Periodontitis, blood lipids and lipoproteins

References

• Liu YC, Lerner UH, Teng YT. Cytokine responses against periodontal infection: protective and destructive roles. Periodontol 2000 52(1), 163–206 (2010).
   Google Scholar
• Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000 14, 9–11 (1997).
   Google Scholar
• Stein JM, Kuch B, Conrads G et al. Clinical periodontal and microbiologic parameters in patients with acute myocardial infarction. J. Periodontol. 80(10), 1581–1589 (2009).
   Google Scholar
• Dietrich T, Jimenez M, Krall Kaye EA, Vokonas PS, Garcia RI. Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 117(13), 1668–1674 (2008).
   Google Scholar
• Humphrey LL, Fu R, Buckley DI, Freeman M, Helfand M. Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J. Gen. Intern. Med. 23(12), 2079–2086 (2008).
   Google Scholar
• Berneis K, Rizzo M. LDL size: does it matter? Swiss Med. Wkly 134(49–50), 720–724 (2004).
   Google Scholar
• Rizzo M, Berneis K, Corrado E, Novo S. The significance of low-density-lipoproteins size in vascular diseases. Int. Angiol. 25(1), 4–9 (2006).
   Google Scholar
• Ramirez-Tortosa MC, Quiles JL, Battino M et al. Periodontitis is associated with altered plasma fatty acids and cardiovascular risk markers. Nutr. Metab. Cardiovasc. Dis. 20(2), 133–139 (2010).
   Google Scholar
• Maekawa T, Takahashi N, Tabeta K et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS ONE 6(5), e20240 (2011).
   Google Scholar
• Rizzo M, Cappello F, Marfil R et al. Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study. Cell Stress Chaperones 17(3), 399–407 (2012).
   Google Scholar
• Buhlin K, Gustafsson A, Pockley AG, Frostegard J, Klinge B. Risk factors for cardiovascular disease in patients with periodontitis. Eur. Heart J. 24(23), 2099–2107 (2003).
   Google Scholar
• Fentoglu O, Koroglu BK, Hicyilmaz H et al. Proinflammatory cytokine levels in association between periodontal disease and hyperlipidaemia. J. Clin. Periodontol. 38(1), 8–16 (2011).
   Google Scholar
• Nibali L, Tatarakis N, Needleman I et al. Clinical review: association between metabolic syndrome and periodontitis: a systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 98(3), 913–920 (2013).
   Google Scholar
• Kwon YE, Ha JE, Paik DI, Jin BH, Bae KH. The relationship between periodontitis and metabolic syndrome among a Korean nationally representative sample of adults. J. Clin. Periodontol. 38(9), 781–786 (2011).
   Google Scholar
• Han DH, Lim SY, Sun BC, Paek D, Kim HD. The association of metabolic syndrome with periodontal disease is confounded by age and smoking in a Korean population: the Shiwha–Banwol Environmental Health Study. J. Clin. Periodontol. 37(7), 609–616 (2010).
   Google Scholar
• Andriankaja OM, Sreenivasa S, Dunford R, Denardin E. Association between metabolic syndrome and periodontal disease. Aust. Dent. J. 55(3), 252–259 (2010).
   Google Scholar
• Morita T, Ogawa Y, Takada K et al. Association between periodontal disease and metabolic syndrome. J. Public Health Dent. 69(4), 248–253 (2009).
   Google Scholar
• Saxlin T, Suominen-Taipale L, Kattainen A, Marniemi J, Knuuttila M, Ylostalo P. Association between serum lipid levels and periodontal infection. J. Clin. Periodontol. 35(12), 1040–1047 (2008).
   Google Scholar
• Sridhar R, Byakod G, Pudakalkatti P, Patil R. A study to evaluate the relationship between periodontitis, cardiovascular disease and serum lipid levels. Int. J. Dent. Hyg. 7(2), 144–150 (2009).
   Google Scholar
• Tamaki N, Tomofuji T, Ekuni D, Yamanaka R, Morita M. Periodontal treatment decreases plasma oxidized LDL level and oxidative stress. Clin. Oral Investig. 15(6), 953–958 (2011).
