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Perspective

Two lipids in the diet, rather than cholesterol, are responsible for heart failure and stroke

Pages 189-204 | Published online: 18 Jan 2017

References

  • Aird WC. Spatial and temporal dynamics of the endothelium. J. Thrombo. Haemost. 3, 1392–1406 (2005).
  • Rose WC, Wixom RL, Lockhart HB, Lambert GF. The amino acid requirements of man. XV. The valine requirement; summary and final observations. J. Biol. Chem. 127, 987 (1955).
  • Kummerow FA. Nutrition imbalance and angiotoxins as dietary risk factors in coronary heart disease. Am. J. Clin. Nutr. 32, 58–83 (1979). • heart failure can occur even without a dietary source of cholesterol.
  • Bloch K. The biological synthesis of cholesterol. J. Biol. Chem. 1, 79–98 (1964).
  • Pilgeram L. Atherogenesis and fibrinogen: historical perspective, biochemical mechanism, and current status. Cardio. Eng. 2, 111–128 (2003).
  • Pilgeram L. Atherogenesis and fibrinogen: historical perspective and current status. Naturwissenschaften 80, 547–555 (1993).
  • Lindgren FT, Nichols AV. Plasma Proteins (Volume 2). Academic Press Inc., NY, USA (1960).
  • Baker HN, Jackson RL, Gotto AM Jr. Isolation and characterization of the cyanogen brominde fragments from the high-density apolopoprotein glutamine I. Biochemistry 12, 3866 (1973).
  • Jackson RL, Morrisett JD, Pownall HJ, Gotto AM Jr. Human high density lipoprotein glutamine II. J. Biol. Chem. 248, 5218 (1973).
  • Jackson RL, Taunton OD, Segura R, Gallagher JG, Hoff HF, Gotto AM Jr. Comparative studies on plasma low density lipoproteins from pig and man. Comp. Biochem. Physiol. 53b, 245 (1976).
  • Jackson RL, Sparrow JT, Baker HN, Morrisett JD, Taunton OD, Gotto AM Jr. The primary structure of apolipoproteinserine. J. Biol. Chem. 249, 5308 (1974).
  • Brown WV, Levy RI, Frederickson DS. Further charaacterization of Apolipoproteins from human plasma very low density lipoproteins. J. Biol. Chem. 245, 6588 (1970).
  • Morrisett Jd, David SK, Powmall HJ, Gotto AM JR. Interaction of an apolipoprotein (ApoLP-alanine) with phosphatidylcholine. Biochemistry 12, 1290 (1973).
  • Shore VG, Shore B. Heterogeneity of human plasma very low density lipoproteins. Seperation of species differing in protein components. Biochemistry 12, 502 (1973).
  • McConathy WJ, Alauppovic P. Isolation and partial characterization of apolipoprotein D: a new protein moiety of the human plasma lipoprotein system. FEBS Lett. 37, 178 (1973).
  • American Heart Association. What Your Numbers Mean. American Heart Association, TX, USA (2006).
  • Steinberg D. The Cholesterol Wars. Academic Press Inc., NY, USA (2007).
  • US Federal Trade Commission Docket #8987. Official transcript of proceedings: National Commission on Egg Nutrition. Washington, DC, USA (1975).
  • US Federal Trade Commission Docket #8987. Final order. National Commission on Egg Nutrition. Washington, DC, USA (1976).
  • Gillinov M, Nissen S. Heart 411: The Only Guide to Heart Health You’ ll Ever Need. Three Rivers, NY, USA (2012).
  • Staprans I, Xian-Manh P, Rapp JH, Feingold KR. Oxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits. Arterioscler. Thromb. Vasc. Biol. 18, 977–983 (1998).
  • Imai H, Werthessen NT, Taylor CB, Lee KT. Angiotoxicity and arteriosclerosis due to contaminants of USP-grade cholesterol. Arch. Pathol. Lab. Med.11, 565–572 (1976).
  • Morin RJ, Peng SK. Cholesterol oxides in plasma and tissues. In: Biological Effects of Cholesterol Oxides. CRC Press, FL, USA, 89–101 (1992).
  • Steinberg D. Oxidative modification of LDL and atherogenesis. Circulation 95, 1062–1071 (1997).
  • Sevanian A, McLeod LL. Cholesterol autoxidation in phospholipid membrane bilayers. Lipids 22, 627–636 (1987).
  • Morrel DW, DiCorleto PE, Chisolm GM. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis 4, 357–364 (1984).
  • Parthasarathy S, Printz DJ, Boyd D, Joy L, Steinberg D. Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis 6, 505–510 (1986).
  • Emanuel HA, Hassel CA, Addis PB, Bergmann SD, Zavoral JH. Plasma cholesterol oxidation products (oxysterols) in human subjects fed a meal rich in oxysterols. J. Food Sci. 56, 843–847 (1991).
