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Review

Current management of colorectal liver metastases

, , , , &
Pages 163-181 | Published online: 16 May 2014

References

  • Ferlay J , ShinHR, BrayF, FormanD, MathersC, ParkinDM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer127(12), 2893–2917 (2010).
  • Stangl R , Altendorf-HofmannA, CharnleyRM, ScheeleJ. Factors influencing the natural history of colorectal liver metastases. Lancet343(8910), 1405–1410 (1994).
  • Weiss L , GrundmannE, TorhorstJet al. Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J. Pathol.150(3), 195–203 (1986).
  • Felekouras ES , KaparelosDC, PapalambrosE. The history of liver surgery, hepatectomy and haemostasis. Hell. J. Surg.82(5), 280–296 (2010).
  • Bouchahda M , LéviF, AdamR, RougierP. Modern insights into hepatic arterial infusion for liver metastases from colorectal cancer. Eur. J. Cancer47(18), 2681–2690 (2011).
  • Logan RF , PatnickJ, NickersonCet al. Outcomes of the bowel cancer screening programme (BCSP) in england after the first 1 million tests. Gut61(10), 1439–1446 (2012).
  • Anaya DA , BeckerNS, AbrahamNS. Global graying, colorectal cancer and liver metastasis: new implications for surgical management. Crit. Rev. Oncol. Hematol.77(2), 100–108 (2011).
  • Merkel S , BialeckiD, MeyerT, MüllerV, PapadopoulosT, HohenbergerW. Comparison of clinical risk scores predicting prognosis after resection of colorectal liver metastases. J. Surg. Oncol.100(5), 349–357 (2009).
  • Chang GJ , SkibberJM, FeigBW, Rodriguez-BigasM. Are we undertreating rectal cancer in the elderly? An epidemiologic study. Ann. Surg.246(2), 215–221 (2007).
  • Haggar FA , BousheyRP. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin. Colon Rectal Surg.22(4), 191–197 (2009).
  • Poston GJ , FiguerasJ, GiulianteFet al. Urgent need for a new staging system in advanced colorectal cancer. J. Clin. Oncol.26(29), 4828–4833 (2008).
  • Lazorthes F , NavarroF, YchouM, DelperoJR, RougierP. Therapeutic management of hepatic metastases from colorectal cancers. Gastroenterol. Clin. Biol.27, B7 (2003).
  • Van Cutsem E , NordlingerB, AdamRet al. Towards a pan-European consensus on the treatment of patients with colorectal liver metastases. Eur. J. Cancer42(14), 2212–2221 (2006).
  • Fong Y , FortnerJ, SunRL, BrennanMF, BlumgartLH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann. Surg.230(3), 309–318; discussion 318–321 (1999).
  • Nordlinger B , GuiguetM, VaillantJCet al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association française de chirurgie. Cancer77(7), 1254–1262 (1996).
  • Rees M , TekkisPP, WelshFK, O’RourkeT, JohnTG. Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann. Surg.247(1), 125–135 (2008).
  • Zakaria S , DonohueJH, QueFGet al. Hepatic resection for colorectal metastases: value for risk scoring systems? Ann. Surg. 246(2), 183–191 (2007).
  • Gomez D , CameronIC. Prognostic scores for colorectal liver metastasis: clinically important or an academic exercise?HPB (Oxford)12(4), 227–238 (2010).
  • Poston GJ , TaitD, O’ConnellS, BennettA, BerendseS; Guideline Development Group. Diagnosis and management of colorectal cancer: summary of NICE guidance. BMJ343, d6751 (2011).
  • Saini S . Imaging of the hepatobiliary tract. N. Engl. J. Med.336(26), 1889–1997 (1894).
  • Garden OJ . Hepatobiliary and Pancreatic Surgery (5th Edition).Elsevier Saunders, Edinburgh, UK (2013).
  • Huppertz A , BalzerT, BlakeboroughAet al. Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology230(1), 266–275 (2004).
  • Xu LH , CaiSJ, CaiGX, PengWJ. Imaging diagnosis of colorectal liver metastases. World J. Gastroenterol.17(42), 4654–4659 (2011).
  • Scurr ED , CollinsDJ, TempleL, KaranjiaN, LeachMO, KohDM. Appearances of colorectal hepatic metastases at diffusion-weighted MRI compared with histopathology: initial observations. Br. J. Radiol.85(1011), 225–230 (2012).