   Google Scholar
• Mattila KJ, Nieminen MS, Valtonen VV et al. Association between dental health and acute myocardial infarction. BMJ 298(6676), 779–781 (1989). • First paper that showed an association between periodontal disease and myocardial infarction.
   Google Scholar
• Destefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. BMJ 306(6879), 688–691 (1993).
   Google Scholar
• Hujoel PP. Does chronic periodontitis cause coronary heart disease? A review of the literature. J. Am. Dent. Assoc. 133(Suppl.), 31S–36S (2002).
   Google Scholar
• Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann. Periodontol. 8(1), 38–53 (2003).
   Google Scholar
• Meurman JH, Sanz M, Janket SJ. Oral health, atherosclerosis, and cardiovascular disease. Crit. Rev. Oral Biol. Med. 15(6), 403–413 (2004).
   Google Scholar
• Beck JD, Eke P, Heiss G et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation 112(1), 19–24 (2005).
   Google Scholar
• Bahekar AA, Singh S, Saha S, Molnar J, Arora R. The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am. Heart J. 154(5), 830–837 (2007).
   Google Scholar
• Mustapha IZ, Debrey S, Oladubu M, Ugarte R. Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis. J. Periodontol. 78(12), 2289–2302 (2007).
   Google Scholar
• Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int. Dent. J. 59(4), 197–209 (2009).
   Google Scholar
• Lockhart PB, Bolger AF, Papapanou PN et al. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: A scientific statement from the American Heart Association. Circulation 125(20), 2520–2544 (2012).
   Google Scholar
• Dietrich T, Sharma P, Walter C, Weston P, Beck J. The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease. J. Clin. Periodontol. 40(Suppl. 14), S70–S84 (2013). •• Recent review that shows the most updated epidemiological evidence about the relationship between cardiovascular disease (CVD) and periodontitis, supported by the EFP/AAP joint 2012 Workshop on Periodontal Medicine.
   Google Scholar
• Cueto A, Mesa F, Bravo M, Ocana-Riola R. Periodontitis as risk factor for acute myocardial infarction. A case control study of Spanish adults. J. Periodontal. Res. 40(1), 36–42 (2005).
   Google Scholar
• Perk J, De Backer G, Gohlke H et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur. Heart J. 33(13), 1635–1701 (2012). •• These guidelines of the European Society of Cardiology are the first ones coming from a cardiology society that consider periodontal disease as a risk factor that needs to be controlled for the prevention of CVD.
   Google Scholar
• Tonetti MS, Van Dyke TE, Working Group 1 of the Joint EFPaaPW: Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J. Clin. Periodontol. 40(Suppl. 14), S24–S29 (2013). • General consensus statement of the EFP/AAP joint 2012 Workshop on Periodontal Medicine that confirms the actual knowledge about periodontitis and atherosclerotic CVD.
   Google Scholar
• Prasad A, Zhu J, Halcox JP, Waclawiw MA, Epstein SE, Quyyumi AA. Predisposition to atherosclerosis by infections: role of endothelial dysfunction. Circulation 106(2), 184–190 (2002).
   Google Scholar
• Leinonen M, Saikku P. Evidence for infectious agents in cardiovascular disease and atherosclerosis. Lancet Infect. Dis. 2(1), 11–17 (2002).
   Google Scholar
• Kiechl S, Egger G, Mayr M et al. Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study. Circulation 103(8), 1064–1070 (2001).
   Google Scholar
• Spahr A, Klein E, Khuseyinova N et al. Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. Arch. Intern. Med. 166(5), 554–559 (2006).
   Google Scholar
• Elkaim R, Dahan M, Kocgozlu L et al. Prevalence of periodontal pathogens in subgingival lesions, atherosclerotic plaques and healthy blood vessels: a preliminary study. J. Periodontal. Res. 43(2), 224–231 (2008).
