Transcriptional regulation of lipogenesis and its contribution to hepatosteatosis

References

• Wong RH, Sul HS. Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective. Curr. Opin. Pharmacol. 10(6), 684–691 (2010).
   Google Scholar
• Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 426(6963), 190–193 (2003).
   Google Scholar
• Poupeau A, Postic C. Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors. Biochim. Biophys. Acta 1812(8), 995–1006 (2011).
   Google Scholar
• Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc. Natl Acad. Sci. USA 98(24), 13710–13715 (2001).
   Google Scholar
• Doiron B, Cuif MH, Chen R, Kahn A. Transcriptional glucose signaling through the glucose response element is mediated by the pentose phosphate pathway. J. Biol. Chem. 271(10), 5321–5324 (1996).
   Google Scholar
• Dentin R, Tomas-Cobos L, Foufelle F et al. Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. J. Hepatol. 56(1), 199–209 (2012).
   Google Scholar
• Benhamed F, Denechaud PD, Lemoine M et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J. Clin. Invest. 122(6), 2176–2194 (2012).
   Google Scholar
• Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7(8), 606–619 (2006).
   Google Scholar
• Taniguchi CM, Kondo T, Sajan M et al. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab. 3(5), 343–353 (2006).
   Google Scholar
• Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl Acad. Sci. USA 107(8), 3441–3446 (2010).
   Google Scholar
• Bakan I, Laplante M. Connecting mTORC1 signaling to SREBP-1 activation. Curr. Opin. Lipidol. 23(3), 226–234 (2012).
   Google Scholar
• Anderson RG. Joe Goldstein and Mike Brown: from cholesterol homeostasis to new paradigms in membrane biology. Trends Cell Biol. 13(10), 534–539 (2003).
   Google Scholar
• Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109(9), 1125–1131 (2002).
   Google Scholar
• Schultz JR, Tu H, Luk A et al. Role of LXRs in control of lipogenesis. Genes Dev. 14(22), 2831–2838 (2000).
   Google Scholar
• Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrateresponse element-binding protein is a target gene of LXR. J. Biol. Chem. 282(1), 743–751 (2007).
   Google Scholar
• Korach-Andre M, Archer A, Gabbi C et al. Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice. Am. J. Physiol. Endocrinol. Metab. 301(1), e210–e222 (2011).
   Google Scholar
• Yellaturu CR, Deng X, Cagen LM et al. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J. Biol. Chem. 284(12), 7518–7532 (2009).
   Google Scholar
• Owen JL, Zhang Y, Bae SH et al. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc. Natl Acad. Sci. USA 109(40), 16184–16189 (2012).
   Google Scholar
• Wang D, Sul HS. Upstream stimulatory factors bind to insulin response sequence of the fatty acid synthase promoter. USF1 is regulated. J. Biol. Chem. 270(48), 28716–28722 (1995).
   Google Scholar
• Griffin MJ, Sul HS. Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c. IUBMB Life 56(10), 595–600 (2004).
   Google Scholar
• Casado M, Vallet VS, Kahn A, Vaulont S. Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver. J. Biol. Chem. 274(4), 2009–2013 (1999).
   Google Scholar
• Pajukanta P, Lilja HE, Sinsheimer JS et al. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat. Genet. 36(4), 371–376 (2004).
   Google Scholar
• Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 136(6), 1056–1072 (2009).
   Google Scholar
• Brady MJ, Saltiel AR. The role of protein phosphatase-1 in insulin action. Recent Prog. Horm. Res. 56, 157–173 (2001).
   Google Scholar
• Wong RH, Sul HS. DNA-PK: relaying the insulin signal to USF in lipogenesis. Cell Cycle 8(13), 1977–1978 (2009).
   Google Scholar
• Latasa MJ, Griffin MJ, Moon YS, Kang C, Sul HS. Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals. Mol. Cell. Biol. 23(16), 5896–5907 (2003).
   Google Scholar
• Griffin MJ, Wong RH, Pandya N, Sul HS. Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter. J. Biol. Chem. 282(8), 5453–5467 (2007).
   Google Scholar
• Chanda D, Li T, Song KH et al. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J. Biol. Chem. 284(42), 28510–28521 (2009).
   Google Scholar
• Wang Y, Wong RH, Tang T et al. Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin. Mol. Cell 49(2), 283–297 (2012).
   Google Scholar
• York LW, Puthalapattu S, Wu GY. Nonalcoholic fatty liver disease and lowcarbohydrate diets. Annu. Rev. Nutr. 29, 365–379 (2009).
   Google Scholar