  • Koh DM , BrownG, RiddellAMet al. Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination. Eur. Radiol.18(5), 903–910 (2008).
  • Wiering B , VogelWV, RuersTJ, OyenWJ. Controversies in the management of colorectal liver metastases: role of PET and PET/CT. Dig. Surg. 25(6), 413–420 (2008).
  • Kochhar R , LiongS, ManoharanP. The role of FDG PET/CT in patients with colorectal cancer metastases. Cancer Biomark.7(4), 235–248.2010.
  • Berger KL , NicholsonSA, DehdashtiF, SiegelBA. FDG PET evaluation of mucinous neoplasms: correlation of FDG uptake with histopathologic features. AJR Am. J. Roentgenol.174(4), 1005–1008 (2000).
  • D’Angelica M , FongY, WeberSet al. The role of staging laparoscopy in hepatobiliary malignancy: prospective analysis of 401 cases. Ann. Surg. Oncol.10(2), 183–189 (2003).
  • Dunne DF , GaughranJ, JonesRPet al. Routine staging laparoscopy has no place in the management of colorectal liver metastases. Eur. J. Surg. Oncol.39(7), 721–725 (2013).
  • Snowden CP , PrentisJ, JacquesBet al. Cardiorespiratory fitness predicts mortality and hospital length of stay after major elective surgery in older people. Ann. Surg.257(6), 999–1004 (2013).
  • Grünhagen D , JonesRP, TreasureT, VasilakisC, PostonGJ. The history of adoption of hepatic resection for metastatic colorectal cancer: 1984–1995. Crit. Rev. Oncol. Hematol.86(3), 222–231 (2013).
  • Minagawa M , MakuuchiM, TorzilliGet al. Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results. Ann. Surg.231(4), 487 (2000).
  • Abdalla EK , AdamR, BilchikAJ, JaeckD, VautheyJN, MahviD. Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann. Surg. Oncol.13(10), 1271–1280 (2006).
  • Malde DJ , KhanA, PrasadKR, ToogoodGJ, LodgeJP. Inferior vena cava resection with hepatectomy: challenging but justified. HPB (Oxford)13(11), 802–810 (2011).
  • Shindoh J , TzengCW, AloiaTAet al. Optimal future liver remnant in patients treated with extensive preoperative chemotherapy for colorectal liver metastases. Ann. Surg. Oncol.20(8), 2493–2500 (2013).
  • Zimmitti G , RosesRE, AndreouAet al. Greater complexity of liver surgery is not associated with an increased incidence of liver-related complications except for bile leak: an experience with 2,628 consecutive resections. J. Gastrointest. Surg.17(1), 57–65 (2013).
  • Guglielmi A , RuzzenenteA, ConciS, ValdegamberiA, IaconoC. How much remnant is enough in liver resection?Dig. Surg.29(1), 6–17 (2012).
  • Roberts KJ , BharathyKG, LodgeJP. Kinetics of liver function tests after a hepatectomy for colorectal liver metastases predict post-operative liver failure as defined by the international study group for liver surgery. HPB (Oxford)15(5), 345–351 (2013).
  • Hanje AJ , PatelT. Preoperative evaluation of patients with liver disease. Nat. Clin. Pract. Gastroenterol. Hepatol.4(5), 266–276 (2007).
  • Yin Z , LiuC, ChenYet al. Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): simultaneous or delayed? Hepatology57(6), 2346–2357 (2013).
  • Mayo SC , PulitanoC, MarquesHet al. Surgical management of patients with synchronous colorectal liver metastasis: a multicenter international analysis. J. Am. Coll. Surg.216(4), 707–716; discussion 716–718 (2013).
  • de Rosa A , GomezD, HossainiSet al. Stage IV colorectal cancer: outcomes following the liver-first approach. J. Surg. Oncol.108(7), 444–449 (2013).
  • Kooby DA , StockmanJ, Ben-PoratLet al. Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases. Ann. Surg.237(6), 860–869; discussion 869–870 (2003).
  • Lesurtel M , SelznerM, PetrowskyH, McCormackL, ClavienPA. How should transection of the liver be performed?: a prospective randomized study in 100 consecutive patients: comparing four different transection strategies. Ann. Surg.242(6), 814–822; discussion 822–823 (2005).