   Google Scholar
• Chen YW, Umeda M, Nagasawa T et al. Periodontitis may increase the risk of peripheral arterial disease. Eur. J. Vasc. Endovasc. Surg. 35(2), 153–158 (2008).
   Google Scholar
• Gaetti-Jardim E Jr., Marcelino SL, Feitosa AC, Romito GA, Avila-Campos MJ. Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. J. Med. Microbiol. 58(Pt 12), 1568–1575 (2009).
   Google Scholar
• Figuero E, Sanchez-Beltran M, Cuesta-Frechoso S et al. Detection of periodontal bacteria in atheromatous plaque by nested polymerase chain reaction. J. Periodontol. 82(10), 1469–1477 (2011).
   Google Scholar
• Chiu B. Multiple infections in carotid atherosclerotic plaques. Am. Heart J. 138(5 Pt 2), S534–S536 (1999).
   Google Scholar
• Andriankaja O, Trevisan M, Falkner K et al. Association between periodontal pathogens and risk of nonfatal myocardial infarction. Community Dent. Oral Epidemiol. 39(2), 177–185 (2011).
   Google Scholar
• Lopez-Jornet P, Berna-Mestre JD, Berna-Serna JD, Camacho-Alonso F, Fernandez-Millan S, Reus-Pintado M. Measurement of atherosclerosis markers in patients with periodontitis: a case–control study. J. Periodontol. 83(6), 690–698 (2012).
   Google Scholar
• Kinane DF, Riggio MP, Walker KF, Mackenzie D, Shearer B. Bacteraemia following periodontal procedures. J. Clin. Periodontol. 32(7), 708–713 (2005).
   Google Scholar
• Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J. Clin. Periodontol. 33(6), 401–407 (2006).
   Google Scholar
• Takeuchi H, Furuta N, Morisaki I, Amano A. Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway. Cell Microbiol. 13(5), 677–691 (2011).
   Google Scholar
• Carrion J, Scisci E, Miles B et al. Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J. Immunol. 189(6), 3178–3187 (2012).
   Google Scholar
• Roth GA, Moser B, Huang SJ et al. Infection with a periodontal pathogen induces procoagulant effects in human aortic endothelial cells. J. Thromb. Haemost. 4(10), 2256–2261 (2006).
   Google Scholar
• Gibson FC 3rd, Hong C, Chou HH et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 109(22), 2801–2806 (2004).
   Google Scholar
• Ford PJ, Gemmell E, Hamlet SM et al. Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis. Oral Microbiol. Immunol. 20(5), 296–302 (2005).
   Google Scholar
• Roth GA, Ankersmit HJ, Brown VB, Papapanou PN, Schmidt AM, Lalla E. Porphyromonas gingivalis infection and cell death in human aortic endothelial cells. FEMS Microbiol. Lett. 272(1), 106–113 (2007).
   Google Scholar
• Schenkein HA, Barbour SE, Berry CR, Kipps B, Tew JG. Invasion of human vascular endothelial cells by Actinobacillus actinomycetemcomitans via the receptor for platelet-activating factor. Infect. Immun. 68(9), 5416–5419 (2000).
   Google Scholar
• Tuomainen AM, Jauhiainen M, Kovanen PT, Metso J, Paju S, Pussinen PJ. Aggregatibacter actinomycetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice. Microb. Pathog. 44(2), 111–117 (2008).
   Google Scholar
• Pussinen PJ, Jauhiainen M, Vilkuna-Rautiainen T et al. Periodontitis decreases the antiatherogenic potency of high density lipoprotein. J. Lipid Res. 45(1), 139–147 (2004).
   Google Scholar
• Bengtsson T, Karlsson H, Gunnarsson P et al. The periodontal pathogen Porphyromonas gingivalis cleaves apoB-100 and increases the expression of apoM in LDL in whole blood leading to cell proliferation. J. Intern. Med. 263(5), 558–571 (2008).
   Google Scholar
• Morishita M, Ariyoshi W, Okinaga T, Usui M, Nakashima K, Nishihara T. A. actinomycetemcomitans LPS enhances foam cell formation induced by LDL. J. Dent. Res. 92(3), 241–246 (2013).