  • Zhou Q, Smith TL, Kummerow FA. Cytotoxicity of oxysterols on cultured smooth muscle cells from umbilical arteries. Proc. Soc. Exp. Bio. Med. 202, 75–80 (1993).
  • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1991s. Nature 362, 801–809 (1993).
  • DeBakey ME, Diethrich EB, Garrett HE, McCutchen JJ. Surgical treatment of cerebrovascular disease. Postgrad. Med. 42, 218–230 (1967).
  • Kummerow FA, Przybylski R, Wasowicz E. Changes in arterial membrane lipid composition may precede growth factor influence in the pathogenesis of atherosclerosis. Artery 21, 63–75 (1994).
  • Kummerow FA, Cook LS, Wasowicz E, Jelen H. Changes in the phospholipid composition of the arterial cell can result in severe atherosclerotic lesions. J. Nutr. Biochem. 12, 602–607 (2001). • coronary artery bypass patients had a greater concentration of oxysterols in their plasma than age- and sex-matched controls without heart disease.
  • Op den Kamp JAF. Lipid asymmetry in membranes. Annu. Rev. Biochem. 48, 47–71 (1979).
  • Smith LL. Cholesterol Autoxidation. Plenum, NY, USA (1981).
  • Calmarz P, Trejo J, Lapresta C, Lopez P. LDL oxidation and its association with carotid artery intima-media thickness and other cardiovascular risk factors in a sample of Spanish general population. Angiology doi:10.1177/0003319713488639 (2013) (Epub ahead of print).
  • Zhou Q, Wasowicz E, Handler B, Fleischer L, Kummerow FA. An excess concentration of oxysterol in the plasma is cytotoxic to cultured endothelial cells. Atherosclerosis 149, 191–197 (2000).
  • Zhou Q, Kummerow FA. Effects of 27-hydroxycholesterol on cellular sphingomyelin synthesis and C++ content in cultures smooth muscle cells. Biomed. Environ. Sci.10, 369–376 (1997).
  • Javitt NB, Kok E, Burstein S, Cohen B, Kutscher J. 26-Hydroxycholesterol, identification and quantitation in human serum. J. Bio. Chem. 256, 12644–12646 (1981).
  • Shah DO, Schulman JH. Interaction of calcium ions with lecithin and sphingomyelin monolayers. Lipids 2, 21–27 (1967).
  • Mahfouz MM, Kummerow FA. Oxysterols and TBARS are among the LDL oxidation products which enhance thromboxane A2 synthesis by platelets. Prostaglandins Other Lipid Mediat.56, 197–217 (1998).
  • Mahfouz MM, Kummerow FA. Oxidized low-density lipoprotein (LDL) enhances thromboxane A2 synthesis by platelets, but lysolecithin as a product of LDL oxidation has an inhibitory effect. Prostaglandins Other Lipid Mediat. 62, 183–200 (2000).
  • Steinberg D. The Cholesterol Wars. Academic Press, NY, USA (2007).
  • Kummerow FA, Olinescu RM, Fleischer L, Handler B, Shinkareva SV. The relationship of oxidized lipids to coronary artery stenosis. Atherosclerosis 149, 18–190 (2000).
  • Ravnskov U, DiNicolantonio JJ, Harcombe Z, Kummerow FA, Okuyama H, Worm N. The questionable benefits of exchanging saturated fat with polyunsaturated. Mayo Clin. Proc. 89(4), 451–453 (2013).
  • Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 7, e1000252 (2010).
  • Negative Population Growth. www.npg.org/facts/us_historical_pops.htm
  • State Population Estimates and Demographic Components of Population Change: July 1, 1998 to July 1, 1999. www.census.gov/population/estimates/state/st-99-1.txt
  • Ash M. US Department of Agriculture. Fats and vegetables oil consumption since 1912. http://factfinder2.census.gov/faces/tableservices/jsf/pages/productview.xhtml?pid=ACS_11_1YR_DP05&prodType=table
  • Kunau WH, Holman RT. Polyunsaturated Fatty Acids. AOCS, Champaign, IL, USA (1977).
  • Astrup A, Dyerberg J, Elwood P et al. The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am. J. Clin. Nutr. 93, 684–688 (2011).
  • Lawrence G. Dietary fats and health: dietary recommendations in the context of scientific evidence. Adv. Nutr. 4, 294–302 (2013).
  • Harcombe Z, Baker J, Davies B. Food for thought: have we been giving the wrong dietary advice?. Food Nutrit. Sci. 4, 240–244 (2013).
  • Burr GO, Burr MM. On the nature and role of the fatty acids essential in nutrition. J. Bio. Chem. 86, 587 (1930).
  • Kummerow FA. Hydrogenated fat for the world population. Prevention Control. 1, 157–164 (2005).
  • James AT, Martin AJ. Gas-liquid partition chromatography: the separation and micro-estimation of ammonia and the methylamines. Biochem. J. 52, 238–242 (1952).
