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Editorials

Will new statin guidelines lead to overtreatment?

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Pages 125-128 | Published online: 18 Jan 2017

References

  • National Cholesterol Education Program Expert Panel. Report on detection, evaluation, and treatment of high blood cholesterol in adults. Arch. Intern. Med. 148, 36–69 (1988).
  • Smith GD, Pekkanen J. Should there be a moratorium on the use of cholesterol lowering drugs? BMJ 304(6824), 431–434 (1992).
  • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285(19), 2486–2497 (2001).
  • Ebrahim S, Casas JP. Statins for all by the age of 50 years? Lancet 380(9841), 545–547 (2012).
  • Herper M. As statins soar, use of other cholesterol medicines declines. Forbes (2013). www.forbes.com/sites/matthewherper/2013/05/29/as-statins-soar-use-of-other-cholesterol-medicines-declines/
  • King S. The best selling drugs of all time; Humira joins the elite. Forbes (2013). www.forbes.com/sites/simonking/2013/01/28/the-bestselling-drugs-of-all-time-humira-joins-the-elite
  • Associated Press. It took a brilliant marketing campaign to create the best-selling drug of all time. Business Insider, 28th December (2011).
  • Stone NJ, Robinson J, Lichtenstein AH et al. 2013 ACC/ AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: a Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. doi:10.1016/j.jacc.2013.11.002 (2013) (Epub ahead of print).
  • Krumholz HM. Target cardiovascular risk rather than cholesterol concentration. BMJ 347, f7110 (2013).
  • Khanna R. 7.5% – what a curious number. JAMA International Medicine Blog, 27th November (2013).
  • Ridker PM, Cook NR. Statins: new American guidelines for prevention of cardiovascular disease. Lancet 382, 1762–1765 (2013).
  • Downs J, Good C. New cholesterol guidelines: has Godot finally arrived? Ann. Intern. Med. doi:10.7326/M13-2850 (2014) (Epub ahead of print).
  • Parker-Pope T. 8 year-olds on statins? A new plan quickly bites back. New York Times, 8th July (2008).
  • Ridker PM, Danielson E, Fonseca FA et al.; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 359(21), 2195–2207 (2008).
  • Kaul S, Morrissey RP, Diamond GA. By Jove! What is a clinician to make of JUPITER? Arch. Intern. Med. 170(12), 1073–1077 (2010).
  • de Lorgeril M, Salen P, Abramson J et al. Cholesterol lowering, cardiovascular diseases, and the rosuvastatin – JUPITER controversy: a critical reappraisal. Arch. Intern. Med. 170(12), 1032–1036 (2010).
  • Brugts JJ, Yetgin T, Hoeks SE et al. The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. BMJ 338, b2376 (2009).
  • Tonelli M, Lloyd A, Clement F et al.; Alberta Kidney Disease Network. Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis. CMAJ 183(16), E1189–E1202 (2011).
  • Taylor F, Huffman MD, Macedo AF et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst. Rev. 1, CD004816 (2013).
  • Thavendiranathan P, Bagai A, Brookhart MA et al. Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomizedcontrolled trials. Arch. Intern. Med. 166(21), 2307–2303 (2006).
  • Ray KK, Seshasai SR, Erqou S et al. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch. Intern. Med. 170(12), 1024–1031 (2010).
  • Therapeutics Initiative. Do statins have a role in primary prevention? An update. Therapeutics Letter 77, 1–2 (2010).
  • Mihaylova B, Emberson J, Blackwell L et al.; Cholesterol Treatment Trialists’ (CTT) Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 380(9841), 581–590 (2012).
  • Abramson JD, Rosenberg HG, Jewell N, Wright JM. Should people at low risk of cardiovascular disease take a statin? BMJ 347, f6123 (2013).
  • The Lancet. Supplementary Appendix. Supplement to: Cholesterol Treatment Trialists’ (CTT) Collaborators. The effects oflowering LDL cholesterol with statin therapy in people at low risk of vascular disease:meta-analysis of individual data from 27 randomised trials. Lancet published online May 17. doi:10.1016/S0140-6736(12)60367-5 (2012). http://download.thelancet.com/mmcs/journals/lancet/PIIS0140673612603675/mmc1.pdf?id=baaMfg8arLLkAezldaauu
  • Newman D. Statin drugs given for 5 years for heart disease prevention (without known heart disease). www.thennt.com/nnt/statins-for-heart-disease-preventionwithout-prior-heart-disease
  • Weymiller AJ, Montori VM, Jones LA et al. Helping patients with Type 2 diabetes mellitus make treatment decisions: statin choice randomized trial. Arch. Intern. Med. 167(10), 1076–1082 (2007).
  • Fernandez G, Spatz ES, Jablecki C et al. Statin myopathy: a common dilemma not reflected in clinical trials. Cleve. Clin. J. Med. 78(6), 393–403 (2011).
  • Carling CL, Kristoffersen DT, Montori VM et al. The effect of alternative summary statistics for communicating risk reduction on decisions about taking statins: a randomized trial. PLoS Med. 6(8), e1000134 (2009).
  • Leape LL, Weissman JS, Schneider EC et al. Adherence to practice guidelines: the role of specialty society guidelines. Am. Heart J. 145(1), 19–26 (2003).
  • Ardery G, Carter BL, Milchak JL et al. Explicit and implicit evaluation of physician adherence to hypertension guidelines. J. Clin. Hypertens. 9(2), 113–119 (2007).
  • McKinlay JB, Link CL, Freund KM et al. Sources of variation in physician adherence with clinical guidelines: results from a factorial experiment. J. Gen. Intern. Med. 22(3), 289–296 (2007).
  • Shaneyfelt TM, Mayo-Smith MF, Rothwangl J. Are guidelines following guidelines? The methodological quality of clinical practice guidelines in the peer-reviewed medical literature. JAMA 281(20), 1900–1905 (1999).
  • Lenzer J, Hoffman JR, Furberg CD et al.; Guideline Panel Review Working Group. Ensuring the integrity of clinical practice guidelines: a tool for protecting patients. BMJ 347, f5535 (2013).
  • Shackelton RJ, Marceau LD, Link CL, McKinlay JB. The intended and unintended consequences of clinical guidelines. J. Eval. Clin. Pract. 15(6), 1035–1042 (2009).
  • Dachs R, Darby-Stewart A, Graber MA. How do clinical practice guidelines go awry? Am. Fam. Physician 86(6), 514–516 (2012).
  • Ransohoff DF, Pignone M, Sox HC. How to decide whether a clinical practice guideline is trustworthy. JAMA 309(2), 139–140 (2013).
  • Grol R, Dalhuijsen J, Thomas S et al. Attributes of clinical guidelines that influence use of guidelines in general practice: observational study. BMJ 317(7162), 858–861 (1998).

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