   Google Scholar
• Takahashi Y, Davey M, Yumoto H, Gibson FC 3rd, Genco CA. Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells. Cell Microbiol 8(5), 738–757 (2006).
   Google Scholar
• Libby P. Inflammation in atherosclerosis. Nature 420(6917), 868–874 (2002).
   Google Scholar
• Blake GJ, Ridker PM. High sensitivity C-reactive protein for predicting cardiovascular disease: an inflammatory hypothesis. Eur. Heart J 22(5), 349–352 (2001).
   Google Scholar
• Loos BG, Craandijk J, Hoek FJ, Wertheim-Van Dillen PM, Van Der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J. Periodontol. 71(10), 1528–1534 (2000).
   Google Scholar
• Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J. Clin. Periodontol. 35(4), 277–290 (2008).
   Google Scholar
• Buhlin K, Hultin M, Norderyd O et al. Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis. Atherosclerosis 206(2), 518–522 (2009).
   Google Scholar
• Yoshii S, Tsuboi S, Morita I et al. Temporal association of elevated C-reactive protein and periodontal disease in men. J. Periodontol. 80(5), 734–739 (2009).
   Google Scholar
• Nakajima T, Honda T, Domon H et al. Periodontitisassociated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. J. Periodontal. Res. 45(1), 116–122 (2010).
   Google Scholar
• Chen H, Zheng P, Zhu H et al. Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease. Clin. Oral Investig. 14(6), 629–636 (2010).
   Google Scholar
• Pussinen PJ, Alfthan G, Rissanen H, Reunanen A, Asikainen S, Knekt P. Antibodies to periodontal pathogens and stroke risk. Stroke 35(9), 2020–2023 (2004).
   Google Scholar
• Beck JD, Eke P, Lin D et al. Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults. Atherosclerosis 183(2), 342–348 (2005).
   Google Scholar
• Lund Haheim L, Olsen I, Nafstad P, Schwarze P, Ronningen KS. Antibody levels to single bacteria or in combination evaluated against myocardial infarction. J. Clin. Periodontol. 35(6), 473–478 (2008).
   Google Scholar
• Pussinen PJ, Alfthan G, Tuomilehto J, Asikainen S, Jousilahti P. High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction. Eur. J. Cardiovasc. Prev. Rehabil 11(5), 408–411 (2004).
   Google Scholar
• Pussinen PJ, Nyyssonen K, Alfthan G, Salonen R, Laukkanen JA, Salonen JT. Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler. Thromb. Vasc. Biol. 25(4), 833–838 (2005).
   Google Scholar
• Rizzo M, Macario AJ, De Macario EC et al. Heat shock protein-60 and risk for cardiovascular disease. Curr. Pharm. Des. 17(33), 3662–3668 (2011).
   Google Scholar
• Novo G, Cappello F, Rizzo M et al. Hsp60 and heme oxygenase-1 (Hsp32) in acute myocardial infarction. Transl. Res. 157(5), 285–292 (2011).
   Google Scholar
• Mayr M, Kiechl S, Willeit J, Wick G, Xu Q. Infections, immunity, and atherosclerosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis. Circulation 102(8), 833–839 (2000).
   Google Scholar
• Leishman SJ, Ford PJ, Do HL et al. Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease. J. Clin. Periodontol. 39(10), 923–930 (2012).
   Google Scholar
• Tabeta K, Yamazaki K, Hotokezaka H, Yoshie H, Hara K. Elevated humoral immune response to heat shock protein 60 (hsp60) family in periodontitis patients. Clin. Exp. Immunol. 120(2), 285–293 (2000).
   Google Scholar
• Chaston R, Sabatini R, Koertge TE, Brooks CN, Schenkein HA. Serum anticardiolipin concentrations in chronic periodontitis patients following scaling and root planing. J. Periodontol. (2013) (In Press).
