621
Views
0
CrossRef citations to date
0
Altmetric
Commentaries

Understanding adipocyte types and adipose tissue dynamics for obesity management

&
Pages 23-26 | Published online: 18 Jan 2017

References

  • Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity: a systematic and clinical review. JAMA 311(1), 74–86 (2014). •• Systematic review examining the long-term benefits of weight loss medications in combination with lifestyle changes.
  • Bremer AA, Jialal I. Adipose tissue dysfunction in nascent metabolic syndrome. J. Obes. 393192, 2013 (2013).
  • Mariman EC. Human biology of weight maintenance after weight loss. J. Nutrigenet. Nutrigenomics 5, 13–25 (2012). • Review examining the factors that affect success in weight reduction.
  • Montani JP, Viecelli AK, Prevot A, Dulloo AG. Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the ‘repeated overshoot’ theory. Int. J. Obes. (Lond.) 30(Suppl. 4), S58–S66 (2006).
  • Ochner CN, Barrios DM, Lee CD, Pi-Sunyer FX. Biological mechanisms that promote weight regain following weight loss in obese humans. Physiol. Behav. 120, 106–113 (2013).
  • Gurr MI, Jung RT, Robinson MP, James WP. Adipose tissue cellularity in man: the relationship between fat cell size and number, the mass and distribution of body fat and the history of weight gain and loss. Int. J. Obes. 6, 419–436 (1982). •• One of the earliest reports examining adipocyte numbers was altered by weight reduction.
  • Spalding KL, Arner E, Westermark PO et al. Dynamics of fat cell turnover in humans. Nature 453, 783–787 (2008). •• Describes the contribution of adipocyte number, size and turnover to total fat mass.
  • Nagel SA, Keuper M, Zagotta I et al. Up-regulation of Bcl-2 during adipogenesis mediates apoptosis resistance in human adipocytes. Mol. Cell Endocrinol. 382, 368–376 (2014).
  • Strissel KJ, Stancheva Z, Miyoshi H et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 56, 2910–2918 (2007). •• Examines the impact of adipocyte death to fat mass in obesity.
  • Kosteli A, Sugaru E, Haemmerle G et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J. Clin. Invest. 120(10), 3466–3479 (2010).
  • Giordano A, Murano I, Mondini E et al. Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J. Lipid Res. 54, 2423–2436 (2013). •• Introduces the concept of pyroptosis to describe adipocyte death.
  • Luther J, Ubieta K, Hannemann N et al. Fra-2/AP-1 controls adipocyte differentiation and survival by regulating PPARgamma and hypoxia. Cell Death Differ. 21(4), 655–664 (2014).
  • Feng D, Tang Y, Kwon H et al. High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation. Diabetes 60, 2134–2143 (2011).
  • Nunez CE, Rodrigues VS, Gomes FS et al. Defective regulation of adipose tissue autophagy in obesity. Int. J. Obes. (London) 37, 1473–1480 (2013).
  • Jansen HJ, van Essen P, Koenen T et al. Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. Endocrinology 153, 5866–5874 (2012).
  • Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19(10), 1338–1344 (2013).
  • Bonet ML, Oliver P, Palou A. Pharmacological and nutritional agents promoting browning of white adipose tissue. Biochim. Biophys. Acta 1831(5), 969–985 (2013). • Presents an extensive overview of different approaches available to induce browning of white adipose tissue.
  • Cousin B, Cinti S, Morroni M et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J. Cell Sci. 103(Pt 4), 931–942 (1992).
  • Giralt M, Villarroya F. White, brown, beige/brite: different adipose cells for different functions? Endocrinology 154, 2992–3000 (2013).
  • Suganami T, Tanaka M, Ogawa Y. Adipose tissue inflammation and ectopic lipid accumulation. Endocr. J. 59(10), 849–857 (2012). • Reviews the factors that lead to accumulation of fat in nonadipose tissues and the sequelae of this process.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.