R, Cook C, Cooper J. Bezafibrate in men with lower extremity arterial disease: randomized controlled trial. BMJ 325, 1139 (2002).
  • Blankenhorn DH, Azen SP, Crawford DW et al. Effects of colestipol-niacin therapy on human femoral atherosclerosis. Circulation 83, 438-447 (1991).
  • Buchwald H, Bourgades HR, Campos CT et al. Impact of cholesterol reduction on peripheral arterial disease in the Program on the Surgical Control of the Hyperlipidemias (POSCH). Surgery 120, 672-679 (1996).
  • Taylor AJ, Sullenberger LE, Lee HJ, Lee JK, Grace KA. Arterial biology for the investigation of the treatment effects of reducing cholesterol (Arbiter ) 2: a double blind, placebocontrolled study of extended-release niacin and atherosclerosis progression in secondary prevention patients treated with statins. Circulation 110, 3512-3517 (2004).
  • Tsimikas S, Tsironis LD, Tselepis AD. New insights into the role of lipoprotein[a]- associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 27, 2094-2099 (2007).
  • Volpato S, Vigna GB, McDermott MM et al. Lipoprotein (a), inflammation and peripheral arterial disease in a community based sample of older men and women (the InCHIANTI study). Am. J. Cardiol. 105(12), 1825-1830 (2010).
  • Marso SP, Hiatt WR. Peripheral arterial disease in patients with diabetes. J. Am. Coll. Cardiol. 47(5), 921-929 (2006).

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