   Google Scholar
• Schenkein HA, Berry CR, Burmeister JA, Brooks CN, Best AM, Tew JG. Locally produced anti-phosphorylcholine and anti-oxidized low-density lipoprotein antibodies in gingival crevicular fluid from aggressive periodontitis patients. J. Periodontol. 75(1), 146–153 (2004).
   Google Scholar
• Schenkein HA, Berry CR, Purkall D, Burmeister JA, Brooks CN, Tew JG. Phosphorylcholine-dependent cross-reactivity between dental plaque bacteria and oxidized low-density lipoproteins. Infect. Immun. 69(11), 6612–6617 (2001).
   Google Scholar
• Turunen SP, Kummu O, Harila K et al. Recognition of Porphyromonas gingivalisgingipain epitopes by natural IgM binding to malondialdehyde modified low-density lipoprotein. PLoS One 7(4), e34910 (2012).
   Google Scholar
• Taylor BA, Tofler GH, Carey HM et al. Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk. J. Dent. Res. 85(1), 74–78 (2006).
   Google Scholar
• Papapanagiotou D, Nicu EA, Bizzarro S et al. Periodontitis is associated with platelet activation. Atherosclerosis 202(2), 605–611 (2009).
   Google Scholar
• Rezavandi K, Palmer RM, Odell EW, Scott DA, Wilson RF. Expression of ICAM-1 and E-selectin in gingival tissues of smokers and non-smokers with periodontitis. J. Oral. Pathol. Med. 31(1), 59–64 (2002).
   Google Scholar
• Pischon N, Hagewald S, Kunze M et al. Influence of periodontal therapy on the regulation of soluble cell adhesion molecule expression in aggressive periodontitis patients. J. Periodontol. 78(4), 683–690 (2007).
   Google Scholar
• Bretz WA, Weyant RJ, Corby PM et al. Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population. J. Am. Geriatr. Soc. 53(9), 1532–1537 (2005).
   Google Scholar
• Bizzarro S, Van Der Velden U, Ten Heggeler JM et al. Periodontitis is characterized by elevated PAI-1 activity. J. Clin. Periodontol. 34(7), 574–580 (2007).
   Google Scholar
• Ying Ouyang X, Mei Xiao W, Chu Y, Ying Zhou S. Influence of periodontal intervention therapy on risk of cardiovascular disease. Periodontol. 2000 56(1), 227–257 (2011).
   Google Scholar
• Ioannidou E, Malekzadeh T, Dongari-Bagtzoglou A. Effect of periodontal treatment on serum C-reactive protein levels: a systematic review and meta-analysis. J. Periodontol. 77(10), 1635–1642 (2006).
   Google Scholar
• Freitas CO, Gomes-Filho IS, Naves RC et al. Influence of periodontal therapy on C-reactive protein level: a systematic review and meta-analysis. J. Appl. Oral. Sci. 20(1), 1–8 (2012).
   Google Scholar
• Hussain Bokhari SA, Khan AA, Tatakis DN, Azhar M, Hanif M, Izhar M. Non-surgical periodontal therapy lowers serum inflammatory markers: a pilot study. J. Periodontol. 80(10), 1574–1580 (2009).
   Google Scholar
• Graziani F, Cei S, Tonetti M et al. Systemic inflammation following non-surgical and surgical periodontal therapy. J. Clin. Periodontol. 37(9), 848–854 (2010).
   Google Scholar
• Amar S, Gokce N, Morgan S, Loukideli M, Van Dyke TE, Vita JA. Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler. Thromb. Vasc. Biol. 23(7), 1245–1249 (2003).
   Google Scholar
• Elter JR, Hinderliter AL, Offenbacher S et al. The effects of periodontal therapy on vascular endothelial function: a pilot trial. Am. Heart J. 151(1), 47 (2006).
   Google Scholar
• Tonetti MS, D’aiuto F, Nibali L et al. Treatment of periodontitis and endothelial function. N. Engl. J. Med. 356(9), 911–920 (2007).