  • Gurusamy KS , PamechaV, SharmaD, DavidsonBR. Techniques for liver parenchymal transection in liver resection. Cochrane Database Syst. Rev.1, CD006880 (2009).
  • van Dam RM , Wong-Lun-HingEM, van BreukelenGJet al. Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II-trial): study protocol for a randomised controlled trial. Trials13, 54 (2012).
  • Nguyen KT , LaurentA, DagherIet al. Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility, and early outcomes. Ann. Surg.250(5), 842–848 (2009).
  • Buell JF , CherquiD, GellerDAet al. The international position on laparoscopic liver surgery: the Louisville statement, 2008. Ann. Surg.250(5), 825–830 (2009).
  • Castaing D , VibertE, RiccaL, AzoulayD, AdamR, GayetB. Oncologic results of laparoscopic versus open hepatectomy for colorectal liver metastases in two specialized centers. Ann. Surg.250(5), 849–855 (2009).
  • Simillis C , ConstantinidesVA, TekkisPPet al. Laparoscopic versus open hepatic resections for benign and malignant neoplasms – a meta-analysis. Surgery141(2), 203–211 (2007).
  • Pathak S , JonesR, TangJMet al. Ablative therapies for colorectal liver metastases: a systematic review. Colorectal Dis.13(9), e252–e265 (2011).
  • Stättner S , JonesRP, YipVSet al. Microwave ablation with or without resection for colorectal liver metastases. Eur. J. Surg. Oncol.39(8), 844–849 (2013).
  • Kingham TP , KarkarAM, D’AngelicaMIet al. Ablation of perivascular hepatic malignant tumors with irreversible electroporation. J. Am. Coll. Surg.215(3), 379–387 (2012).
  • Mulier S , NiY, JamartJ, RuersT, MarchalG, MichelL. Local recurrence after hepatic radiofrequency coagulation: multivariate meta-analysis and review of contributing factors. Ann. Surg.242(2), 158–171 (2005).
  • McCarley JR , SoulenMC. Percutaneous ablation of hepatic tumors. Semin. Intervent. Radiol.27(3), 255–260 (2010).
  • Simon CJ , DupuyDE, Mayo-SmithWW. Microwave ablation: principles and applications. Radiographics25(Suppl. 1), S69–S83 (2005).
  • Wong SL , ManguPB, ChotiMAet al. American Society of Clinical Oncology 2009 clinical evidence review on radiofrequency ablation of hepatic metastases from colorectal cancer. J. Clin. Oncol.28(3), 493–508 (2010).
  • Ruers T , PuntC, Van CoevordenFet al. Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC intergroup Phase II study (EORTC 40004). Ann. Oncol.23(10), 2619–2626 (2012).
  • Evrard S , RivoireM, ArnaudJPet al. Unresectable colorectal cancer liver metastases treated by intraoperative radiofrequency ablation with or without resection. Br. J. Surg.99(4), 558–565 (2012).
  • Abulkhir A , LimongelliP, HealeyAJet al. Preoperative portal vein embolization for major liver resection: a meta-analysis. Ann. Surg.247(1), 49–57 (2008).
  • Covey AM , BrownKT, JarnaginWRet al. Combined portal vein embolization and neoadjuvant chemotherapy as a treatment strategy for resectable hepatic colorectal metastases. Ann. Surg.247(3), 451–455 (2008).
  • Lam VW , SpiroC, LaurenceJMet al. A systematic review of clinical response and survival outcomes of downsizing systemic chemotherapy and rescue liver surgery in patients with initially unresectable colorectal liver metastases. Ann. Surg. Oncol.19(4), 1292–1301 (2012).
  • Schnitzbauer AA , LangSA, GoessmannHet al. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann. Surg.255(3), 405–414 (2012).
  • Li J , GirottiP, KönigsrainerI, LadurnerR, KönigsrainerA, NadalinS. ALPPS in right trisectionectomy: a safe procedure to avoid postoperative liver failure? J. Gastrointest. Surg.17(5), 956–961 (2013).
  • Azoulay D , AndreaniP, MaggiU. Combined liver resection and reconstruction of the supra-renal vena cava: the Paul Brousse experience. Ann. Surg.244(1), 80–88 (2006).