  • Kummerow FA. The negative effects of hydrogenated trans fats and what to do about them. Atherosclerosis 205, 458–465 (2009).
  • Johnston P, Johnson O, Kummerow FA. Occurrence of trans fatty acids in human tissue. Science 126, 698–699 (1957). •• in 1957, we recognized the presence of trans fatty acids in human tissue.
  • Johnston PV, Johnson OC, Kummerow FA. Non-transfer of trans fatty acids from mother to young. Proc. Soc. Exp. Biol. Med. 96, 760–762 (1957).
  • Johnston PV, Kummerow FA, Walton C. Origin of the trans fatty acids in human Tissue. Proc. Soc. Exp. Bio. Med. 99, 735–736 (1958).
  • Johnston PV, Johnson OC, Kummerow FA. Deposition in tissues and fecal excretion of trans fatty acids in the rat. J. Nutr. 65, 13–23 (1958).
  • Kummerow FA, Zhou Q, Mahfouz MM. Effects of trans fatty acids on calcium influx into human arterial cells. Am. J. Clin. Nutr. 70, 832–838 (1999).
  • Kummerow FA, Zhou Q, Mahfouz MM, Smiricky MR, Grieshop CM, Schaeffer DJ. Trans fatty acids in the phospholipid of arterial cells. Life Sci. 74(22), 2707–2723 (2004).
  • Innes SM, King DJ. Trans fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast fed infants. Am. J. Clin. Nutr. 70, 383–390 (1999).
  • Stary HC. Natural history of calcium deposits in atherosclerosis progression and regression. Zeitschrift Kardiologie 89(2), S028–S035 (2000).
  • Emken EA, Dutton HJ. Geometrical and Positional Fatty Acid Isomers. AOCS, Champaign, IL, USA (1979).
  • Kummerow FA. Viewpoint of the report on the National Cholesterol Education Program Expert Panel on the Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. J. Am. Coll. Nutr. 12, 2–13 (1993).
  • Kummerow FA, Mahfouz M, Zhou Q, Masterjohn C. The effects of trans fats on prostacyclin production. Scand. Cardiovasc. J. 47, 377–382 (2013).
  • Linton MF, Fazio S. Cyclooxyenase-2 and atherosclerosis. Curr. Opin. Lipidol. 13, 497 (2002).
  • Vane JR, Bakhle YS, Botting RM. Cyclooxygenase 1 and 2. Ann. Rev. Pharmacol. Toxicol. 38, 97 (1998).
  • Cheng Y, Austin SC, Rocca B et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 296, 539 (2002).
  • Anderson R. Chief Statistician. CDC. Washington DC, USA (2011). •• important because it provides information that trans fatty acids are causing heart failure.
  • CDC: leading causes of death 1900–1908. www.cdc.gov/nchs/data/dvs/lead1900_98.pdf
  • National Vital Statistics Report: the effect of revised populations on mortality statistics for the USA, 2000. www.cdc.gov/nchs/data/nvsr/nvsr51/nvsr51_09.pdf
  • National Vital Statistics Report: deaths: final data for 2010. www.cdc.gov/nchs/data/nvsr/nvsr61/nvsr61_04.pdf
  • Friedewald WT, Thom TJ. Decline of coronary heart disease mortality in the United States. Isr. J. Med. Sci. 22(3–4), 307–312 (1986).
  • Hoyert DL, Xu JQ. Deaths: Preliminary Data. National Vital Statistics Reports. 61(6), National Center for Health Statistics, MD, USA (2012).
  • Jain M. American Chemical Society, news release. 8th September (2013).
  • Food labeling: trans fatty acids in nutrition labeling, nutrient content claims and health claims. Finale rule. Fed. Regist. 68, 41433–41506 (2003). • Trans fatty acids were recognized as risk factors for atherosclerosis.
  • US FDA. Questions and answers about trans fat nutrition labeling. Office of Nutritional Products, Washington, DC, USA (2006).
  • Harvard Health Publications. www.health.harvard.edu/press_releases/natural-trans-fatless-harmful-than-artificial-version
  • Downs S, Thow A, Leeder S. The effectiveness of policies for reading dietary trans fat: a systematic review of the evidence. Bull. World Health Organ. 91, 262H–269H (2013).
  • US FDA. Talking about trans fat: What you need to know. www.fda.gov/Food/IngredientsPackagingLabeling/LabelingNutrition/ucm079609.htm
  • Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC. Trans fatty acids and cardiovascular disease. N. Engl. J. Med. 354, 1601–1313 (2006).
  • Vesper HW, Kuiper HC, Mirel LB, Johnson CL, Pirkle JL. Levels of plasma trans-fatty acids in non-Hispanic white adults in the United States in 2000 and 2009. JAMA 307, 562–563 (2012).
  • CDC press release. www.cdc.gov/media/releases/2012/p0208_trans-fatty_acids.html
  • US Government. Federal Register. 78, 67169–67175 (2013).

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