   Google Scholar
• Lalla E, Kaplan S, Yang J, Roth GA, Papapanou PN, Greenberg S. Effects of periodontal therapy on serum C-reactive protein, sE-selectin, and tumor necrosis factoralpha secretion by peripheral blood-derived macrophages in diabetes. A pilot study. J. Periodontal. Res. 42(3), 274–282 (2007).
   Google Scholar
• Rastogi P, Singhal R, Sethi A, Agarwal A, Singh VK, Sethi R. Assessment of the effect of periodontal treatment in patients with coronary artery disease: a pilot survey. J. Cardiovasc. Dis. Res. 3(2), 124–127 (2012).
   Google Scholar
• Marcaccini AM, Meschiari CA, Sorgi CA et al. Circulating interleukin-6 and high-sensitivity C-reactive protein decrease after periodontal therapy in otherwise healthy subjects. J. Periodontol. 80(4), 594–602 (2009).
   Google Scholar
• Marcaccini AM, Meschiari CA, Zuardi LR et al. Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy. J. Clin. Periodontol. 37(2), 180–190 (2010).
   Google Scholar
• Sun WL, Chen LL, Zhang SZ, Wu YM, Ren YZ, Qin GM. Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with Type 2 diabetes and chronic periodontitis. Intern Med 50(15), 1569–1574 (2011).
   Google Scholar
• Su H, Gornitsky M, Velly AM, Yu H, Benarroch M, Schipper HM. Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease. Free Radic. Biol. Med. 46(7), 914–921 (2009).
   Google Scholar
• Montebugnoli L, Servidio D, Miaton RA et al. Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease. J. Clin. Periodontol. 32(2), 188–192 (2005).
   Google Scholar
• Taylor B, Tofler G, Morel-Kopp MC et al. The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial. Eur. J. Oral Sci. 118(4), 350–356 (2010).
   Google Scholar
• D’aiuto F, Orlandi M, Gunsolley JC. Evidence that periodontal treatment improves biomarkers and CVD outcomes. J. Clin. Periodontol. 40(Suppl. 14), S85–S105 (2013).
   Google Scholar
• Mesa F, Munoz R, Godoy C, O’Valle F. Periodontitis and atherosclerosis, a causal relationship? Anti-Inflamm. Anti-Allerg. Agents Med. Chem. 7(3), 199–205 (2008).
   Google Scholar
• Ebersole JL, Cappelli D, Mott G, Kesavalu L, Holt SC, Singer RE. Systemic manifestations of periodontitis in the non-human primate. J. Periodontal. Res. 34(7), 358–362 (1999).
   Google Scholar
• Fentoglu O, Bozkurt FY. The bi-directional relationship between periodontal disease and hyperlipidemia. Eur. J. Dent. 2(2), 142–146 (2008).
   Google Scholar
• Losche W, Karapetow F, Pohl A, Pohl C, Kocher T. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J. Clin. Periodontol. 27(8), 537–541 (2000).
   Google Scholar
• Katz J, Flugelman MY, Goldberg A, Heft M. Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J. Periodontol. 73(5), 494–500 (2002).
   Google Scholar
• Nibali L, D’aiuto F, Griffiths G, Patel K, Suvan J, Tonetti MS. Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case–control study. J. Clin. Periodontol. 34(11), 931–937 (2007).
   Google Scholar
• Fentoglu O, Oz G, Tasdelen P, Uskun E, Aykac Y, Bozkurt FY. Periodontal status in subjects with hyperlipidemia. J. Periodontol. 80(2), 267–273 (2009).
   Google Scholar
• Rufail ML, Schenkein HA, Koertge TE et al. Atherogenic lipoprotein parameters in patients with aggressive periodontitis. J. Periodontal. Res. 42(6), 495–502 (2007).
   Google Scholar
• Machado AC, Quirino MR, Nascimento LF. Relation between chronic periodontal disease and plasmatic levels of triglycerides, total cholesterol and fractions. Braz. Oral Res. 19(4), 284–289 (2005).
   Google Scholar
• Korhonen S, Saxlin T, Suominen L, Jula A, Knuuttila M, Ylostalo P. Serum cholesterol ratios and periodontal infection: results of the Health 2000 Survey. J. Clin. Periodontol. 38(9), 787–794 (2011).