  • Hemming AW , ReedAI, LanghamMRJr, FujitaS, HowardRJ. Combined resection of the liver and inferior vena cava for hepatic malignancy. Ann. Surg.239(5), 712–719; discussion 719–721 (2004).
  • Kondo S , HiranoS, AmboY, TanakaE, KubotaT, KatohH. Arterioportal shunting as an alternative to microvascular reconstruction after hepatic artery resection. Br. J. Surg.91(2), 248–251 (2004).
  • Lodge JP , AmmoriBJ, PrasadKR, BellamyMC. Ex vivo and in situ resection of inferior vena cava with hepatectomy for colorectal metastases. Ann. Surg.231(4), 471–479 (2000).
  • Nordlinger B , QuilichiniMA, ParcR, HannounL, DelvaE, HuguetC. Hepatic resection for colorectal liver metastases. Influence on survival of preoperative factors and surgery for recurrences in 80 patients. Ann. Surg.205(3), 256–263 (1987).
  • Bhangui P , AdamR. Liver resection of colorectal metastases in elderly patients. Ann. Surg.252(5), 774–787 (2010).
  • Kulik U , BektasH, KlempnauerJ, LehnerF. Repeat liver resection for colorectal metastases. Br. J. Surg.100(7), 926–932 (2013).
  • Jarnagin WR , GonenM, FongYet al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann. Surg.236(4), 397–406; discussion 406–407 (2002).
  • Dindo D , DemartinesN, ClavienPA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann. Surg.240(2), 205–213 (2004).
  • Reddy SK , BarbasAS, TurleyRSet al. A standard definition of major hepatectomy: resection of four or more liver segments. HPB (Oxford)13(7), 494–502 (2011).
  • Cannon RM , MartinRC, CallenderGG, McMastersKM, ScogginsCR. Safety and efficacy of hepatectomy for colorectal metastases in the elderly. J. Surg. Oncol.104(7), 804–808 (2011).
  • Tomlinson JS , JarnaginWR, DeMatteoRPet al. Actual 10-year survival after resection of colorectal liver metastases defines cure. J. Clin. Oncol.25(29), 4575–4580 (2007).
  • Lordan JT , KaranjiaND, QuineyN, FawcettWJ, WorthingtonTR. A 10-year study of outcome following hepatic resection for colorectal liver metastases – the effect of evaluation in a multidisciplinary team setting. Eur. J. Surg. Oncol.35(3), 302–306 (2009).
  • Adamina M , KehletH, TomlinsonGA, SenagoreAJ, DelaneyCP. Enhanced recovery pathways optimize health outcomes and resource utilization: a meta-analysis of randomized controlled trials in colorectal surgery. Surgery149(6), 830–840 (2011).
  • Connor S , CrossA, SakowskaM, LinscottD, WoodsJ. Effects of introducing an enhanced recovery after surgery programme for patients undergoing open hepatic resection. HPB (Oxford)15(4), 294–301 (2013).
  • Schultz NA , LarsenPN, KlarskovBet al. Evaluation of a fast-track programme for patients undergoing liver resection. Br. J. Surg.100(1), 138–143 (2013).
  • Jones C , KelliherL, DickinsonMet al. Randomized clinical trial on enhanced recovery versus standard care following open liver resection. Br. J. Surg.100(8), 1015–1024 (2013).
  • Kopetz S , ChangGJ, OvermanMJet al. Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J. Clin. Oncol.27(22), 3677–3683 (2009).
  • Konopke R , RothJ, VolkAet al. Colorectal liver metastases: an update on palliative treatment options. J. Gastrointest. Liver Dis.21(1), 83–91 (2012).
  • Giacchetti S , BjarnasonG, GarufiCet al. Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Cancer Chronotherapy Group. J. Clin. Oncol.24(22), 3562–3569 (2006).
  • Saltz LB , CoxJV, BlankeCet al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N. Engl. J. Med.343(13), 905–914 (2000).
  • Jones RP , MalikHZ, FenwickSW, PostonGJ. Perioperative chemotherapy for resectable colorectal liver metastases: where now? Eur. J. Surg. Oncol.39(8), 807–811 (2013).
  • Saltz LB , ClarkeS, Díaz-RubioEet al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized Phase III study. J. Clin. Oncol.26(12), 2013–2019 (2008).