   Google Scholar
• Almeida Abdo J, Cirano FR, Casati MZ et al. Influence of dyslipidemia and diabetes mellitus on chronic periodontal disease. J. Periodontol. 84(10), 1401–1408 (2013).
   Google Scholar
• Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J. Clin. Periodontol. 40(Suppl. 14), S51–S69 (2013).
   Google Scholar
• Superko HR, Berneis KK, Williams PT, Rizzo M, Wood PD. Gemfibrozil reduces small low-density lipoprotein more in normolipemic subjects classified as low-density lipoprotein pattern B compared with pattern A. Am. J. Cardiol. 96(9), 1266–1272 (2005).
   Google Scholar
• Rizzo M, Berneis K. The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates. Curr. Med. Res. Opin. 23(5), 1103–1111 (2007).
   Google Scholar
• Iacopino AM, Cutler CW. Pathophysiological relationships between periodontitis and systemic disease: recent concepts involving serum lipids. J. Periodontol. 71(8), 1375–1384 (2000).
   Google Scholar
• Kallio KA, Buhlin K, Jauhiainen M et al. Lipopolysaccharide associates with pro-atherogenic lipoproteins in periodontitis patients. Innate Immun. 14(4), 247–253 (2008).
   Google Scholar
• D’aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS. Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J. Dent. Res. 84(3), 269–273 (2005).
   Google Scholar
• Oz SG, Fentoglu O, Kilicarslan A et al. Beneficial effects of periodontal treatment on metabolic control of hypercholesterolemia. South Med. J. 100(7), 686–691 (2007).
   Google Scholar
• Acharya A, Bhavsar N, Jadav B, Parikh H. Cardioprotective effect of periodontal therapy in metabolic syndrome: a pilot study in Indian subjects. Metab. Syndr. Relat. Disord. 8(4), 335–341 (2010).
   Google Scholar
• Higashi Y, Goto C, Jitsuiki D et al. Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients. Hypertension 51(2), 446–453 (2008).
   Google Scholar
• Kamil W, Al Habashneh R, Khader Y, Al Bayati L, Taani D. Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis. J. Periodontal. Res. 46(5), 616–621 (2011).
   Google Scholar
• Kallio KA, Hyvarinen K, Kovanen PT, Jauhiainen M, Pussinen PJ. Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function. Metabolism 62(5), 661–668 (2013). • Recent article that indicates that periodontitis may provide very low-density lipoprotein particle proatherogenic properties.
   Google Scholar
• Tang K, Lin M, Wu Y, Yan F. Alterations of serum lipid and inflammatory cytokine profiles in patients with coronary heart disease and chronic periodontitis: a pilot study. J. Int. Med. Res. 39(1), 238–248 (2011).
   Google Scholar
• Wiesner P, Choi SH, Almazan F et al. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ. Res. 107(1), 56–65 (2010).
   Google Scholar
• Griffiths R, Barbour S. Lipoproteins and lipoprotein metabolism in periodontal disease. Clin. Lipidol. 5(3), 397–411 (2010). •• Systematic review that suggests that periodontitis shifts the lipoprotein profile to be more proatherogenic.
   Google Scholar
• Miyakawa H, Honma K, Qi M, Kuramitsu HK. Interaction of Porphyromonas gingivalis with low-density lipoproteins: implications for a role for periodontitis in atherosclerosis. J. Periodontal. Res. 39(1), 1–9 (2004).
   Google Scholar
• Rufail ML, Schenkein HA, Barbour SE, Tew JG, Van Antwerpen R. Altered lipoprotein subclass distribution and PAF-AH activity in subjects with generalized aggressive periodontitis. J. Lipid. Res. 46(12), 2752–2760 (2005).
   Google Scholar
• Passoja A, Knuuttila M, Hiltunen L et al. Serum high-density lipoprotein cholesterol level associated with the extent of periodontal inflammation in Type 1 diabetic subjects. J. Clin. Periodontol. 38(12), 1071–1077 (2011).
   Google Scholar
• Andrukhov O, Haririan H, Bertl K et al. Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect. J. Clin. Periodontol. 40(10), 916–923 (2013).
   Google Scholar
• Yu ZR, Liu LS, Luan QX et al. Correlation between periodontitis and metabolic syndrome of the middle-aged and aged population in Shijingshan community of Beijing. Beijing Da Xue Xue Bao 44(4), 633–638 (2012).
   Google Scholar
• Wick PA, Mombelli A, Pagano S et al. Anti-apolipoprotein A-1 autoantibodies as biomarker for atherosclerosis burden in patients with periodontitis. J. Periodontal. Res. 48(3), 350–356 (2013).
   Google Scholar
• Suzuki K, Sakiyama Y, Usui M et al. Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. J. Periodontal. Res. 45(4), 488–495 (2010).
   Google Scholar
• Miyazawa H, Honda T, Miyauchi S et al. Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration. Clin Chim Acta 413(1-2), 154–159 (2012).
   Google Scholar
• Banach M, Rizzo M, Obradovic M et al. PCSK9 inhibition – a novel mechanism to treat lipid disorders? Curr. Pharm. Des. 19(21), 3869–3877 (2013).
   Google Scholar
• Craig RG, Yip JK, So MK, Boylan RJ, Socransky SS, Haffajee AD. Relationship of destructive periodontal disease to the acute-phase response. J. Periodontol. 74(7), 1007–1016 (2003).
   Google Scholar
• Rizzo M, Kotur-Stevuljevic J, Berneis K et al. Atherogenic dyslipidemia and oxidative stress: a new look. Transl. Res. 153(5), 217–223 (2009).
   Google Scholar
• Losche W, Marshal GJ, Apatzidou DA, Krause S, Kocher T, Kinane DF. Lipoprotein-associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease. J. Clin. Periodontol. 32(6), 640–644 (2005).
   Google Scholar
• Oorni K, Kovanen PT. Proteolysis of low density lipoprotein particles by Porphyromonas gingivalis microorganisms: a novel biochemical link between periodontitis and cardiovascular diseases? J Intern Med 263(5), 553–557 (2008).
   Google Scholar
• Nagahama Y, Obama T, Usui M et al. Oxidized low-density lipoprotein-induced periodontal inflammation is associated with the up-regulation of cyclooxygenase-2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells. Biochem. Biophys. Res. Commun. 413(4), 566–571 (2011).
   Google Scholar
• Sakiyama Y, Kato R, Inoue S, Suzuki K, Itabe H, Yamamoto M. Detection of oxidized low-density lipoproteins in gingival crevicular fluid from dental patients. J. Periodontal. Res. 45(2), 216–222 (2010).
   Google Scholar
• Kikuchi T, El Shikh MM, El Sayed RM et al. Antiphosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells. J. Periodontal. Res. 45(6), 720–730 (2010).
   Google Scholar
• Khera AV, Cuchel M, De La Llera-Moya M et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N. Engl. J. Med. 364(2), 127–135 (2011).
   Google Scholar
• Blasco-Baque V, Serino M, Vergnes JN et al. High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens. PLoS ONE 7(11), e48220 (2012).
   Google Scholar
• Fentoglu O, Kirzioglu FY, Ozdem M, Kocak H, Sutcu R, Sert T. Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment. Oral Dis. 18(3), 299–306 (2012).
   Google Scholar
• Kiran M, Arpak N, Unsal E, Erdogan MF. The effect of improved periodontal health on metabolic control in Type 2 diabetes mellitus. J. Clin. Periodontol. 32(3), 266–272 (2005).
   Google Scholar
• Fentoglu O, Sozen T, Oz SG et al. Short-term effects of periodontal therapy as an adjunct to anti-lipemic treatment. Oral Dis. 16(7), 648–654 (2010). • Interesting article suggesting that improved periodontal health may influence metabolic control of hyperlipidemia.
   Google Scholar