  • Hurwitz H , FehrenbacherL, NovotnyWet al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med.350(23), 2335–2342 (2004).
  • Van Cutsem E , KöhneC-H, HitreEet al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med.360(14), 1408–1417 (2009).
  • Vakiani E , JanakiramanM, ShenRet al. Comparative genomic analysis of primary versus metastatic colorectal carcinomas. J. Clin. Oncol.30(24), 2956–2962 (2012).
  • De Roock W , ClaesB, BernasconiDet al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol.11(8), 753–762 (2010).
  • Bokemeyer C , BondarenkoI, MakhsonAet al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol.27(5), 663–671 (2009).
  • Heinemann V , von WeikersthalLF, DeckerTet al. Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS wild-type metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3). J. Clin. Oncol.31(Suppl.), Abstract LBA3506 (2013).
  • Jones RP , DunneD, SuttonPet al. Segmental and lobar administration of drug-eluting beads delivering irinotecan leads to tumour destruction: a case–control series. HPB (Oxford)15(1), 71–77 (2013).
  • Mitry E , FieldsAL, BleibergHet al. Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: a pooled analysis of two randomized trials. J. Clin. Oncol.26(30), 4906–4911 (2008).
  • Morris EJ , FormanD, ThomasJDet al. Surgical management and outcomes of colorectal cancer liver metastases. Br. J. Surg.97(7), 1110–1118 (2010).
  • Ychou M , HohenbergerW, ThezenasSet al. A randomized Phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer. Ann. Oncol.20(12), 1964–1970 (2009).
  • Adam R , DelvartV, PascalGet al. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann. Surg.240(4), 644–657; discussion 657–658 (2004).
  • Adam R , BhanguiP, PostonGet al. Is perioperative chemotherapy useful for solitary, metachronous, colorectal liver metastases? Ann. Surg.252(5), 774–787 (2010).
  • Nordlinger B , SorbyeH, GlimeliusBet al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC intergroup trial 40983): a randomised controlled trial. Lancet371(9617), 1007–1016 (2008).
  • Nordlinger B , Van CutsemE, GruenbergerTet al. Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel. Ann. Oncol.20(6), 985–992 (2009).
  • Nordlinger B , SorbyeH, GlimeliusBet al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, Phase 3 trial. Lancet Oncol.14(12), 1208–1215 (2013).
  • Poston G , AdamR, VautheyJN. Downstaging or downsizing: time for a new staging system in advanced colorectal cancer?J. Clin. Oncol.24(18), 2702–2706 (2006).
  • Bismuth H , AdamR, LéviFet al. Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann. Surg.224(4), 509–520; discussion 520–522 (1996).
  • Poston GJ . Staging of advanced colorectal cancer. Surg. Oncol. Clin. North Am.17(3), 503–517 (2008).
  • Adam R , AvisarE, AricheAet al. Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal [liver] metastases. Ann. Surg. Oncol.8, 347–353 (2001).
  • Folprecht G , GrotheyA, AlbertsS, RaabHR, KöhneCH. Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates. Ann. Oncol.16(8), 1311–1319 (2005).
  • Nordlinger B , Van CutsemE, RougierPet al. Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group. Eur. J. Cancer43(14), 2037–2045 (2007).
  • Tournigand C , AndréT, AchilleEet al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J. Clin. Oncol.22(2), 229–237 (2004).
  • Colucci G , GebbiaV, PaolettiGet al. Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell’Italia Meridionale. J. Clin. Oncol.23(22), 4866–4875 (2005).
  • Falcone A , RicciS, BrunettiIet al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J. Clin. Oncol.25(13), 1670–1676 (2007).
  • Van Cutsem E , KöhneCH, LángIet al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J. Clin. Oncol.29(15), 2011–2019 (2011).
  • Bokemeyer C , BondarenkoI, HartmannJTet al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann. Oncol.22(7), 1535–1546 (2011).
  • Folprecht G , GruenbergerT, BechsteinWOet al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised Phase 2 trial. Lancet Oncol.11(1), 38–47 (2010).
  • Garufi C , TorselloA, TumoloSet al. Cetuximab plus chronomodulated irinotecan, 5-fluorouracil, leucovorin and oxaliplatin as neoadjuvant chemotherapy in colorectal liver metastases: POCHER trial. Br. J. Cancer103(10), 1542–1547 (2010).
  • Van Cutsem E , RiveraF, BerrySet al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann. Oncol.20(11), 1842–1847 (2009).
  • Masi G , LoupakisF, SalvatoreLet al. Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil, and folinate) as first-line treatment for metastatic colorectal cancer: a Phase 2 trial. Lancet Oncol.11(9), 845–852 (2010).
  • Loupakis F , CremoliniC, MasiGet al. FOLFOXIRI plus bevacizumab (bev) versus FOLFIRI plus bev as first-line treatment of metastatic colorectal cancer (MCRC): results of the Phase III randomized TRIBE trial. J. Clin. Oncol.30, (Suppl. 34), Abstract 336 (2012).
  • Fuchs CS , MarshallJ, MitchellEet al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C study. J. Clin. Oncol.25(30), 4779–4786 (2007).
  • Kneuertz PJ , MaithelSK, StaleyCA, KoobyDA. Chemotherapy-associated liver injury: Impact on surgical management of colorectal cancer liver metastases. Ann. Surg. Oncol.18(1), 181–190 (2011).
  • Welsh FK , TilneyHS, TekkisPP, JohnTG, ReesM. Safe liver resection following chemotherapy for colorectal metastases is a matter of timing. Br. J. Cancer96(7), 1037–1042 (2007).
  • Vauthey JN , PawlikTM, RiberoDet al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J. Clin. Oncol.24(13), 2065–2072 (2006).
  • Auer RC , WhiteRR, KemenyNEet al. Predictors of a true complete response among disappearing liver metastases from colorectal cancer after chemotherapy. Cancer116(6), 1502–1509 (2010).
  • Mocellin S , PilatiP, LiseM, NittiD. Meta-analysis of hepatic arterial infusion for unresectable liver metastases from colorectal cancer: the end of an era? J. Clin. Oncol.25(35), 5649–5654 (2007).
  • Kemeny N , HuangY, CohenAMet al. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N. Engl. J. Med.341(27), 2039–2048 (1999).
  • Allen PJ , NissanA, PiconAIet al. Technical complications and durability of hepatic artery infusion pumps for unresectable colorectal liver metastases: an institutional experience of 544 consecutive cases. J. Am. Coll. Surg.201(1), 57–65 (2005).
  • Martin RC , JoshiJ, RobbinsK, TomaltyD, O’HaraR, TatumC. Transarterial chemoembolization of metastatic colorectal carcinoma with drug-eluting beads, irinotecan (DEBIRI): multi-Institutional registry. J. Oncol., 539795 (2009).
  • Richardson AJ , LaurenceJM, LamVW. Transarterial chemoembolization with irinotecan beads in the treatment of colorectal liver metastases: systematic review. J. Vasc. Interv. Radiol.24(8), 1209–1217 (2013).
  • Fiorentini G , AlibertiC, TilliMet al. Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a Phase III study. Anticancer Res.32(4), 1387–1395 (2012).
  • Martin RC , ScogginsCR, TomaltyDet al. Irinotecan drug-eluting beads in the treatment of chemo-naive unresectable colorectal liver metastasis with concomitant systemic fluorouracil and oxaliplatin: results of pharmacokinetics and Phase I trial. J. Gastrointest. Surg.16(8), 1531–1538 (2012).
  • Van Hazel G , BlackwellA, AndersonJet al. Randomised Phase 2 trial of sir-spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer. J. Surg. Oncol.88(2), 78–85 (2004).
  • Sharma RA , WasanHS, LoveSB, DuttonS, StokesJC, SmithJL. FOXFIRE: a Phase III clinical trial of chemo-radio-embolisation as first-line treatment of liver metastases in patients with colorectal cancer. Clin. Oncol.20(3), 261–263 (2008).
  • Segelman J , SingnomklaoT, HellborgH, MartlingA. Differences in multidisciplinary team assessment and treatment between patients with stage IV colon and rectal cancer. Colorectal Dis.11(7), 768–774 (2009).
  • Jones RP , VautheyJN, AdamRet al. Effect of specialist decision-making on treatment strategies for colorectal liver metastases. Br. J. Surg.99(9), 1263–1269 (